LOCUS       NM_001410509            4612 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus neuroblastoma ras oncogene (Nras), transcript variant
            3, mRNA.
ACCESSION   NM_001410509 XM_006501122
VERSION     NM_001410509.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4612)
  AUTHORS   McDaniel,C.G., Fox,D., Pastura,P., Alharbi,S., Huppert,S.S. and
            Cras,T.D.L.
  TITLE     Lyve1-Driven NrasQ61R Causes Edema, Enlarged Lymphatic Vessels, and
            Hepatic Vascular Defects in Embryonic Mice
  JOURNAL   Pediatr Blood Cancer 72 (3), e31492 (2025)
   PUBMED   39723841
REFERENCE   2  (bases 1 to 4612)
  AUTHORS   Chan,A.S.L., Zhu,H., Narita,M., Cassidy,L.D., Young,A.R.J.,
            Bermejo-Rodriguez,C., Janowska,A.T., Chen,H.C., Gough,S.,
            Oshimori,N., Zender,L., Aitken,S.J., Hoare,M. and Narita,M.
  TITLE     Titration of RAS alters senescent state and influences tumour
            initiation
  JOURNAL   Nature 633 (8030), 678-685 (2024)
   PUBMED   39112713
  REMARK    GeneRIF: Titration of RAS alters senescent state and influences
            tumour initiation.
REFERENCE   3  (bases 1 to 4612)
  AUTHORS   Nozawa,A., Abe,T., Niihori,T., Ozeki,M., Aoki,Y. and Ohnishi,H.
  TITLE     Lymphatic endothelial cell-specific NRAS p.Q61R mutant embryos show
            abnormal lymphatic vessel morphogenesis
  JOURNAL   Hum Mol Genet 33 (16), 1420-1428 (2024)
   PUBMED   38743908
REFERENCE   4  (bases 1 to 4612)
  AUTHORS   Holl,D., Hau,W.F., Julien,A., Banitalebi,S., Kalkitsas,J.,
            Savant,S., Llorens-Bobadilla,E., Herault,Y., Pavlovic,G.,
            Amiry-Moghaddam,M., Dias,D.O. and Goritz,C.
  TITLE     Distinct origin and region-dependent contribution of stromal
            fibroblasts to fibrosis following traumatic injury in mice
  JOURNAL   Nat Neurosci 27 (7), 1285-1298 (2024)
   PUBMED   38849523
REFERENCE   5  (bases 1 to 4612)
  AUTHORS   Fuentes-Mateos,R., Garcia-Navas,R., Fernandez-Infante,C.,
            Hernandez-Cano,L., Calzada-Nieto,N., Juan,A.O., Guerrero,C.,
            Santos,E. and Fernandez-Medarde,A.
  TITLE     Combined HRAS and NRAS ablation induces a RASopathy phenotype in
            mice
  JOURNAL   Cell Commun Signal 22 (1), 332 (2024)
   PUBMED   38886790
  REMARK    GeneRIF: Combined HRAS and NRAS ablation induces a RASopathy
            phenotype in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4612)
  AUTHORS   Cases,S. and Dautry,F.
  TITLE     Inactivation of the murine N-ras gene by gene targeting
  JOURNAL   Oncogene 7 (12), 2525-2528 (1992)
   PUBMED   1461656
REFERENCE   7  (bases 1 to 4612)
  AUTHORS   Mangues,R., Seidman,I., Gordon,J.W. and Pellicer,A.
  TITLE     Overexpression of the N-ras proto-oncogene, not somatic mutational
            activation, associated with malignant tumors in transgenic mice
  JOURNAL   Oncogene 7 (10), 2073-2076 (1992)
   PUBMED   1328989
REFERENCE   8  (bases 1 to 4612)
  AUTHORS   Dower,N.A., Seldin,M.F., Pugh,S. and Stone,J.C.
  TITLE     Organization and chromosomal locations of Rap1a/Krev sequences in
            the mouse
  JOURNAL   Mamm Genome 3 (3), 162-167 (1992)
   PUBMED   1617222
REFERENCE   9  (bases 1 to 4612)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
REFERENCE   10 (bases 1 to 4612)
  AUTHORS   Yuasa,Y., Yamazaki,H., Maruo,K., Ueyama,Y., Shibuya,M. and
            Tamaoki,N.
  TITLE     Alterations of mouse proto-oncogenes in sarcomas induced after
            transplantation of human tumors in athymic nude mice
  JOURNAL   Jpn J Cancer Res 81 (4), 333-339 (1990)
   PUBMED   2114387
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163297.4.
            
            On Aug 9, 2022 this sequence version replaced XM_006501122.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253013.886920.1,
                                           SRR14777530.130775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AC163297.4         174690-174992
            304-431             AC163297.4         175268-175395
            432-610             AC163297.4         176564-176742
            611-770             AC163297.4         178737-178896
            771-894             AC163297.4         179693-179816
            895-936             AC163297.4         180479-180520
            937-4612            AC163297.4         180597-184272
FEATURES             Location/Qualifiers
     source          1..4612
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     gene            1..4612
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="neuroblastoma ras oncogene"
                     /db_xref="GeneID:18176"
                     /db_xref="MGI:MGI:97376"
     exon            1..303
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            304..431
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..890
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /EC_number="3.6.5.2"
                     /note="transforming protein N-Ras"
                     /codon_start=1
                     /product="GTPase NRas"
                     /protein_id="NP_001397438.1"
                     /db_xref="GeneID:18176"
                     /db_xref="MGI:MGI:97376"
                     /translation="MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQV
                     VIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKR
                     VKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLV
                     REIRQYRMKKLNSSDDGTQGCMGLPCVLM"
     exon            432..610
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            611..770
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            771..894
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            895..936
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     exon            937..4612
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1357..1362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="hexamer: AATATA"
     polyA_site      1358
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="major polyA site"
     regulatory      4585..4590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="hexamer: AATAAA"
     polyA_site      4612
                     /gene="Nras"
                     /gene_synonym="N-ras"
                     /note="major polyA site"
ORIGIN      
        1 ggggccggaa gtgccgctcc ctggcggggg ctgttcatgg cggtttcggg gtctccaaca
       61 gcttctcagg ttgaagtcca aaagcctccc gaggcggggt ctgcggagtt tgaggtaaag
      121 ctccggcctg cctggcgtcg gacttctcag cgtgtgaacg cctggcgggg cggggagacg
      181 cggagacttg gcgagctgaa acaaaggctt gggtggggga ctctggctgg ctctggggtg
      241 attttcggag ccggaaaggg gagtttcggg aagtggttgt gccaggcgga ccccagagct
      301 tgggtttttg ctggtgtgaa atgactgagt acaaactggt ggtggttgga gcaggtggtg
      361 ttgggaaaag cgccttgacg atccagctaa tccagaacca ctttgtggat gaatatgatc
      421 ccaccataga ggattcttac cgaaagcaag tggtgattga tggtgagacc tgcctgctgg
      481 acatactgga cacagctgga caagaggagt acagtgccat gagagaccag tacatgagga
      541 caggcgaagg gttcctctgt gtatttgcca tcaataatag caaatcattt gcagatatta
      601 acctctacag ggagcaaatt aagcgtgtga aagattctga tgatgtcccc atggtgctgg
      661 taggcaacaa gtgtgacttg ccaacaagga cagttgacac aaagcaagcc cacgaactgg
      721 ccaagagtta cggaattcca ttcattgaga cctcagccaa gacccgacag ggtgtggagg
      781 atgcctttta cacactggta agggagatac gccagtaccg aatgaaaaag ctcaacagca
      841 gtgacgatgg cactcaaggt tgtatggggc tgccctgtgt gctgatgtag taagacactt
      901 tgaaagttct gtcatcagaa aagagccact ttgaagctgc actgatgccc tggttctgac
      961 atccctggag gagacctgtt cctgctgctc tctgcatctc agagaagctc ctgcttcctg
     1021 cttccccgac tcagttactg agcacagcca tctaacctga gacctcttca gaataactac
     1081 ctcctcactc ggctgtctga ccagagaaat agacctgtct ctcccggtcg ttctctgccc
     1141 tgggttcccc tagaaacaga cacagcctcc agctggcttt gtcctctgaa aagcagttta
     1201 cattgatgca gagaaccaaa ctagacatgc cattctgttg acaacagttt cttatactct
     1261 aaggtaacaa ctgctggtga ttttcccctg cccccaactg ttgaacttgg ccttgttggt
     1321 ttggggggaa aatgtcataa attactttct tcccaaaata taattagtgt tgctgattga
     1381 tttgtaatgt gatcagctat attccataaa ctggcatctg ctctgtattc ataaatgcaa
     1441 acacgaatac tctcaactgc atgcaattaa atccaacatt cacaacaaag tgcctttttc
     1501 ctaaaagtgc tctgtaggct ccattacagt ttgtaattgg aatagatgtg tcaagaacca
     1561 ttgtatagga aagtgactct gagccatcta cctttgaggg aaaggtgtat gtacctgatg
     1621 gcagatgctt tgtgtatgca catgaagata gtttccctgt ctgggattct cccaggagaa
     1681 agatggaact gaaacaatta caagtaattt catttaattc tagctaatct tttttttttt
     1741 tttttttttt tttggtagac tatcacctat aaatatttgg aatatcttct agcttactga
     1801 taatctaata attaatgagc ttccattata atgaattggt tcataccagg aagccctcca
     1861 tttatagtat agatactgta aaaattggca tgttgttact ttatagctgt gattaatgat
     1921 tcctcagacc ttgctgagat atagttatta gcagacaggt tatatctttg ctgcatagtt
     1981 tcttcatgga atatatatct atctgtatgt ggagagaacg tggccctcag ttcccttctc
     2041 agcatccctc atctctcagc ctagagaagt tcgagcatcc tagaggggct tgaacagtta
     2101 tctcggttaa accatggtgc taatggaccg ggtcatggtt tcaaaacttg aacaagccag
     2161 ttagcatcac agagaaacag tccatccata tttgctccct gcctattatt cctgcttaca
     2221 gacttttgcc tgatgcctgc tgttagtgct acaaggataa agcttgtgtg gttctcacca
     2281 ggactggaag tacctggtga gctctggggt aagcctagat atctttacat tttcagaccc
     2341 ttattcttag ccacgtggaa actgaagcca gagtccatac ctccatctcc ttcccccccc
     2401 aaaaaaatta gattaatgtt ctttatatag cttttttaaa gtatttaaaa catgtctata
     2461 agttaggctg ccaactaaca aaagctgatg tgtttgttca aataaagagg tatccttcgc
     2521 tactcgagag aagaatgtaa aatgccattg attgttgtca cttggaggct tgatgtttgc
     2581 cctgataatt cattagtggg ttttgtttgt cacatgatac ctaagatgta actcagctca
     2641 gtaattctaa tgaaaacata aattggatac cttaattgaa aaaagcaaac ctaattccaa
     2701 aatggccatt ttctcttctg atcttgtaat acctaaaatt ctgaggtcct tgggattctt
     2761 ttgtttataa caggatcttg ctgtgtagtc ctagctggcc tcaaactcac aatactcttc
     2821 ctggatcaat ctcccaagtg ctgggattac aggcacattc caccacacac acctgactga
     2881 gctcgttcct aatgagtttt cattaagcaa attccccatc accttgaaac taatcagaag
     2941 ggggaagaaa catttgctat gctcctgagt gctaacactg ggatcattca catggggttt
     3001 gcattcctag gcaaactaaa ctgctgcctt ttacaacaag gctcagtcat cttcctgaag
     3061 ctgctgagac cagcacttgg tcttgttttg ttttaatatg tctatatgac tggtggtgga
     3121 tccctaaata gtttattaat taaactccag ttaaggagaa agttactcac cttgacccgt
     3181 ttgaccatat cccgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     3241 cacgcgtatg tacgtacgta tgtatgtagg tatgtaggtg gtttccagta taaacacaga
     3301 aacaaatgga gccaattcag gtttcagatg cccttactaa catatattcc cacggggtgt
     3361 gggttttggc acaacagtga caaacttaaa agccaagtaa gagccgggcg tggtggcgca
     3421 cgcctttaat cccagcactt gggaggcaga ggcaggcgga tttctgagtt ctaggccatc
     3481 ctggtctaca gtgagttcca ggacagccag tgctacacag agaaaccctg tctcgaaaag
     3541 ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa agccaagtag gtccagttgg tatagtatca
     3601 aagtgttttt agagtaatta gtgaaggtct gctttacctc aaagttgcag agcctctctt
     3661 cctgagttta agtgcctggc cggcagtcac aaattaacat gttgctgtaa ggcagttagt
     3721 tgaagctttg ttcacacatt ggagagtatg aaaataaagt gttctaagag cgctgatact
     3781 ggatctgtgt aaacctggta aatgccgttt gtccaggact tagcgtgtgt gagttggtag
     3841 ctcagtacga gtttactagt tccgcagtgt gtacaatgga ggcgggtttg ttttagctgg
     3901 ccacctgtag aatcagcctt taaactgctg tgaactttgt catgacttga atatgaagat
     3961 agacaaaaac tctgtaaaga caaatgtttg ttttccccct tacagaacgt gtgagcttgg
     4021 ttttatcttc ctttgtattt agtcataacc tctcaagctg gcagctccga ccaaggatca
     4081 gaagctgtgt gcgttccacc tggtggaatt agctcagctc tatatgagaa gtggagttaa
     4141 tggaaaacgt gttgactggg tggtttctat ttaaaagagt gatgataatt cttgaacagt
     4201 agtttttatt ttgctatttc tttaagctga ctgatgtgcc acaaaattat tttaaggtat
     4261 ttgtgtttta agagtgttct catgagatta gttgtagata ttttttaaaa tacaactggt
     4321 ttttaaaatc tgagtattgc tctaagcaag tgtttagact cttacgggaa ggtgggtgga
     4381 agttgtttgg cttccgtatt tccatgcgtg ccgtcagaca taggtcagaa cgccaactgt
     4441 gcatcctgct gtttaaagac ctcttggcct ctgtgaccct catgaagggg ctgatatttt
     4501 aagttgactg tttgattgta aattaatcct ttctaatttt taaagacttg cttgactgtt
     4561 ttccttgtta aataatttta aaaaaataaa aaactggaag ttctttgctt aa
//
