LOCUS       NM_001083906            5655 bp    mRNA    linear   ROD 23-NOV-2023
DEFINITION  Mus musculus nuclear receptor subfamily 3, group C, member 2
            (Nr3c2), mRNA.
ACCESSION   NM_001083906
VERSION     NM_001083906.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5655)
  AUTHORS   Chen CM, Meng XQ, Zhu H, Liu T, Liu Y, Zhou LJ, Zhu GD, Chen XB,
            Guo XG and Duan SZ.
  TITLE     Brown adipocyte mineralocorticoid receptor deficiency impairs
            metabolic regulation in diet-induced obese mice
  JOURNAL   J Lipid Res 64 (11), 100449 (2023)
   PUBMED   37734559
REFERENCE   2  (bases 1 to 5655)
  AUTHORS   Gonzalez-Mayoral A, Eid A, Derounian R, Campanella VS, da Silva
            Ramos A, El Khoury R, Massaad C and Le Menuet D.
  TITLE     Mineralocorticoid receptor knockout in Schwann cells alters myelin
            sheath thickness
  JOURNAL   J Endocrinol 258 (2), e220334 (2023)
   PUBMED   37195271
  REMARK    GeneRIF: Mineralocorticoid receptor knockout in Schwann cells
            alters myelin sheath thickness.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5655)
  AUTHORS   Habibi J, Homan C, Naz H, Chen D, Lastra G, Whaley-Connell A,
            Sowers JR and Jia G.
  TITLE     Endothelial MRs Mediate Western Diet-Induced Lipid Disorders and
            Skeletal Muscle Insulin Resistance in Females
  JOURNAL   Endocrinology 164 (7) (2023)
   PUBMED   37289042
REFERENCE   4  (bases 1 to 5655)
  AUTHORS   Sun JY, Du LJ, Shi XR, Zhang YY, Liu Y, Wang YL, Chen BY, Liu T,
            Zhu H, Liu Y, Ruan CC, Gan Z, Ying H, Yin Z, Gao PJ, Yan X, Li RG
            and Duan SZ.
  TITLE     An IL-6/STAT3/MR/FGF21 axis mediates heart-liver cross-talk after
            myocardial infarction
  JOURNAL   Sci Adv 9 (14), eade4110 (2023)
   PUBMED   37018396
REFERENCE   5  (bases 1 to 5655)
  AUTHORS   Barnes CC, Yee KT and Vetter DE.
  TITLE     Conditional Ablation of Glucocorticoid and Mineralocorticoid
            Receptors from Cochlear Supporting Cells Reveals Their Differential
            Roles for Hearing Sensitivity and Dynamics of Recovery from
            Noise-Induced Hearing Loss
  JOURNAL   Int J Mol Sci 24 (4), 3320 (2023)
   PUBMED   36834731
  REMARK    GeneRIF: Conditional Ablation of Glucocorticoid and
            Mineralocorticoid Receptors from Cochlear Supporting Cells Reveals
            Their Differential Roles for Hearing Sensitivity and Dynamics of
            Recovery from Noise-Induced Hearing Loss.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5655)
  AUTHORS   Molkentin JD, Firulli AB, Black BL, Martin JF, Hustad CM, Copeland
            N, Jenkins N, Lyons G and Olson EN.
  TITLE     MEF2B is a potent transactivator expressed in early myogenic
            lineages
  JOURNAL   Mol Cell Biol 16 (7), 3814-3824 (1996)
   PUBMED   8668199
REFERENCE   7  (bases 1 to 5655)
  AUTHORS   Marine JC, Gilbert DJ, Bellefroid EJ, Martial JA, Ihle JN, Copeland
            NG and Jenkins NA.
  TITLE     Chromosomal location of fifteen unique mouse KRAB-containing zinc
            finger loci
  JOURNAL   Mamm Genome 7 (6), 413-416 (1996)
   PUBMED   8662221
REFERENCE   8  (bases 1 to 5655)
  AUTHORS   Anderson DM, Johnson L, Glaccum MB, Copeland NG, Gilbert DJ,
            Jenkins NA, Valentine V, Kirstein MN, Shapiro DN, Morris SW et al.
  TITLE     Chromosomal assignment and genomic structure of Il15
  JOURNAL   Genomics 25 (3), 701-706 (1995)
   PUBMED   7759105
REFERENCE   9  (bases 1 to 5655)
  AUTHORS   Newton G, Weremowicz S, Morton CC, Copeland NG, Gilbert DJ, Jenkins
            NA and Lawler J.
  TITLE     Characterization of human and mouse cartilage oligomeric matrix
            protein
  JOURNAL   Genomics 24 (3), 435-439 (1994)
   PUBMED   7713493
REFERENCE   10 (bases 1 to 5655)
  AUTHORS   Terajima M, Matsui Y, Copeland NG, Gilbert DJ, Jenkins NA and
            Obinata M.
  TITLE     Structural organization of the mouse glycophorin A gene
  JOURNAL   J Biochem 116 (5), 1105-1110 (1994)
   PUBMED   7896738
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ104355.1, BC133713.1, AK136580.1 and BQ174990.1.
            
            [WARNING] On Dec 20, 2023 this sequence was replaced by
            NM_001083906.3.
            
            On Jun 15, 2018 this sequence version replaced NM_001083906.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC133713.1, SRR10223970.10665.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               CJ104355.1         43-220
            179-4265            BC133713.1         1-4087
            4266-4981           AK136580.1         2131-2846
            4982-5655           BQ174990.1         1-674               c
FEATURES             Location/Qualifiers
     source          1..5655
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 36.34 cM"
     gene            1..5655
                     /gene="Nr3c2"
                     /gene_synonym="Mlr; MR"
                     /note="nuclear receptor subfamily 3, group C, member 2"
                     /db_xref="GeneID:110784"
                     /db_xref="MGI:MGI:99459"
     exon            1..211
                     /gene="Nr3c2"
                     /gene_synonym="Mlr; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            212..1970
                     /gene="Nr3c2"
                     /gene_synonym="Mlr; MR"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..3156
                     /gene="Nr3c2"
                     /gene_synonym="Mlr; MR"
                     /note="aldosterone receptor"
                     /codon_start=1
                     /product="mineralocorticoid receptor"
                     /protein_id="NP_001077375.1"
                     /db_xref="CCDS:CCDS40393.1"
                     /db_xref="GeneID:110784"
                     /db_xref="MGI:MGI:99459"
                     /translation="METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTNENSYME
                     IVNVSCVSGATPNNSTQGSSKEKHELLPCLQQDNSRSGILPSDIKTELESKELSATVA
                     ESMGLYMDSVRDAEYTYDQQNQQGSLSPAKIYQNMEQLVKFYKENGHRSSTLSAISRP
                     LRSFMPDSGTSMNGGALRAIVKSPIICHEKSPSVCSPLNMPSSVCSPAGINSMSSSTA
                     SFGSFPVHSPITQGTSLTCSPSVENRGSRSHSPVHASNVGSPLSSPLSSMKSPISSPP
                     SHCSVKSPVSSPNNVPLRSSVSSPANLNNSRCSVSSPSNTNNRSTLSSPTASTVGSIG
                     SPISNAFSYTTSGASAGAGAIQDMVPSPDTHEKGAHDVPFPKTEEVEKAISNGVTGQL
                     NIVQYIKPEPDGAFSSSCLGGNNKINPSSPFSVPIKQESSKHSCSGASFKGNPTVNPF
                     PFMDGSYFSFMDDKDYYSLSGILGPPVPGFDSSCEGSAFPGGIKQEPDDGSYFPETSI
                     PSSAIIGVNSGGQSFHYRIGAQGTISLSRSPRDQSFQHLSSFPPVNALVESWKPHGDL
                     SSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCK
                     VFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLK
                     GLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSALVPQLASITRALTPSPSMILEN
                     IEPEIVYAGYDNSKPDTAESLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLI
                     QYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMRQISLQFV
                     RLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNSSGQSW
                     QRFYQLTKLLDSMHDLVNDLLEFCFYTFRESQALKVEFPAMLVEIISDQLPKVESGNA
                     KPLYFHRK"
     exon            1971..2110
                     /gene="Nr3c2"
                     /gene_synonym="Mlr; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2227
                     /gene="Nr3c2"
                     /gene_synonym="Mlr; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2566
                     /gene="Nr3c2"
                     /gene_synonym="Mlr; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2711
                     /gene="Nr3c2"
                     /gene_synonym="Mlr; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2842
                     /gene="Nr3c2"
                     /gene_synonym="Mlr; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..3000
                     /gene="Nr3c2"
                     /gene_synonym="Mlr; MR"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..5638
                     /gene="Nr3c2"
                     /gene_synonym="Mlr; MR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagagagc caacttcagg ctgctcagag gaagcttgtg caagtcacct gggcgccaag
       61 cgctgctgtc ttgggctctc ccgctgcagg gagagcggca cttgctggcc tggatgtggt
      121 tggatgtagg ggggctccgc agcaggggtg tcgtggaggt ggcaagcact gcaacaggta
      181 gacggcgaga ggacgaccct ggccaaggca gctatggaaa ccaaaggcta ccacagtctc
      241 cctgaaggcc tagatatgga aaggcgctgg agtcaagtgt ctcagacctt ggagcgttct
      301 tctcttggac ctgcagagag gaccaatgag aacagctaca tggagattgt caacgtcagc
      361 tgcgtttccg gtgctactcc gaacaacagt actcaaggga gcagcaaaga aaaacacgaa
      421 ttactccctt gtcttcagca agacaatagt cggtctggga ttttgccatc agatattaaa
      481 actgagctgg aatccaagga actttcagcc acggtggctg agtccatggg tttatacatg
      541 gattctgtga gagatgccga gtacacttat gatcagcaaa accaacaagg aagcctgagc
      601 ccggcaaaga tttatcaaaa catggagcag ctggtgaagt tttacaaaga gaatggtcac
      661 aggtcctcca cactgagtgc tataagcagg cctttgaggt cattcatgcc tgactctggg
      721 acctccatga atggtggggc cttgcgtgcc atcgttaaga gcccaatcat ctgtcatgag
      781 aagagcccct ctgtttgcag cccgctcaac atgccgtctt cagtatgcag ccccgcgggc
      841 atcaactcca tgtcctcctc cacagctagc tttggcagtt tcccagtgca cagtcccatc
      901 actcaaggaa cctcactgac atgctccccc agtgttgaaa atagaggctc aaggtcacac
      961 agccccgtac atgcgagcaa tgtgggctct cctctttcaa gtccattaag cagcatgaaa
     1021 tccccaattt ccagccctcc aagtcactgc agtgtaaaat ctccagtatc cagtccaaac
     1081 aatgtccctc tgcgctcctc tgtgtcaagc ccggcaaatc ttaacaattc aaggtgctct
     1141 gtttccagcc cttccaacac caacaataga tctacactct ccagcccgac agctagcaca
     1201 gtggggtcca ttggcagccc catcagcaat gccttcagct ataccacttc aggcgcttcg
     1261 gctggagccg gtgccatcca ggatatggtt cccagtccag acacccacga gaaaggtgct
     1321 cacgacgttc ctttccctaa gacagaggaa gtcgagaagg ccatttccaa tggtgtgact
     1381 ggtcagctca acattgtcca gtacataaaa ccagaaccag atggggcttt cagcagttcc
     1441 tgcctaggag gaaacaacaa aatcaacccc agttctccgt tctctgtacc aataaagcaa
     1501 gagtcaagca agcactcatg ttcaggcgcc tcttttaaag ggaaccccac agtcaaccca
     1561 tttccattca tggatggctc gtacttttct tttatggatg ataaagacta ttattcccta
     1621 tcaggaatct taggaccacc tgtgcccggc tttgatagta gctgtgaagg cagtgcgttc
     1681 ccggggggga ttaagcaaga accagatgat gggagctatt tccctgaaac cagcatccca
     1741 tcatctgcca tcattggtgt gaattcaggt ggacagtcct ttcactaccg gattggtgct
     1801 caaggtacaa tatctttatc acggtcacct agagaccaat ctttccaaca cttgagttcc
     1861 tttccgcctg tcaatgcatt agtggagtca tggaaaccac acggtgacct gtcatctagg
     1921 agaagtgatg ggtacccggt cctagagtac attccagaaa acgtgtcaag ctctacttta
     1981 cgaagtgttt ctactggatc ctcaagacct tccaagatct gcttggtgtg tggagatgag
     2041 gcttctgggt gtcactatgg ggtagtgacc tgcggcagct gcaaagtctt cttcaaaaga
     2101 gccgtggaag gacaacacaa ctatctgtgt gctggaagaa atgactgcat tattgataag
     2161 attcggagaa agaactgtcc tgcctgcagg ctccagaaat gcctccaagc cggcatgaac
     2221 ttaggagctc gaaagtcaaa gaagctgggg aagttaaaag gccttcacga ggagcagcca
     2281 cagcagcccc caccgccacc accccagagc ccagaagagg ggaccacata cattgctcct
     2341 accaaggagc catcagtgaa ctctgcgctg gtcccgcagc tcgcctcgat cacgcgtgcg
     2401 ctcacgccat ccccgtccat gatcctggag aacatcgagc ccgagatcgt gtatgcaggc
     2461 tacgacaatt ccaagcctga caccgccgag agcctgctct ccacgctcaa ccgcctggcg
     2521 ggcaagcaga tgatccaagt cgtgaagtgg gccaaggtac ttccaggatt taaaaacttg
     2581 cctcttgagg accaaattac cctcatccag tattcttgga tgtgtctatc atcgtttgcc
     2641 ttgagttgga gatcgtacaa acatacgaac agccaatttc tctattttgc accagaccta
     2701 gtttttaatg aagagaagat gcatcagtct gccatgtatg agctgtgcca ggggatgcgg
     2761 cagatcagcc ttcagttcgt gcggcttcag ctgacctttg aggagtactc cataatgaag
     2821 gttttgctgc tactgagcac agttccaaaa gatggcctca agagccaggc tgcgtttgag
     2881 gagatgagga caaattacat caaagaactg aggaaaatgg tcaccaagtg tcccaacagt
     2941 tctggacaga gttggcagag gttctaccaa ctgacgaagc ttctagactc catgcatgat
     3001 ttggtgaatg acctgctaga attctgcttc tataccttcc gagaatccca ggctctgaag
     3061 gtggagtttc ccgccatgct ggtggagatc atcagcgacc agctgccaaa ggtggaatcc
     3121 gggaacgcca agccccttta ctttcacagg aagtgatgga agatgccggc caggaagaac
     3181 tttgccttaa gtttccccac gttgttctac aactacgaag gacccaagaa atcacatttt
     3241 taacatgtga cggcggattg acagttggtc ggcagtttct caagtttaaa atcccatcga
     3301 gggtgtggag tcgggaaagc caggagacct ggatcaggca agcctgagct gactaaggga
     3361 ctcttccctc tccactccca gtgcttagaa aacatgttcc cgttcctctg gatgaaaagc
     3421 catatctagt caataactct gattttgata ttttaacaga tggaagtttt aactatgcca
     3481 tgtggtttct ggtatctctc gcttgttttc aaagggttca aaggactaga gaacttttta
     3541 aagcttaccc ttggtttgca cataaaatgt ctagtcaata tggggcatta atattctttt
     3601 gttatttaaa aacacacaaa aagcatacac aaaaatacat acagattcct ggtatgtaat
     3661 aaacagaaca cgtggcgtgg aactgtggcc ttccaggcac gtttttctgc atcgctggca
     3721 tacacactcg ttagtgtcca tttattattt aattagaatg gataagatgt taaatgcctt
     3781 ggtttcgatt tctagtatct attgtgttgg ctttacaaat aattttttgc agtcttttgc
     3841 tgtgctgtac attactgtat gtataaatcg tgaaggacct gaaataaggt gtaaggaact
     3901 tttgtaaatg agacacaaaa aaaaatcttt aatggttaat aggatgaatg ggaaagtatt
     3961 tttgaaagaa ttctattttg ctggagacta tttaagtact atctttgtct aaacaaggta
     4021 actttttttt gtaagtgaga tgccctgcat gcgtactgaa ccgtttacag tgtatttaag
     4081 aaagggaaag ctgtgccttt ttttagcttc atatctaatt taccatttta cagtctctgt
     4141 tgtaaataac cacacttaaa cctctttggt tgtctctaag cctttctact ttttcagtac
     4201 tatttgtttt gttcttggtc tcctgcgtgg ggtgttcgtg agactccagc gcgtagttct
     4261 ggcttctgct tcttcctgct tccatccggg atgctgctgc agcatctgca gctcctgaca
     4321 ggtgacaggg cccattggac caaggtcctg agagtgctgt ccttccccct ttgctacaag
     4381 aagcagaact tgctcttgga aggggagact ggaaacatag ctcagagagc acaattctcc
     4441 cattccagaa aatcggattt tctcctctgg gggaaaaaaa aaattccatg caccctccac
     4501 atctgtcaaa gatcagaagt cacctctggc cttggacagg gtccttcact cctggagctg
     4561 gtcacaggaa cagcagtcat ggcaggaggt actggggcaa tccatctaag catgagtcgg
     4621 tcagaatgga gacccacaga tcactagaag gtttttagat ttttttaaag gtaggtttta
     4681 aaagtgaaaa ttttatacat aaacagtttt ggaggaaaaa aaccacaaaa acactatgaa
     4741 tcacataagc aagacagtgg cactaaaatt ttaattcatt aatctgtcca atactgatgc
     4801 aatttatggc ttttttcttg ccccaaatca cagacatgtg tatctctggg gaacttcagt
     4861 atgattgcac taaatgatct ttgaatagag gccaaattaa tctttcaaac atgatgatga
     4921 ctctcatcag tactcagtga tcatgaattc ccaaaaccta aaaggtgaag cagaaggctg
     4981 ggacaaagcc cccgtggggt cagcagtttc ccacagggtt caccacgcag gcaacattac
     5041 cttgtctttc aaaagacgcc tgccttctgc aaggggagac ccagggacgc tgaactcaga
     5101 gggagggggc tttcttacat catttgcaat ctggaggatt taatttatag gtctttaaac
     5161 acagtcagct tacatgcaca gcaatatgaa aaccacactt tgaaggccat gaacacacac
     5221 agcatgcaga cgagatgttt ctgggggaaa ggagctgagt taactctaag aaactggaat
     5281 tccaccttag ccaggattga agtggagaag gtctgcatta gctttttgta ttaatgaagt
     5341 tactggctcc tcatgtgtct ccaggtaact ctgcttaact aaacagcaaa gccatattct
     5401 ctaaaattca ctgttgaatg cctgtcccag gccaaactgt ctgtctgctc ttatttttgt
     5461 accatattgc tcttaaaaaa atctcggttt ggtacaattc ataattcacc aaaacttctt
     5521 catataatta aaaacactaa attagtttaa aatgaagcaa tttatatctt tatgcaaaaa
     5581 catgtctgtc tttgcaaagg actgtaagca gattacaata aatcctttac tttaatcaaa
     5641 aaaaaaaaaa aaaaa
//
