LOCUS       NM_001382420            6144 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus neuregulin 2 (Nrg2), transcript variant 2, mRNA.
ACCESSION   NM_001382420 XM_006525461
VERSION     NM_001382420.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6144)
  AUTHORS   Zhang,X., Xiao,G., Johnson,C., Cai,Y., Horowitz,Z.K., Mennicke,C.,
            Coffey,R., Haider,M., Threadgill,D., Eliscu,R., Oldham,M.C.,
            Greenbaum,A. and Ghashghaei,H.T.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6144)
  AUTHORS   Czarnek,M. and Bereta,J.
  TITLE     Proteolytic Processing of Neuregulin 2
  JOURNAL   Mol Neurobiol 57 (4), 1799-1813 (2020)
   PUBMED   31838721
  REMARK    GeneRIF: Proteolytic Processing of Neuregulin 2.
REFERENCE   3  (bases 1 to 6144)
  AUTHORS   Elliott,K.H., Millington,G. and Brugmann,S.A.
  TITLE     A novel role for cilia-dependent sonic hedgehog signaling during
            submandibular gland development
  JOURNAL   Dev Dyn 247 (6), 818-831 (2018)
   PUBMED   29532549
REFERENCE   4  (bases 1 to 6144)
  AUTHORS   Yan,L., Shamir,A., Skirzewski,M., Leiva-Salcedo,E., Kwon,O.B.,
            Karavanova,I., Paredes,D., Malkesman,O., Bailey,K.R., Vullhorst,D.,
            Crawley,J.N. and Buonanno,A.
  TITLE     Neuregulin-2 ablation results in dopamine dysregulation and severe
            behavioral phenotypes relevant to psychiatric disorders
  JOURNAL   Mol Psychiatry 23 (5), 1233-1243 (2018)
   PUBMED   28322273
  REMARK    GeneRIF: Findings reveal a novel role for NRG2 in the modulation of
            behaviors with relevance to psychiatric disorders.
REFERENCE   5  (bases 1 to 6144)
  AUTHORS   Vullhorst,D., Mitchell,R.M., Keating,C., Roychowdhury,S.,
            Karavanova,I., Tao-Cheng,J.H. and Buonanno,A.
  TITLE     A negative feedback loop controls NMDA receptor function in
            cortical interneurons via neuregulin 2/ErbB4 signalling
  JOURNAL   Nat Commun 6, 7222 (2015)
   PUBMED   26027736
  REMARK    GeneRIF: Findings reveal an intimate reciprocal relationship
            between ErbB4 and GluN2b NMDA receptors via NRG2/ErbB4 signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6144)
  AUTHORS   Yamada,K., Ichino,N., Nishii,K., Sawada,H., Higashiyama,S.,
            Ishiguro,H. and Nagatsu,T.
  TITLE     Characterization of the human NTAK gene structure and distribution
            of the isoforms for rat NTAK mRNA
  JOURNAL   Gene 255 (1), 15-24 (2000)
   PUBMED   10974560
REFERENCE   7  (bases 1 to 6144)
  AUTHORS   Pinkas-Kramarski,R., Shelly,M., Guarino,B.C., Wang,L.M., Lyass,L.,
            Alroy,I., Alimandi,M., Kuo,A., Moyer,J.D., Lavi,S., Eisenstein,M.,
            Ratzkin,B.J., Seger,R., Bacus,S.S., Pierce,J.H., Andrews,G.C. and
            Yarden,Y.
  TITLE     ErbB tyrosine kinases and the two neuregulin families constitute a
            ligand-receptor network
  JOURNAL   Mol Cell Biol 18 (10), 6090-6101 (1998)
   PUBMED   9742126
  REMARK    Erratum:[Mol Cell Biol 1998 Dec;18(12):7602. Alamandi M [corrected
            to Alimandi M]]
REFERENCE   8  (bases 1 to 6144)
  AUTHORS   Busfield,S.J., Michnick,D.A., Chickering,T.W., Revett,T.L., Ma,J.,
            Woolf,E.A., Comrack,C.A., Dussault,B.J., Woolf,J., Goodearl,A.D.
            and Gearing,D.P.
  TITLE     Characterization of a neuregulin-related gene, Don-1, that is
            highly expressed in restricted regions of the cerebellum and
            hippocampus
  JOURNAL   Mol Cell Biol 17 (7), 4007-4014 (1997)
   PUBMED   9199335
REFERENCE   9  (bases 1 to 6144)
  AUTHORS   Carraway,K.L. 3rd, Weber,J.L., Unger,M.J., Ledesma,J., Yu,N.,
            Gassmann,M. and Lai,C.
  TITLE     Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases
  JOURNAL   Nature 387 (6632), 512-516 (1997)
   PUBMED   9168115
REFERENCE   10 (bases 1 to 6144)
  AUTHORS   Chang,H., Riese,D.J. 2nd, Gilbert,W., Stern,D.F. and McMahan,U.J.
  TITLE     Ligands for ErbB-family receptors encoded by a neuregulin-like gene
  JOURNAL   Nature 387 (6632), 509-512 (1997)
   PUBMED   9168114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131191.4, AC127350.3 and AC141471.4.
            
            On May 6, 2020 this sequence version replaced XM_006525461.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.696562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-964               AC131191.4         106165-107128
            965-1136            AC127350.3         132624-132795
            1137-1255           AC127350.3         139599-139717
            1256-1376           AC127350.3         147224-147344
            1377-1435           AC127350.3         153634-153692
            1436-1459           AC127350.3         158159-158182
            1460-1562           AC127350.3         161167-161269
            1563-1686           AC127350.3         163146-163269
            1687-1814           AC127350.3         163595-163722
            1815-2042           AC127350.3         164290-164517
            2043-5517           AC127350.3         166893-170367
            5518-6144           AC141471.4         1-627
FEATURES             Location/Qualifiers
     source          1..6144
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.38 cM"
     gene            1..6144
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /note="neuregulin 2"
                     /db_xref="GeneID:100042150"
                     /db_xref="MGI:MGI:1098246"
     exon            1..964
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1136
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1255
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1376
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1435
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1459
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1562
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1686
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1814
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..2042
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..6144
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2891..2896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /note="hexamer: AATAAA"
     polyA_site      2926
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /note="major polyA site"
     regulatory      3941..3946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /note="hexamer: TATAAA"
     regulatory      3945..3950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /note="hexamer: AATAAA"
     polyA_site      3958
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
     polyA_site      3967
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
     regulatory      6124..6129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
                     /note="hexamer: AATAAA"
     polyA_site      6144
                     /gene="Nrg2"
                     /gene_synonym="Don1; NTAK"
ORIGIN      
        1 atcctcctcc aagtcctggc gcacagggag ggagcgctgc gctgcgcccg ggctgcgcat
       61 cgcggcccac ttgccgcctg tcccctgccc tggctgggcc acctccccgg gctgccggtg
      121 gagggcttcg aggcgctaac gttacgctgt ttccggtttt ccagagggct ctgtttcccc
      181 tcccaaggcg gcggcggctg agcggcggag ccccccaaat ggcctggcca gatgcggcag
      241 gtttgctgct cagcgctgcc gccgccactg gagaaggctc ggtgcagcag ctacagctac
      301 agttacagcg acagcagcag cagcaccacc agcagcagca gaagcagcag cagcagcagc
      361 agcagaaaca gcagcagcag caacagcagc agcagcgaga gcagcggcag caacagcggc
      421 agcagcagca tcttccgtcc cgctgcgccc ccagagccgc ggccgcagcc acagccgcag
      481 ccccgcagcc ccgcagcccg gagagccgcc gcccgctcgc gagccgcagc cgccggcggc
      541 atgaggcgcg acccggcccc cggcttctcg atgctgctct tcggtgtgtc actcgcctgc
      601 tactcgccca gcctcaagtc ggtgcaggac caggcgtaca aggcacccgt ggtggtggag
      661 ggcaaggtac agggactggc cccggcaggc ggttccagct ctaacagcac ccgagagccg
      721 cccgcctcgg gtcgggtggc gctggtgaag gtgctggaca agtggccgct ccggagcggg
      781 gggctgcagc gcgagcaggt gatcagcgtg ggctcctgtg cgccgctcga aaggaaccag
      841 cgctacatct ttttcctgga gcccaccgag cagcccttag tttttaagac agcctttgcc
      901 ccggtcgacc ctaacggcaa aaacatcaag aaagaggtgg gcaagatcct gtgcactgac
      961 tgcgccaccc ggcccaagct gaagaagatg aagagccaga caggagaggt gggtgagaag
     1021 cagtcgctca agtgtgaggc agcggcggga aacccccagc cctcctatcg ctggttcaag
     1081 gatggcaagg aactcaaccg gagtcgtgat attcgcatca agtatggcaa tggcagaaag
     1141 aactcacggc tacagttcaa caaagtgagg gtggaggatg ccggggagta cgtctgtgag
     1201 gccgagaaca tccttgggaa ggacaccgtg aggggccgac tccatgtcaa cagcgtgagc
     1261 accactctgt catcctggtc gggacatgcc cggaagtgca atgagaccgc caagtcctac
     1321 tgtgtgaatg gaggcgtgtg ctactacatc gagggcatca accagctctc ctgcaagtgt
     1381 cctgtgggat acaccgggga caggtgtcag cagttcgcaa tggtcaactt ctccaagcac
     1441 cttggatttg aattgaagga ggctgaggag ctgtaccaga agagagtgct gacaattact
     1501 ggtatctgtg tggccctgct ggtcgtgggc atcgtctgtg tggtcgccta ctgcaagacc
     1561 aaaaaacaga ggaggcagat gcatcatcat ctccggcaga acatgtgccc agcccaccag
     1621 aaccgaagcc tggccaacgg gcccagccac cctcggctgg accctgagga gatccagatg
     1681 gcagattaca tctccaaaaa tgtgccagct acagaccacg tgatccggag ggaagctgag
     1741 accacgttct ctgggagcca ctcctgttca ccttctcacc actgctccac agccacgccc
     1801 acctccagcc acagacatga gagccacacg tggagcctgg aacgttcaga gagcctgacc
     1861 tcggattccc agtcaggcat catgctatca tcagtaggca ccagcaagtg caacagccca
     1921 gcatgtgtgg aggcacgggc gcggagggca gcagcctaca gccaggagga gcggcgcagg
     1981 gctgccatgc caccctacca tgactccata gactcgctgc gtgactctcc acacagtgaa
     2041 aggtacgtgt cagccttgac cacgcccgct cgcctctcgc ccgtggactt ccactactcg
     2101 ctggccacgc aggtgccgac tttcgagatc acgtcgccca actctgcgca tgccgtgtcg
     2161 ctgccgcccg ccgcgcccat cagctaccgc ctggcggagc agcagccgct cctgcggcat
     2221 ccagcgccgc ccggcccggg gccggggtcg gggcccggag cggacatgca gcgcagctac
     2281 gacagctact actaccctgc ggcggggccc gggccgcggc gcagcgcctg cgcgctggga
     2341 ggcagcttgg gcagcctgcc cgccagcccc ttccgcatcc cggaggacga cgagtacgag
     2401 accacgcagg agtgcgcgcc cccgccgccg ccgcggccgc gcacgcgcgg cgcgtcccgc
     2461 aggacgtcgg cggggccgcg gcgctggcgg cgctcccggc tcaacgggtt ggcggcgcag
     2521 cgcgcacgcg cggcgcggga ctcgctgtca ttgagcagcg gttcgggctg cggctcggcg
     2581 tcggcctcgg acgacgacgc ggacgacgcg gacggggcgc tggcggccga gagcacgcca
     2641 ttcctcggcc tgcgagcggc gcacgacgcg ttgcgctcgg actcgccgcc gctgtgcccc
     2701 gcggccgaca gcaggactta ctactccctg gacagccaca gcacgcgcgc cagcagcaga
     2761 cacagccggg ggccgcccac gagggccaag caggactcgg ggcccctcta aggccccccg
     2821 cctcgcccgc cccacgtctc caaggagagc ggagaccacc gactggagag ggaaaaggag
     2881 cgaacaaaga aataaaaata tttttatttt ctataaaagg aaaaaagtat aacaaaatgt
     2941 tttattttca ttttagcaaa aaaaattgtc ttataatact agctaacggc aaagacgttt
     3001 ttatagggaa actatttata tgtaacatcc tgatttacag cttcggaaaa aaaaaaagaa
     3061 acaacaaaaa aaaaaataag agagatgggc caattttttg actctttaat agaaacctat
     3121 attgtggtgc cttttgctgt acgctaatct ggggctcctg gagagccgtc tggggtgcag
     3181 tgtgagggtg ggcgcttgta ggatcccaaa ctggtggggg tgagaaaggg cagggaaaga
     3241 agagactgtg aggttctaat ggctctgagg aaagtggaca atgaggaaga aaatgaagat
     3301 aagatgtaat tgtattttcc ccagtcctga gcagagaagg cagggatgtt agccttagag
     3361 ctggaattga gattgggtta tctccaagga cactggcctc cccgctacag caactagaat
     3421 ggggaagggt cctccccagc cctcacagct gctaagggaa agaggacaga gaaggctgtc
     3481 tccccaccag ccccctgccg agggaggggg cagctctacc aggggcccaa ccttcagggc
     3541 tcctcctccc tggcggcctc caggacatcc tctgtcctct gcagcgcctt cgtttacagg
     3601 tcgtcttttc tattttacgc ctgcatgtcc tttgcatttc ggattcttta gattgaatgc
     3661 atggtcacgc tgggacccag aagagccact ccgacagtgt attcgattcc ccttttagca
     3721 ataaagtaac accatgtcct tctcacagcc cagctcccaa cccacctatg acttccatct
     3781 tccaatcctg ccctccccag ccagccctca caactggatc caatgctaat ttgtcaaaaa
     3841 aggcaattgt ctaaaaagca aacaaaaatc ccaaacagaa acaaatggga accctgacat
     3901 gtccgaacac ctgactgttg acacttgaac atttttatat tataaataaa atcagaaata
     3961 actcctgttt gactgtgtgt acctaggtga ggagggaagc taggagggcc taggatgagg
     4021 cacatgggta ctgggaggaa gattggatag ggccaagata gtccctgagc ggaagtgacc
     4081 ctctctccag tccctctggc cccagctccc aggacctgct ccaagtcttt cttccaaatc
     4141 attcataagg tgtccccctg ggtgctaagg aacccagcca agggactgac gcaaatcgtt
     4201 ccgctttaaa cgcagcctca gaactctggc ccagttcctg ccctgcagct aggaagctgg
     4261 actagggcaa cagttttttg cccaggtggg tgaagaggga agggttgtgg ggttggcact
     4321 ggggctgcgg aggcaaagat gacccttggg gcttcaggct cgtcacaggc agagtctgga
     4381 catgtaagac aacataatag gtcccctcat tgccaggagg accagaactg ctcctgagcc
     4441 cacagggtac tgctccttcc ccaattgtat atgctctccc cacaccagag ccagggcctg
     4501 tctaaacctg cggctctgat gaaggtctaa tctcaggcat ggaggaggca gatagagtcc
     4561 agggtaaaca gtctttccca tcagctccct agaataccag gaaccaagat gccagccaga
     4621 acctaaagcc ttcctgggtg aatgtgtgcg catgtgtatg cttatacaaa ttcttgaaag
     4681 ttgcagcgtg gatctagaca gatactcgca gaggagtgag acagagaggc atagtgcgac
     4741 aataggttct gagtccgggt gccacctgtc cctctctagc tatgtggctt ctccaggcca
     4801 cggtttgctt agtgagaaat gaggaagcag tcgcttacct cagcgagtga ctgtggaggt
     4861 tacatgcaga tggacccggc actcttcctg attgatatct agtcttgatg gtcgcggaga
     4921 cggaatcctg tgtcttgtaa ccatgagtca caaagtggta aaaactcaat gaggtgatta
     4981 agaaaagtct aaacttttat aaagttgtta tattcattaa agggtgctga ggggcactta
     5041 ttacaaaggg aaaagatgaa agagaacctt ctagactgaa tgttacacaa acctgtagat
     5101 cacgcccagg cctcaccaga tgaccctgtg gtctgtttgc tttcttaggg tactaatcct
     5161 tacgtgtgac ctctgatctc tatgggaccc cagattaaat gctctgacct cttgttgagc
     5221 ccactgatct cattacgatc taattcagtg tcctcacgta aactgtgtgg gccgggtttg
     5281 ttaccttcta tgtttacatc cagaaaccac ctgtaagact caagtgacct cgtcaatgaa
     5341 cctgtacatg accccatctc attccctcat catctgccct atcttctaag ataccccacc
     5401 aagagtccaa ggccagaact taacctcgct cttcagtgct cccttgattg cattagcccg
     5461 tcttcattgg acaggtatgg ttgggacctg gagcgtgctt gaccagagag ccctcttgat
     5521 caccctgact ctcagggttt agccttcggg acgttgagtg tgtggcttcc caggaagtca
     5581 cttcaggcaa cttcccttct gccaccctgt cccctgggac actcaggaca ctcgggcagc
     5641 ttccaaggtc aaagttctat cccctgctcc ccaagttctt tctctacttt gcattatcac
     5701 ttttagtgtc ttcccagtcc ctctgagtcc tcagtggcca tggtaaccac ttctccccta
     5761 gtctccctcc taacggtgag acccgtgaac acagggaact ggcctctttt accactgtcc
     5821 ctagcacaca gcaacagtgt atggcacatg gttgaccctc acggaagagg gtgaaggcta
     5881 tttgtcaaga attaggcacc aggagttcct gagccctgga gcaaacctcc caggacctgt
     5941 ccttgtgggc ttgttagggg tgacaggaaa gaggaacatg atggtctatt agaatgcagg
     6001 aaaaaaatat tagaactttg atttagattt attttcatct catctttttt aaatttctat
     6061 ttttgtgtat gttttataat gtacataata ttttagtaca gtagtacatg tatataattt
     6121 acaaataaag aattatacaa ttaa
//
