LOCUS       NM_011629               3827 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus nuclear receptor subfamily 2, group C, member 1
            (Nr2c1), transcript variant 1, mRNA.
ACCESSION   NM_011629
VERSION     NM_011629.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3827)
  AUTHORS   Olivares,A.M., Han,Y., Soto,D., Flattery,K., Marini,J., Mollema,N.,
            Haider,A., Escher,P., DeAngelis,M.M. and Haider,N.B.
  TITLE     The nuclear hormone receptor gene Nr2c1 (Tr2) is a critical
            regulator of early retina cell patterning
  JOURNAL   Dev Biol 429 (1), 343-355 (2017)
   PUBMED   28551284
  REMARK    GeneRIF: This study supports a role for Nr2c1 in defining the
            biphasic period of retinal development and specifically influencing
            the early phase of retinal cell fate.
            Erratum:[Dev Biol. 2017 Sep 1;429(1):370. doi:
            10.1016/j.ydbio.2017.07.009.. PMID: 28743516]
REFERENCE   2  (bases 1 to 3827)
  AUTHORS   Baker,J.L., Wood,B., Karpinski,B.A., LaMantia,A.S. and Maynard,T.M.
  TITLE     Testicular receptor 2, Nr2c1, is associated with stem cells in the
            developing olfactory epithelium and other cranial sensory and
            skeletal structures
  JOURNAL   Gene Expr Patterns 20 (1), 71-79 (2016)
   PUBMED   26712358
  REMARK    GeneRIF: Nr2c1 may be a candidate for mediating parallel adaptive
            changes in cranial neural sensory specializations such as the
            olfactory epithelium, retina and mystacial vibrissae and in
            non-neural craniofacial features including teeth
REFERENCE   3  (bases 1 to 3827)
  AUTHORS   Cui,S., Tanabe,O., Sierant,M., Shi,L., Campbell,A., Lim,K.C. and
            Engel,J.D.
  TITLE     Compound loss of function of nuclear receptors Tr2 and Tr4 leads to
            induction of murine embryonic beta-type globin genes
  JOURNAL   Blood 125 (9), 1477-1487 (2015)
   PUBMED   25561507
REFERENCE   4  (bases 1 to 3827)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 3827)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3827)
  AUTHORS   Lee,C.H., Chang,L. and Wei,L.N.
  TITLE     Distinct expression patterns and biological activities of two
            isoforms of the mouse orphan receptor TR2
  JOURNAL   J Endocrinol 152 (2), 245-255 (1997)
   PUBMED   9071982
REFERENCE   7  (bases 1 to 3827)
  AUTHORS   Lee,C.H., Chang,L. and Wei,L.N.
  TITLE     Molecular cloning and characterization of a mouse nuclear orphan
            receptor expressed in embryos and testes
  JOURNAL   Mol Reprod Dev 44 (3), 305-314 (1996)
   PUBMED   8858600
REFERENCE   8  (bases 1 to 3827)
  AUTHORS   Lee,H.J., Young,W.J., Shih,C.Y. and Chang,C.
  TITLE     Suppression of the human erythropoietin gene expression by the TR2
            orphan receptor, a member of the steroid receptor superfamily
  JOURNAL   J Biol Chem 271 (17), 10405-10412 (1996)
   PUBMED   8626614
REFERENCE   9  (bases 1 to 3827)
  AUTHORS   Lin,T.M., Young,W.J. and Chang,C.
  TITLE     Multiple functions of the TR2-11 orphan receptor in modulating
            activation of two key cis-acting elements involved in the retinoic
            acid signal transduction system
  JOURNAL   J Biol Chem 270 (50), 30121-30128 (1995)
   PUBMED   8530418
REFERENCE   10 (bases 1 to 3827)
  AUTHORS   Lee,C.H., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Wei,L.N.
  TITLE     Genomic structure, promoter identification, and chromosomal mapping
            of a mouse nuclear orphan receptor expressed in embryos and adult
            testes
  JOURNAL   Genomics 30 (1), 46-52 (1995)
   PUBMED   8595902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146891.1, AK149374.1 and AC138026.4.
            
            On Apr 2, 2008 this sequence version replaced NM_011629.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149374.1, AK146891.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1775              AK146891.1         14-1788
            1776-2846           AK149374.1         1691-2761
            2847-3827           AC138026.4         6074-7054
FEATURES             Location/Qualifiers
     source          1..3827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 48.81 cM"
     gene            1..3827
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /note="nuclear receptor subfamily 2, group C, member 1"
                     /db_xref="GeneID:22025"
                     /db_xref="MGI:MGI:1352465"
     exon            1..172
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            173..245
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1964
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /note="early embryonic nuclear receptor; 80-3 cNDA; mTR2;
                     testicular receptor 2; orphan nuclear receptor TR2;
                     nuclear receptor subfamily 2, group H, member 1; orphan
                     receptor, TR2-11"
                     /codon_start=1
                     /product="nuclear receptor subfamily 2 group C member 1"
                     /protein_id="NP_035759.3"
                     /db_xref="CCDS:CCDS24131.1"
                     /db_xref="GeneID:22025"
                     /db_xref="MGI:MGI:1352465"
                     /translation="MATIEEIAHQIIDQQMGEIVTEQQTGQKIQIVTALDHSTQGKQF
                     ILANHEGSTPGKVFLTTPDAAGVNQLFFTSPDLSAPHLQLLTEKSPDQGPNKVFDLCV
                     VCGDKASGRHYGAITCEGCKGFFKRSIRKNLVYSCRGSKDCVINKHHRNRCQYCRLQR
                     CIAFGMKQDSVQCERKPIEVSREKSSNCAASTEKIYIRKDLRSPLAATPTFVTDSETA
                     RSAGLLDSGMFVNIHPSGIKTEPAMLMAPDKAESCQGDLSTLASVVTSLANLGKAKDL
                     SHCGGDMPVVQSLRNGDTSFGAFHHDIQTNGDVSRAFDTLAKALTPGESSACQSPEEG
                     MEGSPHLIAGEPSFVEKEGPLLSESHVAFRLTMPSPMPEYLNVHYIGESASRLLFLSM
                     HWALSIPSFQALGQENSISLVKAYWNELFTLGLAQCWQVMNVATILATFVNCLHSSLQ
                     QDKMSPERRKSLMEHIFKLQEFCNSMVKLCIDGHEYAYLKAIVLFSPDHPGLENMELI
                     ERFQEKAYVEFQDYITRTYPDDTYRLSRLLLRLPALRLMNATITEELFFKGLIGNVRI
                     DSVIPHILKMEPADYNSQIIGHSL"
     exon            246..440
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            441..519
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            520..699
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            700..847
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            848..938
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1123
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1283
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1405
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1545
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1683
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1789
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..3827
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2274..2279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /note="hexamer: AATAAA"
     polyA_site      2299
                     /gene="Nr2c1"
                     /gene_synonym="4831444H07Rik; 80.3; Eenr; TR2; Tr2-11"
                     /note="major polyA site"
ORIGIN      
        1 accgcgctaa tgcgcaggcg ccaagagcac cacgcaccgc caagccgagg gtggggtcac
       61 gaactctgac ccccaccccc aaaacacaaa ctcagaaagc tcccctgtcc ccttggcctc
      121 gggtcccctc gcctctgctc tctccagccc agcggccgcc gcggcgggag ggatattttg
      181 accattcgat catggcgacc atagaagaaa ttgcacatca aattatcgac caacagatgg
      241 gtgagattgt tacagagcag cagactggac agaaaatcca gatcgtgaca gcacttgacc
      301 acagcacaca gggcaagcag ttcattctgg caaaccacga gggatccacg ccagggaaag
      361 tcttcctcac aactccagac gccgcaggtg tcaaccagtt gttttttacc agtcctgatc
      421 tgtccgcacc gcacctccag ctcttaacag aaaagtctcc tgaccaggga ccaaataagg
      481 tttttgatct ttgtgtcgtg tgtggagaca aagcatcagg gcgtcattac ggagcaataa
      541 cttgtgaagg ctgcaaagga ttctttaaaa gaagcatccg gaaaaaccta gtctattcct
      601 gtcgaggatc caaagactgc gttatcaata agcaccaccg aaaccgctgc cagtactgca
      661 ggctgcagag gtgcattgcc ttcgggatga agcaagactc tgttcagtgt gaaagaaaac
      721 ccattgaagt ttcccgagaa aaatcttcca actgtgcagc ttcaacagaa aaaatctaca
      781 tccgcaaaga cctccgaagc cctctagccg caacgccaac ctttgtaaca gacagcgaga
      841 ctgccaggtc agctggactg ttggattcag gaatgtttgt gaatattcat ccgtctggaa
      901 taaaaacaga gccagctatg ctaatggcac cagataaggc tgaatcgtgt cagggagact
      961 taagcacatt ggccagtgtg gtcacatcat tagcgaatct cggcaaagct aaagaccttt
     1021 ctcactgcgg tggggatatg cctgtggtgc agagcttacg caatggggat acatccttcg
     1081 gtgcttttca tcatgatatt cagaccaatg gggatgtttc aagggcattt gacactcttg
     1141 caaaagcact gactcccggc gaaagctccg cctgccagag cccagaagag ggcatggagg
     1201 gaagcccgca tctaatcgct ggagagccaa gcttcgtgga gaaggagggg ccgctgctga
     1261 gcgagtcgca cgtagctttc aggctcacca tgccttctcc tatgcccgag tacctgaatg
     1321 tgcactacat tggggagtcg gcctccagac tgctgttctt atcgatgcac tgggcacttt
     1381 ccataccttc tttccaggcg ctagggcagg agaacagcat atcactggta aaagcgtatt
     1441 ggaatgagct ttttaccctt ggtcttgccc agtgctggca agtgatgaac gtggcaacta
     1501 tattagcaac gtttgtcaac tgtcttcaca gtagccttca gcaagataaa atgtccccgg
     1561 aaaggaggaa gtcgttgatg gagcacatct tcaagctaca ggagttctgc aacagcatgg
     1621 ttaagctctg catcgatggg catgagtacg cctacctcaa ggccatcgtc ctcttcagtc
     1681 ccgatcaccc aggcctggag aacatggagc taattgagag atttcaggaa aaggcttatg
     1741 tggaattcca agattatatc accaggacat atccagatga cacctacagg ctgtcgcgat
     1801 tacttctcag actgcccgcc ttgcggctga tgaacgctac cattactgag gagttgttct
     1861 tcaaaggtct cattggcaac gtacggatcg acagtgttat cccacacatt ttaaaaatgg
     1921 agcctgcaga ttacaactct caaataattg gtcacagcct ttgagagctg aggtcacccc
     1981 gctatgaact aagtttactg ttccttctcg ggacacaaga aaccaaatgg agctgttgct
     2041 tccagggagt ctgcgaatag taactgtaag agtaaccaaa attgaaagta tttttctttt
     2101 ggattcctta agaagaaatc aagcgaccag gcaggggtca ggaaatatac taccctgtct
     2161 gtcctctagg gatgatttaa aaaggtactg ggctgctctt ggtgaggatg acacctaaga
     2221 ctgtctcctc ctgaccatct acactaagct ttctcattct attttataaa acaaataaac
     2281 tagtcttttc ccccctgaat tgcgttctct tcctgtttaa ttccattgag ccagaacatt
     2341 aataattaaa cacctaagca gggacttctt acatcttact tatccataat cattttagtt
     2401 accaggtcaa aggttatctt atgctcactt atataatgat aatatcagag ctataggaag
     2461 taagaaatga atatatatat acatatatat atatatatgt atatgctttt ataaacatca
     2521 agcatataac actctcgttg ctggcaatga gacacaagcc atttgtattt tctttcatag
     2581 tgtagtagat tattagttat aagcactttt attcattgcg gtagaaaatt agtcttgaga
     2641 ataagatggg gatcctgttt taaatttggg ggtttactgt gttttaaaca tagtacagac
     2701 tgcccccagg atgtattagt attttagaat ggatactaaa gtagttgctt ttttcattcc
     2761 acagaaagca tctatcctct tctcagacgg gggttcagct ttttcaccct gccctggcct
     2821 ttagccgttt ttattgggtc ctttttaaaa aaactcaccc agtttgctaa gtaatgcaat
     2881 tatcaaagcc aatatggttc caaggtgagt taaataattc aagcaattga taattcataa
     2941 aggcaaaaga ctctgcactg attcttttcc ctgcagagcc gaggaaggct gctctaacaa
     3001 cctcaagttt cattatttgc tacaaccaaa gcattttaga ctcctcagtc ttccacacca
     3061 atatgacagg catcagtcgc tctttgtact gattttataa tggattcctt tagtaaatct
     3121 gttcatctat ttgttgatct tctcccccca tctctcctct tccctttctt ctttctccct
     3181 ctccctctct ccgtccttct tttccacatc tctgttttgt tttcttgaga caggatcttg
     3241 ctacccagcc caagctgaac tcaagtttgc cgttatcttc ctgcctccca ctccccgttg
     3301 ctgggattat agacatgcac cacacgctgg tatttatttt tcaaacacag agattttatt
     3361 gcagttagat tacattcttt attattaata aaaagttttg ctgaattttt ctatgggggg
     3421 tggtggattt tactactaac agtagtaaca aaaagtttaa aagtgtagtc ttgcaaatgt
     3481 taccaactta ctaggagggc tttatttcct gtttcatcct gtcaacagtt ctatttataa
     3541 gaagctgcca gggaatagtg catagagcat aaaatgctca cgcagaaagt ctcagtaggg
     3601 catgtgtaac ctgcatccca gcacatctgt agatgacgat gtcatatcac agtgtcaaaa
     3661 tgttggctcc tttgatacct ttatcatctc aagataataa gccaaggatt caccaaaaaa
     3721 aaaaaagtgt cctaatggtt atttctttga gatatttttc ctgatgaaat ttgtagttac
     3781 attgggaagt ctttttaaaa ctgtattaaa atgtgacttg cattaca
//
