LOCUS       NM_146150               4305 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus nardilysin convertase (Nrdc), transcript variant 2,
            mRNA.
ACCESSION   NM_146150
VERSION     NM_146150.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4305)
  AUTHORS   Batbaatar,M.A., Kinoshita,T., Ikeda,S., Nishi,K., Iwasaki,H.,
            Ganbaatar,N., Ohno,M. and Nishi,E.
  TITLE     Nardilysin in vascular smooth muscle cells controls blood pressure
            via the regulation of calcium dynamics
  JOURNAL   Biochem Biophys Res Commun 712-713, 149961 (2024)
   PUBMED   38648679
  REMARK    GeneRIF: Nardilysin in vascular smooth muscle cells controls blood
            pressure via the regulation of calcium dynamics.
REFERENCE   2  (bases 1 to 4305)
  AUTHORS   Fu,J., Ling,J., Li,C.F., Tsai,C.L., Yin,W., Hou,J., Chen,P.,
            Cao,Y., Kang,Y., Sun,Y., Xia,X., Jiang,Z., Furukawa,K., Lu,Y.,
            Wu,M., Huang,Q., Yao,J., Hawke,D.H., Pan,B.F., Zhao,J., Huang,J.,
            Wang,H., Bahassi,E.I.M., Stambrook,P.J., Huang,P., Fleming,J.B.,
            Maitra,A., Tainer,J.A., Hung,M.C., Lin,C. and Chiao,P.J.
  TITLE     Nardilysin-regulated scission mechanism activates polo-like kinase
            3 to suppress the development of pancreatic cancer
  JOURNAL   Nat Commun 15 (1), 3149 (2024)
   PUBMED   38605037
  REMARK    GeneRIF: Nardilysin-regulated scission mechanism activates
            polo-like kinase 3 to suppress the development of pancreatic
            cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4305)
  AUTHORS   Saijo,S., Ohno,M., Iwasaki,H., Matsuda,S., Nishi,K., Hiraoka,Y.,
            Ide,N., Kimura,T. and Nishi,E.
  TITLE     Nardilysin in adipocytes regulates UCP1 expression and body
            temperature homeostasis
  JOURNAL   Sci Rep 12 (1), 3449 (2022)
   PUBMED   35236897
  REMARK    GeneRIF: Nardilysin in adipocytes regulates UCP1 expression and
            body temperature homeostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4305)
  AUTHORS   Yasuda,D., Hiraoka,Y., Ohno,M., Nishi,K., Iwasaki,H., Kita,T.,
            Nishi,E. and Kume,N.
  TITLE     Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol
            Levels
  JOURNAL   Biol Pharm Bull 44 (3), 363-371 (2021)
   PUBMED   33642545
  REMARK    GeneRIF: Deficiency of Nardilysin in the Liver Reduces Serum
            Cholesterol Levels.
REFERENCE   5  (bases 1 to 4305)
  AUTHORS   Ohno,M., Nishi,K., Hiraoka,Y., Niizuma,S., Matsuda,S., Iwasaki,H.,
            Kimura,T. and Nishi,E.
  TITLE     Nardilysin controls cardiac sympathetic innervation patterning
            through regulation of p75 neurotrophin receptor
  JOURNAL   FASEB J 34 (9), 11624-11640 (2020)
   PUBMED   32683751
  REMARK    GeneRIF: Nardilysin controls cardiac sympathetic innervation
            patterning through regulation of p75 neurotrophin receptor.
REFERENCE   6  (bases 1 to 4305)
  AUTHORS   Ma,Z., Chow,K.M., Csuhai,E. and Hersh,L.B.
  TITLE     The use of proteolysis to study the structure of nardilysin
  JOURNAL   Arch Biochem Biophys 401 (2), 198-204 (2002)
   PUBMED   12054470
  REMARK    GeneRIF: The use of proteolysis to study the structure of
            nardilysin.
REFERENCE   7  (bases 1 to 4305)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4305)
  AUTHORS   Ma,Z., Csuhai,E., Chow,K.M. and Hersh,L.B.
  TITLE     Expression of the acidic stretch of nardilysin as a functional
            binding domain
  JOURNAL   Biochemistry 40 (31), 9447-9452 (2001)
   PUBMED   11478915
  REMARK    GeneRIF: The acidic stretch of nardilysin, expressed as a fusion
            protein with glutathione S-transferase and compared to the native
            enzyme with respect to spermine binding, functions as an autonomous
            domain.
REFERENCE   9  (bases 1 to 4305)
  AUTHORS   Winter,A.G. and Pierotti,A.R.
  TITLE     Gene expression of the dibasic-pair cleaving enzyme NRD convertase
            (N-arginine dibasic convertase) is differentially regulated in the
            GH3 pituitary and Mat-Lu prostate cell lines
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 755-764 (2000)
   PUBMED   11042131
REFERENCE   10 (bases 1 to 4305)
  AUTHORS   Fumagalli,P., Accarino,M., Egeo,A., Scartezzini,P., Rappazzo,G.,
            Pizzuti,A., Avvantaggiato,V., Simeone,A., Arrigo,G., Zuffardi,O.,
            Ottolenghi,S. and Taramelli,R.
  TITLE     Human NRD convertase: a highly conserved metalloendopeptidase
            expressed at specific sites during development and in adult tissues
  JOURNAL   Genomics 47 (2), 238-245 (1998)
   PUBMED   9479496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY732391.1, CF168810.1 and AK031548.1.
            
            On Oct 4, 2017 this sequence version replaced NM_146150.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031548.1, SRR1660815.276224.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                BY732391.1         4-101
            99-99               CF168810.1         75-75
            100-150             BY732391.1         103-153
            151-4305            AK031548.1         1-4155
FEATURES             Location/Qualifiers
     source          1..4305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.77 cM"
     gene            1..4305
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /note="nardilysin convertase"
                     /db_xref="GeneID:230598"
                     /db_xref="MGI:MGI:1201386"
     exon            1..510
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..3664
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /EC_number="3.4.24.61"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; NRD convertase; N-arginine dibasic convertase;
                     nardilysin, N-arginine dibasic convertase, NRD convertase
                     1"
                     /codon_start=1
                     /product="nardilysin isoform 2 precursor"
                     /protein_id="NP_666262.2"
                     /db_xref="CCDS:CCDS18460.1"
                     /db_xref="GeneID:230598"
                     /db_xref="MGI:MGI:1201386"
                     /translation="MLRRVAVAAVCVTGRKLRCEAGRELTALGRIEARGLCEESSKPF
                     PTLTMPGRNKAKSTCSCPDLQPNGQDLGESGRLARLGADESEEEGRSFSNVGDPEIIK
                     SPSDPKQYRYIKLQNGLQALLISDLSNVEGKTGNATDEEEEEEEEEEEEDDDDDDDDD
                     DDDEDSGAEIQDDDEEGFDDEEEFDDDDDDEHDDDDLENEENELEELEERVEARKKTT
                     EKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNA
                     STDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDA
                     NRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKKNNIDTHARLREFWMRYYSAHYMTL
                     VVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFSHLTDPFDTPAFNKLYRVVPIRKIHA
                     LTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQ
                     NSTYSVFSISITLTDEGYEHFYEVAHTVFQYLKMLQKLGPEKRVFEEIQKIEDNEFHY
                     QEQTDPVEYVENMCENMQLYPRQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLS
                     GANEGRCDLKEKWFGTQYSIEDIENSWTELWKSNFDLNPDLHLPAENKYIATDFTLKA
                     FDCPETEYPAKIVNTAQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFV
                     NILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLTEFSST
                     PAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYSRWSMIDKYQALMDGLSLDSLL
                     NFVKDFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFAPLEREMPVQFQVVELPSGH
                     HLCKVRALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYH
                     VYPTCRNTSGILGFSVTVGTQATKYNSETVDKKIEEFLSSFEEKIENLTEDAFNTQVT
                     ALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVSWFKAHRG
                     PGSKMLSVHVVGYGKYELEEDGAPFGEDSNSREGMQLTYLPPSPVLAESTTPITDIRA
                     FTATLSLFPYHKIVK"
     exon            511..841
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..923
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1077
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1151
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1247
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1370
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1428
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1502
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1572
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1650
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1771
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1830
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1885
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1990
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2114
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2201
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2321
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2373
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2524
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2652
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2815
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2847
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2986
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3034
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3087
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3171
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3262
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3379
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3469
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..4305
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3660..3665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /note="hexamer: AATAAA"
     polyA_site      3686
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /note="major polyA site"
     regulatory      3983..3988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
                     /note="hexamer: AGTAAA"
     polyA_site      4010
                     /gene="Nrdc"
                     /gene_synonym="2600011I06Rik; NRD-C; Nrd1"
ORIGIN      
        1 tgtgagcgag gccgggttgg aggaggggtt caggcctgtc ctccccagcg gctggggcag
       61 caacaacgcc ggccgccgcc gtcgcccctg ggacgcggag gaggaggagt ggctggaggt
      121 gtaggaggag gaggtgggcc tggggagcgg gatgtccagc gctacgactt gctggtgaat
      181 gctgaggaga gtcgcggttg ctgcagtctg tgtcaccggg aggaagttgc ggtgtgaggc
      241 cgggcgggag ctcacggctc tggggcgaat cgaagcacgg ggtctgtgcg aagaatcatc
      301 gaaacccttt cctacgctga ccatgcctgg aagaaacaag gcgaagtcca cctgcagttg
      361 cccggacctg cagcccaatg gacaggactt gggcgagagc ggccggcttg ctcgtctagg
      421 agcggatgaa tctgaggagg agggacggtc tttcagtaat gtcggggacc ctgagatcat
      481 caagtctccc agcgatccca agcagtaccg atacatcaaa ttacagaatg gcttgcaggc
      541 acttttgatt tcagatctaa gtaatgtgga aggtaagaca ggaaatgcaa cagatgaaga
      601 ggaggaagaa gaggaggagg aagaggaaga agatgatgat gatgacgacg acgacgacga
      661 tgatgatgaa gactctggag ctgagataca agatgatgat gaggaaggtt ttgatgatga
      721 agaggaattt gatgatgacg atgatgatga acatgatgat gatgatcttg agaatgagga
      781 aaacgaactg gaagagttgg aagagagggt agaagccagg aagaaaacta ctgagaaaca
      841 gtctgcagcg gctctgtgtg ttggagttgg gagctttgct gatccagatg acctgcctgg
      901 gctggcacac tttttggagc acatggtatt catgggtagt ttgaaatacc ctgatgagaa
      961 tggatttgat gccttcctca agaaacatgg aggtagtgat aatgcctcaa ctgattgtga
     1021 acgcacagtc tttcagtttg atgtccagag aaagtatttc aaggaagccc tggatagatg
     1081 ggcccagttc tttatccatc cactgatgat cagagatgca attgaccgag aggtggaagc
     1141 tgtggacagt gagtatcagc ttgcaaggcc ttctgatgca aacagaaaag aaatgttgtt
     1201 tggaagcctc gctagaccgg gacatcctat ggggaagttt ttttggggaa atgctgagac
     1261 actcaagcat gaaccaaaga agaataacat tgatacacat gccagactga gagaattctg
     1321 gatgcgctac tactctgctc attacatgac cttagttgtt cagtccaaag aaaccctgga
     1381 cactttggaa aagtgggtga cggagatctt ctctcagata ccaaacaatg ggctacctaa
     1441 accaaacttt agccatttaa cggatccttt tgacacacca gcatttaaca aactttatag
     1501 agttgttcca atcagaaaaa tccatgctct gaccatcaca tgggcacttc ctcctcagca
     1561 gcagcactac agggtgaagc cacttcatta tatttcctgg cttgttggac atgaaggcaa
     1621 aggcagcatt ctttcttatc ttagaaaaaa gtgctgggct cttgcattgt ttggtggaaa
     1681 tggtgagaca ggttttgagc aaaattctac ttactcagtg ttcagcattt ctattacgct
     1741 gactgatgag ggctatgagc atttttatga ggttgcccac actgtctttc agtatttaaa
     1801 aatgctgcag aagctaggtc cagagaaaag agtttttgaa gagattcaga aaattgagga
     1861 taatgaattt cattatcaag aacagacaga tccagtcgag tatgtggaga acatgtgtga
     1921 gaacatgcag ctgtacccac gtcaggactt tctcaccgga gatcagcttc tgtttgagta
     1981 caagccagaa gtcattgctg aggcccttaa tcagctagtt cctcagaagg caaatctcgt
     2041 tcttctctct ggtgctaatg agggaagatg tgacctcaag gagaagtggt ttgggactca
     2101 gtatagcata gaagatattg aaaactcttg gactgaacta tggaagagta attttgactt
     2161 aaatccagac cttcatcttc cagctgaaaa taagtacata gccacggact ttacgttgaa
     2221 ggcttttgat tgccctgaaa ctgaataccc tgctaaaatt gtcaataccg cacaaggctg
     2281 cttgtggtat aagaaagaca acaaattcaa aatccccaaa gcatatatac gatttcatct
     2341 gatctcacct ttgatacaga aatctgcagc aaatgttgtc ctctttgaca tcttcgtgaa
     2401 tattcttacg cacaaccttg ccgaacccgc ctatgaagct gatgtggcac agctggagta
     2461 taaactggta gctggagaac atgggttaat tattcgagtg aaaggattca accacaaact
     2521 acctctgctc tttcagctca ttattgacta cctgactgag ttcagttcca cacccgctgt
     2581 ctttaccatg ataactgagc aactgaagaa gacctacttc aacatcctca tcaagcccga
     2641 gactctggcc aaagatgtgc ggcttttaat tctggaatat tcccgctggt ctatgattga
     2701 caagtaccaa gctttgatgg atggcctttc ccttgattct ctgctaaact ttgtcaagga
     2761 ttttaaatcc caactttttg ttgagggcct ggtccaaggg aatgtcacca gcacggaatc
     2821 gatggatttc ctaaaatatg ttgttgacaa gctgaacttc gcgcccctgg agcgggagat
     2881 gcctgtgcag ttccaggtgg tggagctgcc gagcggccac cacctgtgca aagtcagagc
     2941 tctgaataaa ggggatgcca actctgaagt cactgtgtac taccagtcag gtacgaggag
     3001 tctgagagaa tatactctta tggagctgct tgtgatgcac atggaagagc cctgctttga
     3061 cttccttcgc accaagcaga cccttgggta ccatgtctac ccaacctgta ggaacacatc
     3121 tggaattcta ggattttctg taactgttgg gactcaggca accaaataca actccgaaac
     3181 tgttgacaag aagatagagg aatttctttc cagctttgag gagaagattg agaacctcac
     3241 agaagatgca ttcaatactc aggtcacagc actgatcaag ttgaaagagt gtgaggacac
     3301 ccaccttggg gaggaggtgg acaggaactg gaatgaagtg gtgacacagc agtatctctt
     3361 tgaccgcctt gcccatgaga ttgaagccct gaagtctttc tcaaagtcag acctggtcag
     3421 ctggttcaag gctcacagag gacctggaag taaaatgctc agcgttcatg ttgttggata
     3481 tgggaagtat gaactggaag aggatggtgc cccttttggt gaggattcaa attctcgtga
     3541 agggatgcag ctaacctacc tgccaccctc tcctgtcctg gcagaatcca ccacccccat
     3601 tactgacatc agggccttca cagcaacact cagcctcttc ccctaccata aaatagtcaa
     3661 ataaactgca gtctcattgg cctgaagcaa cgtgtattta aagacgtgtg tgcattttat
     3721 ggagttacac tgctgcctta gggcttccat tggatttttt cgatggcaac ctaggatttg
     3781 atttactttt tacctttcct ctacaagatt agctcaggat ggcaatgaga tagtaggcaa
     3841 gtgtgaccca aacacttacg tcagcaatgt gggggcccct ggcctgtgtc ctctgaggag
     3901 aacccagctc ttgtgtgcct atctgtaatt aatttgttat agcaccaaac tgccctggtt
     3961 ttgttttttt aatgtacttt aaagtaaaca tagttctgta tatcccttca catcaagcca
     4021 tctgccgtgg cttttttggg ggtggggtgg gggaagtgca gtcctccagc cctgcgaggc
     4081 agtaaggcat ccaggactag ccggagggct tgagtcgggg agcctcagaa aaggctgcca
     4141 ggttggtctg caaggttagg tataaaacaa tgaaagaaac atatttttaa aaaggttgga
     4201 aaattatttt atgaagcctt aagaagcact gcatataatt atacttcagg tttagataca
     4261 atctaatcat agttcaattc taaaataaag gttataggtg aaacc
//
