LOCUS       NM_001358960            5870 bp    mRNA    linear   ROD 19-SEP-2023
DEFINITION  Mus musculus neuropilin 1 (Nrp1), transcript variant 3, mRNA.
ACCESSION   NM_001358960
VERSION     NM_001358960.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5870)
  AUTHORS   Altounian M, Bellon A and Mann F.
  TITLE     Neuronal miR-17-5p contributes to interhemispheric cortical
            connectivity defects induced by prenatal alcohol exposure
  JOURNAL   Cell Rep 42 (9), 113020 (2023)
   PUBMED   37610874
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 5870)
  AUTHORS   Puelles L and Hidalgo-Sanchez M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5870)
  AUTHORS   Bosseboeuf E, Chikh A, Chaker AB, Mitchell TP, Vignaraja D,
            Rajendrakumar R, Khambata RS, Nightingale TD, Mason JC, Randi AM,
            Ahluwalia A and Raimondi C.
  TITLE     Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize
            adherens junctions and prevent activation of endothelium under flow
  JOURNAL   Sci Signal 16 (786), eabo4863 (2023)
   PUBMED   37220183
  REMARK    GeneRIF: Neuropilin-1 interacts with VE-cadherin and TGFBR2 to
            stabilize adherens junctions and prevent activation of endothelium
            under flow.
REFERENCE   4  (bases 1 to 5870)
  AUTHORS   Tsuchimochi R, Yamagami K, Kubo N, Amimoto N, Raudzus F, Samata B,
            Kikuchi T, Doi D, Yoshimoto K, Mihara A and Takahashi J.
  TITLE     Viral delivery of L1CAM promotes axonal extensions by embryonic
            cerebral grafts in mouse brain
  JOURNAL   Stem Cell Reports 18 (4), 899-914 (2023)
   PUBMED   36963389
REFERENCE   5  (bases 1 to 5870)
  AUTHORS   Benwell CJ, Johnson RT, Taylor JAGE, Price CA and Robinson SD.
  TITLE     Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are
            Essential for Tumor Angiogenesis
  JOURNAL   Cancer Res Commun 2 (12), 1626-1640 (2022)
   PUBMED   36970722
  REMARK    GeneRIF: Endothelial VEGFR Coreceptors Neuropilin-1 and
            Neuropilin-2 Are Essential for Tumor Angiogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5870)
  AUTHORS   Kitsukawa T, Shimizu M, Sanbo M, Hirata T, Taniguchi M, Bekku Y,
            Yagi T and Fujisawa H.
  TITLE     Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a
            crucial role in peripheral nerve projection in mice
  JOURNAL   Neuron 19 (5), 995-1005 (1997)
   PUBMED   9390514
REFERENCE   7  (bases 1 to 5870)
  AUTHORS   Chen H, Chedotal A, He Z, Goodman CS and Tessier-Lavigne M.
  TITLE     Neuropilin-2, a novel member of the neuropilin family, is a high
            affinity receptor for the semaphorins Sema E and Sema IV but not
            Sema III
  JOURNAL   Neuron 19 (3), 547-559 (1997)
   PUBMED   9331348
  REMARK    Erratum:[Neuron 1997 Sep;19(3):559]
REFERENCE   8  (bases 1 to 5870)
  AUTHORS   He Z and Tessier-Lavigne M.
  TITLE     Neuropilin is a receptor for the axonal chemorepellent Semaphorin
            III
  JOURNAL   Cell 90 (4), 739-751 (1997)
   PUBMED   9288753
REFERENCE   9  (bases 1 to 5870)
  AUTHORS   Kawakami A, Kitsukawa T, Takagi S and Fujisawa H.
  TITLE     Developmentally regulated expression of a cell surface protein,
            neuropilin, in the mouse nervous system
  JOURNAL   J Neurobiol 29 (1), 1-17 (1996)
   PUBMED   8748368
REFERENCE   10 (bases 1 to 5870)
  AUTHORS   Kitsukawa T, Shimono A, Kawakami A, Kondoh H and Fujisawa H.
  TITLE     Overexpression of a membrane protein, neuropilin, in chimeric mice
            causes anomalies in the cardiovascular system, nervous system and
            limbs
  JOURNAL   Development 121 (12), 4309-4318 (1995)
   PUBMED   8575331
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164378.1, AC139349.4 and AC102856.5.
            
            [WARNING] On Oct 13, 2023 this sequence was replaced by
            NM_001358960.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.132213.1,
                                           SRR1660821.78708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               AK164378.1         3-562
            561-735             AC139349.4         2640-2814           c
            736-917             AC102856.5         58592-58773
            918-1145            AC102856.5         65621-65848
            1146-1301           AC102856.5         71771-71926
            1302-1468           AC102856.5         74088-74254
            1469-1624           AC102856.5         97736-97891
            1625-1769           AC102856.5         100491-100635
            1770-2101           AC102856.5         108226-108557
            2102-2246           AC102856.5         116029-116173
            2247-2351           AC102856.5         120764-120868
            2352-2411           AC102856.5         127776-127835
            2412-2549           AC102856.5         132906-133043
            2550-2821           AC102856.5         137699-137970
            2822-2918           AC102856.5         138384-138480
            2919-5870           AC102856.5         142404-145355
FEATURES             Location/Qualifiers
     source          1..5870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 75.78 cM"
     gene            1..5870
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /note="neuropilin 1"
                     /db_xref="GeneID:18186"
                     /db_xref="MGI:MGI:106206"
     exon            1..560
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..3208
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; transmembrane receptor; A5 protein;
                     Neuropilin-1 precursor (A5 protein)"
                     /codon_start=1
                     /product="neuropilin-1 isoform 3 precursor"
                     /protein_id="NP_001345889.1"
                     /db_xref="GeneID:18186"
                     /db_xref="MGI:MGI:106206"
                     /translation="MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGY
                     PHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGK
                     FCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKS
                     PGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGMFCRYDRLEIWDGFP
                     EVGPHIGRYCGQKTPGRIRSSSGVLSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCM
                     EALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYKEWIQVDLGLLR
                     FVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWISLKEGNKAIIFQGNTNPTDVVL
                     GVFSKPLITRFVRIKPVSWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITAS
                     NQADRNWMPENIRLVTSRTGWALPPSPHPYTNEWLQVDLGDEKIVRGVIIQGGKHREN
                     KVFMRKFKIAYSNNGSDWKTIMDDSKRKAKSFEGNNNYDTPELRTFSPLSTRFIRIYP
                     ERATHSGLGLRMELLGCEVEAPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGT
                     TVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWSVLTSKTGP
                     IQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKL
                     RYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDI
                     SINNHISQEDCARSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGA
                     VCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA"
     exon            561..735
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            736..917
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1145
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1301
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1468
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1624
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1769
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..2101
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2246
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2351
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2411
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2549
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2821
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2918
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..5870
                     /gene="Nrp1"
                     /gene_synonym="C530029I03; NP-1; NPN-1; Npn1; Nrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcattgctc tctctccttc ccgcagacaa cccggacctc ctctgggcgc cagctcctcg
       61 gctccaaccc gtccagaatc aagcgggatt ttttttttct ttccctctag aaattggctt
      121 tggtgtgtcg cccgccctct cccctcctcc tcgcaactcc tcccctcttt tttttcctcc
      181 ttcttcttct tcctgagaca tggcccgggc agtggctcct ggaagaggaa caagtgtggg
      241 aaaagggaga ggaaatcgga gctaaatgac aggatgcagg cgacttgaga cacaaaaaga
      301 aaagcgcttc tcgcgaattc aggcattgcc tcgccgctag ccttccccgc caagacccgc
      361 tgaggatttt ctggttctta ggcggactta agagcgtttc ggattgttaa gattatcgtt
      421 tgctggtttt tcgtccgcgc aatcgtgttc tcctgcggct gcctggggac tggcttggcg
      481 aaggaggatg gagagggggc tgccgttgct gtgcgccacg ctcgcccttg ccctcgccct
      541 ggcgggcgct ttccgcagcg acaaatgtgg cgggaccata aaaatcgaaa acccagggta
      601 cctcacatct cccggttacc ctcattctta ccatccaagt gagaagtgtg aatggctaat
      661 ccaagctccg gaaccctacc agagaatcat gatcaacttc aacccacatt tcgatttgga
      721 ggacagagac tgcaagtatg actacgtgga agtaatcgat ggggagaatg aaggcggccg
      781 cctgtggggg aagttctgtg ggaagattgc accttctcct gtggtgtctt cagggccctt
      841 tctcttcatc aaatttgtct ctgactatga gacacatggg gcagggtttt ccatccgcta
      901 tgaaatcttc aagagagggc ccgaatgttc tcagaactat acagcaccta ctggagtgat
      961 aaagtcccct gggttccctg aaaaataccc caacagcttg gagtgcacct acatcatctt
     1021 tgcaccaaag atgtctgaga taatcctgga gtttgaaagt tttgacctgg agcaagactc
     1081 gaatcctccc ggaggaatgt tctgtcgcta tgaccggctg gagatctggg atggattccc
     1141 tgaagttggc cctcacattg ggcgttattg tgggcagaaa actcctggcc ggatccgctc
     1201 ctcttcaggc gttctatcca tggtctttta cactgacagc gcaatagcaa aagaaggttt
     1261 ctcagccaac tacagtgtgc tacagagcag catctctgaa gattttaagt gtatggaggc
     1321 tctgggcatg gaatctggag agatccattc tgatcagatc actgcatctt cacagtatgg
     1381 taccaactgg tctgtagagc gctcccgcct gaactaccct gaaaatgggt ggactccagg
     1441 agaagactcc tacaaggagt ggatccaggt ggacttgggc ctcctgcgat tcgttactgc
     1501 tgtagggaca cagggtgcca tttccaagga aaccaagaag aaatattatg tcaagactta
     1561 cagagtagac atcagctcca acggagagga ctggatctcc ctgaaagagg gaaataaagc
     1621 cattatcttt cagggaaaca ccaaccccac agatgttgtc ttaggagttt tctccaaacc
     1681 actgataact cgatttgtcc gaatcaaacc tgtatcctgg gaaactggta tatctatgag
     1741 atttgaagtt tatggctgca agataacaga ttatccttgc tctggaatgt tgggcatggt
     1801 gtctggactt atttcagact cccagattac agcatccaat caagccgaca ggaattggat
     1861 gccagaaaac atccgtctgg tgaccagtcg taccggctgg gcactgccac cctcacccca
     1921 cccatacacc aatgaatggc tccaagtgga cctgggagat gagaagatag taagaggtgt
     1981 catcattcag ggtgggaagc accgagaaaa caaggtgttc atgaggaagt tcaagatcgc
     2041 ctatagtaac aatggctctg actggaaaac tatcatggat gacagcaagc gcaaggctaa
     2101 gtcgttcgaa ggcaacaaca actatgacac acctgagctt cggacgtttt cacctctctc
     2161 cacaaggttc atcaggatct accctgagag agccacacac agtgggcttg ggctgaggat
     2221 ggagctactg ggctgtgaag tggaagcacc tacagctgga ccaaccacac ccaatgggaa
     2281 cccagtggat gagtgtgacg acgaccaggc caactgccac agtggcacag gtgatgactt
     2341 ccagctcaca ggaggcacca ctgtcctggc cacagagaag ccaaccatta tagacagcac
     2401 catccaatca gagttcccga catacggttt taactgcgag tttggctggg gctctcacaa
     2461 gacattctgc cactgggagc atgacagcca tgcacagctc aggtggagtg tgctgaccag
     2521 caagacaggg ccgattcagg accatacagg agatggcaac ttcatctatt cccaagctga
     2581 tgaaaatcag aaaggcaaag tagcccgcct ggtgagccct gtggtctatt cccagagctc
     2641 tgcccactgt atgaccttct ggtatcacat gtccggctct catgtgggta cactgagggt
     2701 caaactacgc taccagaagc cagaggaata tgatcaactg gtctggatgg tggttgggca
     2761 ccaaggagac cactggaaag aaggacgtgt cttgctgcac aaatctctga aactatatca
     2821 ggttattttt gaaggtgaaa tcggaaaagg aaaccttggt ggaattgctg tggatgatat
     2881 cagtattaac aaccatattt ctcaggaaga ctgtgcaagg agcactccag gatatgaagg
     2941 agaaggggaa ggtgacaaga acatctccag gaagccaggc aatgtgctta agaccctgga
     3001 tcccatcctg atcaccatca tagccatgag tgccctggga gtactcctgg gtgcagtctg
     3061 tggagttgtg ctgtactgtg cctgttggca caatgggatg tcagaaagga acctatctgc
     3121 cctggagaac tataactttg aacttgtgga tggtgtaaag ttgaaaaaag ataaactgaa
     3181 cccacagagt aattactcag aggcgtgaag gcacggagct ggagggaaca agggaggagc
     3241 acggcaggag aacaggtgga ggcatgggga ctctgttact ctgctttcac tgtaagctgg
     3301 gaagggcggg gactctgtta ctccgctttc actgtaagct cggaagggca tccacgatgc
     3361 catgccaggc ttttctcagg agcttcaatg agcgtcacct acagacacaa gcaggtgact
     3421 gcggtaacaa caggaatcat gtacaagcct gctttcttct cttggtttca tttgggtaat
     3481 cagaagccat ttgagaccaa gtgtgactga cttcatggtt catcctacta gccccctttt
     3541 ttcctctctt tctccttacc ctgtggtgga ttcttctcgg aaactgcaaa atccaagatg
     3601 ctggcactag gcgttattca gtgggccctt ttgatggaca tgtgacctgt agcccagtgc
     3661 ccagagcata ttatcataac cacatttcag gggacaccaa cgtccatcca cctttgcatc
     3721 gctacctgca gcgagcacag gaaaaagaaa cgaaaagaaa agaaaaaaga aaaaagaaaa
     3781 gaaaagaaaa gaaaagaaaa gaaaagaaaa gaaaagaaaa ggaaaggata aagaaaaaga
     3841 attagactat tttgtttgca aagtactgtg gcctcagtac ccatatagct gtcagctctg
     3901 tttaccaagc aataccgaca gattttcttg atgttttcca gtgttgtact gaatctcgtg
     3961 tttgtgacct ccattcagaa taccataccc tgcagccacc aaactgctag cacccgggtg
     4021 tcccgctgat gaccaccaca aaagtcttcg gcactggcta gtcttcgtcc tctcaagtgc
     4081 ctttttgttt gtactggtcc cttgtgtccc gtggatgacc cactctgttt ctggtgaaaa
     4141 cccttctctt caatcagacc tggtggccca ctgactaaga agaaagtata ttttagtgtg
     4201 ctatgccaac cccgggaagg caagggctct gaagacctgg caatgtggct taatcaatct
     4261 gcttttttct gaagttcaat gtcaatgtct cttgaccctt tgtataaagc tgcaatgttc
     4321 tctctcgttg ttcttaccta taggatgtat tttcagatat aaactcttgg ttctttcctt
     4381 ccttcctctc tttttttcct ctggaaatcg aagcatttgc cactgtccag gatgaacctt
     4441 gcagctttaa cctgctggca atggcgaaca attttactag actttatgtt ttaagataat
     4501 taagtaaggg gaactcctaa ctttgtcctc cagagtctaa ctttgggttt cttgttaact
     4561 ggttaaagtg acagtatctt ttttccttaa gccatgtgtt catactttct gattagattg
     4621 cggtttgata tgaatgtttg catctaaaat cataagttga aagaaaaaga ataccaactg
     4681 actttcagac gagacccaca ggaagcaaca agaataaaat ccccaagtct aaaaggacgt
     4741 ggaaacttta catccaaata tgcaaaatga gccctgaaaa ccttcttgtt ttgttactgg
     4801 gtcagaggag aatagtgaaa agaatagctc acttaaggaa taaacaataa tcctgatgcc
     4861 tgaggcaaaa ctagtttaag accaatcaga aggggtatat aaaatcaaaa caaatgttta
     4921 gaacaatcca ttcagcagaa accctgaaaa gataaatttt aatgaatgct tctagaaact
     4981 tccaatgact cataaagaaa aaaaaaaaaa aagcctacct taggactggc aagacgtcca
     5041 cctcaacagc acaaagaggt aaatatttta acccaaagca gcttccggct ggtagatttt
     5101 tgtcttgatg ggctgtccat aagaactccc agttctttcc cttccttgtg tggctgtagg
     5161 tctctctcag ttatgtttct tagagatcac atctgcttcc tggacaaatg ttttttgttc
     5221 accctggttt aatgggattg agaatgtctt ttttccagga aagtattgat cactaaaata
     5281 aagaatatgt ttttattccc agaggcatca attcacttgt tataatcata ctggggggaa
     5341 agcattaagt aagactttgt ttgtaagaca acaaacttga ccagtgtcct cagccaagga
     5401 aaaatgatac tgcaacttta aattttaaag taccttgcac tgataaatat atttaaaagt
     5461 tatatgttta taaagttatt aatttgtaaa ggcagtgtta caaaatgttc agtttatatt
     5521 gttttagatt gtttcgtaat ttttaaaggt gtaaaataac atattttttc tttattgaaa
     5581 tctataagac tttccgtagt aagatgtctc attttctggt atattattgc ttcatgtttt
     5641 gtaccctcat aaaattttgt gcaaattttt tttacagaaa tttttatttt ctatgatgat
     5701 atgtatgaca cttgtaaatt gtttcaaaat gaacagcgaa gccttaactt gaaatgacat
     5761 ttgtattctc tgagtagcat aaaaaccacc tagaatgaac tgtaacttaa tctcgaaact
     5821 acacattcca aagaagcagt tgaattaaac gttttcataa aaatcccaaa
//
