LOCUS       NM_001347181            2563 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus negative regulator of reactive oxygen species (Nrros),
            transcript variant 2, mRNA.
ACCESSION   NM_001347181 XM_006522073
VERSION     NM_001347181.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2563)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2563)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2563)
  AUTHORS   Rutkowski,T.P., Purcell,R.H., Pollak,R.M., Grewenow,S.M.,
            Gafford,G.M., Malone,T., Khan,U.A., Schroeder,J.P., Epstein,M.P.,
            Bassell,G.J., Warren,S.T., Weinshenker,D., Caspary,T. and
            Mulle,J.G.
  TITLE     Behavioral changes and growth deficits in a CRISPR engineered mouse
            model of the schizophrenia-associated 3q29 deletion
  JOURNAL   Mol Psychiatry 26 (3), 772-783 (2021)
   PUBMED   30976085
REFERENCE   4  (bases 1 to 2563)
  AUTHORS   Smith,C., McColl,B.W., Patir,A., Barrington,J., Armishaw,J.,
            Clarke,A., Eaton,J., Hobbs,V., Mansour,S., Nolan,M., Rice,G.I.,
            Rodero,M.P., Seabra,L., Uggenti,C., Livingston,J.H., Bridges,L.R.,
            Jeffrey,I.J.M. and Crow,Y.J.
  TITLE     Biallelic mutations in NRROS cause an early onset lethal
            microgliopathy
  JOURNAL   Acta Neuropathol 139 (5), 947-951 (2020)
   PUBMED   32100099
  REMARK    GeneRIF: Biallelic mutations in NRROS cause an early onset lethal
            microgliopathy.
REFERENCE   5  (bases 1 to 2563)
  AUTHORS   Qin,Y., Garrison,B.S., Ma,W., Wang,R., Jiang,A., Li,J., Mistry,M.,
            Bronson,R.T., Santoro,D., Franco,C., Robinton,D.A., Stevens,B.,
            Rossi,D.J., Lu,C. and Springer,T.A.
  TITLE     A Milieu Molecule for TGF-beta Required for Microglia Function in
            the Nervous System
  JOURNAL   Cell 174 (1), 156-171 (2018)
   PUBMED   29909984
REFERENCE   6  (bases 1 to 2563)
  AUTHORS   Su,X., Mei,S., Liang,X., Wang,S., Liu,J., Zhang,Y., Bao,Y.,
            Chen,Y., Che,Y., Chunhua Zhao,R., Zhang,Z. and Yang,R.
  TITLE     Epigenetically modulated LRRC33 acts as a negative physiological
            regulator for multiple Toll-like receptors
  JOURNAL   J Leukoc Biol 96 (1), 17-26 (2014)
   PUBMED   24550525
  REMARK    GeneRIF: results suggest that LRRC33 and TLRs may form a
            negative-feedback loop, which is important for the maintenance of
            immune homeostasis.
REFERENCE   7  (bases 1 to 2563)
  AUTHORS   Noubade,R., Wong,K., Ota,N., Rutz,S., Eidenschenk,C., Valdez,P.A.,
            Ding,J., Peng,I., Sebrell,A., Caplazi,P., DeVoss,J., Soriano,R.H.,
            Sai,T., Lu,R., Modrusan,Z., Hackney,J. and Ouyang,W.
  TITLE     NRROS negatively regulates reactive oxygen species during host
            defence and autoimmunity
  JOURNAL   Nature 509 (7499), 235-239 (2014)
   PUBMED   24739962
  REMARK    GeneRIF: NRROS provides a hitherto undefined mechanism for
            regulating ROS production--one that enables phagocytes to produce
            higher amounts of ROS, if required to control invading pathogens,
            while minimizing unwanted collateral tissue damage
REFERENCE   8  (bases 1 to 2563)
  AUTHORS   Takase,H., Matsumoto,K., Yamadera,R., Kubota,Y., Otsu,A.,
            Suzuki,R., Ishitobi,H., Mochizuki,H., Kojima,T., Takano,S.,
            Uchida,K., Takahashi,S. and Ema,M.
  TITLE     Genome-wide identification of endothelial cell-enriched genes in
            the mouse embryo
  JOURNAL   Blood 120 (4), 914-923 (2012)
   PUBMED   22535667
REFERENCE   9  (bases 1 to 2563)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   10 (bases 1 to 2563)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135962.4 and BG230063.1.
            
            On Nov 17, 2016 this sequence version replaced XM_006522073.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027411.1, AK128897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC135962.4         190945-191159       c
            216-336             AC135962.4         173118-173238       c
            337-2554            AC135962.4         168353-170570       c
            2555-2563           BG230063.1         1-9                 c
FEATURES             Location/Qualifiers
     source          1..2563
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 22.4 cM"
     gene            1..2563
                     /gene="Nrros"
                     /gene_synonym="E430025L02Rik; Lrcc33; Lrrc33"
                     /note="negative regulator of reactive oxygen species"
                     /db_xref="GeneID:224109"
                     /db_xref="MGI:MGI:2445095"
     exon            1..215
                     /gene="Nrros"
                     /gene_synonym="E430025L02Rik; Lrcc33; Lrrc33"
                     /inference="alignment:Splign:2.1.0"
     exon            216..336
                     /gene="Nrros"
                     /gene_synonym="E430025L02Rik; Lrcc33; Lrrc33"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..2310
                     /gene="Nrros"
                     /gene_synonym="E430025L02Rik; Lrcc33; Lrrc33"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; leucine-rich repeat-containing protein 33;
                     leucine rich repeat containing 33; transforming growth
                     factor beta activator LRRC33"
                     /codon_start=1
                     /product="transforming growth factor beta activator LRRC33
                     isoform 2 precursor"
                     /protein_id="NP_001334110.1"
                     /db_xref="CCDS:CCDS84220.1"
                     /db_xref="GeneID:224109"
                     /db_xref="MGI:MGI:2445095"
                     /translation="MEFPPLWLCLGFHFLIVEWRSGPGTATAASQGGCKVVDGVADCR
                     GLNLASVPSSLPPHSRMLILDANPLKDLWNHSLQAYPRLENLSLHSCHLDRISHYAFR
                     EQGHLRNLVLADNRLSENYKESAAALHTLLGLRRLDLSGNSLTEDMAALMLQNLSSLE
                     VVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLP
                     CIVDFSLTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHNQLLFFPLLPQCGKLHT
                     LLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLD
                     MSQNQFRHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELH
                     LAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISLCPQMVPVDWE
                     GPPSCVDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNWGVLNGSISPLWA
                     VAPTLQVLSLRDVGLGSGAAEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLR
                     RNSLTALPQRVVSEQPLRGLQTIYLSQNPYDCCGVEGWGALQQHFKTVADLSMVTCNL
                     SSKIVRVVELPEGLPQGCKWEQVDTGLFYLVLILPSCLTLLVACTVVFLTFKKPLLQV
                     IKSRCHWSSIY"
     exon            337..2557
                     /gene="Nrros"
                     /gene_synonym="E430025L02Rik; Lrcc33; Lrrc33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2520..2525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrros"
                     /gene_synonym="E430025L02Rik; Lrcc33; Lrrc33"
                     /note="hexamer: AATAAA"
     polyA_site      2525
                     /gene="Nrros"
                     /gene_synonym="E430025L02Rik; Lrcc33; Lrrc33"
                     /note="major polyA site"
     regulatory      2536..2541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrros"
                     /gene_synonym="E430025L02Rik; Lrcc33; Lrrc33"
                     /note="hexamer: CATAAA"
     polyA_site      2557
                     /gene="Nrros"
                     /gene_synonym="E430025L02Rik; Lrcc33; Lrrc33"
                     /note="major polyA site"
ORIGIN      
        1 gcggtggcag ttccttctaa gacgcgggct gagtgctgag tcgctgagag gcgagctctc
       61 catgtgactt cagtttccgt tggttccttc cgcaagtgct aaaataatct gatgccccag
      121 agcgagtagg cagcgcagca gcggcaagtg ctgtccagga ggctggggcc ctggagacga
      181 tgcgccccgc ggagccgcct gggcctgcgg gagcaagctg tgcctgagat ggagttcccg
      241 cccctctggc tttgcctggg ttttcacttc ttgattgtgg aatggaggag cggacctggg
      301 acagccactg cagcttccca aggaggctgc aaggtggtcg acggagtcgc tgactgccgg
      361 ggtctgaacc ttgcttcggt acccagcagc ctcccacccc attcccggat gctcattctg
      421 gatgctaacc ctctcaagga cctgtggaac cattccctcc aggcctaccc acgcctggag
      481 aacctcagcc tgcatagctg tcacctggac cgtatcagcc actacgcctt ccgagagcaa
      541 ggccacttac gcaacctggt tctggcagac aaccgcctct cggagaacta caaggagtca
      601 gccgcagcac tccacaccct gctgggactt cggagactgg acttgtctgg aaactccctg
      661 accgaagaca tggcggctct catgcttcag aacctctcct cgttggaggt tgtgtccttg
      721 gcaaggaata ccctcatgag gctcgacgac tctatctttg agggcctgga acaccttgta
      781 gagctagatt tgcagagaaa ctacatcttt gagatcgagg gcggggcgtt tgacggcttg
      841 actgagctga ggcgtctcaa ccttgcctat aacaacctcc cctgcattgt ggacttcagc
      901 ctcacccagt tacggttcct caacgtcagt tataacatcc tagagtggtt cctggcagcc
      961 agggaggagg tggccttcga attggagata ctggacctgt ctcacaacca gctgctcttc
     1021 ttcccactct tgcctcagtg cggcaagctg cacaccctcc tgctccagga caacaacatg
     1081 ggcttctaca gggagcttta caacacctcc tccccgcagg agatggtggc ccagttcctt
     1141 cttgtggacg gcaatgtgac taacatcaca actgtcaacc tctgggagga gttttcctcc
     1201 agcgacctgt cagctcttcg cttcctggac atgagccaaa accagttccg gcacttgccg
     1261 gatggtttcc tgaagaagac accttccctt tcccacctga acctcaacca gaactgcctg
     1321 aagatgctcc acatccggga gcacgagccg ccgggagcac tcaccgagct ggatctgagc
     1381 cacaaccagt tggcagagct gcacctggct ccggggctca cgggctccct caggaacctc
     1441 cgggtgttca acctgagttc caaccagctc ctgggggtcc ccactggcct tttcgacaat
     1501 gccagcagca tcactacaat cgacatgagt cacaatcaga tctcactttg tcctcagatg
     1561 gtgcccgtag actgggaggg gcctcccagt tgtgtggatt tcagaaacat gggctctttg
     1621 aggagccttt ctctggacgg ctgtgggctg aaggcattac aagactgccc gttccagggg
     1681 acctccctca ctcatttaga cctgtctagc aactgggggg ttctgaatgg gagcatcagc
     1741 cctctctggg ctgttgcccc gacattacag gtcctgtctc tcagggacgt gggccttggt
     1801 tctggcgctg cagagatgga cttctctgcg tttgggaatc tgcgggcgtt ggatctgtcg
     1861 ggaaactccc tgaccagctt cccaaagttc aagggcagtt tggcccttcg gactctcgac
     1921 ctccgcagaa actctctcac ggccctccct cagagggttg tgtccgagca gcctctgagg
     1981 ggtctgcaga ccatctacct cagccagaac ccttatgact gctgtggggt ggaaggatgg
     2041 ggggccctgc agcagcactt caagactgtt gcggacttgt ccatggtcac ttgcaacctc
     2101 tcttccaaga tcgtccgtgt ggtggagctg cccgaaggcc tgcctcaggg ctgtaagtgg
     2161 gaacaggtgg acactggtct cttctacctc gtgctcatcc tgcccagctg cctcaccctg
     2221 ctggtggcct gtactgtcgt cttcctcact tttaagaagc ctttgcttca ggtcatcaag
     2281 agccgctgcc actggtcctc catatactga cccgtgtgcc aaggctagag acttggtttt
     2341 tcctcgagga tgcgtctctc cgctggatct ttacttttgc aggggtcgag tgtgatgcat
     2401 tgaaggttaa aactgaaatt tgaaagagtt ccatcctcag tcccattaac ttctcctccc
     2461 atccgtgtga tttatcctca ttgtcctggt gaaatattta ttaaacgaca ttctgtgaga
     2521 ataaagggtg tgcctcataa atattttaaa aatcaaaaaa aaa
//
