LOCUS       NM_026012               1213 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus neurotrophin receptor associated death domain (Nradd),
            mRNA.
ACCESSION   NM_026012
VERSION     NM_026012.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1213)
  AUTHORS   Unsain,N., Dorval,G., Sheen,J.H. and Barker,P.A.
  TITLE     Generation and characterization of mice bearing null alleles of
            nradd/Nrh2
  JOURNAL   Genesis 54 (12), 605-612 (2016)
   PUBMED   27775873
  REMARK    GeneRIF: The NRADD conditional and complete knockout mouse lines
            generated are new and useful tools to study the physiological roles
            of NRADD.
REFERENCE   2  (bases 1 to 1213)
  AUTHORS   Murphy,M., Wilson,Y.M., Vargas,E., Munro,K.M., Smith,B., Huang,A.,
            Li,Q.X., Xiao,J., Masters,C.L., Reid,C.A. and Barrett,G.L.
  TITLE     Reduction of p75 neurotrophin receptor ameliorates the cognitive
            deficits in a model of Alzheimer's disease
  JOURNAL   Neurobiol Aging 36 (2), 740-752 (2015)
   PUBMED   25443284
  REMARK    GeneRIF: Its reduction ameliorates cognitive deficits in Alzheimer
            disease.
REFERENCE   3  (bases 1 to 1213)
  AUTHORS   Vilar,M., Sung,T.C., Chen,Z., Garcia-Carpio,I., Fernandez,E.M.,
            Xu,J., Riek,R. and Lee,K.F.
  TITLE     Heterodimerization of p45-p75 modulates p75 signaling: structural
            basis and mechanism of action
  JOURNAL   PLoS Biol 12 (8), e1001918 (2014)
   PUBMED   25093680
  REMARK    GeneRIF: These results suggest a mechanism involving both the
            transmembrane domain and the death domain of p45 to regulate
            p75-mediated signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1213)
  AUTHORS   Sung,T.C., Chen,Z., Thuret,S., Vilar,M., Gage,F.H., Riek,R. and
            Lee,K.F.
  TITLE     P45 forms a complex with FADD and promotes neuronal cell survival
            following spinal cord injury
  JOURNAL   PLoS One 8 (7), e69286 (2013)
   PUBMED   23935974
  REMARK    GeneRIF: p45 forms a complex with FADD and diminishes Fas-FADD
            mediated death signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1213)
  AUTHORS   Kim,T. and Hempstead,B.L.
  TITLE     NRH2 is a trafficking switch to regulate sortilin localization and
            permit proneurotrophin-induced cell death
  JOURNAL   EMBO J 28 (11), 1612-1623 (2009)
   PUBMED   19407813
  REMARK    GeneRIF: The authors show that the mammalian p75NTR homologue NRH2
            critically regulates the expression of sortilin on the neuronal
            cell surface and promotes p75NTR and sortilin receptor complex
            formation, rendering cells responsive to proneurotrophins.
REFERENCE   6  (bases 1 to 1213)
  AUTHORS   Gowrishankar,K., Zeidler,M.G. and Vincenz,C.
  TITLE     Release of a membrane-bound death domain by gamma-secretase
            processing of the p75NTR homolog NRADD
  JOURNAL   J Cell Sci 117 (Pt 18), 4099-4111 (2004)
   PUBMED   15280425
REFERENCE   7  (bases 1 to 1213)
  AUTHORS   Murray,S.S., Perez,P., Lee,R., Hempstead,B.L. and Chao,M.V.
  TITLE     A novel p75 neurotrophin receptor-related protein, NRH2, regulates
            nerve growth factor binding to the TrkA receptor
  JOURNAL   J Neurosci 24 (11), 2742-2749 (2004)
   PUBMED   15028767
REFERENCE   8  (bases 1 to 1213)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   9  (bases 1 to 1213)
  AUTHORS   Wang,X., Shao,Z., Zetoune,F.S., Zeidler,M.G., Gowrishankar,K. and
            Vincenz,C.
  TITLE     NRADD, a novel membrane protein with a death domain involved in
            mediating apoptosis in response to ER stress
  JOURNAL   Cell Death Differ 10 (5), 580-591 (2003)
   PUBMED   12728256
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC069856.1.
            
            On May 16, 2004 this sequence version replaced NM_026012.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069856.1, AK160222.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1213
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.26 cM"
     gene            1..1213
                     /gene="Nradd"
                     /gene_synonym="2610311B09Rik; NRDD; NRH2; PLAIDD"
                     /note="neurotrophin receptor associated death domain"
                     /db_xref="GeneID:67169"
                     /db_xref="MGI:MGI:1914419"
     exon            1..79
                     /gene="Nradd"
                     /gene_synonym="2610311B09Rik; NRDD; NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            80..228
                     /gene="Nradd"
                     /gene_synonym="2610311B09Rik; NRDD; NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..878
                     /gene="Nradd"
                     /gene_synonym="2610311B09Rik; NRDD; NRH2; PLAIDD"
                     /note="neurotrophin receptor homolog-2; neurotrophin
                     receptor-alike death domain protein"
                     /codon_start=1
                     /product="death domain-containing membrane protein NRADD"
                     /protein_id="NP_080288.1"
                     /db_xref="CCDS:CCDS23569.1"
                     /db_xref="GeneID:67169"
                     /db_xref="MGI:MGI:1914419"
                     /translation="MLYNVSKGVVYSDTALQGQDGDREGMWVGAGGALAPNTSSLFPP
                     EPPGASSNIIPVYCALLATVILGLLAYVAFKCWRSHKQRQQLAKARTVELGDPDRDQR
                     RGDSNVFVDSPPSLEPCIPSQGPHPDLGCQLYLHIPQQQQEEVQRLLMMGEPAKGWQE
                     LAGHLGYQAEAVETMACDQMPAYTLLRNWAAQEGNRATLRVLEDALAAIGREDVVQVL
                     SSPAESSSVV"
     exon            229..418
                     /gene="Nradd"
                     /gene_synonym="2610311B09Rik; NRDD; NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            419..561
                     /gene="Nradd"
                     /gene_synonym="2610311B09Rik; NRDD; NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            562..1164
                     /gene="Nradd"
                     /gene_synonym="2610311B09Rik; NRDD; NRH2; PLAIDD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1135..1140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nradd"
                     /gene_synonym="2610311B09Rik; NRDD; NRH2; PLAIDD"
                     /note="hexamer: ATTAAA"
     polyA_site      1164
                     /gene="Nradd"
                     /gene_synonym="2610311B09Rik; NRDD; NRH2; PLAIDD"
                     /note="major polyA site"
ORIGIN      
        1 gaacctgccc tctccaggga ctcccgtcgt cttcctagct gagtggatcc tggcaccctc
       61 ggaggggtgg ccgcagaaga gttcctcctt ctgagattca agagaagcag gctccaagct
      121 ccgtcaactc agttctctac acaactcccc ttcaccaaaa aacagcccag caggcagcgc
      181 ctggcagcac catgctttat aacgtcagca aaggtgtggt ctattcagat acagccctgc
      241 aggggcagga cggggacagg gaaggaatgt gggtaggagc tgggggagcc ctagccccca
      301 atacctcctc cctatttccc cctgagcctc caggggcctc gagcaacatc attcctgtct
      361 actgtgctct cctagctaca gtgatccttg gtctgctggc ctatgtggcc ttcaaatgct
      421 ggcgctcaca taagcaaagg caacagttgg ctaaagctcg gactgtagag ctaggggacc
      481 ctgacaggga ccagaggcgt ggtgacagca acgtcttcgt ggactctcct cctagtctgg
      541 agccctgtat tcccagccag ggaccacacc cggaccttgg ctgccagctt tacctgcata
      601 ttccacagca gcagcaggag gaagtccagc ggctcctgat gatgggtgag ccagccaagg
      661 gctggcagga gctggcaggc cacctcggct accaagctga ggctgtggaa accatggcct
      721 gtgaccaaat gccagcctat accctgctaa ggaactgggc tgcccaagaa ggcaatagag
      781 ctaccctcag agtgctggag gatgctctgg ctgccatagg ccgagaagat gtggtccagg
      841 ttttgagctc gccagctgag agctcctcgg tggtgtgagt gccgcctccc agggctgcct
      901 gccctggcct catgtctttc atgggcttcc tagtacttct ctggcttcag cttgctgttg
      961 tggcagcaga acacaaaaga tccggccact tcatgttcct tctccatcct ctccaagata
     1021 gaagcgaggg acatgggggg gtgggtaaga gagtgggcat ggctttgccc acagattctc
     1081 gttctgcccc tttatgtgct tgttattttt tctatttctt tttaagaatc acatattaaa
     1141 ggcacctttg gagttttgtt ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1201 aaaaaaaaaa aaa
//
