LOCUS       NP_775616               1161 aa            linear   ROD 27-APR-2025
DEFINITION  nuclear receptor-interacting protein 1 [Mus musculus].
ACCESSION   NP_775616 NP_032761
VERSION     NP_775616.1
DBSOURCE    REFSEQ: accession NM_173440.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1161)
  AUTHORS   Shi,R., Li,Y., Zhu,W., Xin,H., Yang,H., Feng,X., Wang,Z., Li,S.,
            Cong,B. and Shi,W.
  TITLE     The Regulation of Frontal Cortex Cholesterol Metabolism
            Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of
            Stress-Induced Depression
  JOURNAL   Int J Mol Sci 25 (15), 8075 (2024)
   PUBMED   39125645
  REMARK    GeneRIF: The Regulation of Frontal Cortex Cholesterol Metabolism
            Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of
            Stress-Induced Depression.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1161)
  AUTHORS   Sfeir,N., Kajdan,M., Jalaguier,S., Bonnet,S., Teyssier,C.,
            Pyrdziak,S., Yuan,R., Bousquet,E., Maraver,A., Bernex,F., Pirot,N.,
            Boissiere-Michot,F., Castet-Nicolas,A., Lapierre,M. and
            Cavailles,V.
  TITLE     RIP140 regulates transcription factor HES1 oscillatory expression
            and mitogenic activity in colon cancer cells
  JOURNAL   Mol Oncol 18 (6), 1510-1530 (2024)
   PUBMED   38459621
  REMARK    GeneRIF: RIP140 regulates transcription factor HES1 oscillatory
            expression and mitogenic activity in colon cancer cells.
REFERENCE   3  (residues 1 to 1161)
  AUTHORS   Tsagkaraki,E., Guilherme,A., Nicoloro,S.M., Kelly,M.,
            Lifshitz,L.M., Wang,H., Min,K., Rowland,L.A., Santos,K.B.,
            Wetoska,N., Friedline,R.H., Maitland,S.A., Chen,M., Weinstein,L.S.,
            Wolfe,S.A., Kim,J.K. and Czech,M.P.
  TITLE     Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte
            thermogenic programming
  JOURNAL   Mol Metab 76, 101780 (2023)
   PUBMED   37482187
  REMARK    GeneRIF: Crosstalk between corepressor NRIP1 and cAMP signaling on
            adipocyte thermogenic programming.
REFERENCE   4  (residues 1 to 1161)
  AUTHORS   Yamamoto,T., Maurya,S.K., Pruzinsky,E., Batmanov,K., Xiao,Y.,
            Sulon,S.M., Sakamoto,T., Wang,Y., Lai,L., McDaid,K.S.,
            Shewale,S.V., Leone,T.C., Koves,T.R., Muoio,D.M., Dierickx,P.,
            Lazar,M.A., Lewandowski,E.D. and Kelly,D.P.
  TITLE     RIP140 deficiency enhances cardiac fuel metabolism and protects
            mice from heart failure
  JOURNAL   J Clin Invest 133 (9), e162309 (2023)
   PUBMED   36927960
  REMARK    GeneRIF: RIP140 deficiency enhances cardiac fuel metabolism and
            protects mice from heart failure.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1161)
  AUTHORS   Wang,C. and Li,X.
  TITLE     MiR-499 enhances Porphyromonas gingivalis LPS-induced inflammatory
            response in macrophages by targeting NRIP1 via JAK/STAT pathway
  JOURNAL   J Biosci 48 (2023)
   PUBMED   38047488
  REMARK    GeneRIF: MiR-499 enhances Porphyromonas gingivalis LPS-induced
            inflammatory response in macrophages by targeting NRIP1 via
            JAK/STAT pathway.
REFERENCE   6  (residues 1 to 1161)
  AUTHORS   Wei,L.N., Hu,X., Chandra,D., Seto,E. and Farooqui,M.
  TITLE     Receptor-interacting protein 140 directly recruits histone
            deacetylases for gene silencing
  JOURNAL   J Biol Chem 275 (52), 40782-40787 (2000)
   PUBMED   11006275
REFERENCE   7  (residues 1 to 1161)
  AUTHORS   Lee,C.H. and Wei,L.N.
  TITLE     Characterization of receptor-interacting protein 140 in retinoid
            receptor activities
  JOURNAL   J Biol Chem 274 (44), 31320-31326 (1999)
   PUBMED   10531331
REFERENCE   8  (residues 1 to 1161)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (residues 1 to 1161)
  AUTHORS   Lee,C.H., Chinpaisal,C. and Wei,L.N.
  TITLE     Cloning and characterization of mouse RIP140, a corepressor for
            nuclear orphan receptor TR2
  JOURNAL   Mol Cell Biol 18 (11), 6745-6755 (1998)
   PUBMED   9774688
REFERENCE   10 (residues 1 to 1161)
  AUTHORS   Katsanis,N., Ives,J.H., Groet,J., Nizetic,D. and Fisher,E.M.
  TITLE     Localisation of receptor interacting protein 140 (RIP140) within
            100 kb of D21S13 on 21q11, a gene-poor region of the human genome
  JOURNAL   Hum Genet 102 (2), 221-223 (1998)
   PUBMED   9521594
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145744.3.
            
            On Mar 12, 2003 this sequence version replaced NP_032761.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036273.1, AK156233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1161
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 43.65 cM"
     Protein         1..1161
                     /product="nuclear receptor-interacting protein 1"
                     /note="nuclear factor RIP140; receptor-interacting protein
                     140"
                     /calculated_mol_wt=126207
     Region          1..416
                     /region_name="Interaction with ZNF366.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          21..25
                     /region_name="LXXLL motif 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          27..331
                     /region_name="NRIP1_repr_1"
                     /note="Nuclear receptor-interacting protein 1 repression
                     1; pfam15687"
                     /db_xref="CDD:434859"
     Region          34..68
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          78..335
                     /region_name="Repression domain 1.
                     /evidence=ECO:0000250|UniProtKB:P48552"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            104
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15846843; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            111
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:15879431; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          133..137
                     /region_name="LXXLL motif 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            158
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:15879431; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          185..189
                     /region_name="LXXLL motif 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            207
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:15846843; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            218
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P48552; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          267..271
                     /region_name="LXXLL motif 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            287
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:15879431; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            311
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:15879431; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            358
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15846843; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            380
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15846843; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          382..386
                     /region_name="LXXLL motif 5. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          393..436
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          411..701
                     /region_name="Repression domain 2.
                     /evidence=ECO:0000250|UniProtKB:P48552"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          412..739
                     /region_name="NRIP1_repr_2"
                     /note="Nuclear receptor-interacting protein 1 repression
                     2; pfam15688"
                     /db_xref="CDD:464803"
     Region          432..473
                     /region_name="Required for targeting to small nuclear
                     foci. /evidence=ECO:0000250|UniProtKB:P48552"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          441..447
                     /region_name="CTBP-binding, principal site.
                     /evidence=ECO:0000250|UniProtKB:P48552"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            447
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P48552; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            482
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:15879431; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            488
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15846843; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          501..505
                     /region_name="LXXLL motif 6. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          517..559
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            519
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15846843; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            529
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:15879431; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            531
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15846843; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            543
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15846843; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            565
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P48552; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          566..570
                     /region_name="CTBP-binding.
                     /evidence=ECO:0000250|UniProtKB:P48552"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          604..623
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            607
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:15879431; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          639..702
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            672
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15846843; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          714..718
                     /region_name="LXXLL motif 7. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          717..747
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          736..886
                     /region_name="Repression domain 3.
                     /evidence=ECO:0000250|UniProtKB:P48552"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          754..1161
                     /region_name="Interaction with ZNF366.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          754..841
                     /region_name="NRIP1_repr_3"
                     /note="Nuclear receptor-interacting protein 1 repression
                     3; pfam15689"
                     /db_xref="CDD:406181"
     Site            808
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P48552; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          820..824
                     /region_name="LXXLL motif 8. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          829..848
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          850..1161
                     /region_name="NRIP1_repr_4"
                     /note="Nuclear receptor-interacting protein 1 repression
                     4; pfam15690"
                     /db_xref="CDD:434861"
     Site            932
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:15879431; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          937..941
                     /region_name="LXXLL motif 9. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          947..951
                     /region_name="CTBP-binding.
                     /evidence=ECO:0000250|UniProtKB:P48552"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          950..976
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Site            1003
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15846843; propagated from
                     UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          1063..1076
                     /region_name="Ligand-dependent nuclear receptor binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     Region          1121..1161
                     /region_name="Repression domain 4.
                     /evidence=ECO:0000250|UniProtKB:P48552"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8CBD1.1)"
     CDS             1..1161
                     /gene="Nrip1"
                     /gene_synonym="6030458L20Rik; 8430438I05Rik; 9630050P12;
                     RIP140"
                     /coded_by="NM_173440.3:724..4209"
                     /db_xref="CCDS:CCDS28274.1"
                     /db_xref="GeneID:268903"
                     /db_xref="MGI:MGI:1315213"
ORIGIN      
        1 mthgeelgsd vhqdsivlty legllmhqaa ggsgtainkk saghkeedqn fnlsgsafps
       61 cqsngptvst qtyqgsgmlh lkkarllqss edwnaakrkr lsdsivnlnv kkeallagmv
      121 dsvpkgkqds tllasllqsf ssrlqtvals qqirqslkeq gyalsheslk vekdlrcygv
      181 asshlktllk ksktkdqksg ptlpdvtpnl irdsfvessh pavgqsgtkv mseplscaar
      241 lqavasmvek raspaaspkp svacsqlall lsseahlqqy srehalktqn ahqvaserla
      301 amarlqengq kdvgssqlsk gvsghlngqa ralpasklva nknnaatfqs pmgvvpsspk
      361 ntsyknsler nnlkqaanns lllhllksqt iptpmnghsq nerassfess tpttideysd
      421 nnpsftddss gdessysncv pidlsckhri ekpeaerpvs lenltqslln twdpkipgvd
      481 ikedqdtstn sklnshqkvt llqlllghks eetvernasp qdihsdgtkf spqnytrtsv
      541 iespstnrtt pvstpplyta sqaespinls qhslvikwns ppyacstpas kltntapshl
      601 mdltkgkesq aekpapsega qnsatfsask llqnlaqcgl qssgpgeeqr pckqllsgnp
      661 dkplglidrl nspllsnktn aaeeskafss qpagpepglp gceienller rtvlqlllgn
      721 sskgknekke ktpardeapq ehseraaneq ilmvkiksep cddfqthntn lplnhdaksa
      781 pflgvtpaih rstaalpvse dfksepaspq dfsfskngll srllrqnqes ypadeqdksh
      841 rnselptles knicmvpkkr klyteplenp fkkmkntavd tanhhsgpev lygsllhqee
      901 lkfsrneldy kypaghssas dgdhrsware sksfnvlkql llsencvrdl sphrsdsvpd
      961 tkkkghknna pgskpefgis slnglmyssp qpgscvtdhr tfsypgmvkt plsppfpehl
     1021 gcvgsrpepg llngcsvpge kgpikwviad mdkneyekds prltktnpil yymlqkgggn
     1081 svttqetqdk diwrepasae slsqvtvkee llpaaetkas ffnlrspyns hmgnnasrph
     1141 stngevygll gnaltikkes e
//
