LOCUS       NM_013708               1999 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus nuclear receptor subfamily 2, group E, member 3
            (Nr2e3), mRNA.
ACCESSION   NM_013708
VERSION     NM_013708.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1999)
  AUTHORS   Leung,Y.K., Lee,S.G., Wang,J., Guruvaiah,P., Rusch,N.J., Ho,S.M.,
            Park,C. and Kim,K.
  TITLE     The Loss of an Orphan Nuclear Receptor NR2E3 Augments
            Wnt/beta-catenin Signaling via Epigenetic Dysregulation that
            Enhances Sp1-beta catenin-p300 Interactions in Hepatocellular
            Carcinoma
  JOURNAL   Adv Sci (Weinh) 11 (29), e2308539 (2024)
   PUBMED   38790135
  REMARK    GeneRIF: The Loss of an Orphan Nuclear Receptor NR2E3 Augments
            Wnt/beta-catenin Signaling via Epigenetic Dysregulation that
            Enhances Sp1-beta catenin-p300 Interactions in Hepatocellular
            Carcinoma.
REFERENCE   2  (bases 1 to 1999)
  AUTHORS   Bosze,B., Suarez-Navarro,J., Cajias,I., Brzezinski Iv,J.A. and
            Brown,N.L.
  TITLE     Notch pathway mutants do not equivalently perturb mouse embryonic
            retinal development
  JOURNAL   PLoS Genet 19 (9), e1010928 (2023)
   PUBMED   37751417
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1999)
  AUTHORS   Iwagawa,T., Fukushima,M., Takeuchi,S., Kawamura,Y., Aihara,Y.,
            Ozawa,M., Yakushiji-Kaminatsui,N., Aihara,M., Koseki,H., Suzuki,Y.
            and Watanabe,S.
  TITLE     The histone H3K36 demethylase Fbxl11 plays pivotal roles in the
            development of retinal late-born cell types
  JOURNAL   Genes Cells 28 (7), 482-495 (2023)
   PUBMED   37073980
REFERENCE   4  (bases 1 to 1999)
  AUTHORS   Toms,M., Ward,N. and Moosajee,M.
  TITLE     Nuclear Receptor Subfamily 2 Group E Member 3 (NR2E3): Role in
            Retinal Development and Disease
  JOURNAL   Genes (Basel) 14 (7), 1325 (2023)
   PUBMED   37510230
  REMARK    GeneRIF: Nuclear Receptor Subfamily 2 Group E Member 3 (NR2E3):
            Role in Retinal Development and Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1999)
  AUTHORS   Venturini,G., Kokona,D., Steiner,B.L., Bulla,E.G., Jovanovic,J.,
            Zinkernagel,M.S. and Escher,P.
  TITLE     In vivo analysis of onset and progression of retinal degeneration
            in the Nr2e3rd7/rd7 mouse model of enhanced S-cone sensitivity
            syndrome
  JOURNAL   Sci Rep 11 (1), 19032 (2021)
   PUBMED   34561487
  REMARK    GeneRIF: In vivo analysis of onset and progression of retinal
            degeneration in the Nr2e3(rd7/rd7) mouse model of enhanced S-cone
            sensitivity syndrome.
            Erratum:[Sci Rep. 2021 Oct 13;11(1):20668. doi:
            10.1038/s41598-021-00207-8.. PMID: 34645827]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1999)
  AUTHORS   Haider,N.B., Naggert,J.K. and Nishina,P.M.
  TITLE     Excess cone cell proliferation due to lack of a functional NR2E3
            causes retinal dysplasia and degeneration in rd7/rd7 mice
  JOURNAL   Hum Mol Genet 10 (16), 1619-1626 (2001)
   PUBMED   11487564
REFERENCE   7  (bases 1 to 1999)
  AUTHORS   Akhmedov,N.B., Piriev,N.I., Chang,B., Rapoport,A.L., Hawes,N.L.,
            Nishina,P.M., Nusinowitz,S., Heckenlively,J.R., Roderick,T.H.,
            Kozak,C.A., Danciger,M., Davisson,M.T. and Farber,D.B.
  TITLE     A deletion in a photoreceptor-specific nuclear receptor mRNA causes
            retinal degeneration in the rd7 mouse
  JOURNAL   Proc Natl Acad Sci U S A 97 (10), 5551-5556 (2000)
   PUBMED   10805811
REFERENCE   8  (bases 1 to 1999)
  AUTHORS   Chen,F., Figueroa,D.J., Marmorstein,A.D., Zhang,Q., Petrukhin,K.,
            Caskey,C.T. and Austin,C.P.
  TITLE     Retina-specific nuclear receptor: A potential regulator of cellular
            retinaldehyde-binding protein expressed in retinal pigment
            epithelium and Muller glial cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (26), 15149-15154 (1999)
   PUBMED   10611353
REFERENCE   9  (bases 1 to 1999)
  AUTHORS   Hawes,N.L., Smith,R.S., Chang,B., Davisson,M., Heckenlively,J.R.
            and John,S.W.
  TITLE     Mouse fundus photography and angiography: a catalogue of normal and
            mutant phenotypes
  JOURNAL   Mol Vis 5, 22 (1999)
   PUBMED   10493779
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1999)
  AUTHORS   Kobayashi,M., Takezawa,S., Hara,K., Yu,R.T., Umesono,Y., Agata,K.,
            Taniwaki,M., Yasuda,K. and Umesono,K.
  TITLE     Identification of a photoreceptor cell-specific nuclear receptor
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4814-4819 (1999)
   PUBMED   10220376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131749.2.
            
            On Mar 21, 2007 this sequence version replaced NM_013708.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF204053.1, AK053560.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               AC131749.2         94286-94577         c
            293-419             AC131749.2         93680-93806         c
            420-523             AC131749.2         93423-93526         c
            524-745             AC131749.2         93101-93322         c
            746-903             AC131749.2         92861-93018         c
            904-1144            AC131749.2         91811-92051         c
            1145-1250           AC131749.2         91460-91565         c
            1251-1999           AC131749.2         87269-88017         c
FEATURES             Location/Qualifiers
     source          1..1999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 32.35 cM"
     gene            1..1999
                     /gene="Nr2e3"
                     /gene_synonym="A930035N01Rik; PNR; rd7; RNR"
                     /note="nuclear receptor subfamily 2, group E, member 3"
                     /db_xref="GeneID:23958"
                     /db_xref="MGI:MGI:1346317"
     exon            1..292
                     /gene="Nr2e3"
                     /gene_synonym="A930035N01Rik; PNR; rd7; RNR"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1383
                     /gene="Nr2e3"
                     /gene_synonym="A930035N01Rik; PNR; rd7; RNR"
                     /note="retina-specific nuclear receptor; retinal
                     degeneration 7"
                     /codon_start=1
                     /product="photoreceptor-specific nuclear receptor"
                     /protein_id="NP_038736.1"
                     /db_xref="CCDS:CCDS23255.1"
                     /db_xref="GeneID:23958"
                     /db_xref="MGI:MGI:1346317"
                     /translation="MSSTVAASTMPVSVAASKKESPGRWGLGEDPTGVGPSLQCRVCG
                     DSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCL
                     QAGMNQDAVQNERQPRSMAQVHLDAMETGSDPRSEPVVASPALAGPSPRGPTSVSATR
                     AMGHHFMASLITAETCAKLEPEDAEENIDVTSNDPEFPASPCSLDGIHETSARLLFMA
                     VKWAKNLPVFSNLPFRDQVILLEEAWNELFLLGAIQWSLPLDSCPLLAPPEASGSSQG
                     RLALASAETRFLQETISRFRALAVDPTEFACLKALVLFKPETRGLKDPEHVEALQDQS
                     QVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFLTAERIELLFFRKTIGNTPMEKLLCDM
                     FKN"
     exon            293..419
                     /gene="Nr2e3"
                     /gene_synonym="A930035N01Rik; PNR; rd7; RNR"
                     /inference="alignment:Splign:2.1.0"
     exon            420..523
                     /gene="Nr2e3"
                     /gene_synonym="A930035N01Rik; PNR; rd7; RNR"
                     /inference="alignment:Splign:2.1.0"
     exon            524..745
                     /gene="Nr2e3"
                     /gene_synonym="A930035N01Rik; PNR; rd7; RNR"
                     /inference="alignment:Splign:2.1.0"
     exon            746..903
                     /gene="Nr2e3"
                     /gene_synonym="A930035N01Rik; PNR; rd7; RNR"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1144
                     /gene="Nr2e3"
                     /gene_synonym="A930035N01Rik; PNR; rd7; RNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1250
                     /gene="Nr2e3"
                     /gene_synonym="A930035N01Rik; PNR; rd7; RNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1999
                     /gene="Nr2e3"
                     /gene_synonym="A930035N01Rik; PNR; rd7; RNR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1917..1922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr2e3"
                     /gene_synonym="A930035N01Rik; PNR; rd7; RNR"
                     /note="hexamer: ATTAAA"
     polyA_site      1945
                     /gene="Nr2e3"
                     /gene_synonym="A930035N01Rik; PNR; rd7; RNR"
                     /note="major polyA site"
ORIGIN      
        1 ctggacccag agccagggtg gtgagaacgc ttcagaagga agaaacgctc ctaacttaca
       61 aggcaaggga agtagaggag agacaggcac agactgaaag acagacagac agacagacag
      121 gggttaaaga tggatgcatc ggttgggccc agcaacttct agcaagcagg ctacccttag
      181 gaccatccat atccgatgag ctctacagtg gctgcctcca ctatgcctgt gtctgtggcg
      241 gcctccaaga aggagtctcc aggtagatgg ggccttggag aggatccaac aggtgtgggc
      301 ccctcgctcc agtgccgagt gtgtggggac agcagcagtg ggaaacatta tggcatctat
      361 gcctgcaatg gctgcagtgg cttcttcaag aggagtgtga gaaggaggct catctacagg
      421 tgccaagtcg gggcagggat gtgcccagtg gataaggccc atcgcaatca gtgccaggcc
      481 tgccggctga agaagtgctt acaagcaggc atgaaccaag atgctgtgca gaatgagcgc
      541 caacctcgga gcatggctca ggtccacctg gatgccatgg aaacaggcag tgacccccga
      601 tcagaaccag tggtagcctc tcctgctctg gcagggccca gtccccgggg ccccacgtct
      661 gtgtctgcaa ccagagccat gggccaccac tttatggcca gccttatcac cgccgaaact
      721 tgtgctaaac tggagccaga ggacgctgaa gagaatattg atgtcaccag caatgacccc
      781 gagttccccg catccccctg cagtctggat ggcatccatg agacatctgc tcgcctgctc
      841 ttcatggctg tcaaatgggc caaaaacttg cctgtgtttt ccaacctgcc tttccgggac
      901 caggtgatct tgctggaaga ggcatggaat gagcttttcc ttcttggagc catacagtgg
      961 tctctgcccc tggacagctg cccactgctg gcaccacctg aggcgtccgg cagctctcag
     1021 ggcaggctgg ccttggccag tgcagagacg cgcttcctgc aggaaaccat ctcccggttc
     1081 cgagctctgg cagtggatcc cacagagttt gcctgcctga aggccctggt cctcttcaaa
     1141 cctgaaacac gaggcctgaa ggatcctgag cacgtggagg ctttgcagga ccagtcccag
     1201 gtgatgctaa gccagcatag caaggctcac caccccagcc agcctgtgag gtttgggaaa
     1261 ttgctcctcc tgctcccatc tttgaggttc ctcacggctg agcgcattga gcttctcttc
     1321 ttcagaaaga ccatagggaa cactccgatg gagaagctcc tgtgtgacat gttcaaaaac
     1381 tagttgggag tgccaagtgt ccacaggcac ccaggggggc agcacatctt agaagctaaa
     1441 tagttccctg cctttctcag ccagtaattc cacattcagg tattcctacc tagcagaaat
     1501 ttctcccaaa atatattatt ggcatattca ttgccatcct aatcttaata cccctaactc
     1561 tgcttgggca gtagaatgca tggatgcgtt gttatattca taggagaaac agctttggca
     1621 aaaaatgaaa taaaaaataa aaatgaacag taggtccatg agacatggag acatttcata
     1681 ggctggaagt tgaacaaaag ccaggcacgt ttatcctgtg ttcaagacca gaggcaggga
     1741 ggggaaagga gggagactgg aatgaaaaga aaaggaaatg agcaaagaaa accataatag
     1801 actgatagag agaaagccag aagtcacctc tgggtgggta gggggttgga agaggggaaa
     1861 tagcctcccg cactaggaat gccctttatt tggatccaga tgataagttg atagtcatta
     1921 aagctcattg agcacttaaa atccatgcac tttgctgtat tttatttgac cttagttaaa
     1981 ataaaaccag aaaactgtg
//
