LOCUS       NM_001271916            1966 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus neural retina leucine zipper gene (Nrl), transcript
            variant 3, mRNA.
ACCESSION   NM_001271916
VERSION     NM_001271916.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Li,Y., Xiao,D., Chen,H., Zheng,X.F.S. and Xiang,M.
  TITLE     Maf1 controls retinal neuron number by both RNA Pol III- and Pol
            II-dependent mechanisms
  JOURNAL   iScience 26 (12), 108544 (2023)
   PUBMED   38089586
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Laird,J.G., Kopel,A., Lankford,C.K. and Baker,S.A.
  TITLE     Mouse all-cone retina models of Cav1.4 synaptopathy
  JOURNAL   Front Mol Neurosci 16, 1155955 (2023)
   PUBMED   37181655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Thorson,M.T., Wei,S.E., Johnson,C., Gabriel,C.J., Arshavsky,V.Y.
            and Pearring,J.N.
  TITLE     Nrl:CreERT2 mouse model to induce mosaic gene expression in rod
            photoreceptors
  JOURNAL   Front Mol Neurosci 16, 1161127 (2023)
   PUBMED   37181654
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1966)
  AUTHORS   Kaplan,L., Drexler,C., Pfaller,A.M., Brenna,S., Wunderlich,K.A.,
            Dimitracopoulos,A., Merl-Pham,J., Perez,M.T.,
            Schlotzer-Schrehardt,U., Enzmann,V., Samardzija,M., Puig,B.,
            Fuchs,P., Franze,K., Hauck,S.M. and Grosche,A.
  TITLE     Retinal regions shape human and murine Muller cell proteome profile
            and functionality
  JOURNAL   Glia 71 (2), 391-414 (2023)
   PUBMED   36334068
REFERENCE   5  (bases 1 to 1966)
  AUTHORS   Liang,X., Brooks,M.J. and Swaroop,A.
  TITLE     Developmental genome-wide occupancy analysis of bZIP transcription
            factor NRL uncovers the role of c-Jun in early differentiation of
            rod photoreceptors in the mammalian retina
  JOURNAL   Hum Mol Genet 31 (22), 3914-3933 (2022)
   PUBMED   35776116
  REMARK    GeneRIF: Developmental genome-wide occupancy analysis of bZIP
            transcription factor NRL uncovers the role of c-Jun in early
            differentiation of rod photoreceptors in the mammalian retina.
REFERENCE   6  (bases 1 to 1966)
  AUTHORS   Kawauchi,S., Takahashi,S., Nakajima,O., Ogino,H., Morita,M.,
            Nishizawa,M., Yasuda,K. and Yamamoto,M.
  TITLE     Regulation of lens fiber cell differentiation by transcription
            factor c-Maf
  JOURNAL   J Biol Chem 274 (27), 19254-19260 (1999)
   PUBMED   10383433
REFERENCE   7  (bases 1 to 1966)
  AUTHORS   Liu,Q., Ji,X., Breitman,M.L., Hitchcock,P.F. and Swaroop,A.
  TITLE     Expression of the bZIP transcription factor gene Nrl in the
            developing nervous system
  JOURNAL   Oncogene 12 (1), 207-211 (1996)
   PUBMED   8552394
REFERENCE   8  (bases 1 to 1966)
  AUTHORS   Farjo,Q., Jackson,A.U., Xu,J., Gryzenia,M., Skolnick,C., Agarwal,N.
            and Swaroop,A.
  TITLE     Molecular characterization of the murine neural retina leucine
            zipper gene, Nrl
  JOURNAL   Genomics 18 (2), 216-222 (1993)
   PUBMED   8288222
REFERENCE   9  (bases 1 to 1966)
  AUTHORS   Bespalova,I.N., Farjo,Q., Mortlock,D.P., Jackson,A.U.,
            Meisler,M.H., Swaroop,A. and Burmeister,M.
  TITLE     Mapping of the neural retina leucine zipper gene, Nrl, to mouse
            chromosome 14
  JOURNAL   Mamm Genome 4 (10), 618-620 (1993)
   PUBMED   8268663
REFERENCE   10 (bases 1 to 1966)
  AUTHORS   Swaroop,A., Xu,J.Z., Pawar,H., Jackson,A., Skolnick,C. and
            Agarwal,N.
  TITLE     A conserved retina-specific gene encodes a basic motif/leucine
            zipper domain
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 266-270 (1992)
   PUBMED   1729696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159002.2.
            
            On Sep 13, 2022 this sequence version replaced NM_001271916.1.
            
            Summary: This gene encodes a member of the basic leucine zipper
            domain family of transcription factors. The encoded protein is
            preferentially expressed in the retina and is necessary for rod
            photoreceptor development. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044244.1, BB642178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC159002.2         33057-33115
            60-186              AC159002.2         33824-33950
            187-594             AC159002.2         35543-35950
            595-1966            AC159002.2         37151-38522
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1966
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /note="neural retina leucine zipper gene"
                     /db_xref="GeneID:18185"
                     /db_xref="MGI:MGI:102567"
     exon            1..59
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            60..186
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            187..594
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..927
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /note="isoform 1 is encoded by transcript variant 3;
                     neural retina-specific leucine zipper protein"
                     /codon_start=1
                     /product="neural retina-specific leucine zipper protein
                     isoform 1"
                     /protein_id="NP_001258845.1"
                     /db_xref="CCDS:CCDS27113.1"
                     /db_xref="GeneID:18185"
                     /db_xref="MGI:MGI:102567"
                     /translation="MAFPPSPLAMEYVNDFDLMKFEIKREPSEGRSGVPTASLGSTPY
                     SSVPPSPTFSEPGMVGGGEAPRPGLEELYWLATLQQQLGSDEVLGLSPDEAVELLQNQ
                     GPVSMEGPLGYYSGSPGETGAQHVQLPERFSDAALVSMSVRELNRQLRGCGRDEALRL
                     KQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKAR
                     CDRLTSGGPGSDDHTHLFL"
     exon            595..1966
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1939..1944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /note="hexamer: ATTAAA"
     polyA_site      1966
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /note="major polyA site"
ORIGIN      
        1 agccgtctgg gaatgagcga gagaggagaa gagggactga gacaccgcac ggggaaaagc
       61 ccccttgttc tgaatacagg gacgacacca gcccctgctc tatggagtat ttagtctcca
      121 gggaagctgt gcctttctgg ttctgacagt gactacgtca tctctgccat tacatcatca
      181 cataaagaac acctctctct gctcagtccc agaatggctt tccctcccag tcccttggct
      241 atggaatatg ttaatgactt tgatttgatg aagttcgaaa taaagcggga gccttctgag
      301 ggccgatctg gagtccccac agcctcgttg ggctccacac catacagctc ggtgcctcct
      361 tcacccacct tcagtgagcc aggcatggtg ggtggtggcg aggcccctag gccaggcctg
      421 gaggagctat attggctggc caccctgcag cagcagctgg ggtcggatga ggttctcggg
      481 ctgagtcccg acgaagctgt ggagctgctg cagaaccagg gtcctgtctc tatggaaggg
      541 cctcttggct actattcagg gagcccggga gagacaggag cccagcatgt ccagctgccc
      601 gagagatttt cggacgccgc gctggtctcg atgtctgtgc gcgagttgaa ccggcagctg
      661 cggggctgcg ggcgcgacga ggctctgcgg ctgaagcaga ggcgccgcac gctcaagaac
      721 cgcggctacg ctcaggcttg tcgctccaag cggctgcaac agcggcgcgg gctggaggca
      781 gagcgcgctc gcctggccgc ccagctggat gccctgcggg ccgaggtggc acgcctggct
      841 cgcgagcgcg acctctataa ggcccgctgt gaccggctga cctccggcgg ccctgggtcc
      901 gacgaccaca cacacctctt cctctgagcc tctagggcag ggggtgtggc ggtttggagg
      961 tggctgggta gatggcgcta tacaggagag gtagtaccac taaccaaatc gctacctgtg
     1021 gttttgtgta tgtctataca aatatcccca aacttctgag catcgtggca tgctagaggt
     1081 tagatgctgg tcctttgctg gagatgagtt cccttccctt ttgcaggtca cgactcttca
     1141 tgatttagta gggcactgaa ttctgtagga gctagtgcct gtactgaggg tggaggtgtg
     1201 gaggatgggc aggtggcatg ctgaatggga ggaggaagag gaggaggagg aggaggagga
     1261 ggaggaggag gaggagggga ggaggaggag gagaaggagg gtgcagcttc cctcctatcc
     1321 atatagttct taattcaagg ttttcaatct gtagtgcatt aatgctgtaa ttaacaatga
     1381 agctgcattt tcaccgaatc tttggactct ccattttacg actactggac tgtcaggatt
     1441 tcaatttccc taaacaaaca gtaataggtc aactcaaaat gttcttctct gctcaaccca
     1501 gtggccttta gagtccaaag cagcagaaca agtgccctgg atgggagcct gacgacctgg
     1561 gcagtagtct caactgtgtc acacaggctg tatgtctgtc accttaagca aagcaattgt
     1621 cacaaggttt ctctcatttg aactggatga cttccgacac tgttttagtt ttggcaggtc
     1681 taatggtctc ctcaagaggg cccaagagga ctgtaccaaa gggacatcct gttctgtctc
     1741 atcttccagg ctgtagctta ggcaatagat acacagcatg cctgctctgg ggacgctcac
     1801 ttgtactgcc taagtggccc cctctaggct tcgctggcct ccaaactgca gaaggtgccc
     1861 ttgctacctc ctgcctctca gagctgaagt gagacctcac aggataacag ggagccgaga
     1921 gactgtgact ttttgtgaat taaacctcaa gttcaagaaa aactaa
//
