LOCUS       NM_001267717            2097 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus neuronal regeneration related protein (Nrep),
            transcript variant 5, mRNA.
ACCESSION   NM_001267717
VERSION     NM_001267717.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2097)
  AUTHORS   Chen,C., Tang,Y., Zhu,X., Yang,J., Liu,Z., Chen,Y., Wang,J.,
            Shang,R., Zheng,W., Zhang,X., Hu,X., Tan,J., Zhou,J., Peng,S.,
            Lu,Q., Ju,Z., Luo,G. and He,W.
  TITLE     P311 Promotes IL-4 Receptor-Mediated M2 Polarization of Macrophages
            to Enhance Angiogenesis for Efficient Skin Wound Healing
  JOURNAL   J Invest Dermatol 143 (4), 648-660 (2023)
   PUBMED   36309321
REFERENCE   2  (bases 1 to 2097)
  AUTHORS   Zhang,J., Zhou,Y., Guo,J., Li,L., Liu,H., Lu,C., Jiang,Y. and
            Cui,S.
  TITLE     MicroRNA-7a2 is Required for the Development of Pituitary Stem
            Cells
  JOURNAL   Stem Cells Dev 31 (13-14), 357-368 (2022)
   PUBMED   35652338
REFERENCE   3  (bases 1 to 2097)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2097)
  AUTHORS   Liu,Y., Zhou,X., Hu,N., Wang,C. and Zhao,L.
  TITLE     P311 regulates distal lung development via its interaction with
            several binding proteins
  JOURNAL   Mech Dev 163, 103633 (2020)
   PUBMED   32682987
  REMARK    GeneRIF: P311 regulates distal lung development via its interaction
            with several binding proteins.
REFERENCE   5  (bases 1 to 2097)
  AUTHORS   Du,Y., Yang,Y.T., Tang,G., Jia,J.S., Zhu,N. and Yuan,W.J.
  TITLE     Butyrate alleviates diabetic kidney disease by mediating the
            miR-7a-5p/P311/TGF-beta1 pathway
  JOURNAL   FASEB J 34 (8), 10462-10475 (2020)
   PUBMED   32539181
  REMARK    GeneRIF: Butyrate alleviates diabetic kidney disease by mediating
            the miR-7a-5p/P311/TGF-beta1 pathway.
REFERENCE   6  (bases 1 to 2097)
  AUTHORS   Pan,D., Zhe,X., Jakkaraju,S., Taylor,G.A. and Schuger,L.
  TITLE     P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast
            phenotype
  JOURNAL   J Clin Invest 110 (9), 1349-1358 (2002)
   PUBMED   12417574
  REMARK    GeneRIF: role for P311 in inducing TGF-beta1-independent
            myofibroblast transformation
REFERENCE   7  (bases 1 to 2097)
  AUTHORS   Miura,N. and Naganuma,A.
  TITLE     Metallothionein mediates gene expression of 3.1 mRNA (PTZ17)
            related to epileptic seizure
  JOURNAL   FEBS Lett 479 (3), 146-148 (2000)
   PUBMED   10981724
REFERENCE   8  (bases 1 to 2097)
  AUTHORS   Wakana,S., Sugaya,E., Naramoto,F., Yokote,N., Maruyama,C., Jin,W.,
            Ohguchi,H., Tsuda,T., Sugaya,A. and Kajiwara,K.
  TITLE     Gene mapping of SEZ group genes and determination of
            pentylenetetrazol susceptible quantitative trait loci in the mouse
            chromosome
  JOURNAL   Brain Res 857 (1-2), 286-290 (2000)
   PUBMED   10700579
REFERENCE   9  (bases 1 to 2097)
  AUTHORS   Kajiwara,K., Nagawawa,H., Shimizu-Nishikawa,S., Ookuri,T.,
            Kimura,M. and Sugaya,E.
  TITLE     Molecular characterization of seizure-related genes isolated by
            differential screening
  JOURNAL   Biochem Biophys Res Commun 219 (3), 795-799 (1996)
   PUBMED   8645260
REFERENCE   10 (bases 1 to 2097)
  AUTHORS   Kajiwara,K., Sugaya,E., Kimura,M., Katsuki,M., Nagasawa,H.,
            Yuyama,N., Tsuda,T., Sugaya,A., Motoki,M., Ookura,T. et al.
  TITLE     Cloning and characterization of pentylenetetrazol-related cDNA,
            PTZ-17
  JOURNAL   Brain Res 671 (1), 170-174 (1995)
   PUBMED   7537161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115117.5.
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcripts of
            different breeds and genomic sequence data because no single
            transcript from the same breed was available for the full length of
            the gene. The extent of this transcript is supported by transcript
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189673.77441.1, BI684348.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01766820, SAMN02146468
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC115117.5         154145-154233       c
            90-131              AC115117.5         153977-154018       c
            132-198             AC115117.5         152620-152686       c
            199-276             AC115117.5         133415-133492       c
            277-2097            AC115117.5         127618-129438       c
FEATURES             Location/Qualifiers
     source          1..2097
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.18 cM"
     gene            1..2097
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /note="neuronal regeneration related protein"
                     /db_xref="GeneID:27528"
                     /db_xref="MGI:MGI:99444"
     exon            1..89
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            90..131
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            132..198
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..402
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /note="neuronal protein 3.1; high-altitude regulated
                     protein; protein p311"
                     /codon_start=1
                     /product="neuronal regeneration-related protein"
                     /protein_id="NP_001254646.1"
                     /db_xref="CCDS:CCDS37756.1"
                     /db_xref="GeneID:27528"
                     /db_xref="MGI:MGI:99444"
                     /translation="MVYYPELLVWVSQEPFAYKEMEGGLIKGRLPVPKEVNRKKMEET
                     GAASLTPPGSREFTSPATSYLHPF"
     exon            199..276
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            277..2097
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2073..2078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /note="hexamer: AATAAA"
     polyA_site      2097
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /note="major polyA site"
ORIGIN      
        1 gagacacaca cacagtcttg gagagagcgc gcaaggcagg gaacccttcc cctccttttc
       61 cgaggctgca cttcttggaa gtgaagcggg tgtagaaagc agagagtgaa cagggagcgg
      121 ggcttttgtc tgttggtctc cctggactga aggaagggag aatagaagaa gcccaagact
      181 attaagagtc tcaaaatggt ttactaccca gaactcttgg tctgggtcag ccaagaaccg
      241 tttgcataca aggaaatgga gggaggtctt attaagggaa gacttcccgt gcctaaggaa
      301 gtgaaccgaa agaagatgga ggagactggc gctgcctcgc tgactccgcc aggcagccgt
      361 gaattcacct ctccagctac cagttacctc cacccttttt aatcgtccca cctccatttg
      421 tattgcatat ggtgtatggg gttttgatga ggtcttggta tcatatatgg gatttttttt
      481 ttttctgtgt aaatcatcaa ctataagaag aaactatggg actctaagcc tggctttaga
      541 gaatttacag tggacaaata ggtttcatca aaccagtttt taatcattct gactcaagtg
      601 aaaacgctca gaatttcaca ctgtgaatcc acgtttacaa cccctacagg tgggccttca
      661 ggcctggttc gctacaacaa tgtcttccac aactcaaaac tcctactgcg ctcagatgac
      721 tggtccactc ctgcctttca tcagacagct cccgactgct tcttgcagag gctgagagtc
      781 ccccccacgg tttttttttt tcttcattta gatgtaacaa gcctagtagt ttatgttcat
      841 caattgtctg tatatctata ttttacccat gtactctttt gatgtataga agtagtttga
      901 aactcattgt ttccttgtgg taagtgactg agacgctgcc acagggcctg agacactgat
      961 gaatggtgct attttggact ttcaacatgc tccttggcga ggtagctctg gtggagttgt
     1021 ttttatttcc atgttctaag aaggtgtcgg tactttgttt cctggaatgt tcttctctag
     1081 actggactga cttgtttccc ttgtgtcttg agtgtggctt tcttcttcag ggttgtaggt
     1141 tgagtggatg ctaccaagag tgtgagaggc tgtcctctcg tgactggccc tggtggatgt
     1201 gcagtcacgg tagcgggagc aatcacaaaa ctgtaattga cctaccagat ctcttccttt
     1261 ctgcagcctc acctgcctga cttagaaaaa gaaaagcaat aatttttttc caggcgttct
     1321 gaggttatct ctttggattc tttttgtttg actagatatt gggggagggg ggataaaagt
     1381 ccactctttt aataagtgcc atgtgggaaa aaaaatccaa agtgctggca tttgagtagg
     1441 aatttgaaaa ttatcccttt cccaaagttg aaattggaaa aatgtcttta caaaatagtg
     1501 atgatgaagg tgatgactat gatagtgatg acgatgttgt tgttgttgtt ggtggtggtg
     1561 gtgatgatgg tgatggtggt gaaaggcaaa ataccttttt ggggtggttt tgataagcaa
     1621 ggtgtagatt ttacattttt gtccttgctc ccaatgaaat ggataaacaa aaataaaatc
     1681 tgacaatgcc atctcctcac agaatgttgt tgtgttagcc agactgaaag cccaccttaa
     1741 tttttatata acgtctttgg ctcttccttt gacagggcag gccttgttct gaactgtttg
     1801 cgcttctgac tgttaaacac caatgatgca tgcactgtcc ctcttcactc tttctctcgc
     1861 ttcccctctg gcttgagttt cttgtgcatt ctcgctaccc ccacctctgt tagggtaggt
     1921 atatcagcta tgtaaataaa gcaaggaaac ggtattgtgc atttgtggca ttatgtagaa
     1981 ttgcagtgtg cgctgccgaa aatgcaggct tttgtaacgt ggtcctctca taagtaccca
     2041 atgtatttta gctattttag taggatttgt tcaataaata tgcaagctat aaggtaa
//
