LOCUS       NM_139051               2947 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus nuclear receptor subfamily 5, group A, member 1
            (Nr5a1), transcript variant 2, mRNA.
ACCESSION   NM_139051
VERSION     NM_139051.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2947)
  AUTHORS   Kay,R.G.G., Reeves,R., Siggers,P., Greenaway,S., Mallon,A.M.,
            Wells,S., Koo,B.K., Mayere,C., Nef,S., Greenfield,A. and Simon,M.M.
  TITLE     Gonadal sex reversal at single-cell resolution in Znrf3-deficient
            mice
  JOURNAL   Development 151 (23) (2024)
   PUBMED   39629665
REFERENCE   2  (bases 1 to 2947)
  AUTHORS   Fujiki,J., Maeda,N., Yamaguchi,K., Ohtsuki,Y. and Iwano,H.
  TITLE     DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR
            transcripts in C2C12 myoblasts
  JOURNAL   Mol Cell Endocrinol 593, 112336 (2024)
   PUBMED   39094930
  REMARK    GeneRIF: DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR
            transcripts in C2C12 myoblasts.
REFERENCE   3  (bases 1 to 2947)
  AUTHORS   Diawara,M. and Martin,L.J.
  TITLE     The transcription factors NR5A1 and JUNB cooperate to activate the
            Axl promoter in mouse Sertoli cell lines
  JOURNAL   Mol Biol Rep 51 (1), 982 (2024)
   PUBMED   39271559
  REMARK    GeneRIF: The transcription factors NR5A1 and JUNB cooperate to
            activate the Axl promoter in mouse Sertoli cell lines.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2947)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   5  (bases 1 to 2947)
  AUTHORS   Tagami,A., Ikeda,Y., Ishizuka,K. and Maekawa,M.
  TITLE     Conditional disruption of Nr5a1 directed by Sox9-Cre impairs
            adrenal development
  JOURNAL   Sci Rep 14 (1), 12297 (2024)
   PUBMED   38811798
  REMARK    GeneRIF: Conditional disruption of Nr5a1 directed by Sox9-Cre
            impairs adrenal development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2947)
  AUTHORS   Sadovsky,Y., Crawford,P.A., Woodson,K.G., Polish,J.A.,
            Clements,M.A., Tourtellotte,L.M., Simburger,K. and Milbrandt,J.
  TITLE     Mice deficient in the orphan receptor steroidogenic factor 1 lack
            adrenal glands and gonads but express P450 side-chain-cleavage
            enzyme in the placenta and have normal embryonic serum levels of
            corticosteroids
  JOURNAL   Proc Natl Acad Sci U S A 92 (24), 10939-10943 (1995)
   PUBMED   7479914
REFERENCE   7  (bases 1 to 2947)
  AUTHORS   Swift,S. and Ashworth,A.
  TITLE     The mouse Ftzf1 gene required for gonadal and adrenal development
            maps to mouse chromosome 2
  JOURNAL   Genomics 28 (3), 609-610 (1995)
   PUBMED   7490110
REFERENCE   8  (bases 1 to 2947)
  AUTHORS   Keeney,D.S., Ikeda,Y., Waterman,M.R. and Parker,K.L.
  TITLE     Cholesterol side-chain cleavage cytochrome P450 gene expression in
            the primitive gut of the mouse embryo does not require
            steroidogenic factor 1
  JOURNAL   Mol Endocrinol 9 (8), 1091-1098 (1995)
   PUBMED   7476982
REFERENCE   9  (bases 1 to 2947)
  AUTHORS   Lala,D.S., Rice,D.A. and Parker,K.L.
  TITLE     Steroidogenic factor I, a key regulator of steroidogenic enzyme
            expression, is the mouse homolog of fushi tarazu-factor I
  JOURNAL   Mol Endocrinol 6 (8), 1249-1258 (1992)
   PUBMED   1406703
REFERENCE   10 (bases 1 to 2947)
  AUTHORS   Tsukiyama,T., Ueda,H., Hirose,S. and Niwa,O.
  TITLE     Embryonal long terminal repeat-binding protein is a murine homolog
            of FTZ-F1, a member of the steroid receptor superfamily
  JOURNAL   Mol Cell Biol 12 (3), 1286-1291 (1992)
   PUBMED   1545809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134378.1.
            
            On Apr 11, 2007 this sequence version replaced NM_139051.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134378.1, AK156911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2947              AK134378.1         2-2948
FEATURES             Location/Qualifiers
     source          1..2947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.42 cM"
     gene            1..2947
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /note="nuclear receptor subfamily 5, group A, member 1"
                     /db_xref="GeneID:26423"
                     /db_xref="MGI:MGI:1346833"
     exon            1..186
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            187..303
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1590
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /note="embryonal LTR-binding protein; fushi tarazu factor
                     homolog 1; steroid hormone receptor Ad4BP; steroid
                     hydroxylase positive regulator; embryonal long terminal
                     repeat-binding protein; adrenal 4-binding protein; fushi
                     tarazu 1 factor homolog"
                     /codon_start=1
                     /product="steroidogenic factor 1"
                     /protein_id="NP_620639.1"
                     /db_xref="CCDS:CCDS16011.1"
                     /db_xref="GeneID:26423"
                     /db_xref="MGI:MGI:1346833"
                     /translation="MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNN
                     KHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRD
                     RALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGP
                     LGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPF
                     SGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRSDQPAPFSLLCRMADQTFIS
                     IVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVEL
                     STVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVK
                     DAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRN
                     NLLIEMLQAKQT"
     exon            304..445
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..1074
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1194
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1342
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..2947
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2925..2930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /note="putative"
     polyA_site      2947
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /note="putative"
ORIGIN      
        1 gaggggagga ggaaaggacg atcggacagg gccagtttcc agtccgccgc tgcccgcccg
       61 ctgctgggtg aagaagtttc tgagagcccg ctagccactg ccctacctga ggcctgggag
      121 cctccccacc aggaccctgg tgtccagtgt ccacccttat ccggctgaga attctccttc
      181 cgttcagcgg acgccgcggg catggactat tcgtacgacg aggacctgga cgagctgtgt
      241 ccagtgtgtg gtgacaaggt gtcgggctac cactacgggc tgctcacgtg cgagagctgc
      301 aagggcttct tcaagcgcac agtccagaac aacaagcatt acacgtgcac cgagagtcag
      361 agctgcaaaa tcgacaagac gcagcgtaag cgctgtccct tctgccgctt ccagaagtgc
      421 ctgacggtgg gcatgcgcct ggaagctgtg cgtgctgatc gaatgcgggg tggccggaac
      481 aagtttgggc ccatgtacaa gagagaccgg gccttgaagc agcagaagaa agcacagatt
      541 cgggccaatg gcttcaagct ggagaccgga ccaccgatgg gggtgccccc gccaccccct
      601 cccccaccgg actacatgtt accccctagc ctgcacgcac cggagcccaa ggccctggtc
      661 tctggcccac ccagtgggcc gctgggtgac tttggagccc catctctacc catggctgtg
      721 cctggtcccc acggacctct ggctggctac ctctatcctg ccttctctaa ccgcaccatc
      781 aagtctgagt atccagagcc ctatgccagc cccccacaac agccagggcc accctacagc
      841 tatccagagc ccttctcagg agggcccaat gtaccagagc tcatattgca gctgctgcaa
      901 ctagagccag aggaggacca ggtgcgcgct cgcatcgtgg gctgtctgca ggagccagcc
      961 aaaagccgct ctgaccagcc agcgcccttc agcctcctct gcagaatggc cgaccagacc
     1021 tttatctcca ttgtcgactg ggcacgaagg tgcatggtct ttaaggagct ggaggtggct
     1081 gaccagatga cactgctgca gaactgttgg agcgagctgc tggtgttgga ccacatctac
     1141 cgccaggtcc agtacggcaa ggaagacagc atcctgctgg ttactggaca ggaggtggag
     1201 ctgagcacag tggctgtgca ggctggctcc ctgctgcaca gcctggtgct gcgggcccaa
     1261 gagttagtgc tccagttgca tgcactgcag ctggaccgcc aggagttcgt ctgtctcaag
     1321 ttcctcatcc tcttcagcct cgatgtgaaa ttcctgaaca accacagcct cgtaaaggac
     1381 gcccaggaaa aggccaacgc tgccctgttg gattacacct tgtgtcacta cccacactgc
     1441 ggggacaaat tccagcagtt gctattgtgc ctggtggagg tgcgggccct gagcatgcag
     1501 gccaaggagt acctgtacca caagcatttg ggcaacgaga tgccccgcaa caaccttctc
     1561 attgagatgc tgcaggccaa gcagacttga gcctgggtgc caggcagcgg gcaataggca
     1621 gggatgccac tgcctccaaa agactccttg cattaggtga tccaggagcc ctgtcactaa
     1681 gcccctgccc ctgagctcca gagctgtgtg tttgggcaag gatgggcggg gattggccgg
     1741 ggcaggttgc ctttactagc cattggcctg tgtccgccac ttggagtgcc ccaaaggggg
     1801 cttctaacca ttccttcctc catcagcccc cagctttttt tcctggtatc tgaggtccca
     1861 ggaggaggct caggattccc tggtgggtct ggatgtccct tgggtcagag gtcatccttt
     1921 ccctctctcc tgttatcaga ggcaaaggaa ggtctacagg catcaatgag ggcaaaggag
     1981 ggggtctcca gactccactg aagcaggaag tccactgttg taaactgagt ttgctaaatt
     2041 gggtccccag aggataccat gagagtgggt agggcaaaaa gagccctttc cgccctctac
     2101 ccatctaatt ctgatcctct acctgtagga ggactttggt gtgatcatcc ttctcccagg
     2161 gcccggctac ccagggagga ggagtctggt gtagccaaca ttcctgccct aaccctgccc
     2221 atcaccagct ggctgggctg gtatttatct gcaaggttga agtcactggg attcttttcc
     2281 tttcacctag atagtccttg gaaagtgtgt gagagagaag tgggcaggag acagactggg
     2341 gactgagctg ggatatgggg actagcatca aagctttctc ctgacatctc tttccaagag
     2401 tcggggtggc atctgtaccc cacctcaccc ccgagaagtg ctattgcttg ccctctgcct
     2461 cagccccact aggggaacaa caggaggcct gctggggctt agagtccgtg caggtgggga
     2521 tatgggtaaa tctaggagaa ctcacagatc tttatatgag gacagtgctg aggactttct
     2581 catggctcca tccttttggt ccctcgccac tacccttgaa gctggcttca gttccctggc
     2641 tgctgctttg cctcctgaaa gccactctgt aggaccaagc actcggggga gaggcctaag
     2701 ccatcctctg ttccagactg gacatccact gtctttcctg ctttcgcgtc agatttacag
     2761 cttatgctag gcccacccaa ctggacaagg ctgtctcctg tcttctacta ccctggctca
     2821 gcccccacct ctgcccctga aatgcgtgct cccaccaagg ccagagaccc acagccccaa
     2881 gacaagaagt gcccttataa acccctgcag ccctgcagcc ctgaaataaa ttttgcaatt
     2941 agtttcc
//
