LOCUS       NM_001136074            1946 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus neural retina leucine zipper gene (Nrl), transcript
            variant 2, mRNA.
ACCESSION   NM_001136074
VERSION     NM_001136074.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Li,Y., Xiao,D., Chen,H., Zheng,X.F.S. and Xiang,M.
  TITLE     Maf1 controls retinal neuron number by both RNA Pol III- and Pol
            II-dependent mechanisms
  JOURNAL   iScience 26 (12), 108544 (2023)
   PUBMED   38089586
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Laird,J.G., Kopel,A., Lankford,C.K. and Baker,S.A.
  TITLE     Mouse all-cone retina models of Cav1.4 synaptopathy
  JOURNAL   Front Mol Neurosci 16, 1155955 (2023)
   PUBMED   37181655
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   Thorson,M.T., Wei,S.E., Johnson,C., Gabriel,C.J., Arshavsky,V.Y.
            and Pearring,J.N.
  TITLE     Nrl:CreERT2 mouse model to induce mosaic gene expression in rod
            photoreceptors
  JOURNAL   Front Mol Neurosci 16, 1161127 (2023)
   PUBMED   37181654
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Kaplan,L., Drexler,C., Pfaller,A.M., Brenna,S., Wunderlich,K.A.,
            Dimitracopoulos,A., Merl-Pham,J., Perez,M.T.,
            Schlotzer-Schrehardt,U., Enzmann,V., Samardzija,M., Puig,B.,
            Fuchs,P., Franze,K., Hauck,S.M. and Grosche,A.
  TITLE     Retinal regions shape human and murine Muller cell proteome profile
            and functionality
  JOURNAL   Glia 71 (2), 391-414 (2023)
   PUBMED   36334068
REFERENCE   5  (bases 1 to 1946)
  AUTHORS   Liang,X., Brooks,M.J. and Swaroop,A.
  TITLE     Developmental genome-wide occupancy analysis of bZIP transcription
            factor NRL uncovers the role of c-Jun in early differentiation of
            rod photoreceptors in the mammalian retina
  JOURNAL   Hum Mol Genet 31 (22), 3914-3933 (2022)
   PUBMED   35776116
  REMARK    GeneRIF: Developmental genome-wide occupancy analysis of bZIP
            transcription factor NRL uncovers the role of c-Jun in early
            differentiation of rod photoreceptors in the mammalian retina.
REFERENCE   6  (bases 1 to 1946)
  AUTHORS   Kawauchi,S., Takahashi,S., Nakajima,O., Ogino,H., Morita,M.,
            Nishizawa,M., Yasuda,K. and Yamamoto,M.
  TITLE     Regulation of lens fiber cell differentiation by transcription
            factor c-Maf
  JOURNAL   J Biol Chem 274 (27), 19254-19260 (1999)
   PUBMED   10383433
REFERENCE   7  (bases 1 to 1946)
  AUTHORS   Liu,Q., Ji,X., Breitman,M.L., Hitchcock,P.F. and Swaroop,A.
  TITLE     Expression of the bZIP transcription factor gene Nrl in the
            developing nervous system
  JOURNAL   Oncogene 12 (1), 207-211 (1996)
   PUBMED   8552394
REFERENCE   8  (bases 1 to 1946)
  AUTHORS   Farjo,Q., Jackson,A.U., Xu,J., Gryzenia,M., Skolnick,C., Agarwal,N.
            and Swaroop,A.
  TITLE     Molecular characterization of the murine neural retina leucine
            zipper gene, Nrl
  JOURNAL   Genomics 18 (2), 216-222 (1993)
   PUBMED   8288222
REFERENCE   9  (bases 1 to 1946)
  AUTHORS   Bespalova,I.N., Farjo,Q., Mortlock,D.P., Jackson,A.U.,
            Meisler,M.H., Swaroop,A. and Burmeister,M.
  TITLE     Mapping of the neural retina leucine zipper gene, Nrl, to mouse
            chromosome 14
  JOURNAL   Mamm Genome 4 (10), 618-620 (1993)
   PUBMED   8268663
REFERENCE   10 (bases 1 to 1946)
  AUTHORS   Swaroop,A., Xu,J.Z., Pawar,H., Jackson,A., Skolnick,C. and
            Agarwal,N.
  TITLE     A conserved retina-specific gene encodes a basic motif/leucine
            zipper domain
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 266-270 (1992)
   PUBMED   1729696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159002.2.
            
            On Sep 13, 2022 this sequence version replaced NM_001136074.2.
            
            Summary: This gene encodes a member of the basic leucine zipper
            domain family of transcription factors. The encoded protein is
            preferentially expressed in the retina and is necessary for rod
            photoreceptor development. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031440.1, AK044316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC159002.2         33057-33115
            60-166              AC159002.2         33844-33950
            167-574             AC159002.2         35543-35950
            575-1946            AC159002.2         37151-38522
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1946
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /note="neural retina leucine zipper gene"
                     /db_xref="GeneID:18185"
                     /db_xref="MGI:MGI:102567"
     exon            1..59
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            60..166
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /inference="alignment:Splign:2.1.0"
     exon            167..574
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..907
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /note="isoform 1 is encoded by transcript variant 2;
                     neural retina-specific leucine zipper protein"
                     /codon_start=1
                     /product="neural retina-specific leucine zipper protein
                     isoform 1"
                     /protein_id="NP_001129546.1"
                     /db_xref="CCDS:CCDS27113.1"
                     /db_xref="GeneID:18185"
                     /db_xref="MGI:MGI:102567"
                     /translation="MAFPPSPLAMEYVNDFDLMKFEIKREPSEGRSGVPTASLGSTPY
                     SSVPPSPTFSEPGMVGGGEAPRPGLEELYWLATLQQQLGSDEVLGLSPDEAVELLQNQ
                     GPVSMEGPLGYYSGSPGETGAQHVQLPERFSDAALVSMSVRELNRQLRGCGRDEALRL
                     KQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKAR
                     CDRLTSGGPGSDDHTHLFL"
     exon            575..1946
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1919..1924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /note="hexamer: ATTAAA"
     polyA_site      1946
                     /gene="Nrl"
                     /gene_synonym="D14H14S46E"
                     /note="major polyA site"
ORIGIN      
        1 agccgtctgg gaatgagcga gagaggagaa gagggactga gacaccgcac ggggaaaagg
       61 gacgacacca gcccctgctc tatggagtat ttagtctcca gggaagctgt gcctttctgg
      121 ttctgacagt gactacgtca tctctgccat tacatcatca cataaagaac acctctctct
      181 gctcagtccc agaatggctt tccctcccag tcccttggct atggaatatg ttaatgactt
      241 tgatttgatg aagttcgaaa taaagcggga gccttctgag ggccgatctg gagtccccac
      301 agcctcgttg ggctccacac catacagctc ggtgcctcct tcacccacct tcagtgagcc
      361 aggcatggtg ggtggtggcg aggcccctag gccaggcctg gaggagctat attggctggc
      421 caccctgcag cagcagctgg ggtcggatga ggttctcggg ctgagtcccg acgaagctgt
      481 ggagctgctg cagaaccagg gtcctgtctc tatggaaggg cctcttggct actattcagg
      541 gagcccggga gagacaggag cccagcatgt ccagctgccc gagagatttt cggacgccgc
      601 gctggtctcg atgtctgtgc gcgagttgaa ccggcagctg cggggctgcg ggcgcgacga
      661 ggctctgcgg ctgaagcaga ggcgccgcac gctcaagaac cgcggctacg ctcaggcttg
      721 tcgctccaag cggctgcaac agcggcgcgg gctggaggca gagcgcgctc gcctggccgc
      781 ccagctggat gccctgcggg ccgaggtggc acgcctggct cgcgagcgcg acctctataa
      841 ggcccgctgt gaccggctga cctccggcgg ccctgggtcc gacgaccaca cacacctctt
      901 cctctgagcc tctagggcag ggggtgtggc ggtttggagg tggctgggta gatggcgcta
      961 tacaggagag gtagtaccac taaccaaatc gctacctgtg gttttgtgta tgtctataca
     1021 aatatcccca aacttctgag catcgtggca tgctagaggt tagatgctgg tcctttgctg
     1081 gagatgagtt cccttccctt ttgcaggtca cgactcttca tgatttagta gggcactgaa
     1141 ttctgtagga gctagtgcct gtactgaggg tggaggtgtg gaggatgggc aggtggcatg
     1201 ctgaatggga ggaggaagag gaggaggagg aggaggagga ggaggaggag gaggagggga
     1261 ggaggaggag gagaaggagg gtgcagcttc cctcctatcc atatagttct taattcaagg
     1321 ttttcaatct gtagtgcatt aatgctgtaa ttaacaatga agctgcattt tcaccgaatc
     1381 tttggactct ccattttacg actactggac tgtcaggatt tcaatttccc taaacaaaca
     1441 gtaataggtc aactcaaaat gttcttctct gctcaaccca gtggccttta gagtccaaag
     1501 cagcagaaca agtgccctgg atgggagcct gacgacctgg gcagtagtct caactgtgtc
     1561 acacaggctg tatgtctgtc accttaagca aagcaattgt cacaaggttt ctctcatttg
     1621 aactggatga cttccgacac tgttttagtt ttggcaggtc taatggtctc ctcaagaggg
     1681 cccaagagga ctgtaccaaa gggacatcct gttctgtctc atcttccagg ctgtagctta
     1741 ggcaatagat acacagcatg cctgctctgg ggacgctcac ttgtactgcc taagtggccc
     1801 cctctaggct tcgctggcct ccaaactgca gaaggtgccc ttgctacctc ctgcctctca
     1861 gagctgaagt gagacctcac aggataacag ggagccgaga gactgtgact ttttgtgaat
     1921 taaacctcaa gttcaagaaa aactaa
//
