LOCUS       NM_015743               5573 bp    mRNA    linear   ROD 08-FEB-2024
DEFINITION  Mus musculus nuclear receptor subfamily 4, group A, member 3
            (Nr4a3), transcript variant 1, mRNA.
ACCESSION   NM_015743 XM_006537655
VERSION     NM_015743.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5573)
  AUTHORS   Martinez-Gonzalez,J., Canes,L., Alonso,J., Ballester-Servera,C.,
            Rodriguez-Sinovas,A., Corrales,I. and Rodriguez,C.
  TITLE     NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular
            Remodeling, and Beyond
  JOURNAL   Int J Mol Sci 22 (21), 11371 (2021)
   PUBMED   34768801
  REMARK    GeneRIF: NR4A3: A Key Nuclear Receptor in Vascular Biology,
            Cardiovascular Remodeling, and Beyond.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5573)
  AUTHORS   Mirra,S., Garcia-Arroyo,R., B Domenech,E., Gavalda-Navarro,A.,
            Herrera-Ubeda,C., Oliva,C., Garcia-Fernandez,J., Artuch,R.,
            Villarroya,F. and Marfany,G.
  TITLE     CERKL, a retinal dystrophy gene, regulates mitochondrial function
            and dynamics in the mammalian retina
  JOURNAL   Neurobiol Dis 156, 105405 (2021)
   PUBMED   34048907
REFERENCE   3  (bases 1 to 5573)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5573)
  AUTHORS   Wilkerson,B.A., Zebroski,H.L., Finkbeiner,C.R., Chitsazan,A.D.,
            Beach,K.E., Sen,N., Zhang,R.C. and Bermingham-McDonogh,O.
  TITLE     Novel cell types and developmental lineages revealed by single-cell
            RNA-seq analysis of the mouse crista ampullaris
  JOURNAL   Elife 10, e60108 (2021)
   PUBMED   34003106
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5573)
  AUTHORS   Sekiya,T., Kagawa,S., Masaki,K., Fukunaga,K., Yoshimura,A. and
            Takaki,S.
  TITLE     Regulation of peripheral Th/Treg differentiation and suppression of
            airway inflammation by Nr4a transcription factors
  JOURNAL   iScience 24 (3), 102166 (2021)
   PUBMED   33665581
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5573)
  AUTHORS   Kulkarni,N.H., Karavanich,C.A., Atchley,W.R. and Anholt,R.R.
  TITLE     Characterization and differential expression of a human gene family
            of olfactomedin-related proteins
  JOURNAL   Genet Res 76 (1), 41-50 (2000)
   PUBMED   11006633
REFERENCE   7  (bases 1 to 5573)
  AUTHORS   Maltais,A. and Labelle,Y.
  TITLE     Structure and expression of the mouse gene encoding the orphan
            nuclear receptor TEC
  JOURNAL   DNA Cell Biol 19 (2), 121-130 (2000)
   PUBMED   10701778
REFERENCE   8  (bases 1 to 5573)
  AUTHORS   Maira,M., Martens,C., Philips,A. and Drouin,J.
  TITLE     Heterodimerization between members of the Nur subfamily of orphan
            nuclear receptors as a novel mechanism for gene activation
  JOURNAL   Mol Cell Biol 19 (11), 7549-7557 (1999)
   PUBMED   10523643
REFERENCE   9  (bases 1 to 5573)
  AUTHORS   Cheng,L.E., Chan,F.K., Cado,D. and Winoto,A.
  TITLE     Functional redundancy of the Nur77 and Nor-1 orphan steroid
            receptors in T-cell apoptosis
  JOURNAL   EMBO J 16 (8), 1865-1875 (1997)
   PUBMED   9155013
REFERENCE   10 (bases 1 to 5573)
  AUTHORS   Zetterstrom,R.H., Solomin,L., Mitsiadis,T., Olson,L. and
            Perlmann,T.
  TITLE     Retinoid X receptor heterodimerization and developmental expression
            distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1
  JOURNAL   Mol Endocrinol 10 (12), 1656-1666 (1996)
   PUBMED   8961274
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC038520.1, BC068150.1,
            AL683893.26 and AI606940.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_015743.4.
            
            On or before Apr 28, 2015 this sequence version replaced
            XM_006537655.2, NM_015743.2.
            
            Summary: This gene encodes a member of the NR4A subfamily of
            nuclear hormone receptors that bind to DNA and modulate gene
            expression. The encoded protein has been implicated in T and B
            lymphocyte apoptosis, and immune cell proliferation. Mice lacking
            the encoded protein exhibit partial bidirectional circling behavior
            and inner ear dysfunction. Disruption of this gene in mice also
            results in defective hippocampal axonal growth and postnatal
            neuronal cell death. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068150.1, SRR10662772.2522819.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BC038520.1         75-78
            5-4354              BC068150.1         1-4350
            4355-4355           AL683893.26        103558-103558
            4356-5568           BC068150.1         4352-5564
            5569-5573           AI606940.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..5573
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.07 cM"
     gene            1..5573
                     /gene="Nr4a3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR-1; Nor1; TEC"
                     /note="nuclear receptor subfamily 4, group A, member 3"
                     /db_xref="GeneID:18124"
                     /db_xref="MGI:MGI:1352457"
     exon            1..412
                     /gene="Nr4a3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR-1; Nor1; TEC"
                     /inference="alignment:Splign:2.1.0"
     exon            413..589
                     /gene="Nr4a3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR-1; Nor1; TEC"
                     /inference="alignment:Splign:2.1.0"
     exon            590..1545
                     /gene="Nr4a3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR-1; Nor1; TEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1675
                     /gene="Nr4a3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR-1; Nor1; TEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1848
                     /gene="Nr4a3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR-1; Nor1; TEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2048
                     /gene="Nr4a3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR-1; Nor1; TEC"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2227
                     /gene="Nr4a3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR-1; Nor1; TEC"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..5569
                     /gene="Nr4a3"
                     /gene_synonym="CHN; CSMF; MINOR; NOR-1; Nor1; TEC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacacgcgcg ctcacacgct ccgcacacac actccactct ctcccgcgcg ctcacacccc
       61 tctcacccgg ctccctcgcc agtgtcgcgc cgcgccgcgc cgcagccgga cgcccctcca
      121 gggctcactt tgcaacgctg acagagcccg cagtgtccgt ggaggtggga aacgtggcga
      181 catcctaccc cctggtcgca gccggagact ggatgcctgc ggaacctctc ggcggcgctc
      241 tcccatgagt tgggatcgca gcatcccccg ccagccgctc accgcctctg ggagccgctg
      301 ggtttgtgca ccgcagccct tccgggacag cagctgtgac tctcccccaa tccagatttc
      361 ggggtcgctc tctagaaact cgctctaaag acggaaccgc cacagcaccc aaagcccact
      421 gcgggagagc gcagcccgac aagcccgggc gctgagcctg gaccctcagc agagcgggcc
      481 agcacagcgg ctgctgcttc gcctatcccg acgtccccgc ctcctacact ctcagcctcc
      541 gctggagaga cccccagccc caccattcag cgcgcaagat accctccaga tatgccctgc
      601 gtgcaagccc agtatagccc ttcacctccg gggtccactt acgccacgca gacttatggc
      661 tcggaataca ccacagaaat catgaacccc gactacacca agctgaccat ggacctcggt
      721 agcacgggga tcatggccac cgccactaca tccctgccca gcttcagtac cttcatggag
      781 ggctacccca gcagctgcga actcaagccc tcctgcctgt accaaatgcc gccttctggg
      841 cctcggcctt tgatcaagat ggaagagggt cgcgagcatg gctaccacca ccaccatcac
      901 catcaccatc atcaccacca ccaccagcaa cagcagccgt ccattcctcc tccctccggc
      961 cccgaggacg aggtactgcc cagcacctcc atgtacttca agcagtctcc gccttctaca
     1021 ccgaccactc caggcttccc cccgcaggcg ggggcgctgt gggacgacga gctgccctct
     1081 gcgcctggct gcatcgctcc gggaccgctg ctggacccgc agatgaaggc ggtacccccc
     1141 atggccgctg ctgcgcgctt cccgatcttc ttcaagccct caccgccaca ccctcccgcg
     1201 cccagtccag ccggcggcca ccacctcggc tatgacccca cggccgcagc tgcactcagt
     1261 ctgcccctgg gagccgcggc cgcagcaggc agccaagctg ctgcgctcga gggccaccca
     1321 tacgggctcc cgctggccaa gaggacggcc acgctgacct tccctccgct gggcctcaca
     1381 gcctccccca ccgcgtccag cctgctggga gagagcccca gcctcccatc gccacccaat
     1441 aggagctcat catctgggga aggcacatgt gccgtgtgcg gcgacaacgc tgcctgccag
     1501 cactacggag tccgcacctg cgagggctgc aagggcttct tcaagagaac ggtgcagaaa
     1561 aatgcaaaat atgtttgcct ggcaaataaa aactgcccag tggacaagag acgccgaaac
     1621 cgatgtcagt actgcagatt tcagaagtgt ctcagtgtcg ggatggttaa ggaagttgtg
     1681 cgtacagaca gtctgaaagg gaggagaggt cgtctgcctt ccaaaccaaa gagcccacta
     1741 caacaggagc cctcgcagcc ctccccgcca tctcctccga tctgtatgat gaatgccctt
     1801 gtccgagctt taacagatgc aacacccaga gatcttgatt attccagata ctgtcccacc
     1861 gaccaggcca ctgcaggcac agatgctgag cacgtgcaac agttctacaa ccttctgacg
     1921 gcctccattg acgtgtccag aagctgggca gaaaagatcc caggattcac tgatctcccc
     1981 aaagaagatc agacgttact tatagaatca gcctttttgg agctgtttgt tcttagactt
     2041 tccatcaggt caaacactgc tgaagataag tttgtgttct gcaatggact tgtcctgcat
     2101 cgacttcagt gccttcgagg atttggggag tggctcgact ccattaaaga cttttcttta
     2161 aacttgcaga gcctgaacct tgatatccaa gccttagcct gcctgtcagc actgagtatg
     2221 atcacagagc gacatgggtt aaaagaacca aagagagtgg aggagctatg caccaagatc
     2281 acaagcagct taaaggacca ccagaggaag ggacaggctc tggagccctc ggagcctaag
     2341 gtcctgcgcg cgctggtaga actgagaaag atctgtaccc agggcctcca gcgcatcttc
     2401 tacctgaagc tagaggactt ggtacctcca ccttctgtca tcgacaagct cttccttgac
     2461 accctgcctt tctgagcagg ggaagcctga gcagagagct acttgctctg ctggcacctg
     2521 atcattaagt gagcaaaaga atgggtttga acaccttcca cactcactgt ccttccttca
     2581 ggggaaaagc agctcccgta gaaagcaaag actttttttt cttttcctgg cacctttcct
     2641 tacaacctaa agccagaaac cttgcagagt atcgtgttgg ggttgtgttt tatatttagg
     2701 ctttggtggg tgggttggga gggggtaaat agttcatgag gcttttctaa gaaattgctg
     2761 acaaagcact tttggatgat gctatcccag cagtggggtg gggagaaagg ataatataac
     2821 tgttttgttt ttgtttttgt ttttgttttt aaaaaaaaac tctttctggg gaatatgatt
     2881 atggttgctt tgtatttaaa aataagaaca gccaagggct gttcaccagg gtagggctgt
     2941 gtcctacgac ggatcccttt aggatatact tcctgtgtca agggtagata cgtggtgcaa
     3001 atgaggcaga aaattccctt ttcttcattt ctttcttaaa aaaatggcaa aagatgaaag
     3061 attatctaca aatcagactt agcaaaaatg ataatggcta tttgcttcca tatacaagtg
     3121 caatttttta gagtgctgtc ttactaagtc ttgtttgtga actccccctt attttacatg
     3181 aaaataagaa ggaggcagtc atgctatgaa atggcgcgct cattttccta gctaaggctt
     3241 gatccacctg ccctgtagaa cccttcggag gtgtggccct tctaagactt tcaggccatt
     3301 ctcgatggaa ttcgacccct gatgactatc cagccatcct gaagggggat cgggttataa
     3361 agtggattgc atacaactgt cttcgctgtg ttttgtcaac ctggacagag ttctctaaac
     3421 ctacttcagt tgtagcaagt tcctgattca tccactcaga agcccaatga gcactggttg
     3481 actcaatcaa gtgttaaccc taggagaaca agcaaataag taggaactgg gtcatacagg
     3541 gtaaacacca gagatgataa ggatatatat atatatatat atatatatat atatatatat
     3601 atgtatatgt atatatatat acatattaat ttttgttatt ggttagagac aattttggaa
     3661 agcaagagaa tcatcttttt ttaaaaaaga gagaagaaga agaagaaaag atagtattaa
     3721 cgtgagttct agagaaggtt agtgggttgc ggttcaaaat tccgtgtttg tgcccccttt
     3781 tatatgtttc tactgttgat gccatattat tatgaaatga tttgttgcat agtgtcctta
     3841 tttgtatgaa catttgtatg cacgttatat tgtaatagct ttgcctgtat ttattgcaag
     3901 accaccagct cctggaggct gagatacaga gtaatcaaat ggggtgttcg tggtgacttg
     3961 gatacaccaa ttagaaatta aataagcata tatatatata aacatagccg gttacatata
     4021 tatttataat gtgtcttttt attaaccatt tgtacaagaa atgtcacttc ccacgcagtt
     4081 actttaccct tcacttgcag tgacctttaa ggcagcactg tttagcactt tgatatgaaa
     4141 tttttgctta tgttttgcta aattctaata atgtttgaag attttaaggt ctaaaagtct
     4201 ttatattata tactctgtat caagtcaaga tccctttggc cgttttgcta agactcaaaa
     4261 actttgaatg tcaaactgat gtcacagtag cttttgttag cttttaatca tttttgcttt
     4321 agtttttttt ttaaaaaaaa taacaaacta tactgtttat attgtcatta aattatacaa
     4381 tcaaacaaat gccaaatgaa ttgcctaatt gctgcaaagt gtaacccaga taacaaatca
     4441 tattctctcc tctttttgca actcattcag atgtttgatc ttgtgttttg tttgtataaa
     4501 gattgtatga actatatcac cttcctatca aggtgacagg gcttgagatg ttaagatttt
     4561 tgaacttcag acttggaagg ggcctggctc atcatctggt cagatctatt aaaattcaca
     4621 aaggagaaaa gtgggggccc gttgcagggc aaacagctag caacaggata aaggctcaga
     4681 cttaattcac cttcccttag tctcccccac atcttactgc atctgtagga aaataaactt
     4741 ttaaacatag tcacgcatac taacacttta ccagcagaca gccttgaata aagtagtact
     4801 ttggcattaa tttgttgagc ttatatgcaa acataataaa cattattaaa tatcaggaaa
     4861 gctaacattt cacacgagat cgcttcagac caaattcaat ttgaatttga ataaattaga
     4921 agtactgagc gtacgtaacc ttcttgtgca ccttgagtat tgcaaagttg ctccttggtt
     4981 gttggttttt tttgttgttt cttttcgtcc tgtctgaaag gcaaagcaaa acagcagcac
     5041 ggtgctctgg gaaatgctgt tcccccttct gtcctcacac ccacagattg aagggaaaga
     5101 actgtctaag catctatctg ctggtttgaa gaatgatgaa gccgttttag ttaagggcca
     5161 gacactagtg ctgaaagaaa agactataca gccagtgttc ttctgtcttc catagttatc
     5221 acaactatga gagcctctta ggtcatcatt ttgaaatgtt gacacccaag tgtacccaga
     5281 gtggaaggca cactagctct gcagaggaca agcattaatg caggtgattc ctcccgctga
     5341 ctggagtgca gtctcagtgt gaacccgccc tcagcaggaa atgggaatcc acttgctgtt
     5401 cctggagagt gccttgcttt tgtttcaaat ggccgagtct cccaagccct tctcctctaa
     5461 cagcattgct ttttagtaag tgtgtgttaa cctgtggttt gaaagaaatg ctcttgtaca
     5521 ttaacaatgt aaatttaaat gattaaatta aattacattt taccaatgga aaa
//
