LOCUS       NM_001403176            5501 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus nebulin-related anchoring protein (Nrap), transcript
            variant 4, mRNA.
ACCESSION   NM_001403176 XM_006526745
VERSION     NM_001403176.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5501)
  AUTHORS   Lee,S.Y., Lee,B.Y., Lim,B., Uzzaman,R., Jang,G. and Kim,K.S.
  TITLE     Exploring the importance of predicted camel NRAP exon 4 for
            environmental adaptation using a mouse model
  JOURNAL   Anim Genet 56 (1), e13490 (2025)
   PUBMED   39478283
REFERENCE   2  (bases 1 to 5501)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5501)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   4  (bases 1 to 5501)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
REFERENCE   5  (bases 1 to 5501)
  AUTHORS   Jirka,C., Pak,J.H., Grosgogeat,C.A., Marchetii,M.M. and Gupta,V.A.
  TITLE     Dysregulation of NRAP degradation by KLHL41 contributes to
            pathophysiology in nemaline myopathy
  JOURNAL   Hum Mol Genet 28 (15), 2549-2560 (2019)
   PUBMED   30986853
  REMARK    GeneRIF: Dysregulation of NRAP degradation by KLHL41 contributes to
            pathophysiology in nemaline myopathy.
REFERENCE   6  (bases 1 to 5501)
  AUTHORS   Mohiddin,S.A., Lu,S., Cardoso,J.P., Carroll,S., Jha,S., Horowits,R.
            and Fananapazir,L.
  TITLE     Genomic organization, alternative splicing, and expression of human
            and mouse N-RAP, a nebulin-related LIM protein of striated muscle
  JOURNAL   Cell Motil Cytoskeleton 55 (3), 200-212 (2003)
   PUBMED   12789664
  REMARK    GeneRIF: Highly conserved and exclusively expressed in cardiac and
            skeletal muscle.  Candidate cause for cardiac and skeletal
            myopathies
REFERENCE   7  (bases 1 to 5501)
  AUTHORS   Luo,G., Herrera,A.H. and Horowits,R.
  TITLE     Molecular interactions of N-RAP, a nebulin-related protein of
            striated muscle myotendon junctions and intercalated disks
  JOURNAL   Biochemistry 38 (19), 6135-6143 (1999)
   PUBMED   10320340
REFERENCE   8  (bases 1 to 5501)
  AUTHORS   Lee,C.G., Morse,H.C. 3rd, Kay,B.K. and Kozak,C.A.
  TITLE     Genetic mapping of eight SH3 domain genes on seven mouse
            chromosomes
  JOURNAL   Mamm Genome 10 (4), 402-404 (1999)
   PUBMED   10087302
REFERENCE   9  (bases 1 to 5501)
  AUTHORS   Luo,G., Leroy,E., Kozak,C.A., Polymeropoulos,M.H. and Horowits,R.
  TITLE     Mapping of the gene (NRAP) encoding N-RAP in the mouse and human
            genomes
  JOURNAL   Genomics 45 (1), 229-232 (1997)
   PUBMED   9339382
REFERENCE   10 (bases 1 to 5501)
  AUTHORS   Luo,G., Zhang,J.Q., Nguyen,T.P., Herrera,A.H., Paterson,B. and
            Horowits,R.
  TITLE     Complete cDNA sequence and tissue localization of N-RAP, a novel
            nebulin-related protein of striated muscle
  JOURNAL   Cell Motil Cytoskeleton 38 (1), 75-90 (1997)
   PUBMED   9295142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115771.13.
            
            On Mar 28, 2022 this sequence version replaced XM_006526745.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.20988.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               AC115771.13        160594-160822       c
            230-324             AC115771.13        160178-160272       c
            325-412             AC115771.13        159537-159624       c
            413-511             AC115771.13        156773-156871       c
            512-616             AC115771.13        154847-154951       c
            617-724             AC115771.13        153048-153155       c
            725-829             AC115771.13        152288-152392       c
            830-937             AC115771.13        150994-151101       c
            938-1039            AC115771.13        150604-150705       c
            1040-1144           AC115771.13        149848-149952       c
            1145-1261           AC115771.13        148843-148959       c
            1262-1366           AC115771.13        145152-145256       c
            1367-1474           AC115771.13        143595-143702       c
            1475-1579           AC115771.13        142611-142715       c
            1580-1678           AC115771.13        137163-137261       c
            1679-1783           AC115771.13        136180-136284       c
            1784-1891           AC115771.13        135090-135197       c
            1892-1993           AC115771.13        134714-134815       c
            1994-2191           AC115771.13        132442-132639       c
            2192-2296           AC115771.13        131900-132004       c
            2297-2395           AC115771.13        128079-128177       c
            2396-2500           AC115771.13        126270-126374       c
            2501-2608           AC115771.13        124908-125015       c
            2609-2920           AC115771.13        122220-122531       c
            2921-3025           AC115771.13        121077-121181       c
            3026-3124           AC115771.13        117917-118015       c
            3125-3229           AC115771.13        116248-116352       c
            3230-3337           AC115771.13        115449-115556       c
            3338-3451           AC115771.13        114800-114913       c
            3452-3649           AC115771.13        112927-113124       c
            3650-3754           AC115771.13        111307-111411       c
            3755-3853           AC115771.13        108825-108923       c
            3854-3958           AC115771.13        107270-107374       c
            3959-4066           AC115771.13        106831-106938       c
            4067-4378           AC115771.13        105814-106125       c
            4379-4483           AC115771.13        99784-99888         c
            4484-4582           AC115771.13        99289-99387         c
            4583-4687           AC115771.13        97983-98087         c
            4688-4795           AC115771.13        94676-94783         c
            4796-5107           AC115771.13        92511-92822         c
            5108-5239           AC115771.13        91673-91804         c
            5240-5501           AC115771.13        90829-91090         c
FEATURES             Location/Qualifiers
     source          1..5501
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.8 cM"
     gene            1..5501
                     /gene="Nrap"
                     /note="nebulin-related anchoring protein"
                     /db_xref="GeneID:18175"
                     /db_xref="MGI:MGI:1098765"
     exon            1..229
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            230..324
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            325..412
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            413..511
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            512..616
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            617..724
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            725..829
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            830..937
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1039
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1144
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1261
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1366
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1474
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1579
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1678
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1783
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1891
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1993
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2191
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2296
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2395
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2500
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2608
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2920
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3025
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3124
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3229
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3337
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3451
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3649
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3754
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3853
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            3854..3958
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            3959..4066
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4378
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..4483
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            4484..4582
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            4583..4687
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            4688..4795
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            4796..5107
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            5108..5239
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     exon            5240..5501
                     /gene="Nrap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5476..5481
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrap"
                     /note="hexamer: ATTAAA"
     polyA_site      5501
                     /gene="Nrap"
                     /note="major polyA site"
ORIGIN      
        1 gaaagtcagc tcagtgtagg aaagtggaag ttggattccg aaggctccag gcgtcccgag
       61 gagtttcata gtggtgggct tttgaaggtg gtaccgaccc aagtggaggt tctagtggat
      121 tttgtctgtt gcttctccct gtctcccaca ctccaagatg aatgtgcagg cctgctctag
      181 gtgtggctat ggggtttacc ctgctgagaa gatcagctgc atagatcaga catggcacaa
      241 agcatgtttt cactgtgaag tctgtaagat gatgctttct gttaataact tcgtgagtca
      301 ccagaaaaag ccgtactgtc acgcccacaa ccctaagaac aacacgttca ctagcgtcta
      361 ccacacaccc ttaaatctaa ccttgaagaa gtctgtggca gccatgggag ggattgacgg
      421 caaagaagat ggcgagccat ttaaatccgt tctccattgg gacatgaagt ccaaagctgg
      481 agcaggggca gctagccggc tgatgaatga gagagactac tggccagggt atgcagaagg
      541 gaacacttgg tgtccaggag ctctgccgga ccctgagatt gtaaggatgg ttgaagctcg
      601 acagtctctc ggtgagcagg ggtacacaga agaccgtgaa cagcagcagg gcaaggggag
      661 ctttccagcc atgatcaccc ctgcctacca aagggccaag gcagccaacc agctggccag
      721 ccaggtacaa tacaagagag gccacgatga gcgggtctcc acattcactc cagtggcgga
      781 cacgcccgag ctgctccgtg ccaaagctgg gggacagctt caaaatgacg tgaggtacac
      841 agaagacggt gggcagcaga gagggaaagg cagttttcct gctatgatca caccagctta
      901 tcagatagcc aaaagggcca ctgagctggc gagtgatgtg aggtaccatc aacaatatca
      961 tagagaaatg aagggaatgg ctagtcctgt cggagccgag ggtgggatga caaaggactc
     1021 tgtagaccga tgtggccagg tttactcaga agagtgtgat gaacccagag gaaagggcag
     1081 cttcccggcc atgatcaccc cagcgtatca gaacgccaag aaggccaatg aacttgttag
     1141 tgacataaaa taccggcagg acttccataa gatgaaaggt gcagcgcatt ttcactccct
     1201 tgcagcccag gacaacttgg ttcttaagcg agctcagagt gtgagcaagc ttgtgagtga
     1261 ggtggagtac aagaagggtc tggagaatag taaaggtcac agtatcaact actgtgagac
     1321 accccagttc aggaatgtga gcaagatctc aaaattcacc agcgataata aatataaaga
     1381 aaactatcag acccagctga gaggccacta tgacggagtc ggcatggaca gacgcatgct
     1441 ccacgctctc aaagttggca gcctggctag caatgttgcc tacaaggctg attataaaca
     1501 tgacgttgtg gattacaact acctggccac tgccactcca ttctaccaaa caacgatgag
     1561 gctggttccc ctgaaggatg tcaactacag gcagaacatt gacagaatga agttcagctc
     1621 ggtgacaaac acgccacaga ttgttcaagc taagatcaac gcccagcagc tgagccatgt
     1681 gaattaccga gctgactacg agagaaacaa gctgaactac acattgcccc aggacgcccc
     1741 tcagctgctg aaggccaagg ccaatgcaga actgttcagc gaggtgaagt acaaagaagg
     1801 ctggcagaag acaaagggga aaggctttga gatgaagctg gacgccatgt ctctgttggc
     1861 cgccaaagcc tcgggggagc ttgctagcag cgttaaatac aaagaagaat atgagaaaat
     1921 gaagggcaga gccctgggag ccacagactc taagcttctg cattctctgc aggtggccaa
     1981 gatgagcagc gaggttgaat ataagaaagg gtttgaggag agtaaaaccc actttaacct
     2041 gcccatggac atggtgaacc tcaggcacgc taagaaggcc caagctcttg ccagtgacct
     2101 tgactacaga aagaaactgc atgactacac ggtgctgcct gaagatatga aaactcagtg
     2161 ggccaagaaa gcctacgggc tgcagagcga gctgcagtac aaagctgacc tggcatggat
     2221 gaggggagtc gggtggctga cagaggggag tctcaacctg gaacaggcga agaaggctgg
     2281 acagctcatc agcgagaaaa actaccggca gagggtggat gagctgaagt tcaccagtgt
     2341 ggctgacagc tcccagatgg agcatgccaa gaagagccag gggctgcaga acgcggtggc
     2401 ctacaaggca ggaaacgagc aatccgtcca tcagtacacc atcagcaaag acgagcctct
     2461 cttcttacga gcccgggcca atgctgctca actcagcgag accctgtaca agagcagctg
     2521 ggaaaagcag aaggccaaag ggtttgagct gagacttgac tccttggcat tcctgacagc
     2581 caaagccaag agagacctgg ctagtgaggt gaaatacaaa gaggactatg aaaggtccag
     2641 agggaaactc attggggcga agagtgcaca gggggattcg cagatgagcc actccctgca
     2701 gatgtcgaag ctacagagtg acctggagta caagaagggc tttgaagaca ccagatctca
     2761 gtgccacatc tcccttgaca tggttcacct cgtccatgct cgccaggcac agcacctagc
     2821 cacagacgta ggctacagga cagcgtctca ctgcttcacg gctctgccca cagacatgaa
     2881 ggtggagtgg gccaagaagg cttacggcct gcagagtgat aaccaataca gggcagacat
     2941 gaagtggatg aaaggcacag gctgggtggc caccgggtca ttacatgtgg agcaggcgaa
     3001 gaaggcagga gaactcatta gtgagaagaa gtaccgtcag cacccagatg ctttgaagtt
     3061 taccagtatt aaagacactc cggagatggt ccaggccagg attagttata cccaagcagt
     3121 ggatagactg tacagggagc aaggggagaa tgtgaagcac cactacacac agactgcaga
     3181 cttgcctgaa gtcctgctgg ccaaactgaa cgccatgaac atcagcgaga ctcgctataa
     3241 ggaatcttgg agccggcttc gagatggagg atacaagctg aggctggatg cccttccatt
     3301 ccaggcagca aaggcgtcca gcgaagttat aagtgactac aaatacaaag aagcatttga
     3361 gagaatgaaa ggccagatgc tcggctcccg gagcttggaa gatgacctca gccttgctca
     3421 ttcagtgcac gcgacctcgc tgcagagtga tgtgaattat aagaaaggct ttgaacacgc
     3481 aaaggctcac ttccatctgc cgctggatat ggtgaccttg gtgcatgcca agaaggctca
     3541 aaccctggcc agcgaccagg actacagaca tccgctcccc cagcacacag tcttggcaga
     3601 agatctgagg ctgagctgtg ccaagaaagc tcacaagtta cagagtgaga atctgtaccg
     3661 ctcggacttg aacttcatgc gtggtgttcc ctgtgtcgtt cctggaacac tggagattga
     3721 aggaagaaag aaagcctctg agctcatcag cgagagtaaa taccgccagc atcctgggtc
     3781 attcaagtac acggccgtga cagatactcc caacctcctg catgccaagt acagcaacca
     3841 gatcaccaat gagcgtctct ataaagcggc tggcgaggac gcacggcacc aatacacgat
     3901 gacccttggt ctgcctgagt tcatccgagc caaaaccaac gcagccaacc tgagcgaggc
     3961 aaaatacaag gaggcttggc ataatcttcg tgctcaaggc tacaagctga cgatagacgc
     4021 cctccccttc caggctgctc gggcctctgg agacatagcc agtgactttc tctacaggca
     4081 cgagtttgtg aaggagcgtg gacagctcat tggggtgcgg aatgtgagtg acgacccgcg
     4141 gctactgcac tgcctacgga tgggccagct gcagagtgag aatcagtaca ggaaggaggc
     4201 ggccagcagc caagctcagt gccacctgcc catggatatg atgtacctgg tccatgccag
     4261 gaaggcccag gccctggcca gtgaccacga ctaccggaca cagtgccacg agttcaccgc
     4321 cctgcctgag gatctgaaga tggcctgggc caagaaagcg cacgccctgc agagtgagtt
     4381 tcgctacaag gcggacttga tgggcatgaa agggacagga tggctggctc tgcagtctcc
     4441 tcagatagag agtgcaaaga aggctggaga cctaatcagt gagaccaagt accgtaaaaa
     4501 accagacagc atcaagttca ctaccgtggt tgactctcca gacctcattc atgccaagga
     4561 gagctacatg cactgtaacg agcgcttgta caggttggga gatgcagcct ccctgcatag
     4621 atacacccca atcccagacc acccggattt cacccgagcc cgcatgaacg caatgcattt
     4681 gagtgacaaa gtctacagga atgcctggga gcagagccgg gctggtggct atgacttcag
     4741 gctggatgct atcccattcc agactgcacg ggtgtccagg gatatcgcca gtgatttccg
     4801 gtacaaagag gcatttctga gggaccgggg cctacagatt gggtaccgta gcatcagtga
     4861 cgacccgagg acgacgcact tcctccgagt cggcaggctc cagagtgaca acgagtacag
     4921 gaaggccttt gccaaaggtc gctcccagtt ccacagtcgc gctgaccaac caggcttcct
     4981 ccaggccaag aggagccagc agctggccag cgatgtcctc tataggcagc cactgcctca
     5041 gcacaccagc gacccagaac agctgggcct gaagcatgcc cggaaagccc atcagctgca
     5101 gagtgatgtc aagtacaaat ctgacttgaa cctgactcga ggtgttggct ggacccctcc
     5161 tggctcctac aaagtggaaa tggctcgacg ggctgcagaa ctggccaaca ggaggggccc
     5221 ggggatccgg ggggcttctg tggagccaga ggcagcagcg gcgctaggag atcatcagag
     5281 caggggggtg aacccggatg cctcggagat cctgcatatc cacaagaaga agactctgct
     5341 gatgtgagcc tccttaagaa gcccccttga gggctgcttg ccaaaggcat gcctctgtgg
     5401 ctttggtctg gatgagcgag tgttttaaaa aaaaaaaaaa actggcacac cctccccgtg
     5461 cccacatctg cctttattaa aataacaact ctgaaagcaa a
//
