LOCUS       NM_008734               4012 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus neuregulin 3 (Nrg3), transcript variant 1, mRNA.
ACCESSION   NM_008734 XM_981213 XM_987980
VERSION     NM_008734.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4012)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 4012)
  AUTHORS   Keeley,P.W., Patel,S.S. and Reese,B.E.
  TITLE     Cell numbers, cell ratios, and developmental plasticity in the rod
            pathway of the mouse retina
  JOURNAL   J Anat 243 (2), 204-222 (2023)
   PUBMED   35292986
  REMARK    Review article
REFERENCE   3  (bases 1 to 4012)
  AUTHORS   Zhang,X., Xiao,G., Johnson,C., Cai,Y., Horowitz,Z.K., Mennicke,C.,
            Coffey,R., Haider,M., Threadgill,D., Eliscu,R., Oldham,M.C.,
            Greenbaum,A. and Ghashghaei,H.T.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4012)
  AUTHORS   Ahmad,T., Vullhorst,D., Chaudhuri,R., Guardia,C.M., Chaudhary,N.,
            Karavanova,I., Bonifacino,J.S. and Buonanno,A.
  TITLE     Transcytosis and trans-synaptic retention by postsynaptic ErbB4
            underlie axonal accumulation of NRG3
  JOURNAL   J Cell Biol 221 (7) (2022)
   PUBMED   35579602
REFERENCE   5  (bases 1 to 4012)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   6  (bases 1 to 4012)
  AUTHORS   Assimacopoulos,S., Grove,E.A. and Ragsdale,C.W.
  TITLE     Identification of a Pax6-dependent epidermal growth factor family
            signaling source at the lateral edge of the embryonic cerebral
            cortex
  JOURNAL   J Neurosci 23 (16), 6399-6403 (2003)
   PUBMED   12878679
REFERENCE   7  (bases 1 to 4012)
  AUTHORS   Hobbs,S.S., Coffing,S.L., Le,A.T., Cameron,E.M., Williams,E.E.,
            Andrew,M., Blommel,E.N., Hammer,R.P., Chang,H. and Riese,D.J. 2nd.
  TITLE     Neuregulin isoforms exhibit distinct patterns of ErbB family
            receptor activation
  JOURNAL   Oncogene 21 (55), 8442-8452 (2002)
   PUBMED   12466964
REFERENCE   8  (bases 1 to 4012)
  AUTHORS   Howard,B.A. and Gusterson,B.A.
  TITLE     Mammary gland patterning in the AXB/BXA recombinant inbred strains
            of mouse
  JOURNAL   Mech Dev 91 (1-2), 305-309 (2000)
   PUBMED   10704854
REFERENCE   9  (bases 1 to 4012)
  AUTHORS   Howard,B.A. and Gusterson,B.A.
  TITLE     The characterization of a mouse mutant that displays abnormal
            mammary gland development
  JOURNAL   Mamm Genome 11 (3), 234-237 (2000)
   PUBMED   10723730
REFERENCE   10 (bases 1 to 4012)
  AUTHORS   Zhang,D., Sliwkowski,M.X., Mark,M., Frantz,G., Akita,R., Sun,Y.,
            Hillan,K., Crowley,C., Brush,J. and Godowski,P.J.
  TITLE     Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that
            binds and activates ErbB4
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9562-9567 (1997)
   PUBMED   9275162
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030231.6, CT025583.7, AC109253.9, CT025629.2 and AC154426.2.
            
            On Jun 13, 2010 this sequence version replaced NM_008734.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF010130.1, SRR10662773.1376456.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849379,
                                           SAMN00849384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1117              CT030231.6         102365-103481
            1118-1247           CT025583.7         169210-169339       c
            1248-1321           AC109253.9         176259-176332       c
            1322-1348           CT025629.2         135417-135443       c
            1349-1451           AC154426.2         47260-47362
            1452-1572           AC154426.2         57126-57246
            1573-1700           AC154426.2         72725-72852
            1701-1850           AC154426.2         77993-78142
            1851-1922           AC154426.2         83128-83199
            1923-4012           AC154426.2         83436-85525
FEATURES             Location/Qualifiers
     source          1..4012
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..4012
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /note="neuregulin 3"
                     /db_xref="GeneID:18183"
                     /db_xref="MGI:MGI:1097165"
     exon            1..1117
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..2430
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /note="isoform 1 is encoded by transcript variant 1;
                     scaramanga; pro-NRG3"
                     /codon_start=1
                     /product="pro-neuregulin-3, membrane-bound isoform isoform
                     1"
                     /protein_id="NP_032760.1"
                     /db_xref="CCDS:CCDS26954.1"
                     /db_xref="GeneID:18183"
                     /db_xref="MGI:MGI:1097165"
                     /translation="MSEGAAGASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEG
                     AAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDL
                     VDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTT
                     ITRAPTRFPGHRVPIRASPRSTTARNTAAPPTVLSTTAPFFSSSTPGSRPPMPGAPST
                     QAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAAAASSSSPSSTSSTTTTPETSTSPKF
                     HTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFL
                     PKTDSILSDPTDHLGIEFMESEDVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAK
                     QIQEHLKESQNGKNYSLKASSTKSESLMKSHVHLQNYSKADRHPVTALEKIMESSFSA
                     PQSFPEVTSPDRGSQPIKHHSPGQRSGMLHRNTFRRAPPSPRSRLGGIVGPAYQQLEE
                     SRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYVSNGLRTQQNASINMQLPSR
                     ETNPYFNSLDQKDLVGYLSPRANSVPIIPSMGLEETCMQMPGISDVKSIKWCKNSYSA
                     DIVNASMPVSDCLLEEQQEVKILLETVQEQIRILTDARRSEDFELASMETEDSASENT
                     AFLPLSPTAKSEREAQFVLRNEIQRDSVLTK"
     exon            1118..1247
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1321
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1348
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1451
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1572
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1700
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1850
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1922
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..4012
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3821..3826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /note="hexamer: AATAAA"
     polyA_site      3861
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /note="major polyA site"
     regulatory      3985..3990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrg3"
                     /gene_synonym="ska"
                     /note="hexamer: AATAAA"
     polyA_site      4011
                     /gene="Nrg3"
                     /gene_synonym="ska"
ORIGIN      
        1 cctgaccggc cggcggcgcc cgggccggtc tcgcccctct accgagcgcc tcgccgcccc
       61 ctccccggcc cgcgtcccct cccccgtcct ctcctccccg cccgccgccc gcctctcggg
      121 gggaggggcg tgggggcagg gagccgattt gcatgcggcc gccgcggccg ctgcctgagc
      181 cggagcccgc cgccgccgga gcccgcgccc gcgcccgcgc ccggcccgcg cggccccatg
      241 cctctggcgc ggccctcggg ggggcgaagg tgaagatcgg ctcctaggat gagtgaaggg
      301 gcggccggtg cctcgccacc tggtgccgct tcggcagccg ccgcctcagc cgaggagggc
      361 accgcggcgg ctgcggcggc ggcggcggcg ggcgggggcc cggacggcgg cggagaaggg
      421 gcggccgaac ctccccggga gttacgctgt agcgactgca tcgtgtggaa ccggcagcag
      481 acgtggttgt gcgtggtgcc tctgttcatc ggcttcatcg gcctggggct cagcctcatg
      541 ctgcttaaat ggatcgtggt aggctccgtc aaggagtacg tgcccacgga cctggtggac
      601 tccaagggaa tgggccagga ccccttcttc ctctccaagc ccagctcttt ccccaaggct
      661 atggaaacca ccacaacaac cacttctacc acgtcccccg ccaccccctc tgccggcggc
      721 gccgcttctt ccaggacgcc taaccggatt agcacccgct tgaccaccat cacacgggca
      781 cccacccgct tccctgggca ccgggttccc atccgggcta gcccgcgctc taccacagca
      841 cggaacactg ctgcccctcc gacggtcctg tccaccacgg cccctttctt cagtagcagc
      901 acgcccggct cccgaccccc gatgccagga gcccccagta cgcaggcgat gccttcctgg
      961 cccactgcgg cgtatgctac ctcctcctac ctccacgatt ccactccctc ctggaccctg
     1021 tcaccctttc aggatgctgc tgccgcctct tcctcctcac cctcttccac ctcctccact
     1081 accaccaccc cagaaactag caccagcccc aaatttcata ctacaacata ctccactgaa
     1141 cgatctgagc acttcaaacc ctgtcgagac aaggacctgg cgtattgtct caatgatggt
     1201 gaatgctttg tgattgagac cctgacagga tcccataagc actgtcggtg caaggaaggc
     1261 taccaaggag tccgttgtga tcaatttctg ccgaaaacag actccatctt atcggatcca
     1321 acagaccact tggggattga attcatggag agtgaagacg tttatcaaag gcaggtgctg
     1381 tcaatttcat gtatcatctt tggaattgtc atcgtgggca tgttctgtgc agcattctac
     1441 ttcaaaagca agaaacaagc taaacaaatt caggagcacc tgaaagagtc acagaatggg
     1501 aagaactaca gcctcaaggc atccagcaca aagtctgaga gcttgatgaa gagccatgtc
     1561 catctacaaa attattcaaa ggcggatagg catcctgtga ctgcgctgga gaaaataatg
     1621 gagtcaagtt tttcagctcc ccagtcgttc ccagaagtca cttctcctga ccgaggaagc
     1681 cagcctatca agcaccacag cccaggacaa aggagtggga tgttgcatag gaatactttc
     1741 agaagggcac caccctcacc ccgaagtcga ctgggtggta ttgtaggacc agcatatcaa
     1801 caacttgaag aatcaagaat tccagaccag gatacgatac cttgccaagg gatagaggtc
     1861 aggaagacta tatcccacct gcctatacag ctgtggtgtg ttgaaagacc cctggactta
     1921 aagtatgtgt ccaatggctt aagaacccaa caaaatgcat caataaatat gcaactgcct
     1981 tcaagagaga caaaccccta ttttaatagc ttggatcaaa aggacctggt gggttattta
     2041 tccccaaggg ccaattctgt gcccatcatc ccgtcgatgg gtctagaaga aacctgcatg
     2101 caaatgccag ggatttctga cgtcaaaagc attaaatggt gcaaaaactc ctactccgct
     2161 gacattgtca acgcgagtat gccagtcagt gattgtcttc tagaagaaca acaggaagtg
     2221 aaaatattac tagagactgt gcaggaacag atccggattc tgactgatgc cagacggtca
     2281 gaagacttcg aactggccag catggaaact gaggacagtg cgagcgaaaa cacagccttt
     2341 ctccccctga gtcccacggc caaatcagaa cgagaggcac aatttgtctt aagaaatgaa
     2401 atacaaagag actctgtgct aaccaagtga ctggaaatgt aggaatctgt gcattctatg
     2461 ctttgctcaa caggaaggag aggaaattaa atacaaatta tttatatgca ttaatttaag
     2521 agcatctact tagaagaaac caaatagtct gccaccctca tatcatagtg ttttttaaca
     2581 aaatattttt ttaaagggaa agaagcattt caggagggat aaagcttact actaaagctt
     2641 taggggagaa ttctgaatcc aatttcagtt agtccttaca ttgtcctctt tagctcttgg
     2701 aagatttggc catttccaac ctttggtccc ataatgccag tatctatatg gaaaagaaac
     2761 tggtgttttc ctagcttcaa agagatgaag tttattccaa gggcagatgt gccagttgag
     2821 cagatagccc tggccatttg gctcttcagt tccaacccct aaatttctat tcatcaatgc
     2881 tctctctaca ggttatgtca tgtcaaggaa tgtagtgctt tgtatttgat tttcaaagaa
     2941 tggcaggaaa acatgaaaag gaaggaagac agaaaataga agtaatctgg gcaaacttag
     3001 ctcttctcat gcaccgtctt tctctgtaat ttgaaagcac agaacctcag agggaggtgt
     3061 gaacttatta taggaaaaga gacaaaatga catcgtcgtg ttactaaagt catgctaata
     3121 gaaatgttgt tcttggagag tgtttagaag ctctgaaagt gtgtgtgtgt gtgtgtgtgt
     3181 gtgtgtgtgt gtgtgtgtgt atgcctgtgt gcacatgtat gagggtgcaa gtgttgtggg
     3241 cttactcaca taagcactta tgctagttgc acatgtgtcc cttgtacgta tgtgggtata
     3301 tgtgtgtgca tgtgtgtgtg tgttaaagct tgctaaaatt tgttctgaaa catcagggaa
     3361 actaatattc agaagagatt tcccctttaa gatcttttca ctttaaattt tccattaaat
     3421 gtaaatttgg ttagcgagtt cttgatccaa ggtaacttgc atggcagggt cttataaaac
     3481 tcttgacaat gtctagacca ttttctgatg tgaatactat tgaaaaggac agcctttggc
     3541 ttattgatat cagcatcaca aagcaaatta atggaggatg tgtttagttt gagtcattta
     3601 cttaaattac tgacacaagc cagtcatcaa attgacagtt gactatttta tttcttgtca
     3661 tcctcattgc taatttacag caagtctgct ctgtgtagac agaggcattg gcttctgtaa
     3721 ttaatgtgga aggaataaat tgttgaaaac cacaaatacc agactattca gttcacaagc
     3781 aatgccccca aacaacaaat tgtgttgtat gttcatttgg aataaagcaa tatttttacc
     3841 actgctaagg tgaactgaaa acctctcctg aagatgtgtc tgttttattt tcccttattt
     3901 ccatggggca ttcaaggaaa ctagtgttca catacccagt ctttatccaa ttattggtgg
     3961 tgttgttatg tttacactgt ttaaaataaa aaggcacagt atttgaaagt ac
//
