LOCUS       NM_030676               3720 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus nuclear receptor subfamily 5, group A, member 2
            (Nr5a2), transcript variant 1, mRNA.
ACCESSION   NM_030676 XM_990082
VERSION     NM_030676.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3720)
  AUTHORS   Festuccia,N., Vandormael-Pournin,S., Chervova,A., Geiselmann,A.,
            Langa-Vives,F., Coux,R.X., Gonzalez,I., Collet,G.G.,
            Cohen-Tannoudji,M. and Navarro,P.
  TITLE     Nr5a2 is dispensable for zygotic genome activation but essential
            for morula development
  JOURNAL   Science 386 (6717), eadg7325 (2024)
   PUBMED   39361745
  REMARK    GeneRIF: Nr5a2 is dispensable for zygotic genome activation but
            essential for morula development.
REFERENCE   2  (bases 1 to 3720)
  AUTHORS   Huang,X., Wei,L., Li,M., Zhang,Y., Kuang,S., Shen,Z., Liu,H. and
            Lin,Z.
  TITLE     Diabetic Macrophage Exosomal miR-381-3p Inhibits Epithelial Cell
            Autophagy Via NR5A2
  JOURNAL   Int Dent J 74 (4), 823-835 (2024)
   PUBMED   38685137
  REMARK    GeneRIF: Diabetic Macrophage Exosomal miR-381-3p Inhibits
            Epithelial Cell Autophagy Via NR5A2.
REFERENCE   3  (bases 1 to 3720)
  AUTHORS   Kobayashi,W., Sappler,A.H., Bollschweiler,D., Kummecke,M.,
            Basquin,J., Arslantas,E.N., Ruangroengkulrith,S., Hornberger,R.,
            Duderstadt,K. and Tachibana,K.
  TITLE     Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism
            by DNA minor groove anchor competition
  JOURNAL   Nat Struct Mol Biol 31 (5), 757-766 (2024)
   PUBMED   38409506
REFERENCE   4  (bases 1 to 3720)
  AUTHORS   Zhao,Y., Zhang,M., Liu,J., Hu,X., Sun,Y., Huang,X., Li,J. and
            Lei,L.
  TITLE     Nr5a2 ensures inner cell mass formation in mouse blastocyst
  JOURNAL   Cell Rep 43 (3), 113840 (2024)
   PUBMED   38386558
REFERENCE   5  (bases 1 to 3720)
  AUTHORS   Han,H.K., Mukherjee,S., Park,S.Y., Lee,J.H., Lee,E.H., Kim,S.,
            Lee,Y.H., Song,D.K., Lee,S., Bae,J.H. and Im,S.S.
  TITLE     Regulation of Betaine Homocysteine Methyltransferase by Liver
            Receptor Homolog-1 in the Methionine Cycle
  JOURNAL   Mol Cell Biol 44 (6), 245-258 (2024)
   PUBMED   38804232
  REMARK    GeneRIF: Regulation of Betaine Homocysteine Methyltransferase by
            Liver Receptor Homolog-1 in the Methionine Cycle.
REFERENCE   6  (bases 1 to 3720)
  AUTHORS   Chen,F., Ma,L., Dawson,P.A., Sinal,C.J., Sehayek,E., Gonzalez,F.J.,
            Breslow,J., Ananthanarayanan,M. and Shneider,B.L.
  TITLE     Liver receptor homologue-1 mediates species- and cell line-specific
            bile acid-dependent negative feedback regulation of the apical
            sodium-dependent bile acid transporter
  JOURNAL   J Biol Chem 278 (22), 19909-19916 (2003)
   PUBMED   12456679
  REMARK    GeneRIF: role in mediating species- and cell line-specific bile
            acid-dependent negative feedback regulation of the apical
            sodium-dependent bile acid transporter
REFERENCE   7  (bases 1 to 3720)
  AUTHORS   Suzuki,T., Kasahara,M., Yoshioka,H., Morohashi,K. and Umesono,K.
  TITLE     LXXLL-related motifs in Dax-1 have target specificity for the
            orphan nuclear receptors Ad4BP/SF-1 and LRH-1
  JOURNAL   Mol Cell Biol 23 (1), 238-249 (2003)
   PUBMED   12482977
  REMARK    GeneRIF: the specificities of LXXLL-related motifs in Dax-1 based
            on their amino acid sequences play an important role in regulation
            of orphan receptors.
REFERENCE   8  (bases 1 to 3720)
  AUTHORS   Pare,J.F., Roy,S., Galarneau,L. and Belanger,L.
  TITLE     The mouse fetoprotein transcription factor (FTF) gene promoter is
            regulated by three GATA elements with tandem E box and Nkx motifs,
            and FTF in turn activates the Hnf3beta, Hnf4alpha, and Hnf1alpha
            gene promoters
  JOURNAL   J Biol Chem 276 (16), 13136-13144 (2001)
   PUBMED   11145965
REFERENCE   9  (bases 1 to 3720)
  AUTHORS   Rausa,F.M., Galarneau,L., Belanger,L. and Costa,R.H.
  TITLE     The nuclear receptor fetoprotein transcription factor is
            coexpressed with its target gene HNF-3beta in the developing murine
            liver, intestine and pancreas
  JOURNAL   Mech Dev 89 (1-2), 185-188 (1999)
   PUBMED   10559496
REFERENCE   10 (bases 1 to 3720)
  AUTHORS   Galarneau,L., Pare,J.F., Allard,D., Hamel,D., Levesque,L.,
            Tugwood,J.D., Green,S. and Belanger,L.
  TITLE     The alpha1-fetoprotein locus is activated by a nuclear receptor of
            the Drosophila FTZ-F1 family
  JOURNAL   Mol Cell Biol 16 (7), 3853-3865 (1996)
   PUBMED   8668203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120182.8, BC137845.1 and AC124814.10.
            
            On May 13, 2009 this sequence version replaced NM_030676.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M81385.1, BC137845.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC120182.8         155392-155512
            122-2883            BC137845.1         1-2762
            2884-3720           AC124814.10        114082-114918
FEATURES             Location/Qualifiers
     source          1..3720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 59.98 cM"
     gene            1..3720
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /note="nuclear receptor subfamily 5, group A, member 2"
                     /db_xref="GeneID:26424"
                     /db_xref="MGI:MGI:1346834"
     exon            1..222
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1841
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /note="isoform 1 is encoded by transcript variant 1; liver
                     receptor homolog 1; fetoprotein transcription factor"
                     /codon_start=1
                     /product="nuclear receptor subfamily 5 group A member 2
                     isoform 1"
                     /protein_id="NP_109601.1"
                     /db_xref="CCDS:CCDS15328.1"
                     /db_xref="GeneID:26424"
                     /db_xref="MGI:MGI:1346834"
                     /translation="MSASLDTGDFQEFLKHGLTAIASAPGSETRHSPKREEQLREKRA
                     GLPDRHRRPIPARSRLVMLPKVETEAPGLVRSHGEQGQMPENMQVSQFKMVNYSYDED
                     LEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCP
                     YCRFKKCIDVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMS
                     QVIQAMPSDLTSAIQNIHSASKGLPLSHVALPPTDYDRSPFVTSPISMTMPPHSSLHG
                     YQPYGHFPSRAIKSEYPDPYSSSPESMMGYSYMDGYQTNSPASIPHLILELLKCEPDE
                     PQVQAKIMAYLQQEQSNRNRQEKLSAFGLLCKMADQTLFSIVEWARSSIFFRELKVDD
                     QMKLLQNCWSELLILDHIYRQVAHGKEGTIFLVTGEHVDYSTIISHTEVAFNNLLSLA
                     QELVVRLRSLQFDQREFVCLKFLVLFSSDVKNLENLQLVEGVQEQVNAALLDYTVCNY
                     PQQTEKFGQLLLRLPEIRAISKQAEDYLYYKHVNGDVPYNNLLIEMLHAKRA"
     exon            223..285
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /inference="alignment:Splign:2.1.0"
     exon            286..423
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /inference="alignment:Splign:2.1.0"
     exon            424..542
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /inference="alignment:Splign:2.1.0"
     exon            543..684
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /inference="alignment:Splign:2.1.0"
     exon            685..1325
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1445
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1593
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..3720
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2463..2468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /note="hexamer: TATAAA"
     polyA_site      2489
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /note="major polyA site"
     regulatory      2530..2535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /note="hexamer: AAGAAA"
     polyA_site      2546
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /note="major polyA site"
     regulatory      2756..2761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /note="hexamer: AATAAA"
     polyA_site      2783
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
     regulatory      3583..3588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /note="hexamer: AATAGA"
     regulatory      3608..3613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
                     /note="hexamer: AATATA"
     polyA_site      3609
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
     polyA_site      3626
                     /gene="Nr5a2"
                     /gene_synonym="D1Ertd308e; Ftf; LRH-1; mFTF; UF2-H3B"
ORIGIN      
        1 tgttttttcc ccctttttct taactttcac taaggaaatg agggttactg tagtctgagg
       61 tttccttccc aaagtcacaa aatatgacaa gctgcaatct ttctcacatt caatgatttc
      121 tgctgtaagc caaaggactg ccaataattt cgctaagaat gtctgctagt ttggatactg
      181 gagattttca agaatttctt aagcatggac ttacagctat tgcgtctgca ccagggtcag
      241 agactcgcca ctcccccaaa cgtgaggaac aactccggga aaaacgtgct gggcttccgg
      301 accgacaccg acgccccatt cccgcccgca gccgccttgt catgctgccc aaagtggaga
      361 cggaagcccc aggactggtc cgatcgcatg gggaacaggg gcagatgcca gaaaacatgc
      421 aagtgtctca atttaaaatg gtgaattact cctatgatga agatctggaa gagctatgtc
      481 ctgtgtgtgg cgataaagtg tctgggtacc attacggtct cctcacgtgc gaaagctgca
      541 agggtttttt taagcgaact gtccaaaacc aaaaaaggta cacgtgcata gagaaccaga
      601 attgccaaat tgacaaaacg cagagaaaac gatgtcccta ctgtcgattc aaaaaatgta
      661 tcgatgttgg gatgaagctg gaagccgtaa gagccgaccg catgcgaggg ggcagaaata
      721 agtttgggcc aatgtacaag agagacaggg ctttgaagca gcagaagaaa gccctcattc
      781 gagccaatgg acttaagctg gaagccatgt ctcaggtgat ccaagcaatg ccctcagacc
      841 tgacctctgc aattcagaac attcattccg cctccaaagg cctacctctg agccatgtag
      901 ccttgcctcc gacagactat gacagaagtc cctttgtcac atctcccatt agcatgacaa
      961 tgccacctca cagcagcctg catggttacc aaccctatgg tcactttcct agtcgggcca
     1021 tcaagtctga gtacccagac ccctactcca gctcacctga gtcaatgatg ggttactcct
     1081 acatggatgg ttaccagaca aactccccgg ccagcatccc acacctgata ctggaacttt
     1141 tgaagtgtga accagatgag cctcaagttc aagcgaagat catggcttac ctccagcaag
     1201 agcagagtaa ccgaaacagg caagaaaagc tgagcgcatt tgggctttta tgcaaaatgg
     1261 cggaccagac cctgttctcc attgttgagt gggccaggag tagtatcttc ttcagggaac
     1321 tgaaggttga tgaccaaatg aagctgcttc aaaactgctg gagtgagctc ttgattctcg
     1381 atcacattta ccgacaagtg gcgcatggga aggaagggac aatcttcctg gttactggag
     1441 aacacgtgga ctactccacc atcatctcac acacagaagt cgcgttcaac aacctcctga
     1501 gtctcgcaca ggagctggtg gtgaggctcc gttcccttca gttcgatcag cgggagtttg
     1561 tatgtctcaa gttcctggtg ctgttcagct cagatgtgaa gaacctggag aacctgcagc
     1621 tggtggaagg tgtccaagag caggtgaatg ccgccctgct ggactacacg gtttgcaact
     1681 acccacaaca gactgagaaa ttcggacagc tacttcttcg gctacccgag atccgggcaa
     1741 tcagcaagca ggcagaagac tacctgtact ataagcacgt gaacggggat gtgccctata
     1801 ataacctcct cattgagatg ctgcatgcca aaagagccta agtccccacc cctggaagct
     1861 tgctctagga acacagactg gaaggagaag aggaggacga tgacagaaac acaatactct
     1921 gaactgctcc aagcaatgct aattataaac ttggtttaaa gacactgaat tttaaaagca
     1981 taataattaa atacctaata gcaaataaat gatatatcag ggtatttgta ctgcaaactg
     2041 tgaatcaaag gctgtatgaa tcaaaggatt catatgaaag acattgtaat ggggtggatt
     2101 gaacttacag atggagacca ataccacagc agaataaaaa tggacagaac aatccttgta
     2161 tatttaaact aatctgctat taagaaattc agaagttgat ctctgttatt aattggattt
     2221 gtcctgaatt actccgtggt gacgctgaac aactcaagaa tacatgggct gtgccttggc
     2281 agcccctccc catccctccc accaccacca cccccacccc cacaaggccc tataccttct
     2341 gacctgtgag ccctgaagct attttaagga cttctgttca gccataccca gtagtagctc
     2401 cactaaacca tgatttctgg atgtctgtgt cttagacctg ccaacagcta ataagaacaa
     2461 tgtataaata tgtcagcttg cattttaaat atgtgctgaa gtttgttttg tcgtgtgttc
     2521 gtaattaaaa agaaaacggg cagtaaccct cttctatata agcattagtt aatattaagg
     2581 gaaatcaaac aaatctaagc caatactccc aacaagcaag ttagatctta cttctgctgc
     2641 tgttgctgaa atgtggcttt ggcatggttg ggtttcataa aactttttgg ccaagaggct
     2701 tgttagtata catccatctg tttagtcatc aaggtttgta gttcacttaa aaaaaaataa
     2761 accactagac atcttttgct gaatgtcaaa tagtcacagt ctaagtagcc aaaaagtcaa
     2821 agcgtgttaa acattgccaa atgaaggaaa gggtgagctg caaaggggat ggttcgaggt
     2881 tcattccagt tgtgacccga gcgtccccaa aacctgggat gcaaagacag tgattctgca
     2941 tatggcctgg aaagacagga aagccagtct cctacaaagg ggaatggaag atcctggcct
     3001 ctaagtcata gaccaaagtc tgctgtagaa caaaaaaaaa aatactggag ggcagagata
     3061 gcaaaccaag tctccaaaca atgctgtcag tattagcatg cggtgccgtg ggcatggaaa
     3121 ccttgcctta cttcctggtc ctaaaaggga gctgtgcaga tgtggatcaa catttgttga
     3181 aaataaagta ttaatacttt aaaagtcaaa taaaatatag tgtttacatt ctttaggtcc
     3241 tgggaggagt tggggggggg ggactctgat aatacagata gtaaaagcag taatttcttt
     3301 aatgttattt ttctggttag taattatttt taacagtact taattactgt atgtcgtgag
     3361 acactaaaat caaaaatggg actctcattt tgtctttatt tgttaagatt accagcagca
     3421 caatcatttg tagaaactgt ataaaaaaaa tctcctggtc ccttaatttt tttccacaaa
     3481 tgtttctggc tttggaatag tttatttata ttgtatatca tagtttcaac tatagacaat
     3541 tacaatgcta atttattgtt ccttgggttc ccctttgtat aaaatagagc caagactgaa
     3601 gaaaccaaat atatgtgttt actatagcat gtcttcaagt tagtgaaaca tagttcaggg
     3661 gtatagaagg gtcttaatga ttaaaaccat ccacttgatt acatgtctca aaactcccac
//
