LOCUS       NM_001402047            2972 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus nuclear receptor binding factor 2 (Nrbf2), transcript
            variant 2, mRNA.
ACCESSION   NM_001402047 XM_036155939
VERSION     NM_001402047.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2972)
  AUTHORS   Zhang,S.Q., Deng,Q., Zhu,Q., Hu,Z.L., Long,L.H., Wu,P.F., He,J.G.,
            Chen,H.S., Yue,Z., Lu,J.H., Wang,F. and Chen,J.G.
  TITLE     Cell type-specific NRBF2 orchestrates autophagic flux and adult
            hippocampal neurogenesis in chronic stress-induced depression
  JOURNAL   Cell Discov 9 (1), 90 (2023)
   PUBMED   37644025
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2972)
  AUTHORS   Zeng,H., Chen,H., Li,M., Zhuang,J., Peng,Y., Zhou,H., Xu,C., Yu,Q.,
            Fu,X., Cao,S., Cai,J., Yan,F. and Chen,G.
  TITLE     Autophagy protein NRBF2 attenuates endoplasmic reticulum
            stress-associated neuroinflammation and oxidative stress via
            promoting autophagosome maturation by interacting with Rab7 after
            SAH
  JOURNAL   J Neuroinflammation 18 (1), 210 (2021)
   PUBMED   34530854
  REMARK    GeneRIF: Autophagy protein NRBF2 attenuates endoplasmic reticulum
            stress-associated neuroinflammation and oxidative stress via
            promoting autophagosome maturation by interacting with Rab7 after
            SAH.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2972)
  AUTHORS   Cai,C.Z., Yang,C., Zhuang,X.X., Yuan,N.N., Wu,M.Y., Tan,J.Q.,
            Song,J.X., Cheung,K.H., Su,H., Wang,Y.T., Tang,B.S., Behrends,C.,
            Durairajan,S.S.K., Yue,Z., Li,M. and Lu,J.H.
  TITLE     NRBF2 is a RAB7 effector required for autophagosome maturation and
            mediates the association of APP-CTFs with active form of RAB7 for
            degradation
  JOURNAL   Autophagy 17 (5), 1112-1130 (2021)
   PUBMED   32543313
  REMARK    GeneRIF: NRBF2 is a RAB7 effector required for autophagosome
            maturation and mediates the association of APP-CTFs with active
            form of RAB7 for degradation.
REFERENCE   4  (bases 1 to 2972)
  AUTHORS   Wu,M.Y., Liu,L., Wang,E.J., Xiao,H.T., Cai,C.Z., Wang,J., Su,H.,
            Wang,Y., Tan,J., Zhang,Z., Wang,J., Yao,M., Ouyang,D.F., Yue,Z.,
            Li,M., Chen,Y., Bian,Z.X. and Lu,J.H.
  TITLE     PI3KC3 complex subunit NRBF2 is required for apoptotic cell
            clearance to restrict intestinal inflammation
  JOURNAL   Autophagy 17 (5), 1096-1111 (2021)
   PUBMED   32160108
  REMARK    GeneRIF: PI3KC3 complex subunit NRBF2 is required for apoptotic
            cell clearance to restrict intestinal inflammation.
REFERENCE   5  (bases 1 to 2972)
  AUTHORS   Ouyang,X., Ahmad,I., Johnson,M.S., Redmann,M., Craver,J.,
            Wani,W.Y., Benavides,G.A., Chacko,B., Li,P., Young,M., Jegga,A.G.,
            Darley-Usmar,V. and Zhang,J.
  TITLE     Nuclear receptor binding factor 2 (NRBF2) is required for learning
            and memory
  JOURNAL   Lab Invest 100 (9), 1238-1251 (2020)
   PUBMED   32350405
  REMARK    GeneRIF: Nuclear receptor binding factor 2 (NRBF2) is required for
            learning and memory.
REFERENCE   6  (bases 1 to 2972)
  AUTHORS   Ma,X., Zhang,S., He,L., Rong,Y., Brier,L.W., Sun,Q., Liu,R.,
            Fan,W., Chen,S., Yue,Z., Kim,J., Guan,K.L., Li,D. and Zhong,Q.
  TITLE     MTORC1-mediated NRBF2 phosphorylation functions as a switch for the
            class III PtdIns3K and autophagy
  JOURNAL   Autophagy 13 (3), 592-607 (2017)
   PUBMED   28059666
  REMARK    GeneRIF: This study reveals NRBF2 as a critical molecular switch of
            PtdIns3K and autophagy activation, and its on/off state is
            precisely controlled by MTORC1 through phosphorylation.
REFERENCE   7  (bases 1 to 2972)
  AUTHORS   Lu,J., He,L., Behrends,C., Araki,M., Araki,K., Jun Wang,Q.,
            Catanzaro,J.M., Friedman,S.L., Zong,W.X., Fiel,M.I., Li,M. and
            Yue,Z.
  TITLE     NRBF2 regulates autophagy and prevents liver injury by modulating
            Atg14L-linked phosphatidylinositol-3 kinase III activity
  JOURNAL   Nat Commun 5, 3920 (2014)
   PUBMED   24849286
  REMARK    GeneRIF: These data reveal a key role for NRBF2 in the assembly of
            the specific Atg14L-Beclin 1-Vps34-Vps15 complex for autophagy
            induction.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2972)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 2972)
  AUTHORS   Yasumo,H., Masuda,N., Furusawa,T., Tsukamoto,T., Sadano,H. and
            Osumi,T.
  TITLE     Nuclear receptor binding factor-2 (NRBF-2), a possible gene
            activator protein interacting with nuclear hormone receptors
  JOURNAL   Biochim Biophys Acta 1490 (1-2), 189-197 (2000)
   PUBMED   10786636
REFERENCE   10 (bases 1 to 2972)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155712.8.
            
            On Mar 3, 2022 this sequence version replaced XM_036155939.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2887067.1,
                                           SRR7974084.29686.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1363              AC155712.8         68123-69485         c
            1364-1448           AC155712.8         59758-59842         c
            1449-1489           AC155712.8         54294-54334         c
            1490-2972           AC155712.8         50872-52354         c
FEATURES             Location/Qualifiers
     source          1..2972
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 34.89 cM"
     gene            1..2972
                     /gene="Nrbf2"
                     /gene_synonym="NRBF-2"
                     /note="nuclear receptor binding factor 2"
                     /db_xref="GeneID:641340"
                     /db_xref="MGI:MGI:1354950"
     exon            1..1363
                     /gene="Nrbf2"
                     /gene_synonym="NRBF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1247..2197
                     /gene="Nrbf2"
                     /gene_synonym="NRBF-2"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="nuclear receptor-binding factor 2 isoform 2"
                     /protein_id="NP_001388976.1"
                     /db_xref="GeneID:641340"
                     /db_xref="MGI:MGI:1354950"
                     /translation="MVPSLAPGLQLREIYPRVTNLDPASVSKWITLQANEATLAHQQS
                     RRADRLLAAGKYEEAISCHRKATTYLSEAMKLTESEQAHLSLELQRDSHMKQLLLIQE
                     RWKRAKREERLKAQQSTERDGAPHLQAPPRPSEDAEGQSPLLSQPYIPSTERRLPEVQ
                     GVFDRDPDTLLFLLQQKNEPSEPCIGSKAPKDDKTIIEEQATKIADLKRHVEFLVAEN
                     ERLRKENKQLKAEKARLLKGTAEKELDVDADFVEKSELWGLPSHSESAAASSTWQKFA
                     ANTGKAKDIPIPNLPPLDFPSPELPLMELSEDILKGFMND"
     exon            1364..1448
                     /gene="Nrbf2"
                     /gene_synonym="NRBF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1489
                     /gene="Nrbf2"
                     /gene_synonym="NRBF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..2972
                     /gene="Nrbf2"
                     /gene_synonym="NRBF-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2951..2956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrbf2"
                     /gene_synonym="NRBF-2"
                     /note="hexamer: AATAAT"
     polyA_site      2972
                     /gene="Nrbf2"
                     /gene_synonym="NRBF-2"
                     /note="major polyA site"
ORIGIN      
        1 gacgcgacgt cggaggcgga agtggcgcgg ctgtcgctct tgggctctca ctgccggctc
       61 cgggttctgc gaggagcctc ctgccagccg ccgcgtctcc ctgccctcgc tgcccctcca
      121 tgtgcccggg cgccgccgct ccgcctcggg ccgctgctca ccccggggtt tatggaagtg
      181 atggaaggac ccctcaacct tgtgagtggt cgcgggctga gtcggggacc ggtaggctgc
      241 ggggaaacgc gggctgaggg ggtcaagcgg cactgaaggg ggagccgcga gctcatggag
      301 gggaccctga tccccggggc tcaggcctct ccctcggggc ccgtggcatc tgccctgctg
      361 ggaccgcgtc ccagcgccac gtagccgccg cctgcaggcc gcgggcagag tcggggtgtc
      421 ggggccgcgc ctcgcacacc gcaccccctc ttccctgctg ccctcgcagc tgggctagcg
      481 aaggcccctc tgaaacagct ggatcggaac cccagtccac gccccgcagc ccggtgcctt
      541 tgctttaagg ctcacgaaag taccagacgt gtttgccttt ctcagaaaca catacagaga
      601 gacacacagg gggccgggtc attattgttt ggggcaaaaa ggaacacaca cacacacacc
      661 gccccaaaca accccacaaa accccaaacc tcccacagtt ctgttctaag tgtgatcaca
      721 ggacatcttc gggtttcctg ggaaaaggtt catgaaattc agatgcagac gtctggttcc
      781 ttagtgttgc ggagtaaaac tttgcaagtc ccaagtctgt aggtggtttg cgatgatgcg
      841 gagggattga gagcaggacc gggaaagatt gattgcttcc tttggaactc tgccctccct
      901 cccggcttgg aagagcctgg tccgtgctgt gcagagaagc cagagtctgt ggtttcagac
      961 tatggatttc tggagccaaa ctcctggatt tgaactcggg cttagtcacc taatagcctc
     1021 aagagacctt gaacaaaaat tttcacttca ttgttttttt ttgtttttgt tttaaccctc
     1081 gttcgttgtg aggattaaag gactgaatag ataagagaca cgtagaactg tacgttatgg
     1141 atggaacatt ggaagagtta gttgctccag tgagaccgta gcccctgtca cttaatgaga
     1201 tttgggagtg ttgagcgtca acgctggaga gtgaacacct aaagctatgg ttccatccct
     1261 ggcgccaggt ttgcagctcc gagaaatcta cccaagagtt actaatttag accctgcgtc
     1321 cgtttctaag tggattacac ttcaggctaa tgaggctaca ctggctcacc agcagagccg
     1381 ccgagcagac cgtttgttag ctgctgggaa atacgaagag gcgatttctt gtcacagaaa
     1441 ggcaacaaca tatctctctg aagccatgaa gctgaccgag tctgagcagg ctcacttatc
     1501 actggaactg caaagggaca gccacatgaa acagctgctt ctcatccagg agaggtggaa
     1561 gagagcaaag cgagaggagc ggttgaaagc gcagcagagc acggaacggg acggagcccc
     1621 ccacctgcag gcacctccca ggccctctga ggatgctgaa ggccagagcc ctctgctttc
     1681 tcagccatac atcccttcca cagagaggcg cctccccgag gtgcaggggg tctttgacag
     1741 ggatccagac acattgctgt ttttacttca gcaaaagaat gagccatcag agccctgtat
     1801 tggaagcaaa gccccaaaag atgataaaac gattatagag gagcaggcaa ccaaaatagc
     1861 agatttgaag aggcatgtgg agttccttgt ggctgagaat gaaagattaa ggaaagaaaa
     1921 taaacagcta aaggctgaaa aggccagact cctgaaaggc acagctgaga aggaactgga
     1981 cgtcgatgca gactttgtag agaagtcaga gctgtggggc ttaccttcac actcggaatc
     2041 cgccgctgcc tcttcaacct ggcagaagtt tgcagctaac acggggaaag ccaaggacat
     2101 tccaataccc aaccttcctc ctctggattt cccatctcca gagcttcctc tgatggagct
     2161 ctcggaggac attctgaaag gattcatgaa tgactaagat ggaaggccat tggagaggct
     2221 ggcgacagtt aatccagaaa agaatataaa agggaaagcc acgccccagg ggaatgccag
     2281 agatgctcct tcatctggta tgctgtggga gaagaggtgg tgccaggacc tgggaaagtc
     2341 actgtgaaac atcacttacc ttcgtcacga ctaaagctca tgattccgac tcggcagaca
     2401 ctgaactctt ggcggttcgc tttcttatga tacaaaccaa atggctacct ggaataattt
     2461 ttcaaacagt tatttttctt cagggttaaa tgtataaaag tatgtcatta atctataatg
     2521 ccataaatga taatgcaaaa gctaaatatg gtggcctgag aggctcactt gtatttggaa
     2581 catgctttct atcatgcgtt gactgtatgc attttctgca cattgtgttt gtttgagatg
     2641 tggtgtgtaa gatacacgct tccagatgga actgtacgtg ccacgtttgc actactcgta
     2701 acataatgag aacctcaaga ctatcaggag aaatatttaa atttccattt tatgaagaaa
     2761 ggaaccaaat tattagttac gctttttaaa gaaattacca gtttacataa ttaatcaggg
     2821 tgcatttaag ttctaacttt gtgttatatg atgcatcatt tgaaaatact gaggcactct
     2881 cctttgtgct gaatgatgca tgtgtgaaag caatgctagt tagcagtatt tgattgtaag
     2941 aaataaataa aataattgtg tttcatacct tt
//
