LOCUS       NM_001109989            2108 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus neuronal regeneration related protein (Nrep),
            transcript variant 3, mRNA.
ACCESSION   NM_001109989
VERSION     NM_001109989.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2108)
  AUTHORS   Chen,C., Tang,Y., Zhu,X., Yang,J., Liu,Z., Chen,Y., Wang,J.,
            Shang,R., Zheng,W., Zhang,X., Hu,X., Tan,J., Zhou,J., Peng,S.,
            Lu,Q., Ju,Z., Luo,G. and He,W.
  TITLE     P311 Promotes IL-4 Receptor-Mediated M2 Polarization of Macrophages
            to Enhance Angiogenesis for Efficient Skin Wound Healing
  JOURNAL   J Invest Dermatol 143 (4), 648-660 (2023)
   PUBMED   36309321
REFERENCE   2  (bases 1 to 2108)
  AUTHORS   Zhang,J., Zhou,Y., Guo,J., Li,L., Liu,H., Lu,C., Jiang,Y. and
            Cui,S.
  TITLE     MicroRNA-7a2 is Required for the Development of Pituitary Stem
            Cells
  JOURNAL   Stem Cells Dev 31 (13-14), 357-368 (2022)
   PUBMED   35652338
REFERENCE   3  (bases 1 to 2108)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2108)
  AUTHORS   Liu,Y., Zhou,X., Hu,N., Wang,C. and Zhao,L.
  TITLE     P311 regulates distal lung development via its interaction with
            several binding proteins
  JOURNAL   Mech Dev 163, 103633 (2020)
   PUBMED   32682987
  REMARK    GeneRIF: P311 regulates distal lung development via its interaction
            with several binding proteins.
REFERENCE   5  (bases 1 to 2108)
  AUTHORS   Du,Y., Yang,Y.T., Tang,G., Jia,J.S., Zhu,N. and Yuan,W.J.
  TITLE     Butyrate alleviates diabetic kidney disease by mediating the
            miR-7a-5p/P311/TGF-beta1 pathway
  JOURNAL   FASEB J 34 (8), 10462-10475 (2020)
   PUBMED   32539181
  REMARK    GeneRIF: Butyrate alleviates diabetic kidney disease by mediating
            the miR-7a-5p/P311/TGF-beta1 pathway.
REFERENCE   6  (bases 1 to 2108)
  AUTHORS   Pan,D., Zhe,X., Jakkaraju,S., Taylor,G.A. and Schuger,L.
  TITLE     P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast
            phenotype
  JOURNAL   J Clin Invest 110 (9), 1349-1358 (2002)
   PUBMED   12417574
  REMARK    GeneRIF: role for P311 in inducing TGF-beta1-independent
            myofibroblast transformation
REFERENCE   7  (bases 1 to 2108)
  AUTHORS   Miura,N. and Naganuma,A.
  TITLE     Metallothionein mediates gene expression of 3.1 mRNA (PTZ17)
            related to epileptic seizure
  JOURNAL   FEBS Lett 479 (3), 146-148 (2000)
   PUBMED   10981724
REFERENCE   8  (bases 1 to 2108)
  AUTHORS   Wakana,S., Sugaya,E., Naramoto,F., Yokote,N., Maruyama,C., Jin,W.,
            Ohguchi,H., Tsuda,T., Sugaya,A. and Kajiwara,K.
  TITLE     Gene mapping of SEZ group genes and determination of
            pentylenetetrazol susceptible quantitative trait loci in the mouse
            chromosome
  JOURNAL   Brain Res 857 (1-2), 286-290 (2000)
   PUBMED   10700579
REFERENCE   9  (bases 1 to 2108)
  AUTHORS   Kajiwara,K., Nagawawa,H., Shimizu-Nishikawa,S., Ookuri,T.,
            Kimura,M. and Sugaya,E.
  TITLE     Molecular characterization of seizure-related genes isolated by
            differential screening
  JOURNAL   Biochem Biophys Res Commun 219 (3), 795-799 (1996)
   PUBMED   8645260
REFERENCE   10 (bases 1 to 2108)
  AUTHORS   Kajiwara,K., Sugaya,E., Kimura,M., Katsuki,M., Nagasawa,H.,
            Yuyama,N., Tsuda,T., Sugaya,A., Motoki,M., Ookura,T. et al.
  TITLE     Cloning and characterization of pentylenetetrazol-related cDNA,
            PTZ-17
  JOURNAL   Brain Res 671 (1), 170-174 (1995)
   PUBMED   7537161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115117.5 and CX768079.1.
            
            On Jun 14, 2012 this sequence version replaced NM_001109989.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.143385.1,
                                           SRR9219381.5489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC115117.5         154297-154298       c
            3-707               CX768079.1         1-705
            708-2108            AC115117.5         127618-129018       c
FEATURES             Location/Qualifiers
     source          1..2108
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.18 cM"
     gene            1..2108
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /note="neuronal regeneration related protein"
                     /db_xref="GeneID:27528"
                     /db_xref="MGI:MGI:99444"
     exon            1..100
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            101..142
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            143..209
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..413
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /note="neuronal protein 3.1; high-altitude regulated
                     protein; protein p311"
                     /codon_start=1
                     /product="neuronal regeneration-related protein"
                     /protein_id="NP_001103459.1"
                     /db_xref="CCDS:CCDS37756.1"
                     /db_xref="GeneID:27528"
                     /db_xref="MGI:MGI:99444"
                     /translation="MVYYPELLVWVSQEPFAYKEMEGGLIKGRLPVPKEVNRKKMEET
                     GAASLTPPGSREFTSPATSYLHPF"
     exon            210..287
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     exon            288..2108
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2084..2089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /note="hexamer: AATAAA"
     polyA_site      2108
                     /gene="Nrep"
                     /gene_synonym="D0H4S114; Harp; P311; PTZ17; SEZ17"
                     /note="major polyA site"
ORIGIN      
        1 gagagagaga gagagagaga gagagaggag ttgagattga gagactgatt taaagagaga
       61 gacacgagac acacacacag tcttggagag agcgcgcaag gtgtagaaag cagagagtga
      121 acagggagcg gggcttttgt ctgttggtct ccctggactg aaggaaggga gaatagaaga
      181 agcccaagac tattaagagt ctcaaaatgg tttactaccc agaactcttg gtctgggtca
      241 gccaagaacc gtttgcatac aaggaaatgg agggaggtct tattaaggga agacttcccg
      301 tgcctaagga agtgaaccga aagaagatgg aggagactgg cgctgcctcg ctgactccgc
      361 caggcagccg tgaattcacc tctccagcta ccagttacct ccaccctttt taatcgtccc
      421 acctccattt gtattgcata tggtgtatgg ggttttgatg aggtcttggt atcatatatg
      481 ggattttttt tttttctgtg taaatcatca actataagaa gaaactatgg gactctaagc
      541 ctggctttag agaatttaca gtggacaaat aggtttcatc aaaccagttt ttaatcattc
      601 tgactcaagt gaaaacgctc agaatttcac actgtgaatc cacgtttaca acccctacag
      661 gtgggccttc aggcctggtt cgctacaaca atgtcttcca caactcaaaa ctcctactgc
      721 gctcagatga ctggtccact cctgcctttc atcagacagc tcccgactgc ttcttgcaga
      781 ggctgagagt cccccccacg gttttttttt ttcttcattt agatgtaaca agcctagtag
      841 tttatgttca tcaattgtct gtatatctat attttaccca tgtactcttt tgatgtatag
      901 aagtagtttg aaactcattg tttccttgtg gtaagtgact gagacgctgc cacagggcct
      961 gagacactga tgaatggtgc tattttggac tttcaacatg ctccttggcg aggtagctct
     1021 ggtggagttg tttttatttc catgttctaa gaaggtgtcg gtactttgtt tcctggaatg
     1081 ttcttctcta gactggactg acttgtttcc cttgtgtctt gagtgtggct ttcttcttca
     1141 gggttgtagg ttgagtggat gctaccaaga gtgtgagagg ctgtcctctc gtgactggcc
     1201 ctggtggatg tgcagtcacg gtagcgggag caatcacaaa actgtaattg acctaccaga
     1261 tctcttcctt tctgcagcct cacctgcctg acttagaaaa agaaaagcaa taattttttt
     1321 ccaggcgttc tgaggttatc tctttggatt ctttttgttt gactagatat tgggggaggg
     1381 gggataaaag tccactcttt taataagtgc catgtgggaa aaaaaatcca aagtgctggc
     1441 atttgagtag gaatttgaaa attatccctt tcccaaagtt gaaattggaa aaatgtcttt
     1501 acaaaatagt gatgatgaag gtgatgacta tgatagtgat gacgatgttg ttgttgttgt
     1561 tggtggtggt ggtgatgatg gtgatggtgg tgaaaggcaa aatacctttt tggggtggtt
     1621 ttgataagca aggtgtagat tttacatttt tgtccttgct cccaatgaaa tggataaaca
     1681 aaaataaaat ctgacaatgc catctcctca cagaatgttg ttgtgttagc cagactgaaa
     1741 gcccacctta atttttatat aacgtctttg gctcttcctt tgacagggca ggccttgttc
     1801 tgaactgttt gcgcttctga ctgttaaaca ccaatgatgc atgcactgtc cctcttcact
     1861 ctttctctcg cttcccctct ggcttgagtt tcttgtgcat tctcgctacc cccacctctg
     1921 ttagggtagg tatatcagct atgtaaataa agcaaggaaa cggtattgtg catttgtggc
     1981 attatgtaga attgcagtgt gcgctgccga aaatgcaggc ttttgtaacg tggtcctctc
     2041 ataagtaccc aatgtatttt agctatttta gtaggatttg ttcaataaat atgcaagcta
     2101 taaggtaa
//
