LOCUS       NM_175024                643 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus neuritin 1-like (Nrn1l), transcript variant 1, mRNA.
ACCESSION   NM_175024
VERSION     NM_175024.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 643)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 643)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 643)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 643)
  AUTHORS   Fujino,T., Wu,Z., Lin,W.C., Phillips,M.A. and Nedivi,E.
  TITLE     cpg15 and cpg15-2 constitute a family of activity-regulated ligands
            expressed differentially in the nervous system to promote neurite
            growth and neuronal survival
  JOURNAL   J Comp Neurol 507 (5), 1831-1845 (2008)
   PUBMED   18265009
  REMARK    GeneRIF: CPG15 and CPG15-2 perform similar cellular functions but
            may play distinct roles in vivo through their cell-type- and
            tissue-specific transcriptional regulation
REFERENCE   5  (bases 1 to 643)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC100315.1 and CK030777.1.
            
            On Jul 24, 2014 this sequence version replaced NM_175024.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100315.1, CO808500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-613               BC100315.1         1-613
            614-643             CK030777.1         595-624
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.06 cM"
     gene            1..643
                     /gene="Nrn1l"
                     /gene_synonym="Cpg15-2; G630049C14Rik"
                     /note="neuritin 1-like"
                     /db_xref="GeneID:234700"
                     /db_xref="MGI:MGI:2443642"
     exon            1..101
                     /gene="Nrn1l"
                     /gene_synonym="Cpg15-2; G630049C14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..502
                     /gene="Nrn1l"
                     /gene_synonym="Cpg15-2; G630049C14Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; neuritin-like protein; MRCC2446-like protein;
                     candidate plasticity gene 15-2 protein"
                     /codon_start=1
                     /product="neuritin-like protein isoform 1 precursor"
                     /protein_id="NP_778189.1"
                     /db_xref="CCDS:CCDS22618.1"
                     /db_xref="GeneID:234700"
                     /db_xref="MGI:MGI:2443642"
                     /translation="MMCNCCHCHWRRRCQRLPCALTLLLLLPLAVASEGPNRCDTIYQ
                     GFAECLIRLGDGMGRGGELQTVCRSWNDFHACASRVLSGCPEEAAAVWESLQQEARRA
                     PHPDNLHILCGAPVSVRERIAGPETNQETLRATAPALAPAPAPVLLAAALALACLLGP
                     LA"
     exon            102..216
                     /gene="Nrn1l"
                     /gene_synonym="Cpg15-2; G630049C14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            217..617
                     /gene="Nrn1l"
                     /gene_synonym="Cpg15-2; G630049C14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      592..597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrn1l"
                     /gene_synonym="Cpg15-2; G630049C14Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      613
                     /gene="Nrn1l"
                     /gene_synonym="Cpg15-2; G630049C14Rik"
                     /note="major polyA site"
ORIGIN      
        1 cttacagcca gggatgatgt gcaactgctg ccactgccac tggcgccgcc gctgtcagcg
       61 gctaccctgt gccctgacgc tgttgctgct actaccactc gcagtggcct ctgagggccc
      121 aaaccgctgt gataccatat accaaggctt tgctgaatgt ctcatccgcc tgggggatgg
      181 catgggtcga ggaggcgagc tacagactgt ctgcagatcc tggaatgact tccacgcctg
      241 tgcctctcgg gtcctgtcag gctgcccaga ggaggcggct gcagtgtggg agtcactgca
      301 gcaagaagct cgccgcgccc cacacccaga taatttgcac atcctctgtg gcgctcctgt
      361 gagtgttcgg gagcggattg ctggcccaga gaccaaccag gagacactac gggccacagc
      421 tcctgcactg gctccagctc cagcccctgt gttgctcgcc gccgctctag cgcttgcctg
      481 cctcctgggg cctctggcct aaacagtctg gttggccagc caacagtgcc cttgcctccc
      541 atcactgcat gcagtggctg ccatgtgagc tctgcagtat gcacactttt cattaaaggt
      601 atttatattt gcaccaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
