LOCUS       NM_001358359            3278 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus nuclear receptor binding protein 2 (Nrbp2), mRNA.
ACCESSION   NM_001358359 XM_006520772
VERSION     NM_001358359.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3278)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3278)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   3  (bases 1 to 3278)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3278)
  AUTHORS   Larsson,J., Forsberg,M., Brannvall,K., Zhang,X.Q., Enarsson,M.,
            Hedborg,F. and Forsberg-Nilsson,K.
  TITLE     Nuclear receptor binding protein 2 is induced during neural
            progenitor differentiation and affects cell survival
  JOURNAL   Mol Cell Neurosci 39 (1), 32-39 (2008)
   PUBMED   18619852
  REMARK    GeneRIF: Data show that NRBP2 protein levels increase as neural
            progenitor cells differentiate, and its down regulation renders
            neural progenitor cells more vulnerable to apoptosis, which suggest
            a role in stem cell survival.
REFERENCE   5  (bases 1 to 3278)
  AUTHORS   Sajedi,E., Gaston-Massuet,C., Andoniadou,C.L., Signore,M.,
            Hurd,P.J., Dattani,M. and Martinez-Barbera,J.P.
  TITLE     DNMT1 interacts with the developmental transcriptional repressor
            HESX1
  JOURNAL   Biochim Biophys Acta 1783 (1), 131-143 (2008)
   PUBMED   17931718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ070129.1, BC068117.1, AC116487.14 and BU610466.1.
            
            On Dec 1, 2017 this sequence version replaced XM_006520772.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.1384.1,
                                           SRR7652917.17664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               CJ070129.1         2-186
            186-545             BC068117.1         1-360
            546-561             AC116487.14        6437-6452
            562-635             BC068117.1         361-434
            636-3071            BC068117.1         601-3036
            3072-3278           BU610466.1         88-294
FEATURES             Location/Qualifiers
     source          1..3278
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.35 cM"
     gene            1..3278
                     /gene="Nrbp2"
                     /note="nuclear receptor binding protein 2"
                     /db_xref="GeneID:223649"
                     /db_xref="MGI:MGI:2385017"
     exon            1..320
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1697
                     /gene="Nrbp2"
                     /codon_start=1
                     /product="nuclear receptor-binding protein 2"
                     /protein_id="NP_001345288.1"
                     /db_xref="CCDS:CCDS27561.2"
                     /db_xref="GeneID:223649"
                     /db_xref="MGI:MGI:2385017"
                     /translation="MAAPEPAPRRGREREREDESEDESDILEESPCGRWQKRREQVNQ
                     GNMPGIQSTFLAMDTEEGVEVVWNELHFGDRKAFAAHEEKIQTMFEQLALVDHPNIVK
                     LHKYWLDASEARARVIFITEYVSSGSLKQFLKKTKKNHKAMNARAWKRWCTQILSALS
                     FLHACSPPIIHGNLTSDTIFIQHNGLIKIGSVWYRIFSNALPDDLRSPIRAEREELRN
                     LHFFPPEYGEVNDGTAVDIFSFGMCALEMAVLEIQANGDTRVTEEAIARARHSLSDPN
                     MREFILSCLARDPARRPSAHNLLFHRVLFEVHSLKLLAAHCFIQHQYLMPENVVEEKT
                     KAMDLHAVLAEMPQPHGPPMQWRYSEVSFLELDKFLEDVRNGIYPLMNFAAARPLGLP
                     RVLAPPPEEAQKAKTPTPEPFDSETRKVVQMQCNLERSEDKARWHLTLLLVLEDRLHR
                     QLTYDLLPTDSAQDLAAELVHYGFLHEDDRTKLAAFLETTFLKYRGTQA"
     exon            321..443
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            444..545
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..635
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..676
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..771
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..795
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..879
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..935
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1031
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1164
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1267
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1318
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1454
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1508
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1572
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1628
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..3258
                     /gene="Nrbp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3131..3136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrbp2"
                     /note="hexamer: AATAAA"
     polyA_site      3179
                     /gene="Nrbp2"
                     /note="major polyA site"
     regulatory      3235..3240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrbp2"
                     /note="hexamer: ATTAAA"
     polyA_site      3255
                     /gene="Nrbp2"
ORIGIN      
        1 agaggcggct ccggaggggc ggggcggctc ctccctcggg tccgctgcga gcccgcgcct
       61 cccaattccc ggagccgagg agggctcgcg gcggccgctc cgctgggctc caggttgggc
      121 tgctgggcgc tgggccaggg cgggcgggag cggggcgagg gcttgcgcgg agggcggcgg
      181 cctgggctcg ccgagccatg gcggccccgg agccggcgcc gaggagaggc cgggagcgcg
      241 agcgggagga cgagagcgag gacgagagcg acatcctgga ggagagcccg tgtggccgct
      301 ggcagaagcg gcgggagcag gtgaaccaag ggaacatgcc cgggatccag agcacctttc
      361 tggccatgga cacggaggag ggtgtagaag tggtgtggaa cgaacttcac ttcggggata
      421 ggaaggcctt tgcggcccat gaggagaaga tccagaccat gtttgagcag ctggcgctgg
      481 tggaccatcc caacatcgtc aagctgcaca agtattggct ggacgcctct gaggcccgcg
      541 cgagggtcat cttcatcaca gaatacgtgt cgtctggcag cctcaagcag ttcctcaaaa
      601 agaccaagaa gaaccacaag gccatgaacg cccgggcctg gaagcgctgg tgtacgcaga
      661 tcctgtctgc actcagtttt ttgcacgcct gcagtccccc catcatccac gggaacctga
      721 cgagcgacac catcttcatt cagcacaatg gcctcatcaa gatcggctcc gtgtggtacc
      781 gcatcttctc caatgcactt cctgatgatc tccggagccc tattcgagct gaacgggaag
      841 aactccgaaa cctgcacttt ttcccaccag agtatggcga agtcaatgat gggactgctg
      901 tggacatctt ctccttcggg atgtgtgcac tggagatggc tgtactcgag atccaagcca
      961 acggggatac cagagtcaca gaagaggcca tcgctcgagc caggcactca ctgagtgacc
     1021 ccaacatgcg ggaattcatc ctctcctgcc tggcccggga ccctgcccgc cgaccctcag
     1081 cccacaacct cctcttccac cgagtgctct ttgaggtgca ctcgctgaag ctgctggcag
     1141 ctcactgctt catccagcac cagtacctca tgcctgagaa tgtggtagag gaaaagacca
     1201 aggccatgga cctccatgca gttttggctg agatgccgca gccccatgga cccccaatgc
     1261 agtggcggta ctcagaggtc tccttcttgg agctggacaa attcctagag gatgtcagga
     1321 acgggatcta tccactgatg aactttgcgg ctgctcggcc cttggggctt ccccgtgtgt
     1381 tggccccacc cccagaggaa gcccaaaagg ccaaaactcc aacgccagaa ccctttgact
     1441 cggagaccag gaaggtggtc cagatgcagt gcaacctgga aagaagcgag gacaaggctc
     1501 ggtggcacct tactctgctc ttggtgcttg aggaccggct acatcggcag ctgacctatg
     1561 atctgctccc aacggacagt gcccaggacc tcgctgctga actagtgcat tatggcttcc
     1621 tgcacgagga tgacaggaca aagctagcag cctttctgga gaccactttt ctcaagtacc
     1681 gagggacgca agcgtgacct tcccagtcct gacggcccag cagagataca ggggctcagg
     1741 gttgtccact tggcaaagag cccccacact gctcaaagct gccttctgcc tgtgttccct
     1801 ggaactgaac acaggccctg ctagtgaaga cacccccacc ccccagcttt ctgcagcagt
     1861 gtgggaccct ggggtggtga tggagccctg agcctggacg agagtggata caggtcagtt
     1921 aggggaaccg ctccatctgg tactagacaa cagccatgcc ttcaggtggc atagaaacct
     1981 agggaaggag cctgaactca ggtgtcacag tgctgggcat caggcagacc agacctgacc
     2041 tgattggaga actgtagact agatagcttg gagttgaacc catggccagg gaattccttg
     2101 gtcctgctca gaccagtcct gatcccttgc agacctgcct tgagccctct ttctgatctt
     2161 ccacactctt gagaccagga cctgtgtcct ccccaaagcc cttgggaagg atctttctat
     2221 tcatcatccc tctggcctag gggctcaggg gtcaggcatc ctccacattc cctccctggg
     2281 gaagttgtgt gtttgagttg aggatgtggg ttcctggctc cctctttctc cccagcccaa
     2341 cttgtctctt tcttactggt ttcaaagtcc tgatgaacgc ttcccctcag agccaccctg
     2401 gtttccttgg ttcttgaact gcctctctcc caacttcaaa ccaggtctta aacgtttttt
     2461 aaatgcatat ataaatgtaa tgcagtcacg gtccttttta aacactttgt gtatgaaacc
     2521 aggaaagctc actattgtat taggaatagt tccacattgc tgctgttaac agatatcata
     2581 aacccagtgg tttgagacga cacacacaca cacacacaca cacacacaca gagagagaga
     2641 gagttctgta catcaagtgt gatccaggct ctcactagat taatacccag gctaagttcc
     2701 tttctggaag ctgggactta cctcctgctc cttcaagcta ttggcagaac tcacttccct
     2761 gcaatggtaa ggcagaaatc cctattttct caacagctgc caactaagaa cccctctcag
     2821 cttctagagg ccaccaactt ttcttagttc ttctttctcc cccctcaaga ccagcagcgt
     2881 caagttgaat ctttgtcctg ggctagctga ctggcttgcc actgctggga agagttgggg
     2941 ccttttgtga gtaggttgga cccaccagga taaccgagga tgatcccctt ctcagggtct
     3001 atagatgaac cacacctgcg cagttccttc tgctgtcatc ctgggctttg gtgcttggag
     3061 aacagccgtg ggcggtgggt gttgttactg tggtacctac catgccatct taaccgaaac
     3121 caagacctaa aataaaacag atttgtcatg ggacatctaa taaattaaat gaactctgat
     3181 tatgcatggt ctgacatagt ttatttttaa aatccacaac agactgtaca ggtaattaaa
     3241 ctgaatttga aaacatcaaa aaaaaaaaaa aaaaaaaa
//
