LOCUS       NM_001411254            2690 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus nuclear receptor subfamily 4, group A, member 1
            (Nr4a1), transcript variant 3, mRNA.
ACCESSION   NM_001411254 XM_036159163
VERSION     NM_001411254.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2690)
  AUTHORS   Wang,H., Wei,Z., Xu,C., Fang,F., Wang,Z., Zhong,Y. and Wang,X.
  TITLE     Nuclear receptor 4A1 ameliorates UUO-induced renal fibrosis by
            inhibiting the PI3K/AKT pathway
  JOURNAL   Sci Rep 14 (1), 24787 (2024)
   PUBMED   39433882
  REMARK    GeneRIF: Nuclear receptor 4A1 ameliorates UUO-induced renal
            fibrosis by inhibiting the PI3K/AKT pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2690)
  AUTHORS   Guo,W., Li,Z., Anagnostopoulos,G., Kong,W.T., Zhang,S.,
            Chakarov,S., Shin,A., Qian,J., Zhu,Y., Bai,W., Cexus,O., Nie,B.,
            Wang,J., Hu,X., Bleriot,C., Liu,Z., Shen,B., Venteclef,N., Su,B.
            and Ginhoux,F.
  TITLE     Notch signaling regulates macrophage-mediated inflammation in
            metabolic dysfunction-associated steatotic liver disease
  JOURNAL   Immunity 57 (10), 2310-2327 (2024)
   PUBMED   39317200
REFERENCE   3  (bases 1 to 2690)
  AUTHORS   Collins,C.A., Waller,C., Batourina,E., Kumar,L., Mendelsohn,C.L.
            and Gilbert,N.M.
  TITLE     Nur77 protects the bladder urothelium from intracellular bacterial
            infection
  JOURNAL   Nat Commun 15 (1), 8308 (2024)
   PUBMED   39333075
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2690)
  AUTHORS   Wang,J., Zhuang,H., Jia,L., He,X., Zheng,S., Ji,K., Xie,K.,
            Ying,T., Zhang,Y., Li,C. and Chang,X.
  TITLE     Nuclear receptor subfamily 4 group A member 1 promotes myocardial
            ischemia/reperfusion injury through inducing mitochondrial fission
            factor-mediated mitochondrial fragmentation and inhibiting FUN14
            domain containing 1-depedent mitophagy
  JOURNAL   Int J Biol Sci 20 (11), 4458-4475 (2024)
   PUBMED   39247823
  REMARK    GeneRIF: Nuclear receptor subfamily 4 group A member 1 promotes
            myocardial ischemia/reperfusion injury through inducing
            mitochondrial fission factor-mediated mitochondrial fragmentation
            and inhibiting FUN14 domain containing 1-depedent mitophagy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2690)
  AUTHORS   Hao,J., Li,R., Zhao,X., Liu,X., Chen,X., Xie,T., Li,X., Yao,C.,
            Sun,Q., Wei,K., Gou,M., Chi,X., Xu,W., Ni,L. and Dong,C.
  TITLE     NR4A1 transcriptionally regulates the differentiation of stem-like
            CD8+ T cells in the tumor microenvironment
  JOURNAL   Cell Rep 43 (6), 114301 (2024)
   PUBMED   38823016
REFERENCE   6  (bases 1 to 2690)
  AUTHORS   Law,S.W., Conneely,O.M., DeMayo,F.J. and O'Malley,B.W.
  TITLE     Identification of a new brain-specific transcription factor, NURR1
  JOURNAL   Mol Endocrinol 6 (12), 2129-2135 (1992)
   PUBMED   1491694
REFERENCE   7  (bases 1 to 2690)
  AUTHORS   Nakai,A., Kartha,S., Sakurai,A., Toback,F.G. and DeGroot,L.J.
  TITLE     A human early response gene homologous to murine nur77 and rat
            NGFI-B, and related to the nuclear receptor superfamily
  JOURNAL   Mol Endocrinol 4 (10), 1438-1443 (1990)
   PUBMED   2283997
REFERENCE   8  (bases 1 to 2690)
  AUTHORS   Ryseck,R.P., Macdonald-Bravo,H., Mattei,M.G., Ruppert,S. and
            Bravo,R.
  TITLE     Structure, mapping and expression of a growth factor inducible gene
            encoding a putative nuclear hormonal binding receptor
  JOURNAL   EMBO J 8 (11), 3327-3335 (1989)
   PUBMED   2555161
REFERENCE   9  (bases 1 to 2690)
  AUTHORS   Hazel,T.G., Nathans,D. and Lau,L.F.
  TITLE     A gene inducible by serum growth factors encodes a member of the
            steroid and thyroid hormone receptor superfamily
  JOURNAL   Proc Natl Acad Sci U S A 85 (22), 8444-8448 (1988)
   PUBMED   3186734
REFERENCE   10 (bases 1 to 2690)
  AUTHORS   Tippetts,M.T., Varnum,B.C., Lim,R.W. and Herschman,H.R.
  TITLE     Tumor promoter-inducible genes are differentially expressed in the
            developing mouse
  JOURNAL   Mol Cell Biol 8 (10), 4570-4572 (1988)
   PUBMED   3185562
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163018.3.
            
            On Aug 23, 2022 this sequence version replaced XM_036159163.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861894.2622202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC163018.3         51345-51379
            36-154              AC163018.3         55751-55869
            155-339             AC163018.3         58098-58282
            340-1226            AC163018.3         67526-68412
            1227-1356           AC163018.3         69179-69308
            1357-1508           AC163018.3         69596-69747
            1509-1711           AC163018.3         70161-70363
            1712-1890           AC163018.3         70458-70636
            1891-2690           AC163018.3         71439-72238
FEATURES             Location/Qualifiers
     source          1..2690
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.64 cM"
     gene            1..2690
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /note="nuclear receptor subfamily 4, group A, member 1"
                     /db_xref="GeneID:15370"
                     /db_xref="MGI:MGI:1352454"
     exon            1..35
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /inference="alignment:Splign:2.1.0"
     exon            36..154
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /inference="alignment:Splign:2.1.0"
     exon            155..339
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /inference="alignment:Splign:2.1.0"
     exon            340..1226
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..2147
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /note="nuclear protein N10; orphan nuclear receptor HMR;
                     nuclear hormone receptor NUR/77"
                     /codon_start=1
                     /product="nuclear receptor subfamily 4 group A member 1"
                     /protein_id="NP_001398183.1"
                     /db_xref="GeneID:15370"
                     /db_xref="MGI:MGI:1352454"
                     /translation="MPCIQAQYGTPATSPGPRDHLTGDPLALEFGKPTMDLASPETAP
                     AAPATLPSFSTFMDGYTGEFDTFLYQLPGTTQPCSSACSSASSTSSSSSSATSPASAS
                     FKFEDFQVYGCYPGTLSGPLDETLSSSGSEYYGSPCSAPSPSTPNFQPSQLSPWDGSF
                     GHFSPSQTYEGLWAWTEQLPKASSGPPPPPTFFSFSPPTGPSPSLAQSSLKLFPPPAT
                     HQLGEGESYSMPAAFPGLAPTSPNRDTSGILDAPVTSTKSRSGASGGSEGRCAVCGDN
                     ASCQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVG
                     MVKEVVRTDSLKGRRGRLPSKPKQPPDASPTNLLTSLIRAHLDSGPSTAKLDYSKFQE
                     LVLPRFGKEDAGDVQQFYDLLSGSLDVIRKWAEKIPGFIELCPGDQDLLLESAFLELF
                     ILRLAYRSKPGEGKLIFCSGLVLHQLQCARGFGDWIDNILAFSRSLHSLGVDVPAFAC
                     LSALVLITDRHGLQDPRRVEELQNRIASCLKEHMATVAGDPQPASCLSRLLGKLPELR
                     TLCTQGLQRIFCLKLEDLVPPPPIVDKIFMDTLSF"
     exon            1227..1356
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1508
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1711
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1890
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2690
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2672..2677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /note="hexamer: AATAGA"
     polyA_site      2690
                     /gene="Nr4a1"
                     /gene_synonym="Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B;
                     NGFIB; NP10; nur77; NUR77-1; NUR77-2; TIS1; TR3"
                     /note="major polyA site"
ORIGIN      
        1 attcatgaat tggatgcccg ggtgatgtcc tggaggccac catggacaga gaccagcccc
       61 tgctcctccc tggtgacttg gctatgttgc tgtgccctga agggtgaggg gatgttgtga
      121 gttgttgaca gtccttttgg ttcacccaga gtggaagagg acgcattggc tcggagacag
      181 ttcccatcca gagtttgctc cgtcagtgcc tggcctcagc tgggaaggac aggcgggcca
      241 gctgtcacag atccccacgg agttcctgag gctgtggaaa gaccctccac taaccctgga
      301 ttcctctttt gccccctggg tctgtgagga cacatgctga gatgccctgt attcaagctc
      361 aatatggaac accagcaacg agcccaggac cgcgtgacca cctgaccggt gatcccctgg
      421 cccttgagtt cggcaagcct accatggacc tggccagccc cgagacagca cctgccgcac
      481 ctgctacact gcccagcttc agcaccttca tggacgggta caccggagag tttgacacct
      541 tcctctacca gctgccgggg acgacccagc cgtgctcctc agcttgttcc tctgcctcct
      601 ccacgtcttc ttcctcatcc tcggccacct cccccgcttc ggcgtccttc aagtttgagg
      661 acttccaggt gtacggctgc tacccgggca ccctgagcgg cccattagat gagaccctat
      721 cctccagcgg ctctgagtac tatggcagtc cctgctcagc cccctcgcca tctacaccca
      781 acttccagcc gtcccagctt tctccctggg acggctcatt tggccacttc tccccgagcc
      841 agacttatga aggcctctgg gcatggacag agcagttgcc taaggcttct tcagggcctc
      901 cgccacctcc aaccttcttc tccttcagtc ctcccactgg ccccagcccc agcctggccc
      961 agagttctct gaaattgttc ccaccaccag ccacccacca gcttggggag ggggagagct
     1021 attccatgcc agcagctttc cccggcttgg cacccacctc tccgaaccgt gacacttccg
     1081 gcattctgga cgcacccgtg acctccacca agtcccggag cggggcttca ggtggcagcg
     1141 agggccgctg tgcagtctgt ggtgacaatg cttcgtgtca gcactatggg gtccgcacct
     1201 gtgagggctg caagggcttc ttcaagcgca cagtacagaa aagcgccaag tacatctgcc
     1261 tggcaaacaa ggattgccct gtggacaaga ggcggcggaa ccgctgccag ttctgccgct
     1321 tccagaagtg cctggctgtg ggcatggtga aggaagttgt acggacagac agcctaaaag
     1381 ggcggcgggg ccggctacct tcaaaaccca agcagcctcc agatgcctcc cctaccaatc
     1441 ttctcacttc cctcatccgg gcacacttgg actccgggcc tagcactgcc aaattggact
     1501 attccaagtt ccaggaactg gtgctgcccc gcttcgggaa ggaagatgcc ggtgacgtgc
     1561 aacaatttta tgacttgctc tctggttccc tggacgttat ccgaaagtgg gcagaaaaaa
     1621 tccctggctt cattgagctt tgcccaggag accaagacct gttgctagag tctgccttcc
     1681 tggaactctt catcctccgc ctggcatacc gatctaaacc cggtgagggg aagctcatct
     1741 tctgctcagg cctggtacta caccagctgc agtgtgcccg tggctttggt gattggattg
     1801 acaacatcct ggccttctca cggtccctgc acagcttggg tgttgatgtt cccgcctttg
     1861 cctgcctgtc cgctctggtc ctcatcactg atcgacacgg gctccaggac cctcgtcggg
     1921 tggaagagct gcagaatcgc attgctagct gtctgaagga gcacatggct accgtggcag
     1981 gagacccaca gccggccagc tgcctgtcac gtctgctggg caaactgcct gagcttcgga
     2041 ccctgtgcac tcaaggcctg cagcgcatct tttgcctcaa gttggaggac ttggtacccc
     2101 ctccacctat tgtggacaag atctttatgg acacattgtc tttctgaccc ctgccctgaa
     2161 catgtgtgcg cacacgtgcg tgctcttctg tcacccatgt gcctttaagc ctatagccca
     2221 cggaccccca gaccacccta cccccagcct ggttttgagc taagactgac gtacctcctc
     2281 actccagaag atggacagag aactcaagac ctgggggagg gtgtgtattc acgggggtga
     2341 ccccactatt tgtcttatcc ctccagctca gtcctggcct tcgtgtgttt ttgtaagata
     2401 aaccattttt aacacatacc actctgttgt aaataagctg acgctactgt aaatacagaa
     2461 aggaagaggt tgagatgggg gttgggagga aggggtgggg ctcccaccag ctgggcgagc
     2521 ctccaactcg agatctcttc cgctctcctt ccatgtgtac ataactgtca ctcaagaagg
     2581 tgattgacag attctgattt atatttgtgt attttcctgg atttatagga tgtgactttt
     2641 ctgattaata tatttaatat attgaataaa aaatagacat gtagttgaaa
//
