LOCUS       NP_001390105            1729 aa            linear   ROD 01-MAY-2025
DEFINITION  nebulin-related-anchoring protein isoform 4 [Mus musculus].
ACCESSION   NP_001390105 XP_006526808
VERSION     NP_001390105.1
DBSOURCE    REFSEQ: accession NM_001403176.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1729)
  AUTHORS   Lee,S.Y., Lee,B.Y., Lim,B., Uzzaman,R., Jang,G. and Kim,K.S.
  TITLE     Exploring the importance of predicted camel NRAP exon 4 for
            environmental adaptation using a mouse model
  JOURNAL   Anim Genet 56 (1), e13490 (2025)
   PUBMED   39478283
REFERENCE   2  (residues 1 to 1729)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 1729)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   4  (residues 1 to 1729)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
REFERENCE   5  (residues 1 to 1729)
  AUTHORS   Jirka,C., Pak,J.H., Grosgogeat,C.A., Marchetii,M.M. and Gupta,V.A.
  TITLE     Dysregulation of NRAP degradation by KLHL41 contributes to
            pathophysiology in nemaline myopathy
  JOURNAL   Hum Mol Genet 28 (15), 2549-2560 (2019)
   PUBMED   30986853
  REMARK    GeneRIF: Dysregulation of NRAP degradation by KLHL41 contributes to
            pathophysiology in nemaline myopathy.
REFERENCE   6  (residues 1 to 1729)
  AUTHORS   Mohiddin,S.A., Lu,S., Cardoso,J.P., Carroll,S., Jha,S., Horowits,R.
            and Fananapazir,L.
  TITLE     Genomic organization, alternative splicing, and expression of human
            and mouse N-RAP, a nebulin-related LIM protein of striated muscle
  JOURNAL   Cell Motil Cytoskeleton 55 (3), 200-212 (2003)
   PUBMED   12789664
  REMARK    GeneRIF: Highly conserved and exclusively expressed in cardiac and
            skeletal muscle.  Candidate cause for cardiac and skeletal
            myopathies
REFERENCE   7  (residues 1 to 1729)
  AUTHORS   Luo,G., Herrera,A.H. and Horowits,R.
  TITLE     Molecular interactions of N-RAP, a nebulin-related protein of
            striated muscle myotendon junctions and intercalated disks
  JOURNAL   Biochemistry 38 (19), 6135-6143 (1999)
   PUBMED   10320340
REFERENCE   8  (residues 1 to 1729)
  AUTHORS   Lee,C.G., Morse,H.C. 3rd, Kay,B.K. and Kozak,C.A.
  TITLE     Genetic mapping of eight SH3 domain genes on seven mouse
            chromosomes
  JOURNAL   Mamm Genome 10 (4), 402-404 (1999)
   PUBMED   10087302
REFERENCE   9  (residues 1 to 1729)
  AUTHORS   Luo,G., Leroy,E., Kozak,C.A., Polymeropoulos,M.H. and Horowits,R.
  TITLE     Mapping of the gene (NRAP) encoding N-RAP in the mouse and human
            genomes
  JOURNAL   Genomics 45 (1), 229-232 (1997)
   PUBMED   9339382
REFERENCE   10 (residues 1 to 1729)
  AUTHORS   Luo,G., Zhang,J.Q., Nguyen,T.P., Herrera,A.H., Paterson,B. and
            Horowits,R.
  TITLE     Complete cDNA sequence and tissue localization of N-RAP, a novel
            nebulin-related protein of striated muscle
  JOURNAL   Cell Motil Cytoskeleton 38 (1), 75-90 (1997)
   PUBMED   9295142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115771.13.
            
            On Mar 28, 2022 this sequence version replaced XP_006526808.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.20988.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1729
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.8 cM"
     Protein         1..1729
                     /product="nebulin-related-anchoring protein isoform 4"
                     /note="N-RAP"
                     /calculated_mol_wt=195754
     Region          6..58
                     /region_name="LIM_N_RAP"
                     /note="The LIM domain of N-RAP; cd09446"
                     /db_xref="CDD:188830"
     Site            order(6,9,27,30,33,36,54,57)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188830"
     Region          174..201
                     /region_name="Nebulin 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          202..236
                     /region_name="Nebulin 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          203..231
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Site            204
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          245..272
                     /region_name="Nebulin 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          314..341
                     /region_name="Nebulin 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          314..340
                     /region_name="Nebulin"
                     /note="Nebulin repeat; pfam00880"
                     /db_xref="CDD:459977"
     Region          346..380
                     /region_name="Nebulin 5. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          387..415
                     /region_name="Nebulin 6. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          417..451
                     /region_name="Nebulin 7. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          485..519
                     /region_name="Nebulin 8. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          486..516
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Region          520..554
                     /region_name="Nebulin 9. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          521..551
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Region          556..590
                     /region_name="Nebulin 10. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          562..589
                     /region_name="Nebulin"
                     /note="Nebulin repeat; pfam00880"
                     /db_xref="CDD:459977"
     Region          600..624
                     /region_name="Nebulin 11. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          625..659
                     /region_name="Nebulin 12. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          626..656
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Region          660..690
                     /region_name="Nebulin 13. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          700..722
                     /region_name="Nebulin 14. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          724..758
                     /region_name="Nebulin 15. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          725..755
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Region          759..793
                     /region_name="Nebulin 16. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          760..790
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Region          795..829
                     /region_name="Nebulin 17. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          796..826
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Region          842..867
                     /region_name="Nebulin 18. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          868..894
                     /region_name="Nebulin 19. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          899..933
                     /region_name="Nebulin 20. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          944..961
                     /region_name="Nebulin 21. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          967..1001
                     /region_name="Nebulin 22. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          968..998
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Region          1002..1036
                     /region_name="Nebulin 23. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1003..1031
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Region          1038..1072
                     /region_name="Nebulin 24. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1044..1071
                     /region_name="Nebulin"
                     /note="Nebulin repeat; pfam00880"
                     /db_xref="CDD:459977"
     Region          1076..1110
                     /region_name="Nebulin 25. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Site            1079
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1111..1137
                     /region_name="Nebulin 26. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1142..1176
                     /region_name="Nebulin 27. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1181..1204
                     /region_name="Nebulin 28. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1210..1244
                     /region_name="Nebulin 29. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1211..1241
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Region          1245..1279
                     /region_name="Nebulin 30. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1246..1276
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Region          1281..1315
                     /region_name="Nebulin 31. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1319..1353
                     /region_name="Nebulin 32. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1354..1380
                     /region_name="Nebulin 33. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1355..1380
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Region          1385..1419
                     /region_name="Nebulin 34. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1426..1447
                     /region_name="Nebulin 35. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1453..1479
                     /region_name="Nebulin 36. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1488..1522
                     /region_name="Nebulin 37. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1524..1558
                     /region_name="Nebulin 38. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1562..1596
                     /region_name="Nebulin 39. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1597..1631
                     /region_name="Nebulin 40. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     Region          1598..1624
                     /region_name="NEBU"
                     /note="The Nebulin repeat is present also in Las1;
                     smart00227"
                     /db_xref="CDD:128523"
     Region          1638..1662
                     /region_name="Nebulin 41. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80XB4.3)"
     CDS             1..1729
                     /gene="Nrap"
                     /coded_by="NM_001403176.1:158..5347"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:18175"
                     /db_xref="MGI:MGI:1098765"
ORIGIN      
        1 mnvqacsrcg ygvypaekis cidqtwhkac fhcevckmml svnnfvshqk kpychahnpk
       61 nntftsvyht plnltlkksv aamggidgke dgepfksvlh wdmkskagag aasrlmnerd
      121 ywpgyaegnt wcpgalpdpe ivrmvearqs lgeqgytedr eqqqgkgsfp amitpayqra
      181 kaanqlasqv qykrghderv stftpvadtp ellrakaggq lqndvryted ggqqrgkgsf
      241 pamitpayqi akratelasd vryhqqyhre mkgmaspvga eggmtkdsvd rcgqvyseec
      301 deprgkgsfp amitpayqna kkanelvsdi kyrqdfhkmk gaahfhslaa qdnlvlkraq
      361 svsklvseve ykkglenskg hsinycetpq frnvskiskf tsdnkykeny qtqlrghydg
      421 vgmdrrmlha lkvgslasnv aykadykhdv vdynylatat pfyqttmrlv plkdvnyrqn
      481 idrmkfssvt ntpqivqaki naqqlshvny radyernkln ytlpqdapql lkakanaelf
      541 sevkykegwq ktkgkgfemk ldamsllaak asgelassvk ykeeyekmkg ralgatdskl
      601 lhslqvakms seveykkgfe eskthfnlpm dmvnlrhakk aqalasdldy rkklhdytvl
      661 pedmktqwak kayglqselq ykadlawmrg vgwltegsln leqakkagql iseknyrqrv
      721 delkftsvad ssqmehakks qglqnavayk agneqsvhqy tiskdeplfl raranaaqls
      781 etlyksswek qkakgfelrl dslafltaka krdlasevky kedyersrgk ligaksaqgd
      841 sqmshslqms klqsdleykk gfedtrsqch isldmvhlvh arqaqhlatd vgyrtashcf
      901 talptdmkve wakkayglqs dnqyradmkw mkgtgwvatg slhveqakka gelisekkyr
      961 qhpdalkfts ikdtpemvqa risytqavdr lyreqgenvk hhytqtadlp evllaklnam
     1021 nisetrykes wsrlrdggyk lrldalpfqa akassevisd ykykeaferm kgqmlgsrsl
     1081 eddlslahsv hatslqsdvn ykkgfehaka hfhlpldmvt lvhakkaqtl asdqdyrhpl
     1141 pqhtvlaedl rlscakkahk lqsenlyrsd lnfmrgvpcv vpgtleiegr kkaselises
     1201 kyrqhpgsfk ytavtdtpnl lhakysnqit nerlykaage darhqytmtl glpefirakt
     1261 naanlseaky keawhnlraq gykltidalp fqaarasgdi asdflyrhef vkergqligv
     1321 rnvsddprll hclrmgqlqs enqyrkeaas sqaqchlpmd mmylvharka qalasdhdyr
     1381 tqcheftalp edlkmawakk ahalqsefry kadlmgmkgt gwlalqspqi esakkagdli
     1441 setkyrkkpd sikfttvvds pdlihakesy mhcnerlyrl gdaaslhryt pipdhpdftr
     1501 armnamhlsd kvyrnaweqs raggydfrld aipfqtarvs rdiasdfryk eaflrdrglq
     1561 igyrsisddp rtthflrvgr lqsdneyrka fakgrsqfhs radqpgflqa krsqqlasdv
     1621 lyrqplpqht sdpeqlglkh arkahqlqsd vkyksdlnlt rgvgwtppgs ykvemarraa
     1681 elanrrgpgi rgasvepeaa aalgdhqsrg vnpdaseilh ihkkktllm
//
