LOCUS       NM_001316687            2994 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus nuclear receptor subfamily 5, group A, member 1
            (Nr5a1), transcript variant 1, mRNA.
ACCESSION   NM_001316687 XM_006498062
VERSION     NM_001316687.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2994)
  AUTHORS   Kay,R.G.G., Reeves,R., Siggers,P., Greenaway,S., Mallon,A.M.,
            Wells,S., Koo,B.K., Mayere,C., Nef,S., Greenfield,A. and Simon,M.M.
  TITLE     Gonadal sex reversal at single-cell resolution in Znrf3-deficient
            mice
  JOURNAL   Development 151 (23) (2024)
   PUBMED   39629665
REFERENCE   2  (bases 1 to 2994)
  AUTHORS   Fujiki,J., Maeda,N., Yamaguchi,K., Ohtsuki,Y. and Iwano,H.
  TITLE     DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR
            transcripts in C2C12 myoblasts
  JOURNAL   Mol Cell Endocrinol 593, 112336 (2024)
   PUBMED   39094930
  REMARK    GeneRIF: DNA methylation of Ad4BP/SF-1 suppresses Cyp11a1 and StAR
            transcripts in C2C12 myoblasts.
REFERENCE   3  (bases 1 to 2994)
  AUTHORS   Diawara,M. and Martin,L.J.
  TITLE     The transcription factors NR5A1 and JUNB cooperate to activate the
            Axl promoter in mouse Sertoli cell lines
  JOURNAL   Mol Biol Rep 51 (1), 982 (2024)
   PUBMED   39271559
  REMARK    GeneRIF: The transcription factors NR5A1 and JUNB cooperate to
            activate the Axl promoter in mouse Sertoli cell lines.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2994)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   5  (bases 1 to 2994)
  AUTHORS   Tagami,A., Ikeda,Y., Ishizuka,K. and Maekawa,M.
  TITLE     Conditional disruption of Nr5a1 directed by Sox9-Cre impairs
            adrenal development
  JOURNAL   Sci Rep 14 (1), 12297 (2024)
   PUBMED   38811798
  REMARK    GeneRIF: Conditional disruption of Nr5a1 directed by Sox9-Cre
            impairs adrenal development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2994)
  AUTHORS   Sadovsky,Y., Crawford,P.A., Woodson,K.G., Polish,J.A.,
            Clements,M.A., Tourtellotte,L.M., Simburger,K. and Milbrandt,J.
  TITLE     Mice deficient in the orphan receptor steroidogenic factor 1 lack
            adrenal glands and gonads but express P450 side-chain-cleavage
            enzyme in the placenta and have normal embryonic serum levels of
            corticosteroids
  JOURNAL   Proc Natl Acad Sci U S A 92 (24), 10939-10943 (1995)
   PUBMED   7479914
REFERENCE   7  (bases 1 to 2994)
  AUTHORS   Swift,S. and Ashworth,A.
  TITLE     The mouse Ftzf1 gene required for gonadal and adrenal development
            maps to mouse chromosome 2
  JOURNAL   Genomics 28 (3), 609-610 (1995)
   PUBMED   7490110
REFERENCE   8  (bases 1 to 2994)
  AUTHORS   Keeney,D.S., Ikeda,Y., Waterman,M.R. and Parker,K.L.
  TITLE     Cholesterol side-chain cleavage cytochrome P450 gene expression in
            the primitive gut of the mouse embryo does not require
            steroidogenic factor 1
  JOURNAL   Mol Endocrinol 9 (8), 1091-1098 (1995)
   PUBMED   7476982
REFERENCE   9  (bases 1 to 2994)
  AUTHORS   Lala,D.S., Rice,D.A. and Parker,K.L.
  TITLE     Steroidogenic factor I, a key regulator of steroidogenic enzyme
            expression, is the mouse homolog of fushi tarazu-factor I
  JOURNAL   Mol Endocrinol 6 (8), 1249-1258 (1992)
   PUBMED   1406703
REFERENCE   10 (bases 1 to 2994)
  AUTHORS   Tsukiyama,T., Ueda,H., Hirose,S. and Niwa,O.
  TITLE     Embryonal long terminal repeat-binding protein is a murine homolog
            of FTZ-F1, a member of the steroid receptor superfamily
  JOURNAL   Mol Cell Biol 12 (3), 1286-1291 (1992)
   PUBMED   1545809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844842.29, AK134378.1 and CD348290.1.
            
            On Oct 22, 2015 this sequence version replaced XM_006498062.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               AL844842.29        119612-119840       c
            230-2990            AK134378.1         188-2948
            2991-2994           CD348290.1         784-787
FEATURES             Location/Qualifiers
     source          1..2994
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.42 cM"
     gene            1..2994
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /note="nuclear receptor subfamily 5, group A, member 1"
                     /db_xref="GeneID:26423"
                     /db_xref="MGI:MGI:1346833"
     exon            1..229
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            230..346
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1633
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /note="embryonal LTR-binding protein; fushi tarazu factor
                     homolog 1; steroid hormone receptor Ad4BP; steroid
                     hydroxylase positive regulator; embryonal long terminal
                     repeat-binding protein; adrenal 4-binding protein; fushi
                     tarazu 1 factor homolog"
                     /codon_start=1
                     /product="steroidogenic factor 1"
                     /protein_id="NP_001303616.1"
                     /db_xref="CCDS:CCDS16011.1"
                     /db_xref="GeneID:26423"
                     /db_xref="MGI:MGI:1346833"
                     /translation="MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNN
                     KHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRD
                     RALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGP
                     LGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPF
                     SGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRSDQPAPFSLLCRMADQTFIS
                     IVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVEL
                     STVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVK
                     DAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRN
                     NLLIEMLQAKQT"
     exon            347..488
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..1117
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1237
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1385
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..2994
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2968..2973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /note="hexamer: AATAAA"
     polyA_site      2994
                     /gene="Nr5a1"
                     /gene_synonym="Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1;
                     SF1; STF-1"
                     /note="major polyA site"
ORIGIN      
        1 gcatatagag cggccacccc ggccccgcgc ggcgggttcg cgaagcgcgc agtgcggcgg
       61 aggggcccgg gtcccaggtg cgcctcgagc agccccgcgg gcggcgggcg cggggaggcg
      121 ggggcagagc gggacggtct ccccgccctc ggcccgagtg gccgtcattg cgggcgggcg
      181 gcgctgagcc cgggtgcggc ttcatcgcgg gcggcggcgc ggccaaaagg cggacgccgc
      241 gggcatggac tattcgtacg acgaggacct ggacgagctg tgtccagtgt gtggtgacaa
      301 ggtgtcgggc taccactacg ggctgctcac gtgcgagagc tgcaagggct tcttcaagcg
      361 cacagtccag aacaacaagc attacacgtg caccgagagt cagagctgca aaatcgacaa
      421 gacgcagcgt aagcgctgtc ccttctgccg cttccagaag tgcctgacgg tgggcatgcg
      481 cctggaagct gtgcgtgctg atcgaatgcg gggtggccgg aacaagtttg ggcccatgta
      541 caagagagac cgggccttga agcagcagaa gaaagcacag attcgggcca atggcttcaa
      601 gctggagacc ggaccaccga tgggggtgcc cccgccaccc cctcccccac cggactacat
      661 gttaccccct agcctgcacg caccggagcc caaggccctg gtctctggcc cacccagtgg
      721 gccgctgggt gactttggag ccccatctct acccatggct gtgcctggtc cccacggacc
      781 tctggctggc tacctctatc ctgccttctc taaccgcacc atcaagtctg agtatccaga
      841 gccctatgcc agccccccac aacagccagg gccaccctac agctatccag agcccttctc
      901 aggagggccc aatgtaccag agctcatatt gcagctgctg caactagagc cagaggagga
      961 ccaggtgcgc gctcgcatcg tgggctgtct gcaggagcca gccaaaagcc gctctgacca
     1021 gccagcgccc ttcagcctcc tctgcagaat ggccgaccag acctttatct ccattgtcga
     1081 ctgggcacga aggtgcatgg tctttaagga gctggaggtg gctgaccaga tgacactgct
     1141 gcagaactgt tggagcgagc tgctggtgtt ggaccacatc taccgccagg tccagtacgg
     1201 caaggaagac agcatcctgc tggttactgg acaggaggtg gagctgagca cagtggctgt
     1261 gcaggctggc tccctgctgc acagcctggt gctgcgggcc caagagttag tgctccagtt
     1321 gcatgcactg cagctggacc gccaggagtt cgtctgtctc aagttcctca tcctcttcag
     1381 cctcgatgtg aaattcctga acaaccacag cctcgtaaag gacgcccagg aaaaggccaa
     1441 cgctgccctg ttggattaca ccttgtgtca ctacccacac tgcggggaca aattccagca
     1501 gttgctattg tgcctggtgg aggtgcgggc cctgagcatg caggccaagg agtacctgta
     1561 ccacaagcat ttgggcaacg agatgccccg caacaacctt ctcattgaga tgctgcaggc
     1621 caagcagact tgagcctggg tgccaggcag cgggcaatag gcagggatgc cactgcctcc
     1681 aaaagactcc ttgcattagg tgatccagga gccctgtcac taagcccctg cccctgagct
     1741 ccagagctgt gtgtttgggc aaggatgggc ggggattggc cggggcaggt tgcctttact
     1801 agccattggc ctgtgtccgc cacttggagt gccccaaagg gggcttctaa ccattccttc
     1861 ctccatcagc ccccagcttt ttttcctggt atctgaggtc ccaggaggag gctcaggatt
     1921 ccctggtggg tctggatgtc ccttgggtca gaggtcatcc tttccctctc tcctgttatc
     1981 agaggcaaag gaaggtctac aggcatcaat gagggcaaag gagggggtct ccagactcca
     2041 ctgaagcagg aagtccactg ttgtaaactg agtttgctaa attgggtccc cagaggatac
     2101 catgagagtg ggtagggcaa aaagagccct ttccgccctc tacccatcta attctgatcc
     2161 tctacctgta ggaggacttt ggtgtgatca tccttctccc agggcccggc tacccaggga
     2221 ggaggagtct ggtgtagcca acattcctgc cctaaccctg cccatcacca gctggctggg
     2281 ctggtattta tctgcaaggt tgaagtcact gggattcttt tcctttcacc tagatagtcc
     2341 ttggaaagtg tgtgagagag aagtgggcag gagacagact ggggactgag ctgggatatg
     2401 gggactagca tcaaagcttt ctcctgacat ctctttccaa gagtcggggt ggcatctgta
     2461 ccccacctca cccccgagaa gtgctattgc ttgccctctg cctcagcccc actaggggaa
     2521 caacaggagg cctgctgggg cttagagtcc gtgcaggtgg ggatatgggt aaatctagga
     2581 gaactcacag atctttatat gaggacagtg ctgaggactt tctcatggct ccatcctttt
     2641 ggtccctcgc cactaccctt gaagctggct tcagttccct ggctgctgct ttgcctcctg
     2701 aaagccactc tgtaggacca agcactcggg ggagaggcct aagccatcct ctgttccaga
     2761 ctggacatcc actgtctttc ctgctttcgc gtcagattta cagcttatgc taggcccacc
     2821 caactggaca aggctgtctc ctgtcttcta ctaccctggc tcagccccca cctctgcccc
     2881 tgaaatgcgt gctcccacca aggccagaga cccacagccc caagacaaga agtgccctta
     2941 taaacccctg cagccctgca gccctgaaat aaattttgca attagtttcc agta
//
