LOCUS       NM_009513               2154 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus neurensin 1 (Nrsn1), transcript variant 1, mRNA.
ACCESSION   NM_009513 XM_001005619
VERSION     NM_009513.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2154)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2154)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2154)
  AUTHORS   Cho,J., Yu,N.K., Choi,J.H., Sim,S.E., Kang,S.J., Kwak,C., Lee,S.W.,
            Kim,J.I., Choi,D.I., Kim,V.N. and Kaang,B.K.
  TITLE     Multiple repressive mechanisms in the hippocampus during memory
            formation
  JOURNAL   Science 350 (6256), 82-87 (2015)
   PUBMED   26430118
  REMARK    GeneRIF: In behavioral analyses, overexpressing Nrsn1, one of the
            newly identified genes undergoing rapid translational repression,
            or activating ESR1 in the hippocampus impaired memory formation.
REFERENCE   4  (bases 1 to 2154)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2154)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   6  (bases 1 to 2154)
  AUTHORS   Suzuki,H., Tohyama,K., Nagata,K., Taketani,S. and Araki,M.
  TITLE     Regulatory expression of Neurensin-1 in the spinal motor neurons
            after mouse sciatic nerve injury
  JOURNAL   Neurosci Lett 421 (2), 152-157 (2007)
   PUBMED   17566649
  REMARK    GeneRIF: The results of this study indicate that Nrsn1 plays an
            active role in axonal regeneration as well as in embryonic
            development.
REFERENCE   7  (bases 1 to 2154)
  AUTHORS   Nagata,K., Suzuki,H., Niiya-Kato,A., Kinoshita,S., Taketani,S. and
            Araki,M.
  TITLE     Neurensin-1 expression in the mouse retina during postnatal
            development and in the cultured retinal neurons
  JOURNAL   Brain Res 1081 (1), 65-71 (2006)
   PUBMED   16696124
  REMARK    GeneRIF: Neurensin-1 plays a role in the fiber extension of the
            retinal neurons, and indicate that the developing retina is a
            suitable experimental model for the analysis of Neurensin function,
            both in vivo and in vitro.
REFERENCE   8  (bases 1 to 2154)
  AUTHORS   Nakanishi,K., Ida,M., Suzuki,H., Kitano,C., Yamamoto,A., Mori,N.,
            Araki,M. and Taketani,S.
  TITLE     Molecular characterization of a transport vesicle protein
            Neurensin-2, a homologue of Neurensin-1, expressed in neural cells
  JOURNAL   Brain Res 1081 (1), 1-8 (2006)
   PUBMED   16527258
  REMARK    GeneRIF: Neurensin-2 was expressed in small vesicles including
            lysosomes in the perinuclear region. And was found in cell bodies.
REFERENCE   9  (bases 1 to 2154)
  AUTHORS   Araki,M., Nagata,K., Satoh,Y., Kadota,Y., Hisha,H., Adachi,Y. and
            Taketani,S.
  TITLE     Developmentally regulated expression of Neuro-p24 and its possible
            function in neurite extension
  JOURNAL   Neurosci Res 44 (4), 379-389 (2002)
   PUBMED   12445626
REFERENCE   10 (bases 1 to 2154)
  AUTHORS   Kadota,Y., Niiya,A., Masaki,R., Yamamoto,A., Araki,M. and
            Taketani,S.
  TITLE     A newly identified membrane protein localized exclusively in
            intracellular organelles of neurons
  JOURNAL   Brain Res Mol Brain Res 46 (1-2), 265-273 (1997)
   PUBMED   9191101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU080650.1 and BC052019.1.
            
            On Apr 2, 2008 this sequence version replaced NM_009513.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160941.1, SRR1660813.269107.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               AU080650.1         87-498
            413-2154            BC052019.1         236-1977
FEATURES             Location/Qualifiers
     source          1..2154
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 11.04 cM"
     gene            1..2154
                     /gene="Nrsn1"
                     /gene_synonym="Neurensin-1; Neuro-p24; Vmp"
                     /note="neurensin 1"
                     /db_xref="GeneID:22360"
                     /db_xref="MGI:MGI:894662"
     exon            1..155
                     /gene="Nrsn1"
                     /gene_synonym="Neurensin-1; Neuro-p24; Vmp"
                     /inference="alignment:Splign:2.1.0"
     exon            156..224
                     /gene="Nrsn1"
                     /gene_synonym="Neurensin-1; Neuro-p24; Vmp"
                     /inference="alignment:Splign:2.1.0"
     exon            225..424
                     /gene="Nrsn1"
                     /gene_synonym="Neurensin-1; Neuro-p24; Vmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..823
                     /gene="Nrsn1"
                     /gene_synonym="Neurensin-1; Neuro-p24; Vmp"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vesicular membrane protein p24; vesicular membrane protein
                     of 24 kDa"
                     /codon_start=1
                     /product="neurensin-1 isoform 1"
                     /protein_id="NP_033539.1"
                     /db_xref="CCDS:CCDS26387.1"
                     /db_xref="GeneID:22360"
                     /db_xref="MGI:MGI:894662"
                     /translation="MTSCSNTCGSRRAQADTEGGYQQRYGVRSYLHQFYEDCTASIWE
                     YEDDFQIQRSPNRWSSVFWKVGLISGTVFVILGLTVLAVGFLVPPKIEAFGEADFMVV
                     DTHAVKYNGALDTCKLAGAVLFCIGGTSMAGCLLMSVFAKSYSKEEKFLQQKFKERIA
                     DIKAHTQPITKAPGPGDTKIPVTLSRVQNVQPLSAT"
     exon            425..2137
                     /gene="Nrsn1"
                     /gene_synonym="Neurensin-1; Neuro-p24; Vmp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2115..2120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrsn1"
                     /gene_synonym="Neurensin-1; Neuro-p24; Vmp"
                     /note="hexamer: AATAAA"
     polyA_site      2137
                     /gene="Nrsn1"
                     /gene_synonym="Neurensin-1; Neuro-p24; Vmp"
                     /note="major polyA site"
ORIGIN      
        1 gtcaatcacg tgcagctgag cttggagagg cgggagtggc gacggcggcg gcggcagcgg
       61 cggcggcggc agtggcggcg gtgatgggac cccagcgaga gatctgcagc taggtcggct
      121 gcacttgctc cacgggtcgg ggattggagg gacagagttg aagaatgagc ttctaaaaga
      181 aagaccaaag aataaacagg cagaggacaa ggagaacatt gaagctggga agatgacttc
      241 ttgcagcaac acctgtgggt ccaggcgagc ccaggctgac accgagggtg ggtaccagca
      301 gcgctatgga gttcggtcct acctgcatca gttttatgag gactgcactg cctctatctg
      361 ggagtatgag gatgatttcc agatccagag atcgcctaac aggtggagct cagtattctg
      421 gaaggtcgga ctcatctcag gcactgtctt tgtgattctc ggactaactg tcctggcagt
      481 gggctttctt gtgcccccca aaatcgaagc ttttggcgaa gctgatttca tggtggtgga
      541 cacacatgct gtgaagtaca acggcgccct ggacacatgc aagctggcgg gggctgtgct
      601 cttctgcatc gggggtacat ccatggcagg gtgcctactg atgtctgtgt ttgccaagag
      661 ctattccaaa gaagaaaagt tccttcaaca gaagtttaaa gagcgaatcg cagacattaa
      721 agcccatacc cagcccatca ctaaagctcc aggcccaggg gacaccaaga tccctgtcac
      781 tttgtccaga gttcagaatg tgcagcctct atcagccact tgaaacattt gtcacctcag
      841 gcctcccctc tctgattcac atgcatcctc gttttaaaaa ggtagccagt cagtttttga
      901 gataacatgc atttggcagt gacctatcta tccctagagc tgtgtggggc tggacagggt
      961 gtcatgcaga cttacatgca cttcaggtga cagtggatgt tatgtgtccg ttcgtacctg
     1021 cttctggtgg gttccacaag cccctcttga actagtgtct ctggtgtatc aatgttgtat
     1081 cattttctgt gttacttgaa agcactgagc agagtagacc agcctaccag tcgtcaacgt
     1141 gacccacttc attctctaat aggtttttct gatccctccg tgtggtgctg tcttccatgc
     1201 ctatttctgt gtatgatacc atcatgtgtt cctagaattg cagttccctg attttgatcc
     1261 agatgttaga cttttaactc tatcttagca taaaagtcct aaaagtgagc aggaatttat
     1321 cagtgtcctt tgtaagtcat tttgtttcct ccagatgttg tttcttttca cttaagtaaa
     1381 atcgccagtt ttggaatctt ggtaaaggca gtatcaacaa tgagagtggg agtatacatt
     1441 taggcagcat ctaaaaacag ttaaacactg gaaaacttga gtttctgcca gtacctttgc
     1501 catgtgaaaa aaaaaaatgt tccccagacc tgttttccct cctgtgtaag agggtttcag
     1561 aaccttacct gctcaagtat ccaaatttat tttcctgtgt cactgagtct ctttcctgag
     1621 gatcttgtga tggtttcctg ttggggtatg gtcagaactg gactcctggc acctccaact
     1681 ctgctatttt tcagtattta cccaaaatac ccaaccaagc agattggatg atgccaatgt
     1741 gtttctatag agacgagtat gctattctca aataagaaac cccaaggtgg tgtcaacctt
     1801 aaaaagcatt taaatcgtca aacaggaaaa acggagcccc agatcccttt gttccttgca
     1861 ttttcattta atctgaaaat gtagattagg cagaggagaa gggaaagtct gactctggta
     1921 ttctctcaac tgtgctcctt agagttttgt ctttgtgtgt atacatagtc ttcatctcaa
     1981 cagtaaataa cacatgtgaa tgggcccaac cagaactgca ctgtcatccc tccagtgtag
     2041 ctcttttctc tccaccatgt aattttccat tctgagactg aataagctct gatgtttccc
     2101 tgactaaatg gaagaataaa tgaagcaatt agtggtcaaa aaaaaaaaaa aaaa
//
