LOCUS       NM_053078               2223 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus neuronal regeneration related protein (Nrep),
            transcript variant 1, mRNA.
ACCESSION   NM_053078 NM_001109990
VERSION     NM_053078.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2223)
  AUTHORS   Chen,C., Tang,Y., Zhu,X., Yang,J., Liu,Z., Chen,Y., Wang,J.,
            Shang,R., Zheng,W., Zhang,X., Hu,X., Tan,J., Zhou,J., Peng,S.,
            Lu,Q., Ju,Z., Luo,G. and He,W.
  TITLE     P311 Promotes IL-4 Receptor-Mediated M2 Polarization of Macrophages
            to Enhance Angiogenesis for Efficient Skin Wound Healing
  JOURNAL   J Invest Dermatol 143 (4), 648-660 (2023)
   PUBMED   36309321
REFERENCE   2  (bases 1 to 2223)
  AUTHORS   Zhang,J., Zhou,Y., Guo,J., Li,L., Liu,H., Lu,C., Jiang,Y. and
            Cui,S.
  TITLE     MicroRNA-7a2 is Required for the Development of Pituitary Stem
            Cells
  JOURNAL   Stem Cells Dev 31 (13-14), 357-368 (2022)
   PUBMED   35652338
REFERENCE   3  (bases 1 to 2223)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2223)
  AUTHORS   Liu,Y., Zhou,X., Hu,N., Wang,C. and Zhao,L.
  TITLE     P311 regulates distal lung development via its interaction with
            several binding proteins
  JOURNAL   Mech Dev 163, 103633 (2020)
   PUBMED   32682987
  REMARK    GeneRIF: P311 regulates distal lung development via its interaction
            with several binding proteins.
REFERENCE   5  (bases 1 to 2223)
  AUTHORS   Du,Y., Yang,Y.T., Tang,G., Jia,J.S., Zhu,N. and Yuan,W.J.
  TITLE     Butyrate alleviates diabetic kidney disease by mediating the
            miR-7a-5p/P311/TGF-beta1 pathway
  JOURNAL   FASEB J 34 (8), 10462-10475 (2020)
   PUBMED   32539181
  REMARK    GeneRIF: Butyrate alleviates diabetic kidney disease by mediating
            the miR-7a-5p/P311/TGF-beta1 pathway.
REFERENCE   6  (bases 1 to 2223)
  AUTHORS   Pan,D., Zhe,X., Jakkaraju,S., Taylor,G.A. and Schuger,L.
  TITLE     P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast
            phenotype
  JOURNAL   J Clin Invest 110 (9), 1349-1358 (2002)
   PUBMED   12417574
  REMARK    GeneRIF: role for P311 in inducing TGF-beta1-independent
            myofibroblast transformation
REFERENCE   7  (bases 1 to 2223)
  AUTHORS   Miura,N. and Naganuma,A.
  TITLE     Metallothionein mediates gene expression of 3.1 mRNA (PTZ17)
            related to epileptic seizure
  JOURNAL   FEBS Lett 479 (3), 146-148 (2000)
   PUBMED   10981724
REFERENCE   8  (bases 1 to 2223)
  AUTHORS   Wakana,S., Sugaya,E., Naramoto,F., Yokote,N., Maruyama,C., Jin,W.,
            Ohguchi,H., Tsuda,T., Sugaya,A. and Kajiwara,K.
  TITLE     Gene mapping of SEZ group genes and determination of
            pentylenetetrazol susceptible quantitative trait loci in the mouse
            chromosome
  JOURNAL   Brain Res 857 (1-2), 286-290 (2000)
   PUBMED   10700579
REFERENCE   9  (bases 1 to 2223)
  AUTHORS   Kajiwara,K., Nagawawa,H., Shimizu-Nishikawa,S., Ookuri,T.,
            Kimura,M. and Sugaya,E.
  TITLE     Molecular characterization of seizure-related genes isolated by
            differential screening
  JOURNAL   Biochem Biophys Res Commun 219 (3), 795-799 (1996)
   PUBMED   8645260
REFERENCE   10 (bases 1 to 2223)
  AUTHORS   Kajiwara,K., Sugaya,E., Kimura,M., Katsuki,M., Nagasawa,H.,
            Yuyama,N., Tsuda,T., Sugaya,A., Motoki,M., Ookura,T. et al.
  TITLE     Cloning and characterization of pentylenetetrazol-related cDNA,
            PTZ-17
  JOURNAL   Brain Res 671 (1), 170-174 (1995)
   PUBMED   7537161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ148521.1, AK048361.1 and AV321356.1.
            
            On or before Jun 14, 2012 this sequence version replaced
            NM_001109990.1, NM_053078.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein. Variants 1, 2, 3, 4
            and 5 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X70398.1, SRR1660815.10633.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               CJ148521.1         106-305
            201-2220            AK048361.1         1-2020
            2221-2223           AV321356.1         176-178
FEATURES             Location/Qualifiers
     source          1..2223
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.18 cM"
     gene            1..2223
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /note="neuronal regeneration related protein"
                     /db_xref="GeneID:27528"
                     /db_xref="MGI:MGI:99444"
     exon            1..257
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            258..324
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..528
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /note="neuronal protein 3.1; high-altitude regulated
                     protein; protein p311"
                     /codon_start=1
                     /product="neuronal regeneration-related protein"
                     /protein_id="NP_444308.1"
                     /db_xref="CCDS:CCDS37756.1"
                     /db_xref="GeneID:27528"
                     /db_xref="MGI:MGI:99444"
                     /translation="MVYYPELLVWVSQEPFAYKEMEGGLIKGRLPVPKEVNRKKMEET
                     GAASLTPPGSREFTSPATSYLHPF"
     exon            325..402
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            403..2223
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2199..2204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /note="hexamer: AATAAA"
     polyA_site      2223
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /note="major polyA site"
ORIGIN      
        1 gagacacaca cacagtcttg gagagagcgc gcaaggcagg gaacccttcc cctccttttc
       61 cgaggctgca cttcttggaa gtgaagcggg ctggggtttt gtttcccttc ccccctccgc
      121 cctcctcttc ctccacccct ttcccctccc cctccccctc cccctcagct gtctttctag
      181 catgatgccc tttttcatcc acatttgtgt ttcaggtgta gaaagcagag agtgaacagg
      241 gagcggggct tttgtctgtt ggtctccctg gactgaagga agggagaata gaagaagccc
      301 aagactatta agagtctcaa aatggtttac tacccagaac tcttggtctg ggtcagccaa
      361 gaaccgtttg catacaagga aatggaggga ggtcttatta agggaagact tcccgtgcct
      421 aaggaagtga accgaaagaa gatggaggag actggcgctg cctcgctgac tccgccaggc
      481 agccgtgaat tcacctctcc agctaccagt tacctccacc ctttttaatc gtcccacctc
      541 catttgtatt gcatatggtg tatggggttt tgatgaggtc ttggtatcat atatgggatt
      601 tttttttttt ctgtgtaaat catcaactat aagaagaaac tatgggactc taagcctggc
      661 tttagagaat ttacagtgga caaataggtt tcatcaaacc agtttttaat cattctgact
      721 caagtgaaaa cgctcagaat ttcacactgt gaatccacgt ttacaacccc tacaggtggg
      781 ccttcaggcc tggttcgcta caacaatgtc ttccacaact caaaactcct actgcgctca
      841 gatgactggt ccactcctgc ctttcatcag acagctcccg actgcttctt gcagaggctg
      901 agagtccccc ccacggtttt tttttttctt catttagatg taacaagcct agtagtttat
      961 gttcatcaat tgtctgtata tctatatttt acccatgtac tcttttgatg tatagaagta
     1021 gtttgaaact cattgtttcc ttgtggtaag tgactgagac gctgccacag ggcctgagac
     1081 actgatgaat ggtgctattt tggactttca acatgctcct tggcgaggta gctctggtgg
     1141 agttgttttt atttccatgt tctaagaagg tgtcggtact ttgtttcctg gaatgttctt
     1201 ctctagactg gactgacttg tttcccttgt gtcttgagtg tggctttctt cttcagggtt
     1261 gtaggttgag tggatgctac caagagtgtg agaggctgtc ctctcgtgac tggccctggt
     1321 ggatgtgcag tcacggtagc gggagcaatc acaaaactgt aattgaccta ccagatctct
     1381 tcctttctgc agcctcacct gcctgactta gaaaaagaaa agcaataatt tttttccagg
     1441 cgttctgagg ttatctcttt ggattctttt tgtttgacta gatattgggg gaggggggat
     1501 aaaagtccac tcttttaata agtgccatgt gggaaaaaaa atccaaagtg ctggcatttg
     1561 agtaggaatt tgaaaattat ccctttccca aagttgaaat tggaaaaatg tctttacaaa
     1621 atagtgatga tgaaggtgat gactatgata gtgatgacga tgttgttgtt gttgttggtg
     1681 gtggtggtga tgatggtgat ggtggtgaaa ggcaaaatac ctttttgggg tggttttgat
     1741 aagcaaggtg tagattttac atttttgtcc ttgctcccaa tgaaatggat aaacaaaaat
     1801 aaaatctgac aatgccatct cctcacagaa tgttgttgtg ttagccagac tgaaagccca
     1861 ccttaatttt tatataacgt ctttggctct tcctttgaca gggcaggcct tgttctgaac
     1921 tgtttgcgct tctgactgtt aaacaccaat gatgcatgca ctgtccctct tcactctttc
     1981 tctcgcttcc cctctggctt gagtttcttg tgcattctcg ctacccccac ctctgttagg
     2041 gtaggtatat cagctatgta aataaagcaa ggaaacggta ttgtgcattt gtggcattat
     2101 gtagaattgc agtgtgcgct gccgaaaatg caggcttttg taacgtggtc ctctcataag
     2161 tacccaatgt attttagcta ttttagtagg atttgttcaa taaatatgca agctataagg
     2221 taa
//
