LOCUS       NM_001410222            2280 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus nuclear respiratory factor 1 (Nrf1), transcript
            variant 12, mRNA.
ACCESSION   NM_001410222 XM_011241044
VERSION     NM_001410222.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2280)
  AUTHORS   Yan,J., Zhang,X., Wang,H., Jia,X., Wang,R., Wu,S., Zhu,Z.J., Tan,M.
            and Horng,T.
  TITLE     Macrophage NRF1 promotes mitochondrial protein turnover via the
            ubiquitin proteasome system to limit mitochondrial stress and
            inflammation
  JOURNAL   Cell Rep 43 (10), 114780 (2024)
   PUBMED   39325625
  REMARK    GeneRIF: Macrophage NRF1 promotes mitochondrial protein turnover
            via the ubiquitin proteasome system to limit mitochondrial stress
            and inflammation.
REFERENCE   2  (bases 1 to 2280)
  AUTHORS   Akl,M.G., Li,L. and Widenmaier,S.B.
  TITLE     Protective Effects of Hepatocyte Stress Defenders, Nrf1 and Nrf2,
            against MASLD Progression
  JOURNAL   Int J Mol Sci 25 (15), 8046 (2024)
   PUBMED   39125617
  REMARK    GeneRIF: Protective Effects of Hepatocyte Stress Defenders, Nrf1
            and Nrf2, against MASLD Progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2280)
  AUTHORS   Gong,X., Huang,M. and Chen,L.
  TITLE     NRF1 mitigates motor dysfunction and dopamine neuron degeneration
            in mice with Parkinson's disease by promoting GLRX m6 A methylation
            through upregulation of METTL3 transcription
  JOURNAL   CNS Neurosci Ther 30 (3), e14441 (2024)
   PUBMED   37735974
  REMARK    GeneRIF: NRF1 mitigates motor dysfunction and dopamine neuron
            degeneration in mice with Parkinson's disease by promoting GLRX
            m[6] A methylation through upregulation of METTL3 transcription.
REFERENCE   4  (bases 1 to 2280)
  AUTHORS   Shen,W., Ren,S., Hou,Y., Zuo,Z., Liu,S., Liu,Z., Fu,J., Wang,H.,
            Yang,B., Zhao,R., Chen,Y., Yamamoto,M., Xu,Y., Zhang,Q. and Pi,J.
  TITLE     Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor
            determining the thermogenesis and cellular heterogeneity and
            dynamics of brown adipose tissues in mice
  JOURNAL   Redox Biol 67, 102879 (2023)
   PUBMED   37716088
  REMARK    GeneRIF: Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key
            factor determining the thermogenesis and cellular heterogeneity and
            dynamics of brown adipose tissues in mice.
REFERENCE   5  (bases 1 to 2280)
  AUTHORS   Cheng,C., Tian,Y., Yang,R., Guo,W., Xiao,K., Zhang,F., Tian,J.,
            Deng,Z., Yang,W., Yang,H. and Zhou,Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   6  (bases 1 to 2280)
  AUTHORS   Carmona,M.C., Iglesias,R., Obregon,M.J., Darlington,G.J.,
            Villarroya,F. and Giralt,M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (bases 1 to 2280)
  AUTHORS   Huo,L. and Scarpulla,R.C.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (bases 1 to 2280)
  AUTHORS   Schaefer,L., Engman,H. and Miller,J.B.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (bases 1 to 2280)
  AUTHORS   Huo,L. and Scarpulla,R.C.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (bases 1 to 2280)
  AUTHORS   Virbasius,C.A., Virbasius,J.V. and Scarpulla,R.C.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            On Aug 1, 2022 this sequence version replaced XM_011241044.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.925225.1,
                                           SRR13422590.463995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC134897.4         34966-35070         c
            106-261             AC153632.2         80731-80886         c
            262-496             AC153632.2         79573-79807         c
            497-532             AC153632.2         79415-79450         c
            533-647             AC153632.2         74265-74379         c
            648-774             AC153632.2         71144-71270         c
            775-915             AC153632.2         67410-67550         c
            916-1074            AC153632.2         54548-54706         c
            1075-1272           AC153632.2         53426-53623         c
            1273-1374           AC153632.2         52562-52663         c
            1375-1532           AC153632.2         50613-50770         c
            1533-1657           AC153632.2         43360-43484         c
            1658-2280           AC153632.2         24516-25138         c
FEATURES             Location/Qualifiers
     source          1..2280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     gene            1..2280
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /note="nuclear respiratory factor 1"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
     exon            1..105
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     exon            106..261
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     exon            262..496
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1914
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /note="isoform g is encoded by transcript variant 12;
                     NRF-1; alpha-pal; alpha palindromic-binding protein"
                     /codon_start=1
                     /product="nuclear respiratory factor 1 isoform g"
                     /protein_id="NP_001397151.1"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
                     /translation="MEEHGVTQTEHMATIEAHAVAQQVQQVHVATYTEHSMLSADEDS
                     PSSPEDTSYDDSDILNSTAADEVTAHLAAAVLGIKPRASHILGPVGMAAAAAVATGKK
                     RKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFG
                     AAPLENVVRKYKSMILEDLESALAEHAPAPQEVNSELPPLTIDGIPVSVDKMTQAQLR
                     AFIPEMLKYSTGRGKPGWGKESCKPIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRT
                     IVKNCYKQHGREDLLYAFEDQQTQTQATTTHSIAHLVPSQTVVQTFSNPDGTVSLIQV
                     GTGATVATLADASELPTTVTVAQVNYSAVADGEVEQNWATLQGGEMTIQTTQASEATQ
                     AVASLAEAAVAASQEMQQGATVTMALNSEAAAHAVATLAEATLQGGGQIVLSGETAAA
                     VGALTGVQDANGPDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESS
                     ENAAKAAGKYKQQGRAYVVEDGDIIFFKFNSPQQLKKK"
     exon            497..532
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     exon            533..647
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     exon            648..774
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     exon            775..915
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1074
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1272
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1374
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1532
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1657
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..2280
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1910..1915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /note="hexamer: AATAAA"
     polyA_site      1933
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /note="major polyA site"
     regulatory      2244..2249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /note="hexamer: AATAAA"
     regulatory      2253..2258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /note="hexamer: AATAAA"
     polyA_site      2263
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
     polyA_site      2280
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
ORIGIN      
        1 agaggcggca gcgctcgcca ttgccgctgg tggcaggagg ctgcgaggag ccggcgcggt
       61 cgcagtctcc acggcgcagg cccacggtag cgcagccgct ctgaggtcga atggtatgtg
      121 gttcatgtag accacatttt gtttccctct cacccattga tggacacttg ggtagcttcc
      181 atttttggct gttgtgaata atgctgctat gaacatgggt gtgcacagag ctctctgaga
      241 cgctgctttc agtccttctg gcagtagatc ttcatggagg agcacggagt gacccaaact
      301 gaacacatgg ctaccataga agcccatgca gtggcccagc aagtccagca ggtccatgta
      361 gccacgtaca ctgagcacag tatgctaagt gctgatgaag actccccttc ctcccccgag
      421 gacacttctt atgatgactc ggacatcctc aactccacgg cagctgatga ggtaactgcc
      481 catctggctg ctgcagtgct ggggatcaaa cccagggcct cgcatatact aggtcctgtg
      541 ggaatggccg ctgctgctgc tgtggcaaca gggaagaaac ggaaacggcc tcatgtgttt
      601 gagtctaatc catctatccg aaagagacag cagacacgtt tgcttcggaa actcagagcc
      661 acgttggatg agtacacgac gcgagtggga cagcaagcga ttgtactctg catctcaccc
      721 tccaaaccca accctgtctt caaggtgttt ggcgcagcac ctttggagaa tgtggtgcga
      781 aagtacaaga gcatgatcct ggaagacctc gagtctgctc tggcagaaca cgcccctgcg
      841 ccacaggagg ttaattcaga gctgccgcct ctcaccatcg atgggattcc agtctctgtg
      901 gacaaaatga cccaggctca gcttcgggca tttatcccag agatgctcaa gtattccaca
      961 ggtcggggga aaccaggctg ggggaaagaa agctgcaagc ctatctggtg gccagaagat
     1021 atcccatggg ccaatgtccg cagtgatgtc cgcacagaag agcaaaaaca aagggtttca
     1081 tggacccagg cattacggac catagttaaa aattgctata agcaacatgg gcgggaggat
     1141 cttttatatg cttttgaaga tcagcaaaca caaactcagg ccaccaccac acacagtata
     1201 gctcatctcg taccatcaca gaccgtagta cagaccttca gcaaccctga tggcaccgtg
     1261 tcgctcatcc aggttggtac aggggcaaca gtagccacat tggctgatgc ttcagaactg
     1321 ccaaccacag tcactgttgc ccaagtgaat tactctgctg tggctgatgg agaggtggaa
     1381 caaaactggg ccacgttaca gggcggtgaa atgaccatcc agacgacgca agcatcagag
     1441 gccacccagg cggtagcatc actggcagaa gccgcagtgg cagcttctca ggagatgcag
     1501 cagggagcca ctgtcaccat ggccctcaac agtgaagctg ccgcccatgc tgtcgccact
     1561 ctggcggaag ccaccttaca aggtggggga cagatagtcc tgtctgggga aaccgcagca
     1621 gccgtcggag cacttactgg agtccaagat gctaatggcc cagatggagt tcatgcatgg
     1681 accatcagca aagccgtgac ggctcctcag gctgcaggaa agattcatac agattttgga
     1741 aagggattca ttatggcgga agtaatgaaa gacgaagatc ttaaagagga aagttctgag
     1801 aacgcagcta aggctgctgg gaagtacaaa caacaaggca gagcttacgt tgttgaagac
     1861 ggagatataa tcttcttcaa atttaattca cctcagcaat tgaaaaagaa ataaaaatta
     1921 gcttttaact ttagcatatg tatggtttgg gctttggtct tgactgtggg gtaggtggtt
     1981 tggtttggtt cttaactaca tttctgaaat ctgaaggtac aatgttggaa cgggactcct
     2041 aagttattac tgacattgaa gtagtagaaa ccaagttctg gtttactttt gaaagagttt
     2101 ggggttgcag agctggttgg cagtgtggaa tgctcgccct ctttcagaaa acccatgtga
     2161 ggccggtccc aactgcctgt aagtccagct ccaaggggtc tacatacatc tcattcccct
     2221 acacaggcac acgcatgcat atgaataaag ttaataaaac caagttttta caagaaggaa
//
