LOCUS       NM_009697               4216 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus nuclear receptor subfamily 2, group F, member 2
            (Nr2f2), transcript variant 1, mRNA.
ACCESSION   NM_009697
VERSION     NM_009697.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4216)
  AUTHORS   Moldovan,G.E., Massri,N., Vegter,E.L., Pauneto-Delgado,I.N.,
            Burns,G.W., Joshi,N., Gu,B., Arora,R. and Fazleabas,A.T.
  TITLE     YAP1 and WWTR1 are required for murine pregnancy initiation
  JOURNAL   Reproduction 169 (1), e240355 (2025)
   PUBMED   39503541
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4216)
  AUTHORS   Amato,C.M., Xu,X. and Yao,H.H.
  TITLE     An extragenital cell population contributes to urethra closure
            during mouse penis development
  JOURNAL   Sci Adv 10 (49), eadp0673 (2024)
   PUBMED   39642224
REFERENCE   3  (bases 1 to 4216)
  AUTHORS   Tagami,A., Ikeda,Y., Ishizuka,K. and Maekawa,M.
  TITLE     Conditional disruption of Nr5a1 directed by Sox9-Cre impairs
            adrenal development
  JOURNAL   Sci Rep 14 (1), 12297 (2024)
   PUBMED   38811798
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4216)
  AUTHORS   Wan,R., Long,S., Ma,S., Yan,P., Li,Z., Xu,K., Lian,H., Li,W.,
            Duan,Y., Zhu,M., Wang,L. and Yu,G.
  TITLE     NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial
            cell senescence
  JOURNAL   Respir Res 25 (1), 154 (2024)
   PUBMED   38566093
  REMARK    GeneRIF: NR2F2 alleviates pulmonary fibrosis by inhibition of
            epithelial cell senescence.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4216)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4216)
  AUTHORS   Pereira,F.A., Qiu,Y., Tsai,M.J. and Tsai,S.Y.
  TITLE     Chicken ovalbumin upstream promoter transcription factor (COUP-TF):
            expression during mouse embryogenesis
  JOURNAL   J Steroid Biochem Mol Biol 53 (1-6), 503-508 (1995)
   PUBMED   7626501
  REMARK    Review article
REFERENCE   7  (bases 1 to 4216)
  AUTHORS   Kadowaki,Y., Toyoshima,K. and Yamamoto,T.
  TITLE     Dual transcriptional control by Ear3/COUP: negative regulation
            through the DR1 direct repeat and positive regulation through a
            sequence downstream of the transcriptional start site of the mouse
            mammary tumor virus promoter
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4432-4436 (1995)
   PUBMED   7753823
REFERENCE   8  (bases 1 to 4216)
  AUTHORS   Lopes da Silva,S., Cox,J.J., Jonk,L.J., Kruijer,W. and Burbach,J.P.
  TITLE     Localization of transcripts of the related nuclear orphan receptors
            COUP-TF I and ARP-1 in the adult mouse brain
  JOURNAL   Brain Res Mol Brain Res 30 (1), 131-136 (1995)
   PUBMED   7609634
REFERENCE   9  (bases 1 to 4216)
  AUTHORS   Ben-Shushan,E., Sharir,H., Pikarsky,E. and Bergman,Y.
  TITLE     A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and
            retinoic acid receptor:retinoid X receptor heterodimers regulates
            Oct-3/4 expression in embryonal carcinoma cells
  JOURNAL   Mol Cell Biol 15 (2), 1034-1048 (1995)
   PUBMED   7823919
REFERENCE   10 (bases 1 to 4216)
  AUTHORS   Lu,X.P., Salbert,G. and Pfahl,M.
  TITLE     An evolutionary conserved COUP-TF binding element in a
            neural-specific gene and COUP-TF expression patterns support a
            major role for COUP-TF in neural development
  JOURNAL   Mol Endocrinol 8 (12), 1774-1788 (1994)
   PUBMED   7708064
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC042484.1, BC094360.1 and AC125317.4.
            
            On Aug 17, 2006 this sequence version replaced NM_009697.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042484.1, AK140125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-706               BC042484.1         1-706
            707-1720            BC094360.1         632-1645
            1721-4216           AC125317.4         153155-155650       c
FEATURES             Location/Qualifiers
     source          1..4216
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 38.66 cM"
     gene            1..4216
                     /gene="Nr2f2"
                     /gene_synonym="2700033K02Rik; 9430015G03Rik; Aporp1;
                     ARP-1; COUP-TF2; COUP-TFII; COUPTFB; EAR3; SVP40;
                     Tcfcoup2"
                     /note="nuclear receptor subfamily 2, group F, member 2"
                     /db_xref="GeneID:11819"
                     /db_xref="MGI:MGI:1352452"
     exon            1..706
                     /gene="Nr2f2"
                     /gene_synonym="2700033K02Rik; 9430015G03Rik; Aporp1;
                     ARP-1; COUP-TF2; COUP-TFII; COUPTFB; EAR3; SVP40;
                     Tcfcoup2"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1509
                     /gene="Nr2f2"
                     /gene_synonym="2700033K02Rik; 9430015G03Rik; Aporp1;
                     ARP-1; COUP-TF2; COUP-TFII; COUPTFB; EAR3; SVP40;
                     Tcfcoup2"
                     /note="isoform 1 is encoded by transcript variant 1; COUP
                     transcription factor 2; COUP-TF II; COUP transcription
                     factor II; apolipoprotein AI regulatory protein 1;
                     apolipoprotein regulatory protein 1"
                     /codon_start=1
                     /product="COUP transcription factor 2 isoform 1"
                     /protein_id="NP_033827.2"
                     /db_xref="CCDS:CCDS21359.1"
                     /db_xref="GeneID:11819"
                     /db_xref="MGI:MGI:1352452"
                     /translation="MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPG
                     QGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSF
                     FKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPT
                     HGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAAR
                     MLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLH
                     ASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHV
                     ESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPI
                     ETLIRDMLLSGSSFNWPYMAIQ"
     exon            707..1234
                     /gene="Nr2f2"
                     /gene_synonym="2700033K02Rik; 9430015G03Rik; Aporp1;
                     ARP-1; COUP-TF2; COUP-TFII; COUPTFB; EAR3; SVP40;
                     Tcfcoup2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..4216
                     /gene="Nr2f2"
                     /gene_synonym="2700033K02Rik; 9430015G03Rik; Aporp1;
                     ARP-1; COUP-TF2; COUP-TFII; COUPTFB; EAR3; SVP40;
                     Tcfcoup2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2702..2707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr2f2"
                     /gene_synonym="2700033K02Rik; 9430015G03Rik; Aporp1;
                     ARP-1; COUP-TF2; COUP-TFII; COUPTFB; EAR3; SVP40;
                     Tcfcoup2"
                     /note="hexamer: ATTAAA"
     polyA_site      2727
                     /gene="Nr2f2"
                     /gene_synonym="2700033K02Rik; 9430015G03Rik; Aporp1;
                     ARP-1; COUP-TF2; COUP-TFII; COUPTFB; EAR3; SVP40;
                     Tcfcoup2"
                     /note="major polyA site"
ORIGIN      
        1 cgagggaaac aaacaaaaca aacacaccgg gccagacaag caatcgacaa aactttgcaa
       61 aagcaaaaac aaaaaaacaa aaaaggaaaa actaaccaac ctcaaatcaa ctagccctga
      121 gccacccggg gcgccctccc gcgccctctc gcaccctcgc acacacaaaa ggcggcgcgc
      181 cggagcccga gacccgggag ccgccgccac cccgccgccg cccgcagcca ggggagcaga
      241 agtccggacg cggcccccat agatatggca atggtagtca gcacgtggcg cgacccccag
      301 gacgaggtgc ccggctctca gggcagccag gcctcgcagg cgccgcccgt gccgggcccg
      361 ccgcctggcg ccccgcacac gccacagacg ccgggccaag ggggcccggc cagcacgccg
      421 gcccagacag cggctggcgg ccagggcggc cctggcggcc cgggcagcga caagcagcag
      481 cagcagcagc acatcgagtg cgtggtgtgc ggggacaagt cgagcggcaa gcactacggc
      541 cagttcacgt gcgagggctg caagagcttc ttcaagcgca gcgtgcggag gaacctgagc
      601 tacacgtgcc gcgccaaccg gaactgtccc atcgaccagc accaccgcaa ccagtgccag
      661 tactgccgcc tcaaaaagtg cctcaaagtg ggcatgagac gggaagctgt acagagaggc
      721 aggatgcctc ctacccagcc tacccacggg cagtttgccc tgaccaacgg ggaccccctc
      781 aactgccact cgtacctgtc cggatatatt tccctgctgc tgcgcgcgga gccctacccc
      841 acgtcgcgct tcggcagtca gtgcatgcag cctaacaaca tcatgggcat cgagaacatt
      901 tgcgaactgg ccgcacggat gctcttcagc gccgttgagt gggcccggaa catccccttc
      961 ttccctgacc tgcagatcac ggaccaggtg gccctccttc gcctcacctg gagcgagctg
     1021 ttcgtgttga atgcggccca gtgctccatg cccctccatg tcgccccgct ccttgccgct
     1081 gctggcctgc acgcttcacc catgtcagcc gaccgggtgg tcgcttttat ggaccacata
     1141 cggatcttcc aagagcaagt ggagaagctc aaggcactgc acgtcgactc cgccgagtat
     1201 agctgcctca aggccatagt cctgttcacc tcagatgcct gtggtctgtc tgatgtagcc
     1261 catgtggaaa gcttgcagga aaagtcccag tgtgctttgg aagagtacgt taggagccag
     1321 taccccaacc agccaacacg gttcggaaag ctcttgcttc gtctcccttc cctccgcacg
     1381 gtctcctcct cagtcataga gcaattgttt ttcgtccgtt tggtaggtaa aacccccatc
     1441 gaaaccctca tccgggatat gttactgtcc ggcagcagtt ttaactggcc atatatggca
     1501 attcaataaa taaatcaatc aaaataaggg ggagtgaaac agagaaagaa aaggcaaaag
     1561 actggttttg tttgcttaat ttccttctgt taagaaagga tgttacaagt ttgctaaaaa
     1621 gaagagaggg gaagaattta atggactgtg aatttcaaaa aggagagaga gaaagagaga
     1681 gactgccaaa tgaactttta cagaatgcat taaaaaaaaa gaaagaaaac aactcctgtg
     1741 ttgggcagaa caacctgcta cttatcattt ttgtataaaa aggaaattag tctttttttc
     1801 tttttggtaa atttttgaaa aatattgcta aaagtgcatt taaggagatt gggagaaaat
     1861 tagcagaatg gacaaagtaa gtcatttttt tccaaattat taattgtcct gtgtctatgt
     1921 acctctagtt gttctttttt ttttttttta acttttctgg ttccaaacca gtttattctg
     1981 tggttcaata ataagttttg atataatctt ggcttcttaa aaactgtgta tcattaaaat
     2041 atatgttctg caagaattaa aactgagtcc atgaaaatag cataggaaaa cataaaactt
     2101 taaaaggcaa ctcagagatg gtggaaatgc acttacaagt ggtggccaaa ttgttttttt
     2161 tttttttttt ttaaggtaaa gttgagcact ctaattagca agctggggga atcacatcaa
     2221 cacttagctt ccccaccccc accccatacc atgacaaacc tagcttttta aaaaaaatat
     2281 tttaagaaac agaaggaact gtggaattta ttggcagcca aggaatgtgt ccaagacaca
     2341 agctgaggtt tttgaataaa aagtgaactt ttgtaatttg aattgggtcc ccccccctta
     2401 gttcttgaat tgttatgaat cctatatctg tttgtatatt tgcaagccct ttgtattata
     2461 attgttgata tttccccttt ttaaaaaata ccattgaaat cagcatgaca aaataacact
     2521 gttggcactt ataggtaacg tgattgattc agtatcttag agtttacagt ttgtgttttt
     2581 aaaaaactga aggttttttt tttaagtgca acatttctgt atactgtaaa agttataata
     2641 actgaactgt ttggtcgagt ctttgtgtgt tatattccaa ggaaattgaa agtattcaga
     2701 aattaaaata ttatttgata tctgaaatct gcttggctgt ccccactcac tgtctttcca
     2761 cggagctgag cccctgtgag ttctcgctga gccagcgggg gccccatttg tttactccct
     2821 caatcagttt gttcaaaggt agactagtgt atttgcctgt ttaatttggg tgtggtgtgg
     2881 ggggggagct gaagttaatg gtttagctat ggtttaggaa gtgccacact gatatagtaa
     2941 gccaccccca ttcacctaat cctactttta attaaaaatg gattttccag gaaaaaaata
     3001 aggcccttat atttgtcaca cttaagtgcc tgcttaggga aggtattgtg aaaagtatta
     3061 gaaattttga gatcagtatc tgttttatga tcagaaaaaa aatgctcttt tgtacatttg
     3121 tgacagttat gcagaggact gtccaagcaa gctaatcaca gaactgtaaa tagagggcag
     3181 ttgtttgcaa tgagtttttc cttaagtaag tgtaattttt ctttttcttt ttttcttttt
     3241 tttttaaaaa tatcctgagg ttctcattta gcgtggctgt tgagaggatt ttgaatacag
     3301 tgatgtagct gctagcgacg aagggtctgt ttttcttgta tatacatgat aacttgcagt
     3361 tgccctgcct ttcccctccc cctccctctt cagtctgttg agagcatggc cacaggtcaa
     3421 gggaatcttt accattggag ttatgtacat aaaaaaaaaa aaccatgaac atttggacat
     3481 ttcagattat atagaaacaa tctgtactgc tctgggatcc tttggtctta gaaaccattt
     3541 ttgggggggt ggagagagag agagggagag gagagagaga gagagagaga gagagagaga
     3601 gagagagaga gagagagaga gagagagaga gaataaagaa aactttacag ggtgtgctga
     3661 tttgggaagt caactatttg gttctgtccc ttattctctt ttcctggttt gggaagagct
     3721 cactgctggg aacttgcaat ttgttcttat ttagactttc caagctgccc tccctgacaa
     3781 tacttttacc atgttgtggt ttaatcttaa aacgggggag ggggctggtg acagaggtga
     3841 aagaaaggag atcagtttgc caagtgcatt caactttgat gctcagttct ggttcataca
     3901 tgcagacctg aaaactctgc ctgatttagg cagagatctt tatctgaccc tcagcttccc
     3961 tctgtagata tatagatata taaatataaa tatgaatata agtatgtttt acagcacagc
     4021 atctgacctg tagatggagg ttttgttggt tgtttatttt cccctcttgc aagtgctacc
     4081 catgtgagtg tgtgaagttt ctctactaag taaaacacag gcccttttcc ttgtttgctt
     4141 tgtgttagct tattgtaaac agccatttgt tgtaaattat tattggcatt aaattataat
     4201 ttatgatttt caaagc
//
