LOCUS       NM_152229               3243 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus nuclear receptor subfamily 2, group E, member 1
            (Nr2e1), mRNA.
ACCESSION   NM_152229
VERSION     NM_152229.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3243)
  AUTHORS   Duan,L.J., Jiang,Y., Shi,Y. and Fong,G.H.
  TITLE     Tailless and hypoxia inducible factor-2alpha cooperate to sustain
            proangiogenic states of retinal astrocytes in neonatal mice
  JOURNAL   Biol Open 12 (1) (2023)
   PUBMED   36625299
  REMARK    GeneRIF: Tailless and hypoxia inducible factor-2alpha cooperate to
            sustain proangiogenic states of retinal astrocytes in neonatal
            mice.
REFERENCE   2  (bases 1 to 3243)
  AUTHORS   Hu,R., Hameed,U.F.S., Sun,X., Moorthy,B.S., Zhang,W., Jeffrey,P.D.,
            Zhou,L., Ma,X., Chen,F., Pei,J., Giri,P.K., Mou,Y., Swaminathan,K.
            and Yuan,P.
  TITLE     A NR2E1-interacting peptide of LSD1 inhibits the proliferation of
            brain tumour initiating cells
  JOURNAL   Cell Prolif 56 (1), e13350 (2023)
   PUBMED   36321378
  REMARK    GeneRIF: A NR2E1-interacting peptide of LSD1 inhibits the
            proliferation of brain tumour initiating cells.
REFERENCE   3  (bases 1 to 3243)
  AUTHORS   Kandel,P., Semerci,F., Mishra,R., Choi,W., Bajic,A., Baluya,D.,
            Ma,L., Chen,K., Cao,A.C., Phongmekhin,T., Matinyan,N.,
            Jimenez-Panizo,A., Chamakuri,S., Raji,I.O., Chang,L.,
            Fuentes-Prior,P., MacKenzie,K.R., Benn,C.L., Estebanez-Perpina,E.,
            Venken,K., Moore,D.D., Young,D.W. and Maletic-Savatic,M.
  TITLE     Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers
            hippocampal neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 119 (13), e2023784119 (2022)
   PUBMED   35333654
REFERENCE   4  (bases 1 to 3243)
  AUTHORS   Ypsilanti,A.R., Pattabiraman,K., Catta-Preta,R., Golonzhka,O.,
            Lindtner,S., Tang,K., Jones,I.R., Abnousi,A., Juric,I., Hu,M.,
            Shen,Y., Dickel,D.E., Visel,A., Pennachio,L.A., Hawrylycz,M.,
            Thompson,C.L., Zeng,H., Barozzi,I., Nord,A.S. and Rubenstein,J.L.
  TITLE     Transcriptional network orchestrating regional patterning of
            cortical progenitors
  JOURNAL   Proc Natl Acad Sci U S A 118 (51) (2021)
   PUBMED   34921112
REFERENCE   5  (bases 1 to 3243)
  AUTHORS   Tan,L.L., Alfonso,J., Monyer,H. and Kuner,R.
  TITLE     Neurogenesis in the adult brain functionally contributes to the
            maintenance of chronic neuropathic pain
  JOURNAL   Sci Rep 11 (1), 18549 (2021)
   PUBMED   34535707
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3243)
  AUTHORS   Young,K.A., Berry,M.L., Mahaffey,C.L., Saionz,J.R., Hawes,N.L.,
            Chang,B., Zheng,Q.Y., Smith,R.S., Bronson,R.T., Nelson,R.J. and
            Simpson,E.M.
  TITLE     Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular
            abnormalities are background-dependent
  JOURNAL   Behav Brain Res 132 (2), 145-158 (2002)
   PUBMED   11997145
REFERENCE   7  (bases 1 to 3243)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
REFERENCE   8  (bases 1 to 3243)
  AUTHORS   Yu,R.T., Chiang,M.Y., Tanabe,T., Kobayashi,M., Yasuda,K.,
            Evans,R.M. and Umesono,K.
  TITLE     The orphan nuclear receptor Tlx regulates Pax2 and is essential for
            vision
  JOURNAL   Proc Natl Acad Sci U S A 97 (6), 2621-2625 (2000)
   PUBMED   10706625
REFERENCE   9  (bases 1 to 3243)
  AUTHORS   Monaghan,A.P., Bock,D., Gass,P., Schwager,A., Wolfer,D.P.,
            Lipp,H.P. and Schutz,G.
  TITLE     Defective limbic system in mice lacking the tailless gene
  JOURNAL   Nature 390 (6659), 515-517 (1997)
   PUBMED   9394001
REFERENCE   10 (bases 1 to 3243)
  AUTHORS   Monaghan,A.P., Grau,E., Bock,D. and Schutz,G.
  TITLE     The mouse homolog of the orphan nuclear receptor tailless is
            expressed in the developing forebrain
  JOURNAL   Development 121 (3), 839-853 (1995)
   PUBMED   7720587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166260.7.
            
            On Jun 23, 2018 this sequence version replaced NM_152229.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057104.1, AK132201.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-709               AC166260.7         73457-74165         c
            710-855             AC166260.7         68741-68886         c
            856-943             AC166260.7         64931-65018         c
            944-1179            AC166260.7         63321-63556         c
            1180-1326           AC166260.7         61948-62094         c
            1327-1423           AC166260.7         58948-59044         c
            1424-1573           AC166260.7         58411-58560         c
            1574-1679           AC166260.7         58064-58169         c
            1680-3243           AC166260.7         52538-54101         c
FEATURES             Location/Qualifiers
     source          1..3243
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.89 cM"
     gene            1..3243
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /note="nuclear receptor subfamily 2, group E, member 1"
                     /db_xref="GeneID:21907"
                     /db_xref="MGI:MGI:1100526"
     exon            1..709
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /inference="alignment:Splign:2.1.0"
     CDS             685..1842
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /note="nuclear receptor TLX; protein tailless homolog"
                     /codon_start=1
                     /product="nuclear receptor subfamily 2 group E member 1"
                     /protein_id="NP_689415.1"
                     /db_xref="CCDS:CCDS23813.1"
                     /db_xref="GeneID:21907"
                     /db_xref="MGI:MGI:1100526"
                     /translation="MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSI
                     RRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQ
                     VALYFRGHKEDNGAAAHFPSTALPAPAFFTAVTQLEPHGLELAAVSATPERQTLVSLA
                     QPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLL
                     EDAWRELFVLGIAQWAIPVDANTLLAVSGMNTDNTDSQKLNKIISEIQALQEVVARFR
                     QLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYP
                     TQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI"
     exon            710..855
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            856..943
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1179
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1326
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1423
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1573
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1679
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..3243
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3217..3222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /note="hexamer: AATAAA"
     regulatory      3223..3228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /note="hexamer: AATATA"
     polyA_site      3233
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /note="major polyA site"
     polyA_site      3239
                     /gene="Nr2e1"
                     /gene_synonym="fierce; frc; Mtl1; Mtll; tailless; TLL;
                     Tlx; XTLL"
                     /note="major polyA site"
ORIGIN      
        1 aggcacaaag tcacagggta atgaacttcg gggacccttc gccgctgcgt gcgcggctgt
       61 ccccggaaac tcggatctgg ccacctctcc ccttggaaga tctcccagca atctagtttc
      121 ccctctcggc gccggggctc cggcagcgag gagcttaatc tgcctctgag actgcggctg
      181 tgattttcgc ctttccacag aagatctgca gtctgcagag agctgcccac tctgcacgcc
      241 tgtgtggagg gagagattgg aagcagtacc aagcatgggg aacgagggga agttcgcctt
      301 cgttgctccg taggaagacc atttccgtgt ctccatctct gtccttccat attcccctcg
      361 cgctgtcctc cctcttcagc ctgcctgtcc atctctccat ctgtctgttc aagactgtgt
      421 ccacatcaag ccgcatcccc agcagctgca gttttgctag agccgggaaa gaaacttaag
      481 gatgcttaca tttccactgt ggaacgaatt ctgagcgccg gggagagcag ggcagcgcac
      541 aaccaatagc cacctgtctg tcccgcccgg gagcctcgca ggctggaggg cggctggaga
      601 gcggcggcgg ccggcggcga cgtgggcgcc gtgggtcggg aatccggcag tgcccaccaa
      661 ccgctgcgcc ccgggaccgc cagcatgagc aagcccgccg gatcaacaag ccgcatttta
      721 gatatccctt gcaaagtgtg tggtgaccgc agctccggga agcactacgg ggtctacgct
      781 tgcgacggct gctccggatt cttcaagagg agcattcgaa ggaataggac ctatgtctgc
      841 aagtctggaa accagggagg atgccccgta gacaagacac acagaaacca atgcagggcg
      901 tgtcgactga agaagtgttt ggaagtcaac atgaacaaag atgccgtgca gcacgagcgg
      961 ggtcctcgga cgtccaccat ccgcaaacag gtggctctct acttccgtgg acacaaggaa
     1021 gacaatgggg ccgctgcgca cttcccctcc acggcgctgc cagcccctgc tttcttcaca
     1081 gcggtcacgc agctggagcc gcacggtctg gagttggccg ctgtgtctgc cactcctgaa
     1141 cggcagactc tcgtgagcct ggctcagccc acgcccaagt atccccatga agtgaatggg
     1201 accccaatgt atctctacga agtggccact gagtccgtgt gtgaatcagc tgccaggctt
     1261 ctctttatga gcatcaagtg ggcaaagagt gtgccagcct tttccacttt gtctttacaa
     1321 gatcagctga tgcttttgga agacgcgtgg agagaactgt ttgttctagg aatagcacaa
     1381 tgggccattc cggttgatgc taacactcta ctggctgtat ctggcatgaa tactgacaac
     1441 acagactccc agaagctgaa caagatcata tctgaaatac aggctttgca agaggtggtg
     1501 gctcggttca gacagctccg attagacgcc actgaatttg cctgtctgaa atgtattgtc
     1561 actttcaaag ctgttcctac acacagtggt tctgaactga gaagtttccg gaatgctgcc
     1621 gccattgccg ctctccaaga tgaggctcag ctaactctca acagctacat tcataccaga
     1681 taccccaccc aaccctgccg attcgggaaa ctcctgttgc ttttaccagc tttacggtca
     1741 attagcccat ctaccataga agaagtgttt ttcaaaaaaa ccatcggcaa tgtgccgatt
     1801 acaagactac tttcagatat gtacaaatcc agtgacatct aagggctcca gtacccactt
     1861 ttccaagatg gggcagtatt agatggacat ctacatgcag gtcaagcctc aaaaaaaaag
     1921 actttctgga aggaaaaact tgggagggag tggccttcag gaaaaaaaaa atgccaacgg
     1981 actcaaaaca acagctatga cctgctgtcc ccctgaaaca ggacagctgg aaaggccagg
     2041 tggttacaac agttactgtc gccatgccct gggatggggt gaactgggct caccagcaca
     2101 ggctgagcca ggttctgcct ctgacctgga agatcccgct gaatcattca aagctgaaag
     2161 acaagccatg ctttcttctc cttcgtagca cataaagtca gttgatcaac agtagctttt
     2221 tatgtgacac catcatatac tgcagccttc agaactcgat tgggttggaa catttactta
     2281 aaaaataatg cttaggtttt aaatcaaaag tattatcaaa cattttcctt ctatcataat
     2341 acttcattaa gtggccttca gaaccaagcg agtaagcgaa acgtagctta tgctgtgtga
     2401 tttcctttcc ctcctcctcc tcctcccctt tctgtttttt ttttcttttc tttttttctc
     2461 tcttctcttc tcttctcttc tctcttctct cttctctctt ctctcttctc tcttctctct
     2521 tctctcttct ctctttcttc tctcttctct cttctctctt ctcataccgt aggtcaggca
     2581 acctcgttaa aggaactgag gacaatggca cttctccgca agacttcagg gtgagcgcag
     2641 cggtggtgag acacaacagc tctactgaga acctccgtcc aaggaggagg agtccagaca
     2701 gcaaaaccaa atgacgtgga accaggtgat tgggtgaggt ggtcgctgtc ccgtcatcaa
     2761 agtgctgaaa ccaaaggcca tagggtcagc gagtcacacc agacagtgaa cagggaggga
     2821 cacaagccag aaagaacttc aaggagatgc gtgctaaaca gattcctgaa cgttccattg
     2881 ctaacagcct gagactcttg gatgcctttc agaaaactct ggtttctaat aaagcctcaa
     2941 atgcatacat acacctcccc ccaccctgta ccccccaccc ccacacacca tcctatactc
     3001 tcaagctgct ccttgggtat gaatctatac ttatggaaat atagaaacaa acagttttaa
     3061 atagctgctg tacttttcac gttttgattt attaggtact agcccgaggg gggaaattca
     3121 gcactggctt agcataggat gagtcaaact tctcttgtac aaagtgaatt aactgatttg
     3181 tgaagttaaa aggttgtact cattgtattt acaaagaata aaaatatatt gaatttaaat
     3241 aaa
//
