LOCUS       NM_022029               1293 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus neurogranin (Nrgn), mRNA.
ACCESSION   NM_022029 XM_001478258 XM_001478626
VERSION     NM_022029.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1293)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1293)
  AUTHORS   Tran,H.N., Nguyen,Q.H. and Jeong,Y.
  TITLE     Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron
            fate and regulates differentiation of the dorsal midbrain into the
            inferior and superior colliculi
  JOURNAL   Front Cell Dev Biol 12, 1336308 (2024)
   PUBMED   38344749
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1293)
  AUTHORS   Baranowski,R.W., Braun,J.L., Vandenboom,R. and Fajardo,V.A.
  TITLE     Neurogranin inhibits calcineurin in murine soleus muscle: Effects
            of heterozygous knockdown on muscle adaptations to tenotomy and
            fatigue resistance
  JOURNAL   Biochem Biophys Res Commun 623, 89-95 (2022)
   PUBMED   35878428
  REMARK    GeneRIF: Neurogranin inhibits calcineurin in murine soleus muscle:
            Effects of heterozygous knockdown on muscle adaptations to tenotomy
            and fatigue resistance.
REFERENCE   4  (bases 1 to 1293)
  AUTHORS   Braun,J.L., Ryoo,J., Goodwin,K., Copeland,E.N., Geromella,M.S.,
            Baranowski,R.W., MacPherson,R.E.K. and Fajardo,V.A.
  TITLE     The effects of neurogranin knockdown on SERCA pump efficiency in
            soleus muscles of female mice fed a high fat diet
  JOURNAL   Front Endocrinol (Lausanne) 13, 957182 (2022)
   PUBMED   36072929
  REMARK    GeneRIF: The effects of neurogranin knockdown on SERCA pump
            efficiency in soleus muscles of female mice fed a high fat diet.
            Erratum:[Front Endocrinol (Lausanne). 2022 Sep 21;13:1037434. doi:
            10.3389/fendo.2022.1037434.. PMID: 36213289]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1293)
  AUTHORS   Jorgensen,A.N., Abdullah,C.S., Bhuiyan,M.S., Watt,M., Dominic,P.,
            Kolluru,G.K., Kevil,C.G. and Nam,H.W.
  TITLE     Neurogranin regulates calcium-dependent cardiac hypertrophy
  JOURNAL   Exp Mol Pathol 127, 104815 (2022)
   PUBMED   35870494
REFERENCE   6  (bases 1 to 1293)
  AUTHORS   Pak,J.H., Huang,F.L., Li,J., Balschun,D., Reymann,K.G., Chiang,C.,
            Westphal,H. and Huang,K.P.
  TITLE     Involvement of neurogranin in the modulation of
            calcium/calmodulin-dependent protein kinase II, synaptic
            plasticity, and spatial learning: a study with knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 97 (21), 11232-11237 (2000)
   PUBMED   11016969
REFERENCE   7  (bases 1 to 1293)
  AUTHORS   Jaradat,S.A., Ko,M.S. and Grossman,L.I.
  TITLE     Tissue-specific expression and mapping of the Cox7ah gene in mouse
  JOURNAL   Genomics 49 (3), 363-370 (1998)
   PUBMED   9615220
  REMARK    Erratum:[Genomics 1998 Dec 15;54(3):583-4]
REFERENCE   8  (bases 1 to 1293)
  AUTHORS   Martinez de Arrieta,C., Perez Jurado,L., Bernal,J. and Coloma,A.
  TITLE     Structure, organization, and chromosomal mapping of the human
            neurogranin gene (NRGN)
  JOURNAL   Genomics 41 (2), 243-249 (1997)
   PUBMED   9143500
REFERENCE   9  (bases 1 to 1293)
  AUTHORS   Wydner,K.S., Kim,Y., Csiszar,K., Boyd,C.D. and Passmore,H.C.
  TITLE     An intron capture strategy used to identify and map a lysyl
            oxidase-like gene on chromosome 9 in the mouse
  JOURNAL   Genomics 40 (2), 342-345 (1997)
   PUBMED   9119402
REFERENCE   10 (bases 1 to 1293)
  AUTHORS   Danielson,P.E., Watson,J.B., Gerendasy,D.D., Erlander,M.G.,
            Lovenberg,T.W., de Lecea,L., Sutcliffe,J.G. and Frankel,W.N.
  TITLE     Chromosomal mapping of mouse genes expressed selectively within the
            central nervous system
  JOURNAL   Genomics 19 (3), 454-461 (1994)
   PUBMED   7910582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU604757.1 and AK158630.1.
            
            On or before Jul 25, 2007 this sequence version replaced
            XM_001478258.1, XM_001478626.1, NM_022029.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158630.1, BU559922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BU604757.1         4-20
            18-1293             AK158630.1         5-1280
FEATURES             Location/Qualifiers
     source          1..1293
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.78 cM"
     gene            1..1293
                     /gene="Nrgn"
                     /gene_synonym="0710001B06Rik; NG; NG/RC3; Pss1; RC3"
                     /note="neurogranin"
                     /db_xref="GeneID:64011"
                     /db_xref="MGI:MGI:1927184"
     exon            1..209
                     /gene="Nrgn"
                     /gene_synonym="0710001B06Rik; NG; NG/RC3; Pss1; RC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..431
                     /gene="Nrgn"
                     /gene_synonym="0710001B06Rik; NG; NG/RC3; Pss1; RC3"
                     /note="postsynaptic spine 1; protein kinase C substrate;
                     neurogranin (protein kinase C substrate, RC3)"
                     /codon_start=1
                     /product="neurogranin"
                     /protein_id="NP_071312.1"
                     /db_xref="CCDS:CCDS40585.1"
                     /db_xref="GeneID:64011"
                     /db_xref="MGI:MGI:1927184"
                     /translation="MDCCTESACSKPDDDILDIPLDDPGANAAAAKIQASFRGHMARK
                     KIKSGECGRKGPGPGGPGGAGGARGGAGGGPSGD"
     exon            210..436
                     /gene="Nrgn"
                     /gene_synonym="0710001B06Rik; NG; NG/RC3; Pss1; RC3"
                     /inference="alignment:Splign:2.1.0"
     exon            437..454
                     /gene="Nrgn"
                     /gene_synonym="0710001B06Rik; NG; NG/RC3; Pss1; RC3"
                     /inference="alignment:Splign:2.1.0"
     exon            455..1293
                     /gene="Nrgn"
                     /gene_synonym="0710001B06Rik; NG; NG/RC3; Pss1; RC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1268..1273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrgn"
                     /gene_synonym="0710001B06Rik; NG; NG/RC3; Pss1; RC3"
                     /note="hexamer: AATAAT"
     polyA_site      1276
                     /gene="Nrgn"
                     /gene_synonym="0710001B06Rik; NG; NG/RC3; Pss1; RC3"
ORIGIN      
        1 gcagggctca ggttacattc gcaagagttg cggagcgcgg gagaccggac ccaagaggag
       61 agaggctggt tctgcaagga ttctgcgctg gtcggggagt gcccgacagc ccctgagctg
      121 ccacccagca tcgtacaaac ccacccccgc tctgcgccag gctccacccc agccaaggac
      181 cctcaacacc ggcaatggac tgctgcacgg agagcgcctg ctccaagcca gacgacgata
      241 ttcttgacat cccgctggat gatcccggag ccaacgccgc tgcagccaaa atccaggcga
      301 gtttccgggg ccacatggcg aggaagaaga taaagagcgg agagtgtggc cggaagggac
      361 cgggccccgg gggaccaggc ggagctgggg gcgcccgggg aggcgcgggc ggcggcccca
      421 gcggagacta ggccagagct gaacgtttta gaagttccag aggagagtcg gatgccgcgt
      481 ccccttcgca gtgacaagac ttccctactg tgtttgtgag cccctccttc ccaccaacca
      541 gccagcttca ggagcccccc ccctcccccc gccgcgtccc agagactccc tctcccaggc
      601 tggcttcgtc ttggcgtagc caagtccgtg ccctttttag ctcttcagtc taacgtggtc
      661 tccttttgcc ttttctcccc accctcgtcc caaaccccat actcccaaaa atgtcctttt
      721 gcttcacgcc cacctgtcca cgcgcccagc atgcagctct gcctccgcag cctcggtgcg
      781 cttcgctgcg cgtactgcag agggcgccca atgcgtcgcc caaatactct caaaaaaaga
      841 aagaaaaaaa gaaaaagaaa gaaagaaaaa aaaaagcaac caccaagtcc tttcgttctg
      901 tgggcaacga aagggggcgc ccgcgtcttt ccaccctagc ctaacctcaa cctcctaaac
      961 ctggggctag gaaagagggg aggaggtttt catggttatc tgataatttc ccttgctcaa
     1021 atggaaagtg aagtcctatc ccatacctgc ctgtcaccct cttttttctt gaaaacgcac
     1081 cctgagagca gcccctcccg ctcttctttg tttatgcaaa agcctcctga gcgcctggag
     1141 gctccggcag gaggagactt ccgcagcccc gccccatgat agcctctccc ccgttgggct
     1201 cctggggttg tggctggaag gtttttaatc tctgcgtgtg catgttacca tactgggttg
     1261 gaatgtgaat aataaagagg aatgtctaag tgt
//
