LOCUS       NM_001410511            4375 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus neuroblastoma ras oncogene (Nras), transcript variant
            5, mRNA.
ACCESSION   NM_001410511
VERSION     NM_001410511.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4375)
  AUTHORS   McDaniel,C.G., Fox,D., Pastura,P., Alharbi,S., Huppert,S.S. and
            Cras,T.D.L.
  TITLE     Lyve1-Driven NrasQ61R Causes Edema, Enlarged Lymphatic Vessels, and
            Hepatic Vascular Defects in Embryonic Mice
  JOURNAL   Pediatr Blood Cancer 72 (3), e31492 (2025)
   PUBMED   39723841
REFERENCE   2  (bases 1 to 4375)
  AUTHORS   Chan,A.S.L., Zhu,H., Narita,M., Cassidy,L.D., Young,A.R.J.,
            Bermejo-Rodriguez,C., Janowska,A.T., Chen,H.C., Gough,S.,
            Oshimori,N., Zender,L., Aitken,S.J., Hoare,M. and Narita,M.
  TITLE     Titration of RAS alters senescent state and influences tumour
            initiation
  JOURNAL   Nature 633 (8030), 678-685 (2024)
   PUBMED   39112713
  REMARK    GeneRIF: Titration of RAS alters senescent state and influences
            tumour initiation.
REFERENCE   3  (bases 1 to 4375)
  AUTHORS   Nozawa,A., Abe,T., Niihori,T., Ozeki,M., Aoki,Y. and Ohnishi,H.
  TITLE     Lymphatic endothelial cell-specific NRAS p.Q61R mutant embryos show
            abnormal lymphatic vessel morphogenesis
  JOURNAL   Hum Mol Genet 33 (16), 1420-1428 (2024)
   PUBMED   38743908
REFERENCE   4  (bases 1 to 4375)
  AUTHORS   Holl,D., Hau,W.F., Julien,A., Banitalebi,S., Kalkitsas,J.,
            Savant,S., Llorens-Bobadilla,E., Herault,Y., Pavlovic,G.,
            Amiry-Moghaddam,M., Dias,D.O. and Goritz,C.
  TITLE     Distinct origin and region-dependent contribution of stromal
            fibroblasts to fibrosis following traumatic injury in mice
  JOURNAL   Nat Neurosci 27 (7), 1285-1298 (2024)
   PUBMED   38849523
REFERENCE   5  (bases 1 to 4375)
  AUTHORS   Fuentes-Mateos,R., Garcia-Navas,R., Fernandez-Infante,C.,
            Hernandez-Cano,L., Calzada-Nieto,N., Juan,A.O., Guerrero,C.,
            Santos,E. and Fernandez-Medarde,A.
  TITLE     Combined HRAS and NRAS ablation induces a RASopathy phenotype in
            mice
  JOURNAL   Cell Commun Signal 22 (1), 332 (2024)
   PUBMED   38886790
  REMARK    GeneRIF: Combined HRAS and NRAS ablation induces a RASopathy
            phenotype in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4375)
  AUTHORS   Cases,S. and Dautry,F.
  TITLE     Inactivation of the murine N-ras gene by gene targeting
  JOURNAL   Oncogene 7 (12), 2525-2528 (1992)
   PUBMED   1461656
REFERENCE   7  (bases 1 to 4375)
  AUTHORS   Mangues,R., Seidman,I., Gordon,J.W. and Pellicer,A.
  TITLE     Overexpression of the N-ras proto-oncogene, not somatic mutational
            activation, associated with malignant tumors in transgenic mice
  JOURNAL   Oncogene 7 (10), 2073-2076 (1992)
   PUBMED   1328989
REFERENCE   8  (bases 1 to 4375)
  AUTHORS   Dower,N.A., Seldin,M.F., Pugh,S. and Stone,J.C.
  TITLE     Organization and chromosomal locations of Rap1a/Krev sequences in
            the mouse
  JOURNAL   Mamm Genome 3 (3), 162-167 (1992)
   PUBMED   1617222
REFERENCE   9  (bases 1 to 4375)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   10 (bases 1 to 4375)
  AUTHORS   Yuasa,Y., Yamazaki,H., Maruo,K., Ueyama,Y., Shibuya,M. and
            Tamaoki,N.
  TITLE     Alterations of mouse proto-oncogenes in sarcomas induced after
            transplantation of human tumors in athymic nude mice
  JOURNAL   Jpn J Cancer Res 81 (4), 333-339 (1990)
   PUBMED   2114387
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163297.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.8016790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC163297.4         175086-175193
            109-236             AC163297.4         175268-175395
            237-415             AC163297.4         176564-176742
            416-575             AC163297.4         178737-178896
            576-699             AC163297.4         179693-179816
            700-4375            AC163297.4         180597-184272
FEATURES             Location/Qualifiers
     source          1..4375
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     gene            1..4375
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="neuroblastoma ras oncogene"
                     /db_xref="GeneID:18176"
                     /db_xref="MGI:MGI:97376"
     exon            1..108
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            109..236
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..695
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /EC_number="3.6.5.2"
                     /note="transforming protein N-Ras"
                     /codon_start=1
                     /product="GTPase NRas"
                     /protein_id="NP_001397440.1"
                     /db_xref="GeneID:18176"
                     /db_xref="MGI:MGI:97376"
                     /translation="MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQV
                     VIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKR
                     VKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLV
                     REIRQYRMKKLNSSDDGTQGCMGLPCVLM"
     exon            237..415
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            416..575
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            576..699
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            700..4375
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1120..1125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="hexamer: AATATA"
     polyA_site      1121
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="major polyA site"
     regulatory      4348..4353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="hexamer: AATAAA"
     polyA_site      4375
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="major polyA site"
ORIGIN      
        1 aatctggccc gcactcatct gcaaggaatg ctatgtttct gaatcacttt gagaacttag
       61 tggaaggcca cgtgtatcga atgggtgcct tagaaacaga agagtttggt ttttgctggt
      121 gtgaaatgac tgagtacaaa ctggtggtgg ttggagcagg tggtgttggg aaaagcgcct
      181 tgacgatcca gctaatccag aaccactttg tggatgaata tgatcccacc atagaggatt
      241 cttaccgaaa gcaagtggtg attgatggtg agacctgcct gctggacata ctggacacag
      301 ctggacaaga ggagtacagt gccatgagag accagtacat gaggacaggc gaagggttcc
      361 tctgtgtatt tgccatcaat aatagcaaat catttgcaga tattaacctc tacagggagc
      421 aaattaagcg tgtgaaagat tctgatgatg tccccatggt gctggtaggc aacaagtgtg
      481 acttgccaac aaggacagtt gacacaaagc aagcccacga actggccaag agttacggaa
      541 ttccattcat tgagacctca gccaagaccc gacagggtgt ggaggatgcc ttttacacac
      601 tggtaaggga gatacgccag taccgaatga aaaagctcaa cagcagtgac gatggcactc
      661 aaggttgtat ggggctgccc tgtgtgctga tgtagtaagc tgcactgatg ccctggttct
      721 gacatccctg gaggagacct gttcctgctg ctctctgcat ctcagagaag ctcctgcttc
      781 ctgcttcccc gactcagtta ctgagcacag ccatctaacc tgagacctct tcagaataac
      841 tacctcctca ctcggctgtc tgaccagaga aatagacctg tctctcccgg tcgttctctg
      901 ccctgggttc ccctagaaac agacacagcc tccagctggc tttgtcctct gaaaagcagt
      961 ttacattgat gcagagaacc aaactagaca tgccattctg ttgacaacag tttcttatac
     1021 tctaaggtaa caactgctgg tgattttccc ctgcccccaa ctgttgaact tggccttgtt
     1081 ggtttggggg gaaaatgtca taaattactt tcttcccaaa atataattag tgttgctgat
     1141 tgatttgtaa tgtgatcagc tatattccat aaactggcat ctgctctgta ttcataaatg
     1201 caaacacgaa tactctcaac tgcatgcaat taaatccaac attcacaaca aagtgccttt
     1261 ttcctaaaag tgctctgtag gctccattac agtttgtaat tggaatagat gtgtcaagaa
     1321 ccattgtata ggaaagtgac tctgagccat ctacctttga gggaaaggtg tatgtacctg
     1381 atggcagatg ctttgtgtat gcacatgaag atagtttccc tgtctgggat tctcccagga
     1441 gaaagatgga actgaaacaa ttacaagtaa tttcatttaa ttctagctaa tctttttttt
     1501 tttttttttt ttttttggta gactatcacc tataaatatt tggaatatct tctagcttac
     1561 tgataatcta ataattaatg agcttccatt ataatgaatt ggttcatacc aggaagccct
     1621 ccatttatag tatagatact gtaaaaattg gcatgttgtt actttatagc tgtgattaat
     1681 gattcctcag accttgctga gatatagtta ttagcagaca ggttatatct ttgctgcata
     1741 gtttcttcat ggaatatata tctatctgta tgtggagaga acgtggccct cagttccctt
     1801 ctcagcatcc ctcatctctc agcctagaga agttcgagca tcctagaggg gcttgaacag
     1861 ttatctcggt taaaccatgg tgctaatgga ccgggtcatg gtttcaaaac ttgaacaagc
     1921 cagttagcat cacagagaaa cagtccatcc atatttgctc cctgcctatt attcctgctt
     1981 acagactttt gcctgatgcc tgctgttagt gctacaagga taaagcttgt gtggttctca
     2041 ccaggactgg aagtacctgg tgagctctgg ggtaagccta gatatcttta cattttcaga
     2101 cccttattct tagccacgtg gaaactgaag ccagagtcca tacctccatc tccttccccc
     2161 cccaaaaaaa ttagattaat gttctttata tagctttttt aaagtattta aaacatgtct
     2221 ataagttagg ctgccaacta acaaaagctg atgtgtttgt tcaaataaag aggtatcctt
     2281 cgctactcga gagaagaatg taaaatgcca ttgattgttg tcacttggag gcttgatgtt
     2341 tgccctgata attcattagt gggttttgtt tgtcacatga tacctaagat gtaactcagc
     2401 tcagtaattc taatgaaaac ataaattgga taccttaatt gaaaaaagca aacctaattc
     2461 caaaatggcc attttctctt ctgatcttgt aatacctaaa attctgaggt ccttgggatt
     2521 cttttgttta taacaggatc ttgctgtgta gtcctagctg gcctcaaact cacaatactc
     2581 ttcctggatc aatctcccaa gtgctgggat tacaggcaca ttccaccaca cacacctgac
     2641 tgagctcgtt cctaatgagt tttcattaag caaattcccc atcaccttga aactaatcag
     2701 aagggggaag aaacatttgc tatgctcctg agtgctaaca ctgggatcat tcacatgggg
     2761 tttgcattcc taggcaaact aaactgctgc cttttacaac aaggctcagt catcttcctg
     2821 aagctgctga gaccagcact tggtcttgtt ttgttttaat atgtctatat gactggtggt
     2881 ggatccctaa atagtttatt aattaaactc cagttaagga gaaagttact caccttgacc
     2941 cgtttgacca tatcccgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3001 gtgcacgcgt atgtacgtac gtatgtatgt aggtatgtag gtggtttcca gtataaacac
     3061 agaaacaaat ggagccaatt caggtttcag atgcccttac taacatatat tcccacgggg
     3121 tgtgggtttt ggcacaacag tgacaaactt aaaagccaag taagagccgg gcgtggtggc
     3181 gcacgccttt aatcccagca cttgggaggc agaggcaggc ggatttctga gttctaggcc
     3241 atcctggtct acagtgagtt ccaggacagc cagtgctaca cagagaaacc ctgtctcgaa
     3301 aagccaaaaa aaaaaaaaaa aaaaaaaaaa aaaagccaag taggtccagt tggtatagta
     3361 tcaaagtgtt tttagagtaa ttagtgaagg tctgctttac ctcaaagttg cagagcctct
     3421 cttcctgagt ttaagtgcct ggccggcagt cacaaattaa catgttgctg taaggcagtt
     3481 agttgaagct ttgttcacac attggagagt atgaaaataa agtgttctaa gagcgctgat
     3541 actggatctg tgtaaacctg gtaaatgccg tttgtccagg acttagcgtg tgtgagttgg
     3601 tagctcagta cgagtttact agttccgcag tgtgtacaat ggaggcgggt ttgttttagc
     3661 tggccacctg tagaatcagc ctttaaactg ctgtgaactt tgtcatgact tgaatatgaa
     3721 gatagacaaa aactctgtaa agacaaatgt ttgttttccc ccttacagaa cgtgtgagct
     3781 tggttttatc ttcctttgta tttagtcata acctctcaag ctggcagctc cgaccaagga
     3841 tcagaagctg tgtgcgttcc acctggtgga attagctcag ctctatatga gaagtggagt
     3901 taatggaaaa cgtgttgact gggtggtttc tatttaaaag agtgatgata attcttgaac
     3961 agtagttttt attttgctat ttctttaagc tgactgatgt gccacaaaat tattttaagg
     4021 tatttgtgtt ttaagagtgt tctcatgaga ttagttgtag atatttttta aaatacaact
     4081 ggtttttaaa atctgagtat tgctctaagc aagtgtttag actcttacgg gaaggtgggt
     4141 ggaagttgtt tggcttccgt atttccatgc gtgccgtcag acataggtca gaacgccaac
     4201 tgtgcatcct gctgtttaaa gacctcttgg cctctgtgac cctcatgaag gggctgatat
     4261 tttaagttga ctgtttgatt gtaaattaat cctttctaat ttttaaagac ttgcttgact
     4321 gttttccttg ttaaataatt ttaaaaaaat aaaaaactgg aagttctttg cttaa
//
