LOCUS       NM_025980               2590 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus Notch-regulated ankyrin repeat protein (Nrarp), mRNA.
ACCESSION   NM_025980
VERSION     NM_025980.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2590)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   2  (bases 1 to 2590)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
REFERENCE   3  (bases 1 to 2590)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   4  (bases 1 to 2590)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2590)
  AUTHORS   Bochter,M.S., Servello,D., Kakuda,S., D'Amico,R., Ebetino,M.F.,
            Haltiwanger,R.S. and Cole,S.E.
  TITLE     Lfng and Dll3 cooperate to modulate protein interactions in cis and
            coordinate oscillatory Notch pathway activation in the segmentation
            clock
  JOURNAL   Dev Biol 487, 42-56 (2022)
   PUBMED   35429490
REFERENCE   6  (bases 1 to 2590)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 2590)
  AUTHORS   Zechner,D., Fujita,Y., Hulsken,J., Muller,T., Walther,I.,
            Taketo,M.M., Crenshaw,E.B. 3rd, Birchmeier,W. and Birchmeier,C.
  TITLE     beta-Catenin signals regulate cell growth and the balance between
            progenitor cell expansion and differentiation in the nervous system
  JOURNAL   Dev Biol 258 (2), 406-418 (2003)
   PUBMED   12798297
REFERENCE   8  (bases 1 to 2590)
  AUTHORS   Yun,T.J. and Bevan,M.J.
  TITLE     Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling:
            multiple Notch1 signaling pathways involved in T cell development
  JOURNAL   J Immunol 170 (12), 5834-5841 (2003)
   PUBMED   12794108
  REMARK    GeneRIF: Different effects of Nrarp overexpression suggest that
            alternate Notch signaling pathways mediate T- versus B-cell lineage
            commitment and thymocyte maturation.
REFERENCE   9  (bases 1 to 2590)
  AUTHORS   Lahaye,K., Kricha,S. and Bellefroid,E.J.
  TITLE     XNAP, a conserved ankyrin repeat-containing protein with a role in
            the Notch pathway during Xenopus primary neurogenesis
  JOURNAL   Mech Dev 110 (1-2), 113-124 (2002)
   PUBMED   11744373
  REMARK    GeneRIF: please add ref to Xenopus: 2002 Mechanisms of Development
            110, 113-124.  Where they call it 'Xnap'
REFERENCE   10 (bases 1 to 2590)
  AUTHORS   Krebs,L.T., Deftos,M.L., Bevan,M.J. and Gridley,T.
  TITLE     The Nrarp gene encodes an ankyrin-repeat protein that is
            transcriptionally regulated by the notch signaling pathway
  JOURNAL   Dev Biol 238 (1), 110-119 (2001)
   PUBMED   11783997
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY046077.1.
            
            On Jul 28, 2006 this sequence version replaced NM_025980.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY046077.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2590
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="AKR/J"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.05 cM"
     gene            1..2590
                     /gene="Nrarp"
                     /gene_synonym="2700054M22Rik"
                     /note="Notch-regulated ankyrin repeat protein"
                     /db_xref="GeneID:67122"
                     /db_xref="MGI:MGI:1914372"
     exon            1..2582
                     /gene="Nrarp"
                     /gene_synonym="2700054M22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..698
                     /gene="Nrarp"
                     /gene_synonym="2700054M22Rik"
                     /codon_start=1
                     /product="notch-regulated ankyrin repeat-containing
                     protein"
                     /protein_id="NP_080256.2"
                     /db_xref="CCDS:CCDS38066.1"
                     /db_xref="GeneID:67122"
                     /db_xref="MGI:MGI:1914372"
                     /translation="MSQAELSTCSAPQTQRIFQEAVRKGNTQELQSLLQNMTNCEFNV
                     NSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRLANRDGWSALHIAAFGGHQDIVLY
                     LITKAKYAASGR"
     regulatory      1342..1347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrarp"
                     /gene_synonym="2700054M22Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      1349
                     /gene="Nrarp"
                     /gene_synonym="2700054M22Rik"
                     /note="major polyA site"
     regulatory      1720..1725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrarp"
                     /gene_synonym="2700054M22Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1744
                     /gene="Nrarp"
                     /gene_synonym="2700054M22Rik"
     regulatory      1847..1852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrarp"
                     /gene_synonym="2700054M22Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1872
                     /gene="Nrarp"
                     /gene_synonym="2700054M22Rik"
     regulatory      2131..2136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrarp"
                     /gene_synonym="2700054M22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2163
                     /gene="Nrarp"
                     /gene_synonym="2700054M22Rik"
ORIGIN      
        1 gaactatttt gcaaagggac gcgggtggag ttcagctgga gcgaagccta acctcgaagg
       61 gaccacgact gcgagtgtcg cggcctccgg ctgccccagg ttctgcgaac cagcacccag
      121 ccctgtcgcc cgcccgcttg ggcgcggctg gatgcagcag gggtcccgcg ccagcggccc
      181 tcggccccga acgcccggag tgcgcagggg cggcgtgcgg ggcccgaggg cgcagcgccc
      241 tccatgcgcc gaggcgtacc tcgagacacg ccccgagaca gcccggggcc cgcactgcag
      301 ccgccgcccg cgctaagccg gggcgcggct cgcagcccta gctctgcggc aacatgagcc
      361 aagccgagct gtccacctgc tcggcgccac agacgcagcg catcttccag gaagcggtgc
      421 gcaagggcaa cacgcaggag ctgcagtcgc tgctgcagaa catgactaac tgcgaattca
      481 acgtgaactc gttcgggccg gagggccaga cagcactaca ccagtcagtc atcgacggca
      541 acctggagct ggtgaagctg ttggtcaagt tcggagccga catccgccta gctaaccgcg
      601 acggctggag cgcgctacac atcgccgctt tcgggggcca ccaggacatc gtgctctatc
      661 tcatcaccaa ggccaagtac gcggccagcg gccggtgata gccacccgga ctccggcccc
      721 tggcccccac ccgcgtcgtc tctgctgtac cttcccgcca actacctcgg tgtgcgccag
      781 gtttgctggt ccgcgtggaa atcgggctaa gtctctacgt ccgcggccac gaccaaagta
      841 gcgcatccgt ggaccccagg gttcggctct ccgcaaaaga gcgcctcccc ttggcagtcc
      901 tctgagcccc gcggggcccc agagccttcc cacggccccg accgcctaga gggtgggggc
      961 ggggcgcagg ctccagtccg ttttgaaatt tgagtctcac accgggagac ttcggaatcc
     1021 cgagataccg gatcctccgc ttgaaatgtt ttctccggaa ggtgaaaggc gcgggcggac
     1081 tcgcgctcca gccgccgctc gtgagacccg gccgctcaca gtgcggcgcc cgccgctggc
     1141 agccgccaaa caaccattac cgggctccac catctgcgcg ccctcgcact taggaaggga
     1201 aggggacgct ccgggttcct gatgtcctca actatttatc acgtgtgtgt atatttgtgg
     1261 gtgaagtttg tgcgcctgag ttttttgttt ggaaatattg tgcgtggtta tgggagaaag
     1321 atgcattttt tttcctttaa aactaaaaac ttgagtctac cattttttgg ttgcactgaa
     1381 aataccgcct agccctatgg ttttcccatt gctagcccct cccccaccga gtccctaatc
     1441 ttccacacct cattcctctt ttcctctccc tggattctga gtttagagag cctaggatct
     1501 gtctcccttt cccctcccgt gagaggccac cattccccac acaggctggt ttagcaaagt
     1561 tccaaagggc tcttgaagcc cgcgtggctg ggacgtgggg attctgagag catggtaccc
     1621 ttcctagtga cttctattat agttaatagt cggttgcaca cttttttaaa aaagtaaatg
     1681 aatttgccac gattaaatgt cataacattt atgacagaat ataaaatatt aacatatttt
     1741 aagccaagtt ttaggtgtat ttttttgaat cttggttatg aacccaattt taaagggcgt
     1801 tgtatccagc gttgtgaagg ctgttgtgta cccatattta tatttttata aaattcctat
     1861 aaagactgtg aatctctcat actattgctg aatgagtgga agggctgctg tgctctttct
     1921 gccttcccca atccccatcc ccaccctcaa accctgctcc aaggccctat tatgatctga
     1981 ggatccagcc atgagggagg ggctgtgcca aggaccaggg ctggaggagg tgctggagcg
     2041 tcactggctg tcccagaaag gagacttcct ggtttctgtg gttccaattt tctatgcatc
     2101 tccattcccc ttcttgtttt gatcctggga aataaaaggg aggctgaatt attcaaattt
     2161 aaatgaggtt tccccttcgt agaagtgctg ctgaccctgc gtgcaaaaat ggggagcact
     2221 tgaggacaca ggtgggtgga gccctttgtg ccgcctggcc atattcttcg gtcttctgcg
     2281 cttttatgaa ccagtgtggg aggaatagtg ataatgtcat gagaatggca gacactgaga
     2341 caagcacaga ttacttcaaa aggagttctg tatggttttt ctacacgcaa atgccttttt
     2401 aattatgtta attaatgtta aaacgtactg ggcctatgtt gaagcttcag atgggtcctg
     2461 gttggtctct tctatctgta tgaagtctgt ggcacactcc taagcgtacg atatagactt
     2521 gtagcccatc gtgaaaaatt tataaataaa tttttcattg gtctttttat attaaaaaaa
     2581 aaaaaaaaaa
//
