LOCUS       NM_001347342            7752 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus nuclear receptor subfamily 2, group C, member 2
            (Nr2c2), transcript variant 1, mRNA.
ACCESSION   NM_001347342 XM_006505903
VERSION     NM_001347342.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7752)
  AUTHORS   Hirata,Y., Nakata,Y., Komatsu,H., Kudoh,Y., Takahashi,M.,
            Taguchi,S., Noguchi,T. and Matsuzawa,A.
  TITLE     Roquin-2 promotes oxidative stress-induced cell death by
            ubiquitination-dependent degradation of TAK1
  JOURNAL   Free Radic Biol Med 221, 31-39 (2024)
   PUBMED   38729452
  REMARK    GeneRIF: Roquin-2 promotes oxidative stress-induced cell death by
            ubiquitination-dependent degradation of TAK1.
REFERENCE   2  (bases 1 to 7752)
  AUTHORS   Wang,D., Li,Y., Yang,H., Shen,X., Shi,X., Li,C., Zhang,Y., Liu,X.,
            Jiang,B., Zhu,X., Zhang,H., Li,X., Bai,H., Yang,Q., Gao,W., Bai,F.,
            Ji,Y., Chen,Q. and Ben,J.
  TITLE     Disruption of TIGAR-TAK1 alleviates immunopathology in a murine
            model of sepsis
  JOURNAL   Nat Commun 15 (1), 4340 (2024)
   PUBMED   38773142
  REMARK    GeneRIF: Disruption of TIGAR-TAK1 alleviates immunopathology in a
            murine model of sepsis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7752)
  AUTHORS   Wang,H., Zhu,S., Zhou,Z., Wang,Z., Zhuang,W., Xue,D., Lu,Z.,
            Zheng,Q., Ding,L., Ren,L., Luo,W., Wang,R., Ge,G., Xia,L., Li,G.
            and Wu,H.
  TITLE     TR4 worsen urosepsis by regulating GSDMD
  JOURNAL   Eur J Med Res 29 (1), 151 (2024)
   PUBMED   38429762
  REMARK    GeneRIF: TR4 worsen urosepsis by regulating GSDMD.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7752)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 7752)
  AUTHORS   Ma,M., Dang,Y., Chang,B., Wang,F., Xu,J., Chen,L., Su,H., Li,J.,
            Ge,B., Chen,C. and Liu,H.
  TITLE     TAK1 is an essential kinase for STING trafficking
  JOURNAL   Mol Cell 83 (21), 3885-3903 (2023)
   PUBMED   37832545
  REMARK    GeneRIF: TAK1 is an essential kinase for STING trafficking.
REFERENCE   6  (bases 1 to 7752)
  AUTHORS   Lee,Y.F., Young,W.J., Burbach,J.P. and Chang,C.
  TITLE     Negative feedback control of the retinoid-retinoic acid/retinoid X
            receptor pathway by the human TR4 orphan receptor, a member of the
            steroid receptor superfamily
  JOURNAL   J Biol Chem 273 (22), 13437-13443 (1998)
   PUBMED   9593676
REFERENCE   7  (bases 1 to 7752)
  AUTHORS   Young,W.J., Smith,S.M. and Chang,C.
  TITLE     Induction of the intronic enhancer of the human ciliary
            neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan
            receptor. A member of steroid receptor superfamily
  JOURNAL   J Biol Chem 272 (5), 3109-3116 (1997)
   PUBMED   9006963
REFERENCE   8  (bases 1 to 7752)
  AUTHORS   Hirose,T., O'Brien,D.A. and Jetten,A.M.
  TITLE     Cloning of the gene encoding the murine orphan receptor TAK1 and
            cell-type-specific expression in testis
  JOURNAL   Gene 163 (2), 239-242 (1995)
   PUBMED   7590273
REFERENCE   9  (bases 1 to 7752)
  AUTHORS   Hirose,T., Fujimoto,W., Tamaai,T., Kim,K.H., Matsuura,H. and
            Jetten,A.M.
  TITLE     TAK1: molecular cloning and characterization of a new member of the
            nuclear receptor superfamily
  JOURNAL   Mol Endocrinol 8 (12), 1667-1680 (1994)
   PUBMED   7708055
REFERENCE   10 (bases 1 to 7752)
  AUTHORS   Law,S.W., Conneely,O.M. and O'Malley,B.W.
  TITLE     Molecular cloning of a novel member of the nuclear receptor
            superfamily related to the orphan receptor, TR2
  JOURNAL   Gene Expr 4 (1-2), 77-84 (1994)
   PUBMED   7841789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121593.3 and AC164642.3.
            
            On Aug 8, 2022 this sequence version replaced NM_001347342.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 3 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-413               AC121593.3         22955-23367         c
            414-497             AC121593.3         10404-10487         c
            498-608             AC164642.3         37490-37600
            609-809             AC164642.3         47314-47514
            810-912             AC164642.3         50025-50127
            913-1092            AC164642.3         52045-52224
            1093-1240           AC164642.3         54282-54429
            1241-1334           AC164642.3         55116-55209
            1335-1468           AC164642.3         56040-56173
            1469-1646           AC164642.3         56922-57099
            1647-1768           AC164642.3         58029-58150
            1769-1908           AC164642.3         59623-59762
            1909-2046           AC164642.3         60831-60968
            2047-2152           AC164642.3         61898-62003
            2153-7752           AC164642.3         65169-70768
FEATURES             Location/Qualifiers
     source          1..7752
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 41.03 cM"
     gene            1..7752
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /note="nuclear receptor subfamily 2, group C, member 2"
                     /db_xref="GeneID:22026"
                     /db_xref="MGI:MGI:1352466"
     exon            1..413
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            414..497
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             438..2327
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear receptor subfamily 2, group H, member 2;
                     testicular receptor 4; orphan nuclear receptor TR4; orphan
                     nuclear receptor TAK1; orphan receptor, TR4"
                     /codon_start=1
                     /product="nuclear receptor subfamily 2 group C member 2
                     isoform 1"
                     /protein_id="NP_001334271.1"
                     /db_xref="CCDS:CCDS85096.1"
                     /db_xref="GeneID:22026"
                     /db_xref="MGI:MGI:1352466"
                     /translation="MATNMEGLVQHRVGTQQVAEVPRTQTSWPESPGMTSPSPRIQII
                     STDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSSKQQFILTSPDGAGTGKVILASP
                     ETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKADVQRPQVVEYCVVCGDKASGR
                     HYGAVSCEGCKGFFKRSVRKNLTYSCRSSQDCIINKHHRNRCQFCRLKKCLEMGMKME
                     SVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPG
                     MLVNIQQPLIREDGTVLLAADSKAETSQGALGTLANVVTSLANLSESLNNGDASEMQP
                     EDQSASEITRAFDTLAKALNTTDSASPPSLADGIDASGGGSIHVISRDQSTPIIEVEG
                     PLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTS
                     LVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKL
                     QEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTGTSQIEKFQEKAQMELQDYVQKTY
                     SEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQI
                     TGASL"
     exon            498..608
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            609..809
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            810..912
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1092
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1240
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1334
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1468
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1646
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1768
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1908
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2046
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2152
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..7752
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7732..7737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /note="hexamer: ATTAAA"
     polyA_site      7752
                     /gene="Nr2c2"
                     /gene_synonym="mKIAA4145; TAK1; Tr4"
                     /note="major polyA site"
ORIGIN      
        1 agcctctgag gaacttggtg ggtctcgggc tgggaagctg gtgatgcttt ttgaacccat
       61 ggcgcggcca gaagggaaga gttcgtcggc acttggaggc tctccggggt tcgcgctttc
      121 ctcacgactc tggacggagc ccctctggcg ggctcaattt cagtccatga aattgggaca
      181 ccagacgttc ttgccaagcc tcgcctctct cctcagcatt gtttgaggga ctgttctctg
      241 aaaatggagt ccaagctact ctgccagcct caaaagtaat ttgcaaatgg tggtgttagt
      301 tttttcgtct tattgtggtg ctggggacgg ccctgccatt gagtaacatc cctagtccca
      361 aaatggtgat gtggaaatat ataaggaacc aactggagtg gaaaacttgt gaggttctct
      421 aatgatcttg cttcaccatg gctacaaata tggaggggct ggttcagcac agagtgggga
      481 cccagcaggt ggctgaggta ccacgtacac agacctcttg gccggaatct ccagggatga
      541 ccagcccctc cccgcgcatc cagataattt ccaccgactc tgcggtagcc tcacctcagc
      601 gcattcagat tgtaacagac cagcagacag gacaaaagat ccagatagtc accgcagtgg
      661 atgcctctgg atcctctaaa cagcagttca tcctaaccag cccagatgga gctggaactg
      721 ggaaggtgat cctggcttct ccggaaacat ccagtgccaa gcagctcata ttcaccacct
      781 cggacaacct tgtccctggc aggatccaga tcgtcacgga ttctgcttct gtggagcgtt
      841 tgctggggaa ggcagacgtc cagcggcccc aggtggtgga gtactgtgtg gtctgtggcg
      901 acaaagcctc tggccggcac tatggggctg tcagttgtga aggttgcaaa ggtttcttca
      961 aaaggagcgt gaggaagaat ctgacctaca gctgtcggag cagccaagac tgcatcatca
     1021 acaagcacca ccgtaaccgc tgccagttct gccggctgaa gaagtgcctg gagatgggca
     1081 tgaaaatgga gtctgtacag agtgaacgga agccctttga tgtgcaacgg gagaaaccaa
     1141 gcaattgtgc tgcttccact gagaagatct atatccggaa agacctgaga agtcctctga
     1201 tagccactcc cacatttgtg gcagacaaag atggagcaag acaaacaggt cttcttgatc
     1261 cagggatgct tgtgaacatc caacagcctt tgatacgtga ggatggtaca gttctcctgg
     1321 ccgcggattc caaggctgaa acaagccaag gagctctagg tacactggca aatgtagtga
     1381 cctctttggc caacctgagt gaatctttga acaacggtga tgcttcagaa atgcagccag
     1441 aggaccagtc tgcaagtgag attactcggg catttgacac cttagcgaaa gcacttaata
     1501 ccacagatag tgcttcacct ccaagcctgg cagatgggat agatgctagt ggaggaggga
     1561 gtatccatgt catcagcaga gatcagtcaa cacccatcat tgaagttgaa ggccctctcc
     1621 tttcagacac acatgtcaca ttcaagctta caatgcccag tcctatgcca gagtacctca
     1681 atgtacatta catctgtgag tctgcatccc gcctgctttt cctctccatg cactgggcaa
     1741 ggtcaatccc agccttccag gcacttggac aggactgtaa taccagcctg gtgagggcct
     1801 gctggaatga gctcttcact cttggcctgg cccagtgtgc ccaggtcatg agtctctcca
     1861 ccatcctggc agccattgtc aaccacctac agaacagcat ccaggaagat aagctttctg
     1921 gtgaccggat aaagcaagtg atggagcaca tctggaagct gcaggagttc tgtaacagca
     1981 tggcgaaact ggatatagac ggctatgagt acgcatacct taaagctata gttctcttta
     2041 gtcccgatca tccaggtttg acaggcacaa gccagattga gaaatttcag gagaaggcac
     2101 agatggaatt acaggactat gtgcagaaaa cctactctga agatacttac agattggcca
     2161 ggattcttgt ccgcctacca gcactcaggc tcatgagctc caacataaca gaagaacttt
     2221 tttttactgg tctcattggc aatgtttcaa tagacagcat aattccttac atcctcaaga
     2281 tggagacagc agaatataat ggccagatca ctggagccag tctatagtgc acaaccaaca
     2341 gctgccaaca gtgggatgcc tcctagaact gtgcaggtgc aagggaaggg aagtgtagca
     2401 gtgtcttggt gtgcacaggt gtctccagtg tgtcagccac ttcttcctgt tcatcccaga
     2461 caatagcaac taaagatgaa ctcttccctg ccctaagaaa tgttttaaca ccttttggtg
     2521 atgcagattt tggaacaatc ttttaattca atttgtattt taaaattctc aaagggcaaa
     2581 aaacaatact gaagttttat aatgtcagag actagtatta aaagaaccta agaacagtat
     2641 gtgtaaatac attaaaaaaa aaaagtcctt ggaattaata gctactaatt accagggtaa
     2701 tgttagcact ttctaagcac ttcttatcaa atctgcaatg ttaacatctt acctgtggac
     2761 agggcaaatg gaaaactgtg tctcttttgt caaaatgcta atgatttctg tgaaaattca
     2821 ctagggtaca ggagacaatc gttcacattt gtaagagggc agcacttcta gctgtgtgca
     2881 gtggtggtgc tacgctaaat tcctgtgagt aaaatgtgga ttcctggcat tgtgtgcagg
     2941 ggatataact tgcagtgacc caataagagc tgctatgcca gcagagatag cctgtcaggg
     3001 tccttaccct catggttggt cccaatccct gatgcctttc tgcagactct tccagaacat
     3061 gggctccact aattttcaga attagattgc agcttgtcag aatgcctgtg ataagggtcc
     3121 tgtaattctt ccagtgactg aaagtacacc tggatccctc taccaacttg taggaactgg
     3181 agcctttgac cagagtgcaa ggtggttgac tgcacccttt gacatgacct gttgtccagg
     3241 ttgagtgtgg cttctgcagt gagagttcct attcctggtg catgtggaga ggggccagta
     3301 tctgatcatt cagaacctgc agctgggtgg gggttgtgta tcctcgctgt ctggtgaggg
     3361 actggcctta gattgtgaaa caaaaggcat caagagaaat actttctgat cttttaagta
     3421 ttagtgattt tagtgtactg ggacacgatg ttcttcagtt ctcccaggta tgtgctagtc
     3481 caacaaagct ctctggggca tttgagataa caaaagtaga tcatcttctc tctgaaagag
     3541 aatccaaaaa taatcctcag tcagggcaca tagtgcaggc ctgtaacccc agcacttggg
     3601 aggctgaggc acaagaatta tactttgaag gccaatctgc gcaacttaat gaggaaactc
     3661 ctgagtttta aaggagttta agggagtggg gtagggtggt gacttaagtg gtaatgtgct
     3721 tgcctagcat gcacaaggtc ttgggttcca tccccagtac caaaagaaaa aagaaaaacc
     3781 ttcattcaca aattccctta cgttataatg actatagttt ccaacaagaa agaatacaga
     3841 attcagttcc aaggaagtta gatctgactt aaagctcttt gcattcctat ggacaggaga
     3901 ctgggaaaaa aaaaagtgga aatatacttg gtatttgcat ttagattagc agaacttaag
     3961 caaaatacct cctgtaaggt taagtttgta cctgtttatg ggcaggtaca gccatggggc
     4021 tcaaggctag ataggctgtt tccttttgag gagttaatga cactttattc actgctagtg
     4081 ggatttaagt acagaagtat ctctaacttc taaattccca gctagatttg gaagccagtg
     4141 ttggagaaca gcagggattg ccagtataaa atgatggaaa ggacataatt ttgccagctt
     4201 aaagcttttt ttttttttat gtatgtattc aaaattaaga caaaagctct ggacaccagt
     4261 atagttcgag tctattttaa tctctgtaga gattcctgta gtacattaat cagtacacct
     4321 tacagtgctg gctttgcttc ccttagggtt ttagaatgtg agccactcag acagggcctg
     4381 gacagcctgg ctcccatttg gtatttagac cacatagttg gataagaagt accagcctct
     4441 aagatgacac tgaaggggga aaaatttttt tttttttaat atagaaaaga gttggtgatt
     4501 ctaactctgg tcctttgtaa gttccgtcat tagtaatggc caattgacag ggccactttg
     4561 ggccaaactc cttcactggt tgtccagatc gttgtggcct tacctttaac aattgtatcc
     4621 atacaatgtt ctcattaact gaaatcattt caaactttga atgatgctcc attccatggc
     4681 ttgtcgaatg acctatgaag gtcagcccca gttgcttctg ggcttcagct ttcagggctt
     4741 tccacccttg atttatgagt ctgtgatact ccaagcctta tgaagcaggg ctgacctgtc
     4801 tagacacccc tctcagggag gtggacagac acactgacct ggctactttt gcagataggc
     4861 tagggtggag agatacacac caaccctggc taactaggct cttttccaga aaggtcttaa
     4921 atgttgatag ttccatgtta aaatttggga taaaatatga caggagatgt agacagagac
     4981 caaattcctt aagcaagtca tcctagttac tcctcaaatg ttacaatgtg tcgctgtcct
     5041 tccagtttgc agtgtgtgtt gaagaggctc ttcactgcct cttctctttc tgaggctgca
     5101 gttggggttg tggtgtcttg agtttctata atgaaattca agtgagtcac ttatgccctt
     5161 ggaatggttt tctagtttgt cagtgtcagt attagatgtg gatggtgttc tgaggtagtc
     5221 atggcatcaa tcagggtggt cagtatggct ttcaaatgga gcagcagcat ccacactata
     5281 taaaattgtt ttgaagggta gtactgctca tgcagttctc tggtcagtat ccctaagagc
     5341 tggacctatt gtctgggacc tgatgtcatg ggggtctgga agactgttgc tgctttccag
     5401 tggctgggtg cagcggggct gttggtgctg ctgaaattct agatccaggc cttgaaaagc
     5461 atcacttgac agctgctttt ttttcccagg gggaaggtcc tggtaagaca gatgcccacc
     5521 tctttccttt gcctatctcc aattacggag aaccaatctc cagattacgg ttctttgcaa
     5581 aaagtcttaa ctcttatgtc aatttctaaa gacaactcca aaatgagatg aggttgacct
     5641 aggtgttttg tacaaggttc tggacctcct cattgagtgc ctcccatcag tgtgtacttt
     5701 ctgtgcacaa cctgtccctt cagccacact gtgcatgtcc agagttacag gcctagatga
     5761 ctgaatgaat gtacatgtgt tcatattatc ttctttgtac agtgtatata atgtgtgtac
     5821 ataggtgtac attatgtata cagacatgta gccacatatt caaacttcta tgttgtcaag
     5881 agttgatgct agcgttgcta atgtgaatag atattggggt tgcaaggttc ccttaacagg
     5941 aacgttgtgc aggtgagttt cttaccaact tcattttcct tagacaggga gctgcctggg
     6001 ccaggtggca ctaattcctg cacaaggaag cctcgagcca gaaaagtcca gataggaggg
     6061 cagttctcta aatttacaag ggcccagaag ctgcaagaga tgttagccta atatcctaaa
     6121 ctaaggataa acttcctttt cacaaaccag tttagcataa ctggaaggag cttggtgact
     6181 gagacccttg gtcttcttca aaggctccaa agctggagct tcgtgtggct cagacatggg
     6241 catttgggat ccaggggctg cagcagtctc ccttgtttac cctgggctct gtcagcaaga
     6301 catgggggct ctctggtggt aaaaacaaaa taccagtcta ccaaacattc tatgaaaaca
     6361 gtgcagatag ctaaaaactg caatcagtaa attatcctaa cttagctaca ttctgtagaa
     6421 gttgtattta atagtacgaa agctaaggct gacattttcc tcatctagcg ggtctttgct
     6481 gatattcgtc ccctatgatt gggatttttg ggctgagatg tggacttggg agacagggcc
     6541 cagcttggca gagactgctc gtggccacag tgagcaggca tctggcttgg atgaagccaa
     6601 gtgcaaaaat ttgcctgacc cacaggttgc tctttgtgtt tttgaagtaa attactggag
     6661 tgttttaaga aataattgtt aagactatag tcctcagtgc ctttggtgag acgtgggtct
     6721 tttggcttca gcttcccact cgtgtccctg gcctcaccct ttgtggttgt tcaatcttgc
     6781 ctgtgtcatt gcctgttgtg acaatcacac tattaaaagt ggctttccaa gtaaaacaca
     6841 gggaagcttg gtagtcccta aatgaatcct tccattttct ctttgggggc tattgtctta
     6901 gcagcaacct aacagtaaac ttaaaagtgg cttaggaagg ggaaaccatc agacatttct
     6961 aatgctcagc aatatgcact tttagttaat tttcaatatt gatatttata catggaatgt
     7021 aggaaaatgc tcaatattac cactcttaag ttttagtgtt tgggtaacat ttggtgtaga
     7081 ctgcacatta aaaatagcct ttcttcagga aagtaccatc agttgtcatc ccaacagcct
     7141 actcattcat ggacgctaat gctgctgcac acacagctca agtgctggaa tatttttcta
     7201 gtctgttttc ccaattaact tgtaaatcag tgttcaacta gttttataac tgaaaagctg
     7261 cacatttttg tcatagtacc aactagtttg tacctgtagt ttgaatttct ctgttaagat
     7321 aaaaccttat caccccccac cctcaactcc ctttttagag gacatctact aaaagaaagt
     7381 ccagtgtggc attttcttgg gtaatgactg gttgtgtaat ttctgccctt cacactgtag
     7441 aaaacaccat ggatgccatt accttctgat tccaggttaa aaacctgcag agagctgcca
     7501 ttttgtacag cttttctccc catgtaaatg agctatgtga tggcatttaa aacccgcatg
     7561 ttctttttaa actgaatttt ctatctaatc aatgtcttca gtcctgaagg agaatctgca
     7621 ttgttgtctg tatagagagt tgctgtgcat ggttacgagc gccttttact aaatgctgtt
     7681 caatgtggct ttgttgttgt ggcttaatac tacctacatg aggtttatac tattaaagta
     7741 aattcaagac ta
//
