LOCUS       NM_001361211            6629 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus nuclear receptor subfamily 3, group C, member 1
            (Nr3c1), transcript variant 4, mRNA.
ACCESSION   NM_001361211 XM_006525666
VERSION     NM_001361211.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6629)
  AUTHORS   Zhou,L., Mu,S., Zhang,Y. and Song,H.
  TITLE     USP10-mediated deubiquitination of NR3C1 regulates bone homeostasis
            by controlling CST3 expression
  JOURNAL   Biochem Pharmacol 229, 116519 (2024)
   PUBMED   39236936
  REMARK    GeneRIF: USP10-mediated deubiquitination of NR3C1 regulates bone
            homeostasis by controlling CST3 expression.
REFERENCE   2  (bases 1 to 6629)
  AUTHORS   Zhou,L., Pereiro,M.T., Li,Y., Derigs,M., Kuenne,C., Hielscher,T.,
            Huang,W., Kranzlin,B., Tian,G., Kobayashi,K., Lu,G.N., Roedl,K.,
            Schmidt,C., Gunther,S., Looso,M., Huber,J., Xu,Y., Wiech,T.,
            Sperhake,J.P., Wichmann,D., Grone,H.J. and Worzfeld,T.
  TITLE     Glucocorticoids induce a maladaptive epithelial stress response to
            aggravate acute kidney injury
  JOURNAL   Sci Transl Med 16 (767), eadk5005 (2024)
   PUBMED   39356748
REFERENCE   3  (bases 1 to 6629)
  AUTHORS   Liu,Y., Wang,X., Wang,J., Jin,Q., Cai,W., Pan,C., Nivar,J., Tao,Y.,
            Cao,H. and Li,J.
  TITLE     ClassIIb histone deacetylase participates in perioperative
            neurocognitive disorders in elderly mice via HSP90/GR signaling
            pathway
  JOURNAL   Exp Neurol 380, 114922 (2024)
   PUBMED   39142371
  REMARK    GeneRIF: ClassIIb histone deacetylase participates in perioperative
            neurocognitive disorders in elderly mice via HSP90/GR signaling
            pathway.
REFERENCE   4  (bases 1 to 6629)
  AUTHORS   Shi,R., Li,Y., Zhu,W., Xin,H., Yang,H., Feng,X., Wang,Z., Li,S.,
            Cong,B. and Shi,W.
  TITLE     The Regulation of Frontal Cortex Cholesterol Metabolism
            Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of
            Stress-Induced Depression
  JOURNAL   Int J Mol Sci 25 (15), 8075 (2024)
   PUBMED   39125645
  REMARK    GeneRIF: The Regulation of Frontal Cortex Cholesterol Metabolism
            Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of
            Stress-Induced Depression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6629)
  AUTHORS   Diba,F., Watson,C.S. and Gametchu,B.
  TITLE     5'UTR sequences of the glucocorticoid receptor 1A transcript encode
            a peptide associated with translational regulation of the
            glucocorticoid receptor
  JOURNAL   J Cell Biochem 81 (1), 149-161 (2001)
   PUBMED   11180405
REFERENCE   6  (bases 1 to 6629)
  AUTHORS   Chen,F., Watson,C.S. and Gametchu,B.
  TITLE     Association of the glucocorticoid receptor alternatively-spliced
            transcript 1A with the presence of the high molecular weight
            membrane glucocorticoid receptor in mouse lymphoma cells
  JOURNAL   J Cell Biochem 74 (3), 430-446 (1999)
   PUBMED   10412044
REFERENCE   7  (bases 1 to 6629)
  AUTHORS   Chen,F., Watson,C.S. and Gametchu,B.
  TITLE     Multiple glucocorticoid receptor transcripts in membrane
            glucocorticoid receptor-enriched S-49 mouse lymphoma cells
  JOURNAL   J Cell Biochem 74 (3), 418-429 (1999)
   PUBMED   10412043
REFERENCE   8  (bases 1 to 6629)
  AUTHORS   Strahle,U., Schmidt,A., Kelsey,G., Stewart,A.F., Cole,T.J.,
            Schmid,W. and Schutz,G.
  TITLE     At least three promoters direct expression of the mouse
            glucocorticoid receptor gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6731-6735 (1992)
   PUBMED   1495961
REFERENCE   9  (bases 1 to 6629)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   10 (bases 1 to 6629)
  AUTHORS   Johnson,K.R. and Davisson,M.T.
  TITLE     A multipoint genetic linkage map of mouse chromosome 18
  JOURNAL   Genomics 13 (4), 1143-1149 (1992)
   PUBMED   1354640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124417.5 and AC007995.23.
            
            On Apr 27, 2018 this sequence version replaced XM_006525666.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.154344.1,
                                           SRR1660825.50160.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               AC124417.5         38362-38661         c
            301-1548            AC124417.5         34883-36130         c
            1549-1712           AC007995.23        162142-162305       c
            1713-1829           AC007995.23        157908-158024       c
            1830-2105           AC007995.23        156013-156288       c
            2106-2250           AC007995.23        154932-155076       c
            2251-2381           AC007995.23        154101-154231       c
            2382-2539           AC007995.23        149221-149378       c
            2540-6629           AC007995.23        144070-148159       c
FEATURES             Location/Qualifiers
     source          1..6629
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 21.09 cM"
     gene            1..6629
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /note="nuclear receptor subfamily 3, group C, member 1"
                     /db_xref="GeneID:14815"
                     /db_xref="MGI:MGI:95824"
     exon            1..300
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /inference="alignment:Splign:2.1.0"
     exon            301..1548
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1712
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1829
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2105
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2250
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2381
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2539
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..6629
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6593..6598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /note="hexamer: AATAAA"
     polyA_site      6617
                     /gene="Nr3c1"
                     /gene_synonym="GR; Grl-1; Grl1"
                     /note="major polyA site"
ORIGIN      
        1 gtcgccgccc gcccgtcggg gacggattct aagtgggtgg aacaagacgc cgcagccggg
       61 cggcgcggcg ccgggacggg agaacgcgcg cggggagacg ggagcggcgc gggggcccgg
      121 cttgtcagcc gggaacgggt gactttccgc gctaggggct ctcccctccc ccatggaaaa
      181 gagggggcga ctgttgactt ccttctccgt gacacgcgcg cctcccgcgt ccgcacgccg
      241 acttgtttat ctggctgcgg tgggagccgc aggcgggcgg gcgagcgcgc cggtgctgag
      301 ttaatatttg ccaatggact ccaaagaatc cttagctccc cctggtagag acgaagtccc
      361 cagcagtttg cttggccggg ggaggggaag cgtgatggac ttgtataaaa ccctgagggg
      421 tggagctaca gtcaaggttt ctgcgtcttc accctcagtg gctgctgctt ctcaggcaga
      481 ttccaagcag cagaggattc tccttgattt ttcaaaaggc tcagcaagca atgcgcagca
      541 gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcagccgc agccagattt
      601 atccaaagcc gtttcactgt ccatgggact gtatatggga gagaccgaaa caaaagtgat
      661 ggggaatgac ttgggctacc cacagcaggg ccagcttggc ctctcctctg gggaaacaga
      721 ctttcggctt ctggaagaaa gcattgcaaa cctcaatagg tcgaccagcc gtccagagaa
      781 ccccaagagt tcaacacctg cagctgggtg tgctaccccg acagagaagg agtttcccca
      841 gactcactct gatccatctt cagaacagca aaatagaaaa agccagcctg gcaccaacgg
      901 tggcagtgtg aaattgtata ccacagacca aagcaccttt gacatcttgc aggatttgga
      961 gttttctgcc gggtccccag gtaaagagac aaacgagagt ccttggaggt cagacctgtt
     1021 gatagatgaa aacttgcttt ctcctttggc gggagaagat gatccattcc ttctggaagg
     1081 ggacgtgaat gaggattgca agcctcttat tttaccggac actaaaccta aaattcagga
     1141 tactggagat acaatcttat caagccccag cagtgtggca ctgccccaag tgaaaacaga
     1201 gaaagatgat ttcattgagc tttgcacccc tggggtaatt aagcaagaga aactgggccc
     1261 ggtttattgc caggcaagct tttctgggac aaatataatt gggaataaaa tgtctgccat
     1321 ttctgttcat ggcgtgagta cctctggagg acagatgtac cactatgaca tgaatacagc
     1381 atccctttct cagcagcagg atcagaagcc tgtttttaat gtcattccac caattcctgt
     1441 tggttctgaa aactggaata ggtgccaagg gtctggagag gacaacctga cttccttggg
     1501 ggctatgaac ttcgcaggcc gctcagtgtt ttctaatgga tattcaagcc ctggaatgag
     1561 accagatgtg agttctcctc cgtccagctc ctccacagca acgggaccac ctcccaaact
     1621 ctgcctggtg tgctccgatg aagcttcggg atgccattat ggggtgctga cgtgtggaag
     1681 ctgtaaagtc ttctttaaaa gagcagtgga aggacagcac aattaccttt gtgctggaag
     1741 aaatgattgc atcattgata aaattcgaag aaaaaactgt ccagcatgcc gctatcgaaa
     1801 atgtcttcaa gctggaatga acctggaagc tcgaaaaacg aagaaaaaaa ttaaaggaat
     1861 tcagcaagcc actgcaggag tctcacaaga cacttctgaa aacgctaaca aaacaatagt
     1921 tcctgccgcg ctgccacagc ttacccctac cctggtgtca ctgctggagg tgatcgagcc
     1981 tgaggtgtta tatgcaggat atgacagctc tgttccagac tcagcatgga gaattatgac
     2041 cacgctcaac atgttaggtg ggcgccaagt gattgccgca gtgaaatggg caaaggcgat
     2101 accaggattc agaaacttac acctggatga ccaaatgacc cttctacagt actcatggat
     2161 gtttctcatg gcatttgccc tgggttggag atcatacaga caagcaagtg gaaacctgct
     2221 atgctttgct cctgatctga ttattaatga gcagagaatg actctaccct gcatgtatga
     2281 ccaatgtaaa cacatgctgt ttatctccac tgaattacaa agattgcagg tatcctatga
     2341 agagtatctc tgtatgaaaa ccttactgct tctctcctca gttcctaagg aaggtctgaa
     2401 gagccaagag ttatttgatg agattcgaat gacttatatc aaagagctag gaaaagccat
     2461 tgtcaaaagg gaaggaaact ccagtcagaa ttggcagcgg ttttatcaac tgacaaaact
     2521 tttggactcc atgcatgatg tggttgaaaa tctccttagc tactgcttcc aaacattttt
     2581 ggataagtcc atgagtattg aattcccaga gatgttagct gaaatcatca ctaatcagat
     2641 accaaaatac tcaaatggaa atatcaaaaa gcttctgttt catcagaaat gactgcctta
     2701 ctaagaaagg ctgccttaaa gaaagttgaa tttatagctt ttactgtaca aacttatcaa
     2761 cttgtcttgt agatgttttg tcgttctttt tgtttgtctt gtttgttttc tatacgcact
     2821 acatgtggtc tctagagggc caagacttgg caacagaagc agatgagcca tcacttttca
     2881 gtgacaggaa agcagacagt gatgtgcatt ggctggtgta tcacagaaac tagaacagtt
     2941 agtggagaca tgtccactat cagagaagga ccgcacctga accaccagtg cccaaagtcc
     3001 atgtgatcaa ctttctgctc aactttcagt tggctggata acactttcta gacttttctg
     3061 ttggtgtatt tttcccatgt atagttagga tagcattttg atttatgcat ggaaacctga
     3121 aaaaagttta cacgtgtata tcagaaaagg gaagttgtgc cttttatagc tattactgtc
     3181 tggttttaac aatttccttt atattcagtg aactatgctt gctcgttttt cttaaataat
     3241 ttttgtattc tagttattgt atagctgttt aagatgggca gctgcctcac agctctccta
     3301 gacgctaaca ttaatttccg tgtgaaaatg ggtcggtgct cctaccctga tggcactcag
     3361 ctatcagaag accacagaaa ttgactcaga tctccagtat tcttgtcaaa agctcttact
     3421 ctgtatatat ctgcttccat ggggaattat ataggttgtg cagattaacc gtcctaactg
     3481 gtatagagca cctagtccag tgacctgctg ggtaaactgt ggatgatggt tacaaaagac
     3541 taattgtaaa acagtgccca ccaacaggcc ccgtttgcac ccaatgcacc atctcttcag
     3601 tggtgcgata gcaacaaagt ttgtaactca gctctttcag gaccttcggg agtagtttgt
     3661 gtaacatttt aaaatgtatt attccagata accagctgtg ataaagccga gagattgttt
     3721 taatcagacc aagtaacttc tctcattaaa cgttaccctc aactaagtct ctaatatggc
     3781 aagaatggct agacacccat tttcacatcc cacctgtcac caattggtct agctttcctg
     3841 gtggtacagg aaaatcagct actgattttt tgttatttag aactgaatgt caggcatcca
     3901 tgtttgtcca actatacatc cctacatgtg ccatagaatc taacacaagt cttgtgaact
     3961 tcttcacact gagagttatc attttaaaca aaacagaagc tgtagtagcc ctttctgtgt
     4021 gcaccttacc aactttctgt gactcaaagc ttaacacact tactaagcca caagaaatct
     4081 gatttctact taaggtggcc aaattatttg tgtaatagaa aactgaaaat ctaatattaa
     4141 aaatatgaaa cttctaatat atttttatat ttagttctag tttcagatat atatcatatt
     4201 ggtattcact aatctgggaa gggaagggct actgcagctg tacatgcaat ttattaacat
     4261 gattgtaaaa tagctgtata gtgtaaaata agaatgattt ttagatgaga ttgttttatc
     4321 atgacatgtt atatattttt tgtaggggtc aaagaaatgt tgatggatat cctataagat
     4381 ttatagtata taagagcatc catacaggcc tcagtggtct tggaaattaa aacaggtttg
     4441 ctctaagcta gggagaggga gctgggactg gccctgtgtg cagtgcaggt cctgagggtt
     4501 tgacccgatc agatcacagg ggaactaatt ccctcccatc taaccatcct catccgacca
     4561 tggccctgtc agtgcaggct ggctttatta aatccaggac agaaaggtgg cgcttatgta
     4621 cttagaggca ccgtccagta acagggttgt tcccacatgc agcctccgca cgggttaaca
     4681 gaaacagagg ctttagaagt ttggcaataa tgtgcataga ggttccagca atatgtaaat
     4741 actaaagaat cgcataggaa gccaataata cactaatcct ctccatccta caagagtcca
     4801 tttccaagta agatgaggac atgtttatgt tttctttgaa tgctttttga atgttgttat
     4861 tttcagtatt ttgcagaaat tatttaataa aaaaaagtat aatcatttgc tttttgaatt
     4921 ctctctaaaa gggaatgttc agtttgtaat ggtttaaatt ggtctcaaag tactttaaaa
     4981 taattgtaac ccagctggat gtgaaattta tggtgcctaa gaaataccac ttgaagatta
     5041 tcaatgacag tgttaagttt caaaatgagc ttctcaaaaa tagattattg tacatttatg
     5101 gaatgttata tggttaaacc caaaaagcac atcacacata aatctgcttt cagttccaac
     5161 cagcttggct ttcaaaaata gagctccaaa aaaaaaaaag gaaaaaaaag atatatatgc
     5221 tttgttatta acagaaggca gcagacattc ataaaactac tatcggaagt tttccattag
     5281 atgtataaag agctatcctt tggtatgtgg gaaagaagaa agctgtcata attctgattg
     5341 agtataagtg agagagatac ggtactgttt gagagcagct ccttttctgc gtgtggcttc
     5401 ataccgttcc aaactatgta gattttataa tagcttcagt gagaattggt aacatgcctg
     5461 tatgactcac aacagatctt gaaaactatc tttaattact ggtaggacaa aaagggacat
     5521 tctggttatt ttaggcactg gcttggaaca ctgtatatgc agaagaaaga agacaggcaa
     5581 tctggggaaa ggaaggggac ctgggaagca ctgccttctt taaggaaaga cacaccaata
     5641 gatgagatca tcccaaaggc acagggacca cagagtgtga gtccttagtg acgagtcagg
     5701 tgagctctgg tgagcttgga gaagccagcc ccaccagcag agcaggcacg gcagggatgg
     5761 gacaagcagg gacgacaatt ccagctggac actggtccca gtattttgct ccctcttata
     5821 taccgtgagg cagtatcacc gtgggatgaa ccatggtagc acgttttgat ctgtcagcac
     5881 tcaaggatca tggtagcctt cgggagcttt aggttttggt tggtcacccc aacgatcagc
     5941 tgtagttgaa tgtgtttctt atgtgcctgg tttcagtgtt agaaggtgaa atagagtgtg
     6001 caaaggacac tgcaaaccac ttcggatgga agttttctca ttttccagac tattttcggt
     6061 cagcctggtc tatcaagatc ggtaaccagg tcttcaggaa agggttggct tctatctagg
     6121 acatgcctga aaggatttta ttttctgata aatggctgta tgaaaatacc ctcctaaata
     6181 ccctgcttaa ctacatatag atttcagtgt gtcaatattc tattttgtat attaaacaaa
     6241 tgctatataa tggggacaaa tctatattat actgtgtatg gcattattaa gaagcttttt
     6301 cattattttt tatcacagta atttttaaat gtgtaaaaat taaaaaccag tgactcctgt
     6361 ttaaaaataa aagttgtagt tttttattca tgctgaataa cctgtagttt aaaaacctgt
     6421 ctttctacta cacagtgaga tgtcagactg taaagttttg tgtggaaatg tttaactttt
     6481 atttttcatt tcaatttgct gttctggtat taccaaacca cacatttgta atgaattggc
     6541 agtaaatgtt agtcagccat ttacagcaat gccaaatatg gataaacatc ataataaaag
     6601 tatctgcttt ttcattatgt gactcccaa
//
