LOCUS       NM_001364423            6298 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus neuregulin 1 (Nrg1), transcript variant 4, mRNA.
ACCESSION   NM_001364423 XM_006509069
VERSION     NM_001364423.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6298)
  AUTHORS   Amato,C.M., Xu,X. and Yao,H.H.
  TITLE     An extragenital cell population contributes to urethra closure
            during mouse penis development
  JOURNAL   Sci Adv 10 (49), eadp0673 (2024)
   PUBMED   39642224
REFERENCE   2  (bases 1 to 6298)
  AUTHORS   Rajebhosale,P., Jone,A., Johnson,K.R., Hofland,R., Palarpalar,C.,
            Khan,S., Role,L.W. and Talmage,D.A.
  TITLE     Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis and
            Regulates a Schizophrenia Susceptibility Gene Network within the
            Mouse Dentate Gyrus
  JOURNAL   J Neurosci 44 (43), e0063242024 (2024)
   PUBMED   39214704
  REMARK    GeneRIF: Neuregulin1 Nuclear Signaling Influences Adult
            Neurogenesis and Regulates a Schizophrenia Susceptibility Gene
            Network within the Mouse Dentate Gyrus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6298)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6298)
  AUTHORS   Wu,L.F., Zhou,Z.J., Zeng,Y.H., Yang,S.L. and Zhang,Q.Y.
  TITLE     Circular RNA RRM2 alleviates metabolic dysfunction-associated
            steatotic liver disease by targeting miR-142-5p to increase NRG1
            expression
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 327 (4), G485-G498 (2024)
   PUBMED   39259911
  REMARK    GeneRIF: Circular RNA RRM2 alleviates metabolic
            dysfunction-associated steatotic liver disease by targeting
            miR-142-5p to increase NRG1 expression.
REFERENCE   5  (bases 1 to 6298)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6298)
  AUTHORS   Gassmann,M., Casagranda,F., Orioli,D., Simon,H., Lai,C., Klein,R.
            and Lemke,G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (bases 1 to 6298)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (bases 1 to 6298)
  AUTHORS   Moscoso,L.M., Chu,G.C., Gautam,M., Noakes,P.G., Merlie,J.P. and
            Sanes,J.R.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (bases 1 to 6298)
  AUTHORS   Yang,Y., Spitzer,E., Meyer,D., Sachs,M., Niemann,C., Hartmann,G.,
            Weidner,K.M., Birchmeier,C. and Birchmeier,W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (bases 1 to 6298)
  AUTHORS   Ho,W.H., Armanini,M.P., Nuijens,A., Phillips,H.S. and Osheroff,P.L.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722.. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132407.3 and AC127374.4.
            
            On Jun 16, 2018 this sequence version replaced XM_006509069.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.82550.1,
                                           SRR1660811.90461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1307              AC132407.3         60264-61570
            1308-1437           AC132407.3         129668-129797
            1438-1496           AC132407.3         141379-141437
            1497-1574           AC127374.4         178993-179070       c
            1575-1598           AC127374.4         177045-177068       c
            1599-1701           AC127374.4         172093-172195       c
            1702-1828           AC127374.4         170284-170410       c
            1829-1959           AC127374.4         168067-168197       c
            1960-2166           AC127374.4         167082-167288       c
            2167-6298           AC127374.4         160391-164522       c
FEATURES             Location/Qualifiers
     source          1..6298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     gene            1..6298
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /note="neuregulin 1"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
     exon            1..1307
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1437
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1496
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1574
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1598
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1701
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1828
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1959
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2166
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..6298
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6270..6275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /note="hexamer: ACTAAA"
     polyA_site      6298
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /note="major polyA site"
ORIGIN      
        1 actgtttgcc gtgatgctca gagggcaggc acctgctgct ctgtaatgat tcagcctctt
       61 tcagccgctg cgttaacacg acaggatgct gttgctactg tcgctgctgc ccctcctgcc
      121 gccgccgctg ctgctgccgc cgcctcctct ggtcttgctt ttgcttttac ttctcctgca
      181 tgacagttgt tttcttcctc taagcagaca ccagcttcag acgcttgagg tgagaaacat
      241 gcctttcagt ttgggatact ggtttactta atcagctagg catcagcttg cttcctcttt
      301 tggtcccctg ccttcttgaa ccaaccggga tggtttggag aagcctttga aagaactgaa
      361 aaagtgtccc agaaacaaca gctcaagata tttcggtaca cttctatttc atagttgcta
      421 gaagcccttc ctttttcgtt tctttttctt tttttttttt tccttttttt ttttttttat
      481 ctttttcttg cttcctctta agctctctta ctttggataa tggccttgga cttgggtgcc
      541 ttatcgattt cccccttcaa gatgctgtat catttggttg gggggagctc tgcatggtaa
      601 tgcactgtga gagaggccgg gccttctgga ggtgatccgg atggagattt atcccccaga
      661 catgtctgag ggagctggcg ggaggtcctc cagcccctcc actcagctga gtgcagaccc
      721 atctctcgat gggcttccgg cagcggaaca tatgccagac acccacacag aagatgggag
      781 aagccctgga ctcctgggcc tggccgtgcc ctgctgtgtc tgcctggaag cggagcgtct
      841 cagagggtgc ctcaactccg agaagatctg cattgttccc attctggctt gtctagtaag
      901 cctctgcctc tgcattgctg gcctaaagtg ggtatttgtg gacaagatat tcgaatacga
      961 ctctcctacc caccttgacc ctggggggtt aggccaggac cctgttattt ctctggatcc
     1021 aacggctgcc tccgctgttc tggtctcatc cgaggcatac acttcacctg tctctaaggc
     1081 tcagtctgaa gccgaggctc atgttacagg gcaaggtgac catgtcgctg tggcctctga
     1141 accttccgca gtacccaccc ggaagaaccg gctgtctgct tttcctccct tacactccac
     1201 tccaccgccc ttcccttctc cagctcggac ccctgaggtg agaacaccca agtcaggaac
     1261 tcagccacaa acaacagaaa ctaatctgca aactgctcct aaactttcca catctacatc
     1321 cacgactggg accagccatc tcataaagtg tgcggagaag gagaaaactt tctgtgtgaa
     1381 tggaggcgag tgcttcatgg tgaaggacct gtcaaacccc tcaagatact tgtgcaagtg
     1441 cccaaatgag tttactggtg atcgttgcca aaactacgta atggccagct tctacatgac
     1501 ttctaggagg aaaaggcaag aaacagagaa gcctctagaa agaaaattgg atcatagcct
     1561 tgtgaaagaa acgaagcatc ttgggattga atttatggaa gcggaggagc tctaccagaa
     1621 gagggtactg acaattactg gcatctgtat cgccctgttg gtggtcggca tcatgtgtgt
     1681 ggtggcctac tgcaaaacca agaaacagcg gcagaagctt catgatcggc tccggcagag
     1741 ccttcggtca gaacgaaaca acatggtgaa catagcgaat ggccctcacc atccaaaccc
     1801 accaccagag aatgtgcaac tggtgaatca atatgtatct aaaaacgtca tctccagtga
     1861 gcatattgtg gagagagaag tggagacctc cttttccacc agtcactaca cttccacagc
     1921 tcatcactcc acgactgtca cccagactcc tagtcacagc tggagtaatg ggcacacaga
     1981 aagcatcatt tcagaaagcc actctgtaat catgatgtca tcggtagaga acagcaggca
     2041 cagcagccca gctgggggcc cacgaggacg tcttcatggc ctgggaggcc ctcgcgaatg
     2101 taacagcttc ctcaggcatg ccagagaaac ccctgactcc tacagagact ctcctcatag
     2161 tgaaaggtat gtatcagcca tgaccacccc ggctcgtatg tcacctgtag atttccacac
     2221 gccaagctcc cctaaatcgc ccccttcgga aatgtctcca cccgtgtcca gcatgacggt
     2281 gtccatgccc tctgtggcag tcagcccctt tgtggaagaa gagaggcctc tgcttcttgt
     2341 gacgccaccg aggctacggg agaagaagta tgatcatcac ccccagcaac tcaactcctt
     2401 tcatcacaac cctgcacatc agagtaccag cctcccccct agcccattga ggatagtgga
     2461 ggatgaggaa tacgaaacga cccaggagta tgagccaatt caagagccta ttaagaaagt
     2521 caccaatagc cggcgggcca aaagaaccaa gcccaatggc cacattgcca ataggttgga
     2581 aatggacagc aacccaagtt ctgtgagcag taactcagaa agtgagacag aagatgaaag
     2641 agtaggtgaa gatacaccat tcctgggcat acagaacccc ctggcagcca gccttgaggt
     2701 ggcccctgcc ttccgtctgg ctgagagcag gactaaccca gcaggccgct tctccacaca
     2761 ggaagaatta caggccaggc tgtctagtgt aatcgctaac caagacccta ttgctgtata
     2821 aaacctaaat aaacacatag attcacctgt aaaactttat tttatataat aaagtatttc
     2881 accttaaatt aaacaattta ttttatttta gcagttctgc aaatagaaaa caggaagaaa
     2941 aaaactttta taaattaaat atatgtatgt aaaaatgtgt tatgtgccat atgtagcaat
     3001 tttttacagt atttcaaaaa aacgagaaag atatcaatgg tgcctttatg ttatgttatg
     3061 tcgagagcaa gttttataaa gttacggtgg ttgctttttc acagtatttc agcgaaacct
     3121 cccatatatt cagtttttgc tggctttttg tgcattgcat tatgatgttg actggatgta
     3181 tggtttgcaa ggctagcagc tgtccctctc tttgcttcca gtagcaccca accagtactg
     3241 tcttgaaatg gcacatccat ccaaatacct ttctactttg tataaagttt ctttgctttc
     3301 ccaatataaa atgagttctc tctactctgt cagccaaagg tttgcttcac tggactctga
     3361 gataatagta gacccaacag catgctacta ttacatatag caggaaactg cacctaagta
     3421 atgttaaata ttagggagaa agtaatactg tgatttttaa aacaaacaat attattaatc
     3481 agaagacagc ttgctcttgc taaaaggagc taccattgac tctaatttta actttttagt
     3541 tattgctgtt cttgataaag agtaacagct ttaagtacag cttaggaaaa tgggttctgg
     3601 cttgctatca ggataaatct atcaacttag aaaggactca acttcacttt ctctcttgga
     3661 ggaaatgacc cagcagctca tctgttgacc agccaaccac agctgctaaa ggtgcaatcc
     3721 tttctgacat attttttaac tgactggttg tacccgcttg ttggctccag aagaggctca
     3781 gagtgtcatg aagcctcaga cccaagagta cactcagcca tctgccccaa ccacttgtat
     3841 gatgtacctg tggtacatag cagtgacttg gccattgttt catgctagag catttaggag
     3901 tgagtgtgta gaagttacaa ggggaaagca gctgcactac ccagtgacat tttaacttgg
     3961 tttggttggc cactcctttc tccccattat gtttctcttg tgttcaacat tgccttgatt
     4021 aggtcataac tatgcatgaa tatataattt ttttttgcca ggaatggcca atgtgcatgt
     4081 gatttgtgat tagcaagaac ttcccgtagt ggtgcctcac tagggagtgt caatagcatt
     4141 gggaagattg cagcttttct tgcagaagtg accccccccc actcatggac tgatctctct
     4201 ccataaatag cctgtatctt ccatctctct tctctaagta attttcccca tactgtctca
     4261 aaagcaggac taagattgtt ctcttgtgat tggaaagcca atggacactt atagatatta
     4321 acaaatgaac aactgctaat ccagagggga aaaaaaagaa aactgtgggg gtgggggtgg
     4381 ggaataacct ttcagaaccc tgtgtattct ctgcctgtta tctgtcaatc aagaccggag
     4441 cttcttgagt ttcttagtag gctcttagga gttccatagc aaaattggga aggagttgaa
     4501 cagaggattg gcaaagccaa tggcaatgat agattcttgt tcccagttga accgaatcta
     4561 ttttctttac cgagctttgt tataagtcaa gggaagtaat aacccacaag aaggtcttag
     4621 aaaaaacact gcaggctggc caccagtcca tgtgttacac tcctccatat tactaagaga
     4681 agcttgagtg gaaacccttc aagttactcg tagtatgtgc agtctctcat ttcttgccac
     4741 tggtcacagg gcagttctct gtgtgtacag tgatttttaa cttttgttat acacagagga
     4801 ataaacccct gcaggtggaa gcctaatgct gacttcccag tgttgcagag agtggtcaac
     4861 tccccacagg gaggaaaagt caacaggttt gagcatgttc tctcagctct ccatgttgcc
     4921 tttaaaggtc agagtcaccc tatcactcaa tagagaaatt tctttattgt tattttaaaa
     4981 ctctaaaaaa aaaatcagtt tcaaatctgt tagtcaccag ggtattagga aggtcccttc
     5041 tgaaaaacag actcctctga taacacttta aatatttttt taaagcagca ttttactagc
     5101 atgaaaagct atacaatttt tcaaatcgca aatatacgtg attttttttc ttctgtgctt
     5161 tatctggtaa tctactattg ccatgttagt tgagaaagct tttttttttc caagagaaca
     5221 cagctttcct tgaggagaac agccacgtgg ctggtcaggg ctatctgttg tagcctctgg
     5281 atttatatgt ccaggaacat ctctacagtg cttcactgcc aggtctctct caagcatcct
     5341 gtttatgaat ccaggcagag ctgtaatagg gcaaaagaat gcacacctgt ggtcctggca
     5401 tgggtgaaga tgccttgtat tttaagggag gacaaattac tcagaattta ataacaacta
     5461 tgtttcctgg gtcttaaatc aaaaactact gagagttata tagtggggta tagtagatag
     5521 caaactcctt tgtacttact caagatttgc tttctgccct gatttcccct ccattcatcc
     5581 ctctaccctc aagagtgcct ggtggacagt cttctgctaa ctacaaaatg gccctctgtg
     5641 taagagagaa tgtatctcaa gcagcaatat gccatctctt tcttgtgtct gtgtgactgt
     5701 caatatgggt ggcgtctatc cagggtaact ttctctgtat gtatttctct tttggcctga
     5761 agttgaaggt atatggcccc tattcgtgaa taaggaagat ctggccttcc cttttagtcc
     5821 tggctgcatt tccagcagct gccaagattt ctatccacta agatccatga aacactatga
     5881 agaaatgcag acaaaaggaa atggccacac atcacaattt ctattatata ttcttttgta
     5941 aatacacatt gtatagtact tagatgtttt cttaagtcat ttactgtctt tatgagttaa
     6001 tgttagtttt tactctctaa acttactgta ttacattgta aataacatat tttcctttat
     6061 tatttatatt taaacatcta acatagagaa ttgttttcat ataagtttaa gataaatgtt
     6121 taaaatatat gtttttcttt gctttaaaat tatgtacctt ttcctttttt ccatttttta
     6181 aagaataatt tattgttcag gaaaaagaat atatatgtaa ttgaaactat ttgaagaatg
     6241 cacatttgaa ggccatggag tactgataaa ctaaagaatt tattatctca aatactaa
//
