LOCUS       NM_001410513            4491 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus neuroblastoma ras oncogene (Nras), transcript variant
            7, mRNA.
ACCESSION   NM_001410513
VERSION     NM_001410513.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4491)
  AUTHORS   McDaniel,C.G., Fox,D., Pastura,P., Alharbi,S., Huppert,S.S. and
            Cras,T.D.L.
  TITLE     Lyve1-Driven NrasQ61R Causes Edema, Enlarged Lymphatic Vessels, and
            Hepatic Vascular Defects in Embryonic Mice
  JOURNAL   Pediatr Blood Cancer 72 (3), e31492 (2025)
   PUBMED   39723841
REFERENCE   2  (bases 1 to 4491)
  AUTHORS   Chan,A.S.L., Zhu,H., Narita,M., Cassidy,L.D., Young,A.R.J.,
            Bermejo-Rodriguez,C., Janowska,A.T., Chen,H.C., Gough,S.,
            Oshimori,N., Zender,L., Aitken,S.J., Hoare,M. and Narita,M.
  TITLE     Titration of RAS alters senescent state and influences tumour
            initiation
  JOURNAL   Nature 633 (8030), 678-685 (2024)
   PUBMED   39112713
  REMARK    GeneRIF: Titration of RAS alters senescent state and influences
            tumour initiation.
REFERENCE   3  (bases 1 to 4491)
  AUTHORS   Nozawa,A., Abe,T., Niihori,T., Ozeki,M., Aoki,Y. and Ohnishi,H.
  TITLE     Lymphatic endothelial cell-specific NRAS p.Q61R mutant embryos show
            abnormal lymphatic vessel morphogenesis
  JOURNAL   Hum Mol Genet 33 (16), 1420-1428 (2024)
   PUBMED   38743908
REFERENCE   4  (bases 1 to 4491)
  AUTHORS   Holl,D., Hau,W.F., Julien,A., Banitalebi,S., Kalkitsas,J.,
            Savant,S., Llorens-Bobadilla,E., Herault,Y., Pavlovic,G.,
            Amiry-Moghaddam,M., Dias,D.O. and Goritz,C.
  TITLE     Distinct origin and region-dependent contribution of stromal
            fibroblasts to fibrosis following traumatic injury in mice
  JOURNAL   Nat Neurosci 27 (7), 1285-1298 (2024)
   PUBMED   38849523
REFERENCE   5  (bases 1 to 4491)
  AUTHORS   Fuentes-Mateos,R., Garcia-Navas,R., Fernandez-Infante,C.,
            Hernandez-Cano,L., Calzada-Nieto,N., Juan,A.O., Guerrero,C.,
            Santos,E. and Fernandez-Medarde,A.
  TITLE     Combined HRAS and NRAS ablation induces a RASopathy phenotype in
            mice
  JOURNAL   Cell Commun Signal 22 (1), 332 (2024)
   PUBMED   38886790
  REMARK    GeneRIF: Combined HRAS and NRAS ablation induces a RASopathy
            phenotype in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4491)
  AUTHORS   Cases,S. and Dautry,F.
  TITLE     Inactivation of the murine N-ras gene by gene targeting
  JOURNAL   Oncogene 7 (12), 2525-2528 (1992)
   PUBMED   1461656
REFERENCE   7  (bases 1 to 4491)
  AUTHORS   Mangues,R., Seidman,I., Gordon,J.W. and Pellicer,A.
  TITLE     Overexpression of the N-ras proto-oncogene, not somatic mutational
            activation, associated with malignant tumors in transgenic mice
  JOURNAL   Oncogene 7 (10), 2073-2076 (1992)
   PUBMED   1328989
REFERENCE   8  (bases 1 to 4491)
  AUTHORS   Dower,N.A., Seldin,M.F., Pugh,S. and Stone,J.C.
  TITLE     Organization and chromosomal locations of Rap1a/Krev sequences in
            the mouse
  JOURNAL   Mamm Genome 3 (3), 162-167 (1992)
   PUBMED   1617222
REFERENCE   9  (bases 1 to 4491)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   10 (bases 1 to 4491)
  AUTHORS   Yuasa,Y., Yamazaki,H., Maruo,K., Ueyama,Y., Shibuya,M. and
            Tamaoki,N.
  TITLE     Alterations of mouse proto-oncogenes in sarcomas induced after
            transplantation of human tumors in athymic nude mice
  JOURNAL   Jpn J Cancer Res 81 (4), 333-339 (1990)
   PUBMED   2114387
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163297.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.9873016.1,
                                           SRR13948564.5594547.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AC163297.4         175086-175395
            311-489             AC163297.4         176564-176742
            490-649             AC163297.4         178737-178896
            650-773             AC163297.4         179693-179816
            774-815             AC163297.4         180479-180520
            816-4491            AC163297.4         180597-184272
FEATURES             Location/Qualifiers
     source          1..4491
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     gene            1..4491
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="neuroblastoma ras oncogene"
                     /db_xref="GeneID:18176"
                     /db_xref="MGI:MGI:97376"
     exon            1..310
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..769
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /EC_number="3.6.5.2"
                     /note="transforming protein N-Ras"
                     /codon_start=1
                     /product="GTPase NRas"
                     /protein_id="NP_001397442.1"
                     /db_xref="GeneID:18176"
                     /db_xref="MGI:MGI:97376"
                     /translation="MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQV
                     VIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKR
                     VKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLV
                     REIRQYRMKKLNSSDDGTQGCMGLPCVLM"
     exon            311..489
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            490..649
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            650..773
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            774..815
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            816..4491
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1236..1241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="hexamer: AATATA"
     polyA_site      1237
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="major polyA site"
     regulatory      4464..4469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="hexamer: AATAAA"
     polyA_site      4491
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="major polyA site"
ORIGIN      
        1 aatctggccc gcactcatct gcaaggaatg ctatgtttct gaatcacttt gagaacttag
       61 tggaaggcca cgtgtatcga atgggtgcct tagaaacaga agagtttggt aaactcatag
      121 aagcccttga agtattgtag gtttggtttg ccagtttaat cgtaattgct gcttttctac
      181 aggtttttgc tggtgtgaaa tgactgagta caaactggtg gtggttggag caggtggtgt
      241 tgggaaaagc gccttgacga tccagctaat ccagaaccac tttgtggatg aatatgatcc
      301 caccatagag gattcttacc gaaagcaagt ggtgattgat ggtgagacct gcctgctgga
      361 catactggac acagctggac aagaggagta cagtgccatg agagaccagt acatgaggac
      421 aggcgaaggg ttcctctgtg tatttgccat caataatagc aaatcatttg cagatattaa
      481 cctctacagg gagcaaatta agcgtgtgaa agattctgat gatgtcccca tggtgctggt
      541 aggcaacaag tgtgacttgc caacaaggac agttgacaca aagcaagccc acgaactggc
      601 caagagttac ggaattccat tcattgagac ctcagccaag acccgacagg gtgtggagga
      661 tgccttttac acactggtaa gggagatacg ccagtaccga atgaaaaagc tcaacagcag
      721 tgacgatggc actcaaggtt gtatggggct gccctgtgtg ctgatgtagt aagacacttt
      781 gaaagttctg tcatcagaaa agagccactt tgaagctgca ctgatgccct ggttctgaca
      841 tccctggagg agacctgttc ctgctgctct ctgcatctca gagaagctcc tgcttcctgc
      901 ttccccgact cagttactga gcacagccat ctaacctgag acctcttcag aataactacc
      961 tcctcactcg gctgtctgac cagagaaata gacctgtctc tcccggtcgt tctctgccct
     1021 gggttcccct agaaacagac acagcctcca gctggctttg tcctctgaaa agcagtttac
     1081 attgatgcag agaaccaaac tagacatgcc attctgttga caacagtttc ttatactcta
     1141 aggtaacaac tgctggtgat tttcccctgc ccccaactgt tgaacttggc cttgttggtt
     1201 tggggggaaa atgtcataaa ttactttctt cccaaaatat aattagtgtt gctgattgat
     1261 ttgtaatgtg atcagctata ttccataaac tggcatctgc tctgtattca taaatgcaaa
     1321 cacgaatact ctcaactgca tgcaattaaa tccaacattc acaacaaagt gcctttttcc
     1381 taaaagtgct ctgtaggctc cattacagtt tgtaattgga atagatgtgt caagaaccat
     1441 tgtataggaa agtgactctg agccatctac ctttgaggga aaggtgtatg tacctgatgg
     1501 cagatgcttt gtgtatgcac atgaagatag tttccctgtc tgggattctc ccaggagaaa
     1561 gatggaactg aaacaattac aagtaatttc atttaattct agctaatctt tttttttttt
     1621 tttttttttt ttggtagact atcacctata aatatttgga atatcttcta gcttactgat
     1681 aatctaataa ttaatgagct tccattataa tgaattggtt cataccagga agccctccat
     1741 ttatagtata gatactgtaa aaattggcat gttgttactt tatagctgtg attaatgatt
     1801 cctcagacct tgctgagata tagttattag cagacaggtt atatctttgc tgcatagttt
     1861 cttcatggaa tatatatcta tctgtatgtg gagagaacgt ggccctcagt tcccttctca
     1921 gcatccctca tctctcagcc tagagaagtt cgagcatcct agaggggctt gaacagttat
     1981 ctcggttaaa ccatggtgct aatggaccgg gtcatggttt caaaacttga acaagccagt
     2041 tagcatcaca gagaaacagt ccatccatat ttgctccctg cctattattc ctgcttacag
     2101 acttttgcct gatgcctgct gttagtgcta caaggataaa gcttgtgtgg ttctcaccag
     2161 gactggaagt acctggtgag ctctggggta agcctagata tctttacatt ttcagaccct
     2221 tattcttagc cacgtggaaa ctgaagccag agtccatacc tccatctcct tcccccccca
     2281 aaaaaattag attaatgttc tttatatagc ttttttaaag tatttaaaac atgtctataa
     2341 gttaggctgc caactaacaa aagctgatgt gtttgttcaa ataaagaggt atccttcgct
     2401 actcgagaga agaatgtaaa atgccattga ttgttgtcac ttggaggctt gatgtttgcc
     2461 ctgataattc attagtgggt tttgtttgtc acatgatacc taagatgtaa ctcagctcag
     2521 taattctaat gaaaacataa attggatacc ttaattgaaa aaagcaaacc taattccaaa
     2581 atggccattt tctcttctga tcttgtaata cctaaaattc tgaggtcctt gggattcttt
     2641 tgtttataac aggatcttgc tgtgtagtcc tagctggcct caaactcaca atactcttcc
     2701 tggatcaatc tcccaagtgc tgggattaca ggcacattcc accacacaca cctgactgag
     2761 ctcgttccta atgagttttc attaagcaaa ttccccatca ccttgaaact aatcagaagg
     2821 gggaagaaac atttgctatg ctcctgagtg ctaacactgg gatcattcac atggggtttg
     2881 cattcctagg caaactaaac tgctgccttt tacaacaagg ctcagtcatc ttcctgaagc
     2941 tgctgagacc agcacttggt cttgttttgt tttaatatgt ctatatgact ggtggtggat
     3001 ccctaaatag tttattaatt aaactccagt taaggagaaa gttactcacc ttgacccgtt
     3061 tgaccatatc ccgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgc
     3121 acgcgtatgt acgtacgtat gtatgtaggt atgtaggtgg tttccagtat aaacacagaa
     3181 acaaatggag ccaattcagg tttcagatgc ccttactaac atatattccc acggggtgtg
     3241 ggttttggca caacagtgac aaacttaaaa gccaagtaag agccgggcgt ggtggcgcac
     3301 gcctttaatc ccagcacttg ggaggcagag gcaggcggat ttctgagttc taggccatcc
     3361 tggtctacag tgagttccag gacagccagt gctacacaga gaaaccctgt ctcgaaaagc
     3421 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa gccaagtagg tccagttggt atagtatcaa
     3481 agtgttttta gagtaattag tgaaggtctg ctttacctca aagttgcaga gcctctcttc
     3541 ctgagtttaa gtgcctggcc ggcagtcaca aattaacatg ttgctgtaag gcagttagtt
     3601 gaagctttgt tcacacattg gagagtatga aaataaagtg ttctaagagc gctgatactg
     3661 gatctgtgta aacctggtaa atgccgtttg tccaggactt agcgtgtgtg agttggtagc
     3721 tcagtacgag tttactagtt ccgcagtgtg tacaatggag gcgggtttgt tttagctggc
     3781 cacctgtaga atcagccttt aaactgctgt gaactttgtc atgacttgaa tatgaagata
     3841 gacaaaaact ctgtaaagac aaatgtttgt tttccccctt acagaacgtg tgagcttggt
     3901 tttatcttcc tttgtattta gtcataacct ctcaagctgg cagctccgac caaggatcag
     3961 aagctgtgtg cgttccacct ggtggaatta gctcagctct atatgagaag tggagttaat
     4021 ggaaaacgtg ttgactgggt ggtttctatt taaaagagtg atgataattc ttgaacagta
     4081 gtttttattt tgctatttct ttaagctgac tgatgtgcca caaaattatt ttaaggtatt
     4141 tgtgttttaa gagtgttctc atgagattag ttgtagatat tttttaaaat acaactggtt
     4201 tttaaaatct gagtattgct ctaagcaagt gtttagactc ttacgggaag gtgggtggaa
     4261 gttgtttggc ttccgtattt ccatgcgtgc cgtcagacat aggtcagaac gccaactgtg
     4321 catcctgctg tttaaagacc tcttggcctc tgtgaccctc atgaaggggc tgatatttta
     4381 agttgactgt ttgattgtaa attaatcctt tctaattttt aaagacttgc ttgactgttt
     4441 tccttgttaa ataattttaa aaaaataaaa aactggaagt tctttgctta a
//
