LOCUS       NM_013724               6604 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus Nik related kinase (Nrk), mRNA.
ACCESSION   NM_013724
VERSION     NM_013724.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6604)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6604)
  AUTHORS   Denda,K., Ida,K., Tanno,M., Nakao-Wakabayashi,K., Komada,M. and
            Hayashi,N.
  TITLE     Proteomic analysis of Nrk gene-disrupted placental tissue cells
            explains physiological significance of NRK
  JOURNAL   BMC Res Notes 12 (1), 785 (2019)
   PUBMED   31783915
  REMARK    GeneRIF: protein expression profiles were analyzed in the Nrk-null
            placenta.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6604)
  AUTHORS   Chan,W.H., Komada,M., Fukushima,T., Southard-Smith,E.M.,
            Anderson,C.R. and Wakefield,M.J.
  TITLE     RNA-seq of Isolated Chromaffin Cells Highlights the Role of
            Sex-Linked and Imprinted Genes in Adrenal Medulla Development
  JOURNAL   Sci Rep 9 (1), 3929 (2019)
   PUBMED   30850723
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6604)
  AUTHORS   Morioka,Y., Nam,J.M. and Ohashi,T.
  TITLE     Nik-related kinase regulates trophoblast proliferation and
            placental development by modulating AKT phosphorylation
  JOURNAL   PLoS One 12 (2), e0171503 (2017)
   PUBMED   28152035
  REMARK    GeneRIF: regulates trophoblast proliferation and placental
            development by modulating AKT phosphorylation
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6604)
  AUTHORS   Yanagawa,T., Denda,K., Inatani,T., Fukushima,T., Tanaka,T.,
            Kumaki,N., Inagaki,Y. and Komada,M.
  TITLE     Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers
            Breast Tumor in Mice
  JOURNAL   Am J Pathol 186 (10), 2751-2760 (2016)
   PUBMED   27634343
  REMARK    GeneRIF: The results suggest that Nrk suppresses the excessive
            proliferation of mammary epithelial cells during pregnancy, and the
            impairment of this regulatory system leads to frequent occurrence
            of breast tumor in Nrk mutant mice.
REFERENCE   6  (bases 1 to 6604)
  AUTHORS   Denda,K., Nakao-Wakabayashi,K., Okamoto,N., Kitamura,N., Ryu,J.Y.,
            Tagawa,Y.I., Ichisaka,T., Yamanaka,S. and Komada,M.
  TITLE     Nrk, an X-linked protein kinase in the germinal center kinase
            family, is required for placental development and fetoplacental
            induction of labor
  JOURNAL   J Biol Chem 286 (33), 28802-28810 (2011)
   PUBMED   21715335
  REMARK    GeneRIF: Nrk, an X-linked protein kinase in the germinal center
            kinase family, is required for placental development and
            fetoplacental induction of labor.
REFERENCE   7  (bases 1 to 6604)
  AUTHORS   Nakano,K., Kanai-Azuma,M., Kanai,Y., Moriyama,K., Yazaki,K.,
            Hayashi,Y. and Kitamura,N.
  TITLE     Cofilin phosphorylation and actin polymerization by NRK/NESK, a
            member of the germinal center kinase family
  JOURNAL   Exp Cell Res 287 (2), 219-227 (2003)
   PUBMED   12837278
REFERENCE   8  (bases 1 to 6604)
  AUTHORS   Nakano,K., Yamauchi,J., Nakagawa,K., Itoh,H. and Kitamura,N.
  TITLE     NESK, a member of the germinal center kinase family that activates
            the c-Jun N-terminal kinase pathway and is expressed during the
            late stages of embryogenesis
  JOURNAL   J Biol Chem 275 (27), 20533-20539 (2000)
   PUBMED   10801798
REFERENCE   9  (bases 1 to 6604)
  AUTHORS   Kanai-Azuma,M., Kanai,Y., Okamoto,M., Hayashi,Y., Yonekawa,H. and
            Yazaki,K.
  TITLE     Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase
            gene expressed in skeletal muscle
  JOURNAL   Mech Dev 89 (1-2), 155-159 (1999)
   PUBMED   10559491
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX324117.16 and BX784027.3.
            
            On Mar 21, 2009 this sequence version replaced NM_013724.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139029.1, AB035267.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               BX324117.16        66839-67217
            380-445             BX324117.16        73448-73513
            446-502             BX324117.16        110759-110815
            503-574             BX324117.16        112026-112097
            575-700             BX324117.16        115692-115817
            701-811             BX324117.16        117313-117423
            812-902             BX324117.16        118795-118885
            903-1033            BX324117.16        120077-120207
            1034-1088           BX324117.16        122743-122797
            1089-1167           BX324117.16        124197-124275
            1168-1343           BX324117.16        125212-125387
            1344-1407           BX324117.16        127053-127116
            1408-2536           BX324117.16        127546-128674
            2537-2635           BX324117.16        131069-131167
            2636-2703           BX324117.16        133479-133546
            2704-2819           BX324117.16        135048-135163
            2820-2917           BX324117.16        136251-136348
            2918-3273           BX324117.16        137589-137944
            3274-3535           BX324117.16        139087-139348
            3536-3692           BX324117.16        141104-141260
            3693-3764           BX324117.16        142427-142498
            3765-3908           BX324117.16        144400-144543
            3909-4067           BX324117.16        146565-146723
            4068-4168           BX324117.16        148290-148390
            4169-4318           BX324117.16        150229-150378
            4319-4454           BX324117.16        153191-153326
            4455-4594           BX784027.3         3230-3369
            4595-6604           BX784027.3         6353-8362
FEATURES             Location/Qualifiers
     source          1..6604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 61.15 cM"
     gene            1..6604
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /note="Nik related kinase"
                     /db_xref="GeneID:27206"
                     /db_xref="MGI:MGI:1351326"
     exon            1..379
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..4690
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /EC_number="2.7.11.1"
                     /note="NIK-like embryo-specific kinase; nck-interacting
                     kinase-like embryo specific kinase"
                     /codon_start=1
                     /product="nik-related protein kinase"
                     /protein_id="NP_038752.2"
                     /db_xref="CCDS:CCDS41143.1"
                     /db_xref="GeneID:27206"
                     /db_xref="MGI:MGI:1351326"
                     /translation="MAGPGSWRDKEVTDLGQLPDPTGIFSLDKAIGLGTYGRIFLGIH
                     EKTGSLVAVKVMSARKTPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSF
                     HKNIVTFYGAFFKLNPPGHQHQLWMVMELCAAGSVTDVVRMTRNQSLKEDWIAYICRE
                     ILQGLAHLHAHQVIHRDIKGQNVLLTHDAEVKIVDFGVSAQVSRTNGRRNSFIGTPYW
                     MAPEVIHCDEDPRCSYDYRSDVWSVGITAIEMAEGAPPLCKLQPLEALCVILREAAPK
                     VKSSGWSRKFQNFMENCMIKNFLFRPTSGNMLLHPFVHDIKNERRVVESLTKHLTGII
                     QKREKKGIPVAFEGEEAAKEQYITRRFRGPSCTPELLRVPTSSRCRPLRVLHGEPPQP
                     RWLPDQEDPQDQELQQLQKAAGVFMPLHSQDNTSKLFPKQVEVAPYLRGAAQVVMPVL
                     VQVEAPPQVSKAAQMLKSLPTQDNKATSPEVQAPVAEGQQAQHEALETEQPKDLDQVP
                     EEFQGQDRAPEQPRQGQAAEQQQIHNPVPEQPPEEDREPEQAEVQEEAVEPPQAEIED
                     KEPEVVQVHAQVLLPLLSQNRHVLLPLHLDRQLLIPVGEQNEEVPRAQAWDLEASRAV
                     GAVQALIEGLSRDLLRAPNAFVTKPLGPLQIFLENLSTDGFYTEPEPTQKKKSKVASL
                     RKAIAKRLRPKRFRAKALWRLEDFEFSDVETSRRRRHRRWEDIFNQHEEQLRRVENDR
                     EDDSSDNDEVFHSIQAEVQIEPHAANPAGNEVHERSAPMPCNRNRTHRVKFSPSVGEE
                     EPSLEEAQPQQQQQQPMNIRPRNCLNPQNFQAQSDSSSEEDSPVTRRKSQSSPPYSTI
                     DQKLLIDIHVPDGFKVGKISPPVYLTNEWVGYNALSEIFWDDWIMPTRPARPPEEDGD
                     YVELYDADANANGDEEVANGAYEDPRDGANGHDDMNNQLDQANGYEGHGAAGYNGGDV
                     GGNHGAAFNGPRANYPRAGILKNGHNDGRALNRGAFGVFGDNAARAFHGAAGEAGAAF
                     GNHGANRGNGRGNRNREANGRNEENGAFGRDQHVFPEFEHEESDRGTETSDSIALEIT
                     SFDGEQNSGRPVSSTTMGFPIGRSSPRGSDFGSDISYNSPILHVYEKDFSSEVYCGSL
                     WGVNLLLGTQSHLYLMDRSGKAEIVKLIKRRPFRQIQVVEQLNLLITISGKKNRLRVY
                     HLSWLRNKILNNDPKSKKRQKAMRKKEEACKAIDKLIGCEHFSVLQHEETTYIAVAVK
                     SSIHLFAWAPKSFDENTAIKVFPTRDLKPLTVDLAVGSEKTLKIFFSSANGYHIIDAE
                     SEVMSEVTLPNNNVVILPDCLGLGVMLSLNAEAASEEANEQLLKKILDVWKDIPSSVA
                     FECTKRITGWDQKAIEVRSLQSTILENELKRRSIKKLRFLCARGDKMFFASTLSNDHS
                     RVYLMSLGKLEELHRSYAV"
     exon            380..445
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            446..502
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            503..574
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            575..700
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            701..811
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            812..902
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1033
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1088
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1167
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1343
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1407
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..2536
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2635
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2703
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2819
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..2917
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3273
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3535
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            3536..3692
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3764
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3908
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..4067
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            4068..4168
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            4169..4318
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            4319..4454
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            4455..4594
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     exon            4595..6604
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5209..5214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /note="hexamer: AATAAA"
     regulatory      5213..5218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /note="hexamer: AATACA"
     polyA_site      5226
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /note="major polyA site"
     polyA_site      5232
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /note="major polyA site"
     regulatory      5523..5528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrk"
                     /gene_synonym="Nesk"
                     /note="hexamer: ATTAAA"
     polyA_site      5546
                     /gene="Nrk"
                     /gene_synonym="Nesk"
ORIGIN      
        1 tgcgctctcg ccgcggagca cccttctggc ttcttcgtct ctcggacgga cggacgctag
       61 agctctcttc tccttccctt agccaaactt actttcccgc ctcccgaaaa actccagctt
      121 ccctcttcct cctcccgctc ggctctcggc tcttttcctc tccacttccc tctcctctcc
      181 cgaaccacaa acccaccttc ccattcctct ctcccatccc atcctccctt cccgggaccc
      241 ccaaaactct tcctccttca cctcagacgc agtcccagcg cgcctgctgg acgcggtctc
      301 ccgcttggtt cttctcgaag ccatggcagg acctgggagt tggagggaca aggaggtgac
      361 agatcttggc cagttgccgg atccaactgg aatattctca ctagataaag ccattggtct
      421 tggtacttat ggaagaatct ttttgggaat ccatgaaaag actggttcat tggtggctgt
      481 taaagtaatg agtgccagga agactccttt gcctgagata ggaagacggg tgagagtgaa
      541 taaataccaa aagtctgttg gatggagata cagcgatgaa gaagaggatc ttaggacgga
      601 actcaacctg ctgaggaagt actctttcca caaaaacatt gtgaccttct atggagcatt
      661 tttcaagctg aatcctcctg gccatcagca ccaactttgg atggtaatgg agctatgtgc
      721 agcaggctca gtcactgatg tagtgaggat gacaagaaat cagagtttaa aagaagactg
      781 gatcgcttat atctgtcgag aaatccttca gggcttagct caccttcatg cacaccaagt
      841 aattcaccgg gacatcaaag gacaaaatgt gctgctgact catgatgctg aagtcaaaat
      901 agtggatttt ggagtgagtg cccaagtgag cagaacaaat ggacggagaa atagcttcat
      961 tggtacaccg tactggatgg ccccagaggt gattcattgt gatgaggacc caaggtgttc
     1021 ctatgattac agaagtgatg tgtggtctgt gggaatcact gctattgaaa tggctgaagg
     1081 ggctcctcct ctgtgtaagc ttcagcctct ggaagccctt tgtgttattc tacgggaagc
     1141 cgctcccaaa gtcaaatcca gtggatggtc ccgtaagttc cagaatttca tggaaaattg
     1201 catgataaaa aatttcctat ttcgtcctac atctggaaac atgcttcttc acccatttgt
     1261 ccatgatata aaaaatgaac gacgtgttgt ggagtccttg acaaaacatc ttactgggat
     1321 cattcaaaag agagagaaaa aaggaatacc tgtggccttt gaaggagaag aagctgctaa
     1381 ggaacagtac atcacaagga gattcagagg gccttcttgc actcctgagc ttctcagagt
     1441 gccaaccagc agcagatgca gaccactcag agtcctgcat ggagagcccc ctcagccaag
     1501 gtggctacct gatcaagaag acccacagga ccaagaactt caacaactgc agaaggcagc
     1561 cggagtgttc atgcctctac attctcagga caatacatcc aagcttttcc caaagcaggt
     1621 tgaggtagca ccctatctcc gtggggcagc tcaggtggtc atgccagtac tggtacaggt
     1681 tgaagcaccg ccccaagtaa gcaaagcagc ccagatgctc aagtcactcc ccactcagga
     1741 caacaaagct acttctccag aggtccaggc ccccgtagcc gaaggacagc aggcccagca
     1801 tgaggcctta gagacagaac agcctaaaga tttggaccag gtgccagaag aatttcaggg
     1861 gcaagacagg gcacctgaac agccaaggca gggccaggct gctgagcagc agcagataca
     1921 taatccggtt cctgagcagc cgccggagga ggatagggag cctgagcaag ctgaggtgca
     1981 ggaagaggct gtggagcctc cccaagctga gatcgaggac aaggaacctg aggtagtgca
     2041 agtgcacgcc caggtgctcc tgcctttact gtcccagaac cgtcacgtgc tcttgcctct
     2101 tcatttggat agacagctgc tcattccggt aggggaacaa aatgaagagg taccacgagc
     2161 ccaggcctgg gatctagagg cctcaagggc agttggtgca gtgcaagcgc tgatcgaggg
     2221 actatccagg gacttgcttc gagcaccaaa tgcatttgtc acaaaaccac ttggtccgct
     2281 gcagatcttc ttggaaaatt tgtctacaga cgggttttac actgagccgg aaccgacaca
     2341 gaagaaaaag tcgaaagttg ctagtctaag gaaagcaata gcaaaacgac taagacccaa
     2401 gaggttcaga gcaaaggcat tatggcgact tgaagatttt gaattctcag atgtagaaac
     2461 cagcaggaga cggcgccacc gtagatggga ggacatcttt aatcagcatg aagagcaact
     2521 gagacgagtt gaaaatgaca gagaagatga ctcatcagac aatgatgaag tgtttcattc
     2581 aattcaggct gaagtccaaa tagaaccaca cgctgcaaat cctgcaggaa atgaggtcca
     2641 tgagagatct gctcccatgc cttgcaaccg gaatcgcaca catcgtgtga aattttctcc
     2701 aagtgttggt gaggaagagc cttctttgga agaagcccag ccgcagcagc agcagcagca
     2761 gcccatgaac atccgaccga ggaattgcct aaatcctcag aattttcaag ctcaatcaga
     2821 ctcatcttct gaggaggaca gtcctgtgac taggaggaag tcccagtcat caccgcctta
     2881 ttctactatt gatcagaagc tactgattga tatccacgtt ccagatggat ttaaagtggg
     2941 gaaaatatca cctcctgtgt acttgacaaa tgaatgggta ggctataatg cactctctga
     3001 aatcttctgg gatgactgga taatgcctac acgtcccgct cggccacctg aagaagatgg
     3061 tgattatgtt gaactctatg atgctgatgc caatgctaat ggtgatgaag aagttgcaaa
     3121 cggtgcttat gaagatcctc gtgatggtgc caatggccat gatgacatga ataaccagct
     3181 tgatcaagca aatggttatg aaggccatgg tgctgctggc tacaatggtg gagacgttgg
     3241 tggtaatcat ggtgctgctt tcaatgggcc aagagcaaat tatcccagag cgggaatctt
     3301 gaaaaacggt cataatgatg gacgtgctct aaacagggga gcttttggag tctttggaga
     3361 caatgcagcc agagctttcc atggagctgc cggtgaagca ggtgcagcct ttggaaacca
     3421 tggagccaat aggggcaatg gaagaggtaa cagaaacagg gaggccaatg gaaggaatga
     3481 agagaatgga gcatttggac gggatcaaca tgtatttcca gagtttgaac atgaggaatc
     3541 agatcgtgga actgagacct cagattcaat tgccttggag atcacatcct ttgatggtga
     3601 gcaaaacagt ggtagaccag tatcatcaac aacaatgggt tttcctattg gacgctcatc
     3661 tcctagaggt tctgattttg ggagtgacat ctcatataac agcccaatac tacatgtgta
     3721 tgaaaaggat ttctcatctg aggtctactg tggttctttg tggggagtca atttgttgct
     3781 gggcacccaa tctcatctgt atctgatgga ccgaagtgga aaggcagaaa ttgttaaact
     3841 tataaagcga agaccattcc ggcagattca agtcgtggag cagctcaatt tgctgattac
     3901 catctctggc aaaaagaaca gacttcgcgt gtatcatctg tcttggctga ggaacaaaat
     3961 tctgaataat gatccaaaga gtaagaaaag gcagaaggcg atgaggaaga aagaggaagc
     4021 ttgcaaagct atcgataagt tgattggctg tgaacacttc agtgtccttc aacatgaaga
     4081 aacaacatac attgcggttg ctgtgaagtc atcaattcac ctctttgcat gggcaccaaa
     4141 atcctttgat gaaaacactg ccattaaagt gtttccaact cgtgatctta agccactgac
     4201 agttgacctg gctgttggtt cagagaaaac actgaagatt ttcttcagct cagctaatgg
     4261 atatcatatc atcgatgcag aatctgaagt tatgtctgag gtgaccttgc caaataataa
     4321 tgtcgtcatt ttacctgatt gcttgggact tggtgtgatg ctctccctca atgctgaagc
     4381 tgcctccgag gaagcaaacg aacaactcct taagaagatc ctggacgtgt ggaaggacat
     4441 accgtcttct gtggcttttg agtgtacaaa gagaatcact ggatgggacc aaaaggctat
     4501 tgaagtgcgc tctcttcagt caactattct cgagaatgag ctgaagcgcc gctcaatcaa
     4561 gaaactgaga tttctctgtg cccgtggtga caagatgttc tttgcttcta cactgagcaa
     4621 tgaccacagc cgggtttacc ttatgagcct tggaaaactt gaagagctcc atagaagcta
     4681 tgctgtttaa aggggtccag tgatcgacta caacctttac atccaccaca cacatgccat
     4741 tgaatcctaa catcagaatt ttatcattag agaaaacttt catcagaggc ttttaatgta
     4801 gcacagaata gtttggataa gaaatgaagc tttataaaga aaattaacta tagcaagctc
     4861 tatgtactcc agtggtgtac aatctgtttt gcacaaactt tgtaactttt gttactgtga
     4921 attcaaacat ttctcttagg acagtttgga cagtatctgt attcagattt acagcatgga
     4981 gtaaagaaac ctgttataaa ttgcatcacc agcaactttc aaaggaattg gccctaatta
     5041 agcttttcca aaacaaaaaa atagatacat gttttttttt tccaagtgaa ggttagatta
     5101 aaagacaaaa cataatgaat tttgcaaccc agactaaggt tgaacaacct gtgtgcgcaa
     5161 agaaaattac atagatcaag gggaacattc tacccaattc tttttcacaa taaatacaca
     5221 actgaagacc aattgtgact tttttccagc cccttgttaa atttaatttt tctatataga
     5281 aaaagagaag aaaacctcag atgcttgctt ctgcccccct aaaagcccca aatatgtgta
     5341 agaactgttt ttataaagta ccaaacaata tatttactat cttgaataca ggactgaact
     5401 ccaatgcaca tgtactgtag aaaaaaaatt ttaacacatc aaacgaggcg tcaaattttg
     5461 tcccccaaat tggctaagtt ttgaatttta ttatatagcc aatgctgtga ccatcagaca
     5521 acattaaata tttttaaata ttgaaatatg ttttaaatac attaaagtat ataaaatgtc
     5581 ctccaagtta ttaagcaaag caatataaca aaaggagaag aatgttgatt ggcaataatt
     5641 atatttttac atttttatca ctacaaattc aaaattaaga taatcaaggt gataatccaa
     5701 atttagagtc attcgttcta ggtatgaaaa ttacaagaat tttagaaaaa atataacatc
     5761 cactgtatac taaagtctgc aaaactgaag cagtgaaatt catgccagtc catatccaca
     5821 tattttatag acgccaaaaa taggtgatat ttcctcacct atggtaactg ctacctgatt
     5881 tttttaaagc gtgatttata cctatccatc ctcaatgaca tggttagttc tggggtaata
     5941 ggaaaaacta cagaacctac cacaaagtat acctcaataa gtcctctagc tctgcttctc
     6001 aaatctgaag agtgtgctag caggataata atttttaaac tacctggtta accaaaacaa
     6061 aaagcagctg actatgtgtg atttcctgat agtacatcat ttcctggtac ctttgtgcca
     6121 gaaatgaatg aagatttgga ttttcctaat gactcctatc aagagtgtag taactcagtg
     6181 ttcagattat aggagaacct gaatccacaa gttaactgtg attcgcattt ctgttactgt
     6241 gacacactaa tgtgacccaa aaactggctt atccttgagt gtttacaatt caaattactt
     6301 tttttaagtt cagtagttat tttaaataag caaactttaa tgtcaaatta atacattaga
     6361 agtagctttc tttaaaacaa aaaaaaaaat gtacaccaaa aggccatgag gaactttgtg
     6421 caagtacctt atcgctgagg aaatggagct tgctatgttg gaggttcaga actatttctc
     6481 atttaagtag tatgtaggat caaacctttt aagaattttt ttcttcatat ttactcaaaa
     6541 ataagcttac aataagtttt atcttaaaat catatgttta aggcagtaag acactaaacc
     6601 aaaa
//
