LOCUS       NM_032002               1952 bp    mRNA    linear   ROD 17-SEP-2023
DEFINITION  Mus musculus neuregulin 4 (Nrg4), mRNA.
ACCESSION   NM_032002
VERSION     NM_032002.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1952)
  AUTHORS   Zhang Y, Zhu Y, Wang J, Jin L, Guo M, Chen L, Zhang L, Li Y, Wan B,
            Zhang R, Jia W and Hu C.
  TITLE     Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons
            and Preserve Metabolic Homeostasis
  JOURNAL   Adv Sci (Weinh) 10 (16), e2204824 (2023)
   PUBMED   37060105
  REMARK    GeneRIF: Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin
            Neurons and Preserve Metabolic Homeostasis.
REFERENCE   2  (bases 1 to 1952)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1952)
  AUTHORS   Shi L, Li Y, Xu X, Cheng Y, Meng B, Xu J, Xiang L, Zhang J, He K,
            Tong J, Zhang J, Xiang L and Xiang G.
  TITLE     Brown adipose tissue-derived Nrg4 alleviates endothelial
            inflammation and atherosclerosis in male mice
  JOURNAL   Nat Metab 4 (11), 1573-1590 (2022)
   PUBMED   36400933
  REMARK    GeneRIF: Brown adipose tissue-derived Nrg4 alleviates endothelial
            inflammation and atherosclerosis in male mice.
            Erratum:[Nat Metab. 2022 Dec 26;:. PMID: 36572825]
REFERENCE   4  (bases 1 to 1952)
  AUTHORS   Wang H, Wang L, Hu F, Wang P, Xie Y, Li F and Guo B.
  TITLE     Neuregulin-4 attenuates diabetic cardiomyopathy by regulating
            autophagy via the AMPK/mTOR signalling pathway
  JOURNAL   Cardiovasc Diabetol 21 (1), 205 (2022)
   PUBMED   36221104
  REMARK    GeneRIF: Neuregulin-4 attenuates diabetic cardiomyopathy by
            regulating autophagy via the AMPK/mTOR signalling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1952)
  AUTHORS   Zhang P, Chen Z, Kuang H, Liu T, Zhu J, Zhou L, Wang Q, Xiong X,
            Meng Z, Qiu X, Jacks R, Liu L, Li S, Lumeng CN, Li Q, Zhou X and
            Lin JD.
  TITLE     Neuregulin 4 suppresses NASH-HCC development by restraining
            tumor-prone liver microenvironment
  JOURNAL   Cell Metab 34 (9), 1359-1376 (2022)
   PUBMED   35973424
  REMARK    GeneRIF: Neuregulin 4 suppresses NASH-HCC development by
            restraining tumor-prone liver microenvironment.
REFERENCE   6  (bases 1 to 1952)
  AUTHORS   Bernard JK, McCann SP, Bhardwaj V, Washington MK and Frey MR.
  TITLE     Neuregulin-4 is a survival factor for colon epithelial cells both
            in culture and in vivo
  JOURNAL   J Biol Chem 287 (47), 39850-39858 (2012)
   PUBMED   23033483
  REMARK    GeneRIF: Pharmacological inhibition of PI3K/Akt signaling reversed
            the anti-apoptotic effects of NRG4, confirming the role of this
            cascade in NRG4-induced cell survival
REFERENCE   7  (bases 1 to 1952)
  AUTHORS   Assimacopoulos S, Grove EA and Ragsdale CW.
  TITLE     Identification of a Pax6-dependent epidermal growth factor family
            signaling source at the lateral edge of the embryonic cerebral
            cortex
  JOURNAL   J Neurosci 23 (16), 6399-6403 (2003)
   PUBMED   12878679
REFERENCE   8  (bases 1 to 1952)
  AUTHORS   Hobbs SS, Coffing SL, Le AT, Cameron EM, Williams EE, Andrew M,
            Blommel EN, Hammer RP, Chang H and Riese DJ 2nd.
  TITLE     Neuregulin isoforms exhibit distinct patterns of ErbB family
            receptor activation
  JOURNAL   Oncogene 21 (55), 8442-8452 (2002)
   PUBMED   12466964
REFERENCE   9  (bases 1 to 1952)
  AUTHORS   Huotari MA, Miettinen PJ, Palgi J, Koivisto T, Ustinov J, Harari D,
            Yarden Y and Otonkoski T.
  TITLE     ErbB signaling regulates lineage determination of developing
            pancreatic islet cells in embryonic organ culture
  JOURNAL   Endocrinology 143 (11), 4437-4446 (2002)
   PUBMED   12399441
REFERENCE   10 (bases 1 to 1952)
  AUTHORS   Harari D, Tzahar E, Romano J, Shelly M, Pierce JH, Andrews GC and
            Yarden Y.
  TITLE     Neuregulin-4: a novel growth factor that acts through the ErbB-4
            receptor tyrosine kinase
  JOURNAL   Oncogene 18 (17), 2681-2689 (1999)
   PUBMED   10348342
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX530002.1, AF083067.2, AK080058.1 and BC027677.1.
            
            [WARNING] On Oct 26, 2023 this sequence was replaced by
            NM_032002.3.
            
            On Oct 3, 2007 this sequence version replaced NM_032002.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AA238077.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: PMID: 23033483
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               BX530002.1         27-148
            123-849             AF083067.2         1-727
            850-1669            AK080058.1         802-1621
            1670-1952           BC027677.1         725-1007
FEATURES             Location/Qualifiers
     source          1..1952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.87 cM"
     gene            1..1952
                     /gene="Nrg4"
                     /note="neuregulin 4"
                     /db_xref="GeneID:83961"
                     /db_xref="MGI:MGI:1933833"
     exon            1..129
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     exon            130..195
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..533
                     /gene="Nrg4"
                     /note="pro-NRG4"
                     /codon_start=1
                     /product="pro-neuregulin-4, membrane-bound isoform"
                     /protein_id="NP_114391.1"
                     /db_xref="CCDS:CCDS52801.1"
                     /db_xref="GeneID:83961"
                     /db_xref="MGI:MGI:1933833"
                     /translation="MPTDHEQPCGPRHRSFCLNGGICYVIPTIPSPFCRCIENYTGAR
                     CEEVFLPSSSIPSESNLSAAFVVLAVLLTLTIAALCFLCRKGHLQRASSVQCEISLVE
                     TNNTRTRHSHREH"
     exon            196..289
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     exon            290..436
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     exon            437..516
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     exon            517..602
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     exon            603..741
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
     exon            742..1928
                     /gene="Nrg4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaatccgatt tttgacacgt tgtaaagttc gagtcacagt tgctgaagtc ctcagtgttc
       61 aaacacttgt gaaacgctgc atgtctagca aaattttctt tttttatggg aatataaatt
      121 tctgttgagg tgctgatttt caaccttaat tcttccatca agaatgaaac tatttaaaaa
      181 ttaagatgcc aacagatcac gagcagccct gtggtcccag gcacaggtca ttttgcctca
      241 atggggggat ttgttatgtg atccctacta tccccagccc attctgtagg tgcattgaaa
      301 attacaccgg agcacgctgc gaagaggttt ttctcccaag ctccagcatc ccaagcgaaa
      361 gtaatctgtc ggcagctttc gtggtgctgg cggtcctcct cactcttacc atcgcggcgc
      421 tctgcttcct gtgcaggaag ggccaccttc agagggccag ttcagtccag tgtgagatca
      481 gcctggtaga gacaaacaat accagaaccc gtcacagcca cagagaacac tgaagacata
      541 catccccagt gaagggcatc attacctaca aaggcggact gtggaccata cgacgagaga
      601 agcccatcat catggatgtg tcccatcatt tctatggcag tcccaggatc tcactcttct
      661 tgatgctcta ctgtttgatt gttcatcgtt cacatacaga aatgacgctg gtttcctgtg
      721 ttgaccttgc accctgctac tgtcatcact ggcctggaag tcagcagtat agataaggct
      781 ggccctgaat tcaagagact cacctgtttt tgcctactca gagttactgg aattaaaggc
      841 ataacaacac tatactctgc ttgattcctc taatttcttt tttaaaaacc taaaagtatt
      901 gaggacctga aatcaaatat ttctatttac ccacggggga agagcaaagt actcaggctt
      961 acttctcaca agtaagtgaa gacaaattgt ccacctggcc tccagccaag atgatattca
     1021 tatcgctgaa agtgctgact acccgatgca ggtaattact ggctcccacc ttacagcagt
     1081 tatagccaaa gacaaggacc acacgaagtt cagggttgtc cagaagacct gcagagaagt
     1141 gagggacaga gacagcctta aacagcatga actgttgctc ctgttgactg gcactcccag
     1201 tgtgttctgc agtgctgaag tgctcagttc tccgattctt agagcctgag attactcact
     1261 caagccttag ttatgatttt tccattaata aaacctatgg ctatttgaat gtaatatgcc
     1321 tcacataagc aagggcattt tgcagagtgc tatacacaga catgttgaag tgaataactg
     1381 cagtgccagc tccacatctt cattcctcgc acaccagtga cctcgagctt atcttctcag
     1441 atgtggtctt aaagcagctt gcatcactgg caggcagcag agctccgaga gccagtggcc
     1501 atctctcccc agagcttcca ctgaacctct ggtactttct tttcattcat tgagaccagt
     1561 cagtgttgaa caggataatc ccacttaact cagccacacg acttccaaag cagccaggcc
     1621 actcactaag ccagagtgaa gcaggccaca ggggaaggag gcggcgccct gcagaccaag
     1681 agtccagcac atcaacaccg aactccacac acgccagaga cctccagttt taattaccca
     1741 atgttacctc gccctgcacc ccagcagcca tccagagtcc agctaaactc taatggcaga
     1801 gcacctgtag agacgacatg tggccctcct ctgcagagcc cactttctga gtgtctctca
     1861 accctgtgcg gaaactggta ttgaaaacct ccttttaata aactccgact ctactttgca
     1921 ctagctcaaa aaaaaaaaaa aaaaaaaaaa aa
//
