LOCUS       NM_147201               2146 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nuclear receptor binding protein 1 (Nrbp1), transcript
            variant 2, mRNA.
ACCESSION   NM_147201
VERSION     NM_147201.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2146)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2146)
  AUTHORS   Cao,C., Sun,G., Le,K., Xu,Q. and Liu,C.
  TITLE     The Circular RNA Circ_0085494 Regulates Prostate Cancer Progression
            Through NRBP1/miR-497-5p Axis
  JOURNAL   Biochem Genet 61 (5), 1775-1790 (2023)
   PUBMED   36790665
  REMARK    GeneRIF: The Circular RNA Circ_0085494 Regulates Prostate Cancer
            Progression Through NRBP1/miR-497-5p Axis.
REFERENCE   3  (bases 1 to 2146)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   4  (bases 1 to 2146)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2146)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   6  (bases 1 to 2146)
  AUTHORS   Wilson,C.H., Crombie,C., van der Weyden,L., Poulogiannis,G.,
            Rust,A.G., Pardo,M., Gracia,T., Yu,L., Choudhary,J., Poulin,G.B.,
            McIntyre,R.E., Winton,D.J., March,H.N., Arends,M.J., Fraser,A.G.
            and Adams,D.J.
  TITLE     Nuclear receptor binding protein 1 regulates intestinal progenitor
            cell homeostasis and tumour formation
  JOURNAL   EMBO J 31 (11), 2486-2497 (2012)
   PUBMED   22510880
  REMARK    GeneRIF: Using a novel combination of RNAi screens in worms
            together with detailed follow-up experiments in mouse and human
            cells, it was shown that NRBP1 is a tumour suppressor that plays a
            critical role in intestinal cell homoeostasis.
REFERENCE   7  (bases 1 to 2146)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 2146)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2146)
  AUTHORS   Lim,R., Winteringham,L.N., Williams,J.H., McCulloch,R.K.,
            Ingley,E., Tiao,J.Y., Lalonde,J.P., Tsai,S., Tilbrook,P.A., Sun,Y.,
            Wu,X., Morris,S.W. and Klinken,S.P.
  TITLE     MADM, a novel adaptor protein that mediates phosphorylation of the
            14-3-3 binding site of myeloid leukemia factor 1
  JOURNAL   J Biol Chem 277 (43), 40997-41008 (2002)
   PUBMED   12176995
REFERENCE   10 (bases 1 to 2146)
  AUTHORS   De Langhe,S., Haataja,L., Senadheera,D., Groffen,J. and
            Heisterkamp,N.
  TITLE     Interaction of the small GTPase Rac3 with NRBP, a protein with a
            kinase-homology domain
  JOURNAL   Int J Mol Med 9 (5), 451-459 (2002)
   PUBMED   11956649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114619.9.
            
            On Mar 21, 2007 this sequence version replaced NM_147201.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF302138.1, BC004756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC114619.9         87341-87425         c
            86-314              AC114619.9         84352-84580         c
            315-437             AC114619.9         84055-84177         c
            438-539             AC114619.9         83784-83885         c
            540-629             AC114619.9         83377-83466         c
            630-670             AC114619.9         82940-82980         c
            671-765             AC114619.9         82498-82592         c
            766-849             AC114619.9         80918-81001         c
            850-908             AC114619.9         80601-80659         c
            909-1007            AC114619.9         80347-80445         c
            1008-1140           AC114619.9         78662-78794         c
            1141-1246           AC114619.9         78349-78454         c
            1247-1297           AC114619.9         78203-78253         c
            1298-1433           AC114619.9         77978-78113         c
            1434-1487           AC114619.9         77746-77799         c
            1488-1551           AC114619.9         77599-77662         c
            1552-1607           AC114619.9         77396-77451         c
            1608-2146           AC114619.9         76780-77318         c
FEATURES             Location/Qualifiers
     source          1..2146
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.27 cM"
     gene            1..2146
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /note="nuclear receptor binding protein 1"
                     /db_xref="GeneID:192292"
                     /db_xref="MGI:MGI:2183436"
     exon            1..85
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            86..314
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            315..437
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            438..539
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            540..629
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            630..670
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            671..765
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            766..849
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            850..908
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1007
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1140
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1246
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1297
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1433
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1487
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1551
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1607
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..2146
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2124..2129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /note="hexamer: AATAAA"
     polyA_site      2146
                     /gene="Nrbp1"
                     /gene_synonym="B230344L17Rik; Nrbp"
                     /note="major polyA site"
ORIGIN      
        1 cgcagctgtg agggagtcgc tgggatccga ggccccggaa cccgagctgg agctgaagcg
       61 caggctgcgg gcgcggagtc gggaggctga gtgttcattc cagcatgtcg gaaggggagt
      121 cccaaacagt agtcagcagt ggctcagacc caaaggtaga atcctcatct ttagctcctg
      181 gcctgacttc tgtgtcacct cctgtgacct ctacaacttc agctgcttct cccgaggaag
      241 aagaagaaag tgaagatgag tctgagatct tggaagagtc accctgtggg cgctggcaga
      301 agaggcgaga agaggtgaat cagcgtaatg taccaggcat tgacagtgca tacctggcca
      361 tggatacaga ggaaggtgtg gaggttgtgt ggaatgaggt acagttctct gaacgcaaga
      421 actacaaact gcaggaggaa aaggtccgtg cagtgtttga taatctgatt cagctggaac
      481 atcttaacat tgttaagttt cacaaatatt gggctgatgt taaagagaac aaggctaggg
      541 tgattttcat cacagaatac atgtcctctg ggagtcttaa gcagtttctg aagaagacca
      601 aaaagaacca caagactatg aatgaaaagg cttggaaacg ctggtgtaca cagatcctct
      661 ctgccctaag ctacctgcac tcctgtgacc ctcccatcat ccatgggaac ctgacctgtg
      721 acaccatctt catccagcac aacggactca tcaagattgg ctctgtggct cctgacacta
      781 tcaacaatca cgtgaagact tgccgggaag aacagaagaa cctacacttt tttgcaccag
      841 agtatggaga agtcacaaac gtgacaacag cagtggacat ctactccttt ggcatgtgtg
      901 cactggagat ggcagtgctg gagattcagg gcaatggcga gtcctcatat gtgccacagg
      961 aagccatcag cagtgccatc cagctactag aagactcatt acagagggag tttattcaaa
     1021 agtgcctgca gtctgagcct gctcggagac caacagccag agaacttctg ttccacccag
     1081 cactgtttga agtgccctca ctcaagcttc ttgctgctca ctgtatcgtg gggcaccaac
     1141 acatgatccc agagaacgct ctagaggaga tcaccaagaa catggatacc agtgctgtac
     1201 tagctgaaat tcccgcaggg ccaggacgag aaccagttca gactttgtac tctcagtcac
     1261 cagccctaga attagacaaa ttccttgaag atgtcaggaa tgggatctac cctctgacag
     1321 cctttgggct acctcggcct cagcagccac agcaggagga ggtgacatca cctgttgtgc
     1381 ccccctctgt caagactcca actcctgagc cagctgaagt ggagacacga aaggtggtgc
     1441 tgatgcagtg caacatcgaa tctgtggagg agggagtcaa acaccatcta acacttctgc
     1501 tgaagctgga ggacaaattg aaccggcacc tgagctgtga cctgatgcca aatgagagca
     1561 tcccggactt ggcagctgag ctggtgcagc tgggcttcat tagtgaggct gatcagagcc
     1621 gcctgacttc tctgctggag gagacgctca acaagttcaa cttcaccagg aacagtacac
     1681 tcaacacagc cactgtcacc gtctcctcgt agagctcact tgagccaggc ccctagccag
     1741 gctgtggctg tccctgggca tgctgcagtc ctcctgtccc ttctccccag tcagtattac
     1801 ccttcgcgcc catattattt aggagggctt taggggctcc ctggttgagt atcaccctgc
     1861 cccttcccct ctcttcctcc cctctgcact ttgtttactt gttttgcaca gacgtgggcc
     1921 tgggccttct cagcagccac cttctagctg ggggctagta gctgacctgc tgcctcctgc
     1981 cctacttgtg tggacaggag gcccacgggc actggggaag ctgagttcta caatcccgct
     2041 ggggcgcatg ggcaggagag aaaggtggtg ctgcaggggt ggccccccgg ggggggcatt
     2101 cgaatcacct cagttgctgc tgtaataaag tctacttttt gctaaa
//
