LOCUS       NM_013613               3172 bp    mRNA    linear   ROD 18-MAR-2023
DEFINITION  Mus musculus nuclear receptor subfamily 4, group A, member 2
            (Nr4a2), transcript variant 1, mRNA.
ACCESSION   NM_013613
VERSION     NM_013613.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3172)
  AUTHORS   Kastriti ME, Faure L, Von Ahsen D, Bouderlique TG, Bostrom J,
            Solovieva T, Jackson C, Bronner M, Meijer D, Hadjab S, Lallemend F,
            Erickson A, Kaucka M, Dyachuk V, Perlmann T, Lahti L, Krivanek J,
            Brunet JF, Fried K and Adameyko I.
  TITLE     Schwann cell precursors represent a neural crest-like state with
            biased multipotency
  JOURNAL   EMBO J 41 (17), e108780 (2022)
   PUBMED   35815410
REFERENCE   2  (bases 1 to 3172)
  AUTHORS   Funk OH, Qalieh Y, Doyle DZ, Lam MM and Kwan KY.
  TITLE     Postmitotic accumulation of histone variant H3.3 in new cortical
            neurons establishes neuronal chromatin, transcriptome, and identity
  JOURNAL   Proc Natl Acad Sci U S A 119 (32), e2116956119 (2022)
   PUBMED   35930666
REFERENCE   3  (bases 1 to 3172)
  AUTHORS   Ashraf S, Taegtmeyer H and Harmancey R.
  TITLE     Prolonged cardiac NR4A2 activation causes dilated cardiomyopathy in
            mice
  JOURNAL   Basic Res Cardiol 117 (1), 33 (2022)
   PUBMED   35776225
  REMARK    GeneRIF: Prolonged cardiac NR4A2 activation causes dilated
            cardiomyopathy in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3172)
  AUTHORS   Pulcrano S, De Gregorio R, De Sanctis C, Lahti L, Perrone-Capano C,
            Ponti D, di Porzio U, Perlmann T, Caiazzo M, Volpicelli F and
            Bellenchi GC.
  TITLE     Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of
            Nurr1-Mediated Dopaminergic Differentiation
  JOURNAL   Int J Mol Sci 23 (13), 6961 (2022)
   PUBMED   35805964
  REMARK    GeneRIF: Lmx1a-Dependent Activation of miR-204/211 Controls the
            Timing of Nurr1-Mediated Dopaminergic Differentiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3172)
  AUTHORS   Abdollahi M and Fahnestock M.
  TITLE     Nurr1 Is Not an Essential Regulator of BDNF in Mouse Cortical
            Neurons
  JOURNAL   Int J Mol Sci 23 (12), 6853 (2022)
   PUBMED   35743300
  REMARK    GeneRIF: Nurr1 Is Not an Essential Regulator of BDNF in Mouse
            Cortical Neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3172)
  AUTHORS   Zetterstrom RH, Solomin L, Mitsiadis T, Olson L and Perlmann T.
  TITLE     Retinoid X receptor heterodimerization and developmental expression
            distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1
  JOURNAL   Mol Endocrinol 10 (12), 1656-1666 (1996)
   PUBMED   8961274
REFERENCE   7  (bases 1 to 3172)
  AUTHORS   Pena de Ortiz S and Jamieson GA Jr.
  TITLE     HZF-3, an immediate-early orphan receptor homologous to NURR1/NOT:
            induction upon membrane depolarization and seizures
  JOURNAL   Brain Res Mol Brain Res 38 (1), 1-13 (1996)
   PUBMED   8737662
REFERENCE   8  (bases 1 to 3172)
  AUTHORS   Mages HW, Rilke O, Bravo R, Senger G and Kroczek RA.
  TITLE     NOT, a human immediate-early response gene closely related to the
            steroid/thyroid hormone receptor NAK1/TR3
  JOURNAL   Mol Endocrinol 8 (11), 1583-1591 (1994)
   PUBMED   7877627
REFERENCE   9  (bases 1 to 3172)
  AUTHORS   Kuhn R, Lohler J, Rennick D, Rajewsky K and Muller W.
  TITLE     Interleukin-10-deficient mice develop chronic enterocolitis
  JOURNAL   Cell 75 (2), 263-274 (1993)
   PUBMED   8402911
REFERENCE   10 (bases 1 to 3172)
  AUTHORS   Law SW, Conneely OM, DeMayo FJ and O'Malley BW.
  TITLE     Identification of a new brain-specific transcription factor, NURR1
  JOURNAL   Mol Endocrinol 6 (12), 2129-2135 (1992)
   PUBMED   1491694
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC137715.1, AK087495.1, CJ059409.1 and BE864591.1.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_013613.3.
            
            On Nov 19, 2008 this sequence version replaced NM_013613.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158607.1, BC137715.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1383              BC137715.1         313-1695
            1384-2881           AK087495.1         1262-2759
            2882-2887           CJ059409.1         206-211
            2888-3172           BE864591.1         1-285
FEATURES             Location/Qualifiers
     source          1..3172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 31.66 cM"
     gene            1..3172
                     /gene="Nr4a2"
                     /gene_synonym="HZF-3; NOT; Nurr1; RNR-1; TINOR; TINUR"
                     /note="nuclear receptor subfamily 4, group A, member 2"
                     /db_xref="GeneID:18227"
                     /db_xref="MGI:MGI:1352456"
     exon            1..321
                     /gene="Nr4a2"
                     /gene_synonym="HZF-3; NOT; Nurr1; RNR-1; TINOR; TINUR"
                     /inference="alignment:Splign:2.1.0"
     exon            322..443
                     /gene="Nr4a2"
                     /gene_synonym="HZF-3; NOT; Nurr1; RNR-1; TINOR; TINUR"
                     /inference="alignment:Splign:2.1.0"
     exon            444..1309
                     /gene="Nr4a2"
                     /gene_synonym="HZF-3; NOT; Nurr1; RNR-1; TINOR; TINUR"
                     /inference="alignment:Splign:2.1.0"
     CDS             446..2242
                     /gene="Nr4a2"
                     /gene_synonym="HZF-3; NOT; Nurr1; RNR-1; TINOR; TINUR"
                     /note="NUR-related factor 1; orphan nuclear receptor
                     NURR1; nur related protein 1"
                     /codon_start=1
                     /product="nuclear receptor subfamily 4 group A member 2"
                     /protein_id="NP_038641.1"
                     /db_xref="CCDS:CCDS16043.1"
                     /db_xref="GeneID:18227"
                     /db_xref="MGI:MGI:1352456"
                     /translation="MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSM
                     DLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQ
                     HSHLPPQSEEMMPHSGSVYYKPSSPPTPSTPSFQVQHSPMWDDPGSLHNFHQNYVATT
                     HMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTF
                     AVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYG
                     VRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVR
                     TDSLKGRRGRLPSKPKSPQDPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPD
                     YQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLR
                     LAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAA
                     LAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLC
                     TQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF"
     exon            1310..1439
                     /gene="Nr4a2"
                     /gene_synonym="HZF-3; NOT; Nurr1; RNR-1; TINOR; TINUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1603
                     /gene="Nr4a2"
                     /gene_synonym="HZF-3; NOT; Nurr1; RNR-1; TINOR; TINUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1806
                     /gene="Nr4a2"
                     /gene_synonym="HZF-3; NOT; Nurr1; RNR-1; TINOR; TINUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1985
                     /gene="Nr4a2"
                     /gene_synonym="HZF-3; NOT; Nurr1; RNR-1; TINOR; TINUR"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..3172
                     /gene="Nr4a2"
                     /gene_synonym="HZF-3; NOT; Nurr1; RNR-1; TINOR; TINUR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggagcgcg gcggctcggc gattggaccg cgggccgctg acgcgggctg acgcgcgcag
       61 actttaggtg catgttggca gcagcagctc gagccacata aacaaaggca cattggcggc
      121 cagggccagt ccgccccgcg gctccgcaca gctccgcgtc cctctctccg gccccgctgg
      181 ctgcctccct ctcctgcggc cgggctggct gcgtgtggct ctccgcgccc cgcttccgca
      241 gcgctcccgc ggacccgggc tcctctgctc ccggagggaa ctgcacttcg gcggagttga
      301 atgaatgaag agagcggaca aggagatctg acgggctgga ttcccaatag ctctttttta
      361 aaatcttgga aactttgtcc ttcgctgaat tacgacactg tccaccttta atttcctcga
      421 aaactccaat aactctgctg aagccatgcc ttgtgttcag gcgcagtatg ggtcctcgcc
      481 tcaaggagcc agccccgctt ctcagagcta cagttaccac tcttcgggag aatacagctc
      541 cgatttctta actccagagt ttgtcaagtt tagcatggac ctcaccaaca ctgaaattac
      601 tgccaccact tctctcccca gcttcagtac ctttatggac aactacagca caggctacga
      661 cgtcaagcca ccttgcttgt accaaatgcc cctgtccgga cagcagtcct ccattaaggt
      721 agaagacatt cagatgcaca actaccagca acacagccac ctgccccctc agtccgagga
      781 gatgatgcca cacagcgggt cggtttacta caagccctct tcgcccccga cacccagcac
      841 cccgagcttc caggtgcagc atagcccgat gtgggacgat ccgggctccc ttcacaactt
      901 ccaccagaac tacgtggcca ctacgcatat gatcgagcag aggaagacac ctgtctcccg
      961 cctgtcactc ttctccttta agcagtcgcc cccgggcact cctgtgtcta gctgccagat
     1021 gcgcttcgac gggcctctgc acgtccccat gaacccggag cccgcgggca gccaccacgt
     1081 agtggatggg cagaccttcg ccgtgcccaa ccccattcgc aagccggcat ccatgggctt
     1141 cccgggcctg cagatcggcc acgcatcgca gttgcttgac acgcaggtgc cctcgccgcc
     1201 gtcccggggc tctccctcca atgagggtct gtgcgctgtt tgcggtgaca acgcggcctg
     1261 tcagcactac ggtgttcgca cttgtgaggg ctgcaaaggt ttctttaagc gcacggtgca
     1321 aaaaaacgcg aaatatgtgt gtttagcaaa taaaaactgc ccagtggaca agcgccgccg
     1381 aaatcgttgt cagtactgtc ggtttcagaa gtgcctagct gttgggatgg ttaaagaagt
     1441 ggttcgcacg gacagtttaa aaggccggag aggtcgttta ccctcgaagc cgaagagccc
     1501 acaggatccc tctcccccct cacctccggt gagtctgatc agtgccctcg tcagagccca
     1561 cgtcgattcc aatccggcaa tgaccagcct ggactattcc aggttccagg caaaccctga
     1621 ctatcagatg agtggagatg atacccaaca tatccagcag ttctacgatc tcctgaccgg
     1681 ctctatggag atcatcagag ggtgggcaga gaagatccct ggctttgctg acctgcccaa
     1741 agccgaccag gacctgcttt ttgaatcagc tttcttagaa ttatttgttc tgcgcttagc
     1801 atacaggtcc aacccagtgg agggtaaact catcttttgc aatggggtgg tcttgcacag
     1861 gttgcaatgc gtgcgtggct ttggggaatg gattgattcc attgttgaat tctcctccaa
     1921 cttgcagaat atgaacatcg acatttctgc cttctcctgc attgctgccc tggctatggt
     1981 cacagagaga cacgggctca aggaacccaa gagagtggaa gagctacaaa acaaaattgt
     2041 aaattgtctt aaagaccatg tgactttcaa taatgggggt ttgaaccgac ccaactacct
     2101 gtctaaactg ttggggaagc tgccagaact ccgcaccctt tgcacacagg gcctccagcg
     2161 cattttctac ctgaaattgg aagacttggt accaccacca gcaataattg acaaactttt
     2221 cctggacacc ttacctttct aagaccttct cccaagcacg tcaaagaact ggaaagaaaa
     2281 aaaaaataac atccagaggg ggctggtcac atgggcagag agctggttga agtgtccagt
     2341 tcaccttatc tcccttctgt agacccctag ccctcacccc ttaagtaaac aaacaaacaa
     2401 acaaaccaca aataaaaact gtcgctattt cctaacctgc aggcagaacc tgaaagggca
     2461 ttttggctcc ggggcatcct ggatttagaa aacggacagc acacagtaca gtggtataaa
     2521 ctttttatta tcagttcaaa atcagtttgt tgttcagaag aaagattgct aatgtatgat
     2581 gggaaatgtt tggccatgct tgcttgttgc agttaagaca aatgtaacac acacacacac
     2641 acacacacac acacacacac acacacacct taatgggacc ctcctatttt gccctttaac
     2701 aagacttcaa agttttctgc tgtaaagaaa gctgtaatat atagtaaaac taaatgttgc
     2761 gtgggtggca tgaattgaag gcagaggctt gtaaatttat ccaatgcagt ttggcttttt
     2821 aaattatttt gtgcctattt atgaataaat attacaaatt ctaaaaagta agtgtgtttg
     2881 caaaaaaaaa aaaagaaaat aactacataa aaaggggaca agcatgtgat tctaggttga
     2941 agatgttata ggcacttgct acttcagtaa tgtctatatt atataaatag tatttcagac
     3001 actatgtagt ctgttagatt ttataaagat tggtagttat ctgagcttaa acatttttct
     3061 caattgtata ataggtgggc acaagtatca gtacattgga aaatcctgac aaaagggaca
     3121 catagtgttt gtaacaccgc ccaacattcc ttgtttgtaa gtgttgtatg ta
//
