LOCUS       NM_010264               6185 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus nuclear receptor subfamily 6, group A, member 1
            (Nr6a1), transcript variant 1, mRNA.
ACCESSION   NM_010264
VERSION     NM_010264.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6185)
  AUTHORS   Chang YC, Manent J, Schroeder J, Wong SFL, Hauswirth GM, Shylo NA,
            Moore EL, Achilleos A, Garside V, Polo JM, Trainor P and McGlinn E.
  TITLE     Nr6a1 controls Hox expression dynamics and is a master regulator of
            vertebrate trunk development
  JOURNAL   Nat Commun 13 (1), 7766 (2022)
   PUBMED   36522318
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6185)
  AUTHORS   Tan P, Xue T, Wang Y, Hu Z, Su J, Yang R, Ji J, Ye M, Chen Z, Huang
            C and Lu X.
  TITLE     Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to the
            development of depression-like behaviors in mice
  JOURNAL   Neuropharmacology 209, 108990 (2022)
   PUBMED   35183538
  REMARK    GeneRIF: Hippocampal NR6A1 impairs CREB-BDNF signaling and leads to
            the development of depression-like behaviors in mice.
REFERENCE   3  (bases 1 to 6185)
  AUTHORS   Koutelou E, Wang L, Schibler AC, Chao HP, Kuang X, Lin K, Lu Y,
            Shen J, Jeter CR, Salinger A, Wilson M, Chen YC, Atanassov BS, Tang
            DG and Dent SYR.
  TITLE     USP22 controls multiple signaling pathways that are essential for
            vasculature formation in the mouse placenta
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30718289
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6185)
  AUTHORS   Valdmanis PN, Kim HK, Chu K, Zhang F, Xu J, Munding EM, Shen J and
            Kay MA.
  TITLE     miR-122 removal in the liver activates imprinted microRNAs and
            enables more effective microRNA-mediated gene repression
  JOURNAL   Nat Commun 9 (1), 5321 (2018)
   PUBMED   30552326
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6185)
  AUTHORS   Weikum ER, Tuntland ML, Murphy MN and Ortlund EA.
  TITLE     A Structural Investigation into Oct4 Regulation by Orphan Nuclear
            Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor
            Homolog-1 (LRH-1)
  JOURNAL   J Mol Biol 428 (24 Pt B), 4981-4992 (2016)
   PUBMED   27984042
  REMARK    GeneRIF: Here, the authors present the first structure of mouse
            GCNF DNA-binding domain in complex with the Oct4 DR0. The overall
            structure revealed two molecules bound in a head-to-tail fashion on
            opposite sides of the DNA at a DR0 motif located within the Oct4
            promoter.
REFERENCE   6  (bases 1 to 6185)
  AUTHORS   Kapelle M, Kratzschmar J, Husemann M and Schleuning WD.
  TITLE     cDNA cloning of two closely related forms of human germ cell
            nuclear factor (GCNF)
  JOURNAL   Biochim Biophys Acta 1352 (1), 13-17 (1997)
   PUBMED   9177477
REFERENCE   7  (bases 1 to 6185)
  AUTHORS   Yan ZH, Medvedev A, Hirose T, Gotoh H and Jetten AM.
  TITLE     Characterization of the response element and DNA binding properties
            of the nuclear orphan receptor germ cell nuclear factor/retinoid
            receptor-related testis-associated receptor
  JOURNAL   J Biol Chem 272 (16), 10565-10572 (1997)
   PUBMED   9099702
REFERENCE   8  (bases 1 to 6185)
  AUTHORS   Joos TO, David R and Dreyer C.
  TITLE     xGCNF, a nuclear orphan receptor is expressed during neurulation in
            Xenopus laevis
  JOURNAL   Mech Dev 60 (1), 45-57 (1996)
   PUBMED   9025060
REFERENCE   9  (bases 1 to 6185)
  AUTHORS   Hirose T, O'Brien DA and Jetten AM.
  TITLE     RTR: a new member of the nuclear receptor superfamily that is
            highly expressed in murine testis
  JOURNAL   Gene 152 (2), 247-251 (1995)
   PUBMED   7835709
REFERENCE   10 (bases 1 to 6185)
  AUTHORS   Chen F, Cooney AJ, Wang Y, Law SW and O'Malley BW.
  TITLE     Cloning of a novel orphan receptor (GCNF) expressed during germ
            cell development
  JOURNAL   Mol Endocrinol 8 (10), 1434-1444 (1994)
   PUBMED   7854358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935155.13, CN538225.1, CK638822.1, CN532747.1 and AL844842.29.
            
            [WARNING] On Jan 10, 2024 this sequence was replaced by
            NM_010264.5.
            
            On Apr 21, 2009 this sequence version replaced NM_010264.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U09563.1, U14666.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               AL935155.13        107291-107634       c
            345-1031            CN538225.1         16-702
            1032-1572           CK638822.1         121-661
            1573-2186           CN532747.1         86-699
            2187-6185           AL844842.29        130980-134978       c
FEATURES             Location/Qualifiers
     source          1..6185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.42 cM"
     gene            1..6185
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /note="nuclear receptor subfamily 6, group A, member 1"
                     /db_xref="GeneID:14536"
                     /db_xref="MGI:MGI:1352459"
     exon            1..344
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1732
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mGCNF; retinoid receptor-related testis-specific receptor;
                     germ cell nuclear factor"
                     /codon_start=1
                     /product="nuclear receptor subfamily 6 group A member 1
                     isoform 1"
                     /protein_id="NP_034394.1"
                     /db_xref="CCDS:CCDS16012.1"
                     /db_xref="GeneID:14536"
                     /db_xref="MGI:MGI:1352459"
                     /translation="MERDERPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELD
                     PGTNGETDSLTLGQGHIPVSVPDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRS
                     ICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGP
                     VQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSSRSVE
                     LNGFMAFRDQYMGMSVPPHYQYIPHLFSYSGHSPLLPPQARSLDPQSYSLIHQLMSAE
                     DLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCL
                     LSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYH
                     KFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYKYTHQPN
                     RFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSTVKE"
     exon            345..386
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /inference="alignment:Splign:2.1.0"
     exon            387..431
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /inference="alignment:Splign:2.1.0"
     exon            432..674
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /inference="alignment:Splign:2.1.0"
     exon            675..730
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /inference="alignment:Splign:2.1.0"
     exon            731..885
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1113
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1368
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1490
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1643
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..6185
                     /gene="Nr6a1"
                     /gene_synonym="1700113M01Rik; Gcnf; NCNF; RTR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaattcctca cgggcatgtg cgtggcagcg gcgcgtgacg tcagaggagg gagctggcca
       61 gtgctgaggg ggcgcggcgc ggaggggcgc ggagccgggc ggctcagggg cccagagagt
      121 gcggcggccg agagcctgcc ggcccctgac agccccctcc ccccgtggaa gaccaggacg
      181 acgactacga aggcgcaagt catggcggag cagcgaagcc cgagagggcc ctgagcaccg
      241 ccgcatggag cgggacgaac ggccacctag cggaggggga ggcggcgggg gctcggcggg
      301 gttcctggag ccgcccgccg cgctccctcc gccgccgcgc aacggtttct gtcaggatga
      361 attggcagag cttgatccag gcactaatgg agagactgac agtttaacac ttggccaagg
      421 ccatatacct gtttccgtcc cagatgatcg agctgaacaa cgaacctgtc tcatctgtgg
      481 ggaccgcgct acgggcttgc actatgggat catctcctgc gagggctgca aggggttttt
      541 caagaggagc atttgcaaca aacgggtgta tcggtgcagt cgtgacaaga actgtgtcat
      601 gtcccggaag cagaggaaca gatgtcagta ctgccgcctg ctcaagtgtc tccagatggg
      661 catgaacagg aaggctatca gagaagatgg catgcctgga ggccggaaca agagcattgg
      721 accagtccag atatcagaag aagaaattga aagaatcatg tctggacagg agtttgagga
      781 agaagccaat cactggagca accatggtga cagcgaccac agttcccctg ggaacagggc
      841 ttcagagagc aaccagccct caccaggctc cacactatca tccagtaggt ctgtggaact
      901 aaatggattc atggcattca gggatcagta catggggatg tcagtgcctc cacattatca
      961 atacatacca caccttttta gctattctgg ccactcacca cttttgcccc cacaagctcg
     1021 aagcctggac cctcagtcct acagtctgat tcatcagctg atgtcagccg aagacctgga
     1081 gccattgggc acacctatgt tgattgaaga tgggtatgct gtgacacagg cagaactgtt
     1141 tgctctgctt tgccgcctgg ccgacgagtt gctctttagg cagattgcct ggatcaagaa
     1201 gctgcctttc ttctgcgagc tctcaatcaa ggattacacg tgcctcttga gctctacgtg
     1261 gcaggagtta atcctgctct cctccctcac agtgtacagc aagcagatct ttggggagct
     1321 ggctgatgtc acagccaagt actcaccctc tgatgaagaa ctccacagat ttagtgatga
     1381 agggatggag gtgattgaac gactcatcta cctatatcac aagttccatc agctgaaggt
     1441 cagcaacgag gagtacgcat gcatgaaagc aattaacttc ctgaatcaag atatcagggg
     1501 tctgaccagt gcctcacagc tggaacaact gaacaagcgg tattggtaca tttgtcagga
     1561 tttcactgaa tataaataca cacatcagcc aaaccgcttt cctgatctta tgatgtgctt
     1621 gccagagatc cgatacatcg caggcaagat ggtgaatgtg cccctggagc agctgcccct
     1681 cctctttaag gtggtgctgc actcctgcaa gacaagtacg gtgaaggagt gacctgtgcc
     1741 ctgcacctcc ttgggccacc cacagtgcct tgggtaggca gcacaggctc cagaggaaag
     1801 agccagagac caagatggag actgtggagc agctacctcc atcacaagaa gaatttgttt
     1861 gtttgtctgt ttttaacctc atttttctat atatttattt cacgacagag ttgaatgtat
     1921 ggccttcaac atgatgcaca tgcttttgtg tgaatgcagc agatgcattt ccttgcagtt
     1981 tacagaatgt gaagatgttt aatgttaccg tgttgtcatt gtttagagat aggttttttt
     2041 gtattttgag ggagagggta ggatggacta gatgagtatt tccataatgt tgacaaagac
     2101 aactacctca atggaaacag gtgtatgacc atccctacct tttccacatt ttctcagcag
     2161 atacacactt gtctgttaga gagcaaactg ccttttttat agccacagac ttctaagtaa
     2221 aagaagcaaa caaaggagcg aagtggtata gggagattta ctaatggcca gtgggacatc
     2281 tgagaggcaa tttgattttg atcatctcat cccacaagcc tgaagggcag aaactctgcc
     2341 ttaccttctg ctgcacccct cccccacacg ctgttgtctg ttgatgctgc tgtcaagttt
     2401 tcatccaggt agagtcctaa caataagcca gtatgtagga cttgcctccc agcgcccttg
     2461 tagctcatag ctgcctagtt tgctgttcta gatctaccaa ggcctacctt cttcagaccc
     2521 catccctacc tcttatgaat ttgacttcct gtcagtcctt tagaaaggga caggaaaatg
     2581 ccatgttctg aattctgatg ccatttctga tttgtttttt acattgtttc cctcaaaagg
     2641 tagaggggca aagaccaggc tgctgaaaga ataaagactt ctttggaagt cgctgttctc
     2701 acccaacctt atcctctgaa ccaaatccaa aatccaaaac tgccactttt aaacagtaga
     2761 aaggaccaga aactttgctg caaatttttg ttgtaagttc tcccattagt cccaaaatga
     2821 gatttgtttg ccagggtcta gaacagaaag tcaagaccca gagaagccca gctcttcctt
     2881 caagtattat cagggatcta acctaccaag gtttggaggg atggagccag aaagacctag
     2941 aaaggaaagg ggcattaaac tacctcatgt ttctaagggc taggctgctg ctctgcagct
     3001 gcagcctggg cccctgtgct ttactgccta ccccatctag ttctaggaag agtttttacc
     3061 ctccagactt tggccagacc aactaggttt gtcttagagc tgtttcagct gcttttccct
     3121 ttctttgtac caggctctcc taccactagt accccagaca catgctccac tggctggtat
     3181 ctcgtgctgg gtctgcctca cccacagtat cttttttagc ctgttttgtc aggaactgtt
     3241 tacacttccc cagtgaagcc tattaactta ccctggagac aacagcatcc tgtgcctcct
     3301 aggtagtgcc tccatttgtc agtttttctc tttagtgaaa tgatacaggt accagcaaag
     3361 tgacaatatg tcctttgatg tccaaagttc agaacattat ttcttctcat tcttattccc
     3421 cagccacttg agagagaaaa agttccagat agaatgtttt tcacgtttgt gggaagatat
     3481 atgtattgat gtgtctgttt ctgagctcac aatattttca tgtttgcctg aatttttata
     3541 tttaaccaac cagatcatgt tatttggctc tgggtcagat tctcagctgc tttcctcaag
     3601 ctagaaatca gagacacagt tcagagacag cacctctgtg cacacagcag ccttctttgc
     3661 ttagacttcc atttatcaaa ttggtacttt tttaaattgc ttttcaaatt agcattttac
     3721 ctgttgtgtt gaatgtcaaa gctctgatga gacaagaaca tatctttcca ataatgtagt
     3781 attaaacaga gcaagttgtt aatttgtaga gtgggggaaa ggttctgcaa gttgccattg
     3841 tacaaatcca tttttacaaa tgtttgcagc agattccaca gaacaaagag cccattcatt
     3901 gccaagagcc ctgcagaatc tctgagccaa gtggctgtgt gttccgagct ggagcctgac
     3961 ctgtggaccg cctttaatgt cttctgcacc cagtcctttt atgacatggg cttcttttaa
     4021 acagggtaaa gtaaatgggc tgctttgcaa actcaggtat tatgaggaga aggtaggagt
     4081 gtagctagca gcgtggagac attaggtcag ccactagatg tatttgtgat tttggtttga
     4141 aggacacaga gaaaggttgg aggaggaggt ttggtatgct tgttttttgc cttttttcct
     4201 ataatgtttg attaacaggc agccttttag ctagtggaag aaggaaaaac ttgtgcatgc
     4261 tatatctcat tcccccctct ctctctcctg tcctctctga tccagaccac caaaaatact
     4321 cactttgagt gagaattttt caaccataaa aacatatagc ccccaaagcc atgtggagaa
     4381 ggagagccca cctccttgca ctgtgctgaa acatagaggt ttccccctgc cttttcttat
     4441 gtatgctttc ttgacccaag gcagaagtgt ggagtcttag agctttgtaa ttcctgttct
     4501 ctggctccct ttaaaggcca tttttgtcct ttgcaaggtt tggtagtctc acccttagtt
     4561 cgatgaaatt ccctacaact cctctcaaag cactctacct gggtccggac acccagtccc
     4621 cagggccaac ctacaagtga aggagacagg tctctagggt agagggaagc aggcaggaac
     4681 ctccctgtcc tgatcttaga acagtggaag tgaagaacac cccacactct ctagctttag
     4741 aatactgggg ttttggtttt ggttttttaa attgcagttg ttttaagaaa ttcaaccttt
     4801 cagaccagcc cttccactaa actttgattc tttttcttta ctgctttttt aaacctaaaa
     4861 aaaaaaaaaa aagaaaaaaa aaggaaagaa agcaagcgca ctcagtgact cccccacctt
     4921 ggtctgtggg aatgcccgcc cgcactctgc cgtccatcct cctcccttct cctcatgcag
     4981 tgtctgtgaa gtagttttat ctgtttctta ggatgaaaaa cggcaatcat cccaccaggt
     5041 gctggaaact ggtcagcctt gaagcaggca cttctgggac cacagctcag ggatgtgtat
     5101 ttaattacag ggtccccaga aagcctctct tggctgccac aagtagcatc tttcctggac
     5161 ttggagtcag accctgacaa cttcctctga gtgagcagcc ccaggccact gaactgaacg
     5221 caagcttgcc tatgggtctg ggcttcctca agacttttga ccgtcttaca cgtgagcttc
     5281 tctagtgctc atgagaagcc tagacccttt gcccagggtc ttatctggca gtcctaagta
     5341 cacccagctc gcttgggtat cagctgtagg ctcaaatgga agctgtggga aaggctaagg
     5401 cctgctccaa acccaagaaa aatgtgctac tggtggaagc tagtcttcta acctggaagc
     5461 cagccaaagg gttctcttgc tctttgctga cctttttctt agccgaaata taataggtga
     5521 taatgttttt tactcaaatt tccatggggg aaaaaagact acctcttgag tgacatcctg
     5581 gtcgattcct ctctgaggag tcctgtggga aaagaatact gtagctcccg tgctgtttac
     5641 atgtttctgt cgggaatgaa accctggact gttgtgtttt tgtctgtgtt gccatcccag
     5701 gcctgtgata ggagcttgtg gctgtattgt aatgtctggg cagtgtctgg ggagtccttt
     5761 tcacctgccc aaatagggac aagccatcgc tagaagaggc ctccaccccc ttcctatgct
     5821 ccatagcttg gatttcaggg actctgatgg caagtgcatc atgaacctac ctcaggctac
     5881 ctcccagtcc tcccacagtc ctatgtagga atcgaatgaa tggatgtctc tgagcccttg
     5941 ttcccaaagg gccggccaag ggctgcctgc cagcctggct ccatcaaccc tgcatgacca
     6001 aatgatagtt ggcgggctct gcaggctgct caggccctct gctacctccc acacttgcct
     6061 gctggcaagg ggtgggccct gttctgtgaa ttgactacct gtggaaatgt gaccaattag
     6121 tatgaaatgc atgtttagca agtattaggt actgtatttg aaccaataaa tgtgaatcct
     6181 ctgca
//
