LOCUS       NM_009803               1428 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Mus musculus nuclear receptor subfamily 1, group I, member 3
            (Nr1i3), transcript variant 1, mRNA.
ACCESSION   NM_009803
VERSION     NM_009803.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1428)
  AUTHORS   Shizu,R., Makida,N., Sobe,K., Ishimura,M., Takeshita,A., Hosaka,T.,
            Kanno,Y., Sasaki,T. and Yoshinari,K.
  TITLE     Interaction with YAP underlies the species differences between
            humans and rodents in CAR-dependent hepatocyte proliferation
  JOURNAL   Toxicol Sci 198 (1), 101-112 (2024)
   PUBMED   38128062
  REMARK    GeneRIF: Interaction with YAP underlies the species differences
            between humans and rodents in CAR-dependent hepatocyte
            proliferation.
REFERENCE   2  (bases 1 to 1428)
  AUTHORS   Oliviero,F., Klement,W., Mary,L., Dauwe,Y., Lippi,Y., Naylies,C.,
            Gayrard,V., Marchi,N. and Mselli-Lakhal,L.
  TITLE     CAR Protects Females from Diet-Induced Steatosis and Associated
            Metabolic Disorders
  JOURNAL   Cells 12 (18), 2218 (2023)
   PUBMED   37759441
  REMARK    GeneRIF: CAR Protects Females from Diet-Induced Steatosis and
            Associated Metabolic Disorders.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1428)
  AUTHORS   Yang,X., Weber,A.A., Mennillo,E., Paszek,M., Wong,S., Le,S.,
            Teo,J.Y.A., Chang,M., Benner,C.W., Tukey,R.H. and Chen,S.
  TITLE     Oral arsenic administration to
            humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1
            through a dependence on Nrf2 and PXR
  JOURNAL   J Biol Chem 299 (3), 102955 (2023)
   PUBMED   36720308
REFERENCE   4  (bases 1 to 1428)
  AUTHORS   Shin,A. and Waxman,D.J.
  TITLE     Impact of Neonatal Activation of Nuclear Receptor CAR (Nr1i3) on
            Cyp2 Gene Expression in Adult Mouse Liver
  JOURNAL   Toxicol Sci 187 (2), 298-310 (2022)
   PUBMED   35285501
  REMARK    GeneRIF: Impact of Neonatal Activation of Nuclear Receptor CAR
            (Nr1i3) on Cyp2 Gene Expression in Adult Mouse Liver.
REFERENCE   5  (bases 1 to 1428)
  AUTHORS   Skoda,J., Dohnalova,K., Chalupsky,K., Stahl,A., Templin,M.,
            Maixnerova,J., Micuda,S., Grontved,L., Braeuning,A. and Pavek,P.
  TITLE     Off-target lipid metabolism disruption by the mouse constitutive
            androstane receptor ligand TCPOBOP in humanized mice
  JOURNAL   Biochem Pharmacol 197, 114905 (2022)
   PUBMED   34971590
REFERENCE   6  (bases 1 to 1428)
  AUTHORS   Waxman,D.J.
  TITLE     P450 gene induction by structurally diverse xenochemicals: central
            role of nuclear receptors CAR, PXR, and PPAR
  JOURNAL   Arch Biochem Biophys 369 (1), 11-23 (1999)
   PUBMED   10462436
  REMARK    Review article
REFERENCE   7  (bases 1 to 1428)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
REFERENCE   8  (bases 1 to 1428)
  AUTHORS   Choi,H.S., Chung,M., Tzameli,I., Simha,D., Lee,Y.K., Seol,W. and
            Moore,D.D.
  TITLE     Differential transactivation by two isoforms of the orphan nuclear
            hormone receptor CAR
  JOURNAL   J Biol Chem 272 (38), 23565-23571 (1997)
   PUBMED   9295294
REFERENCE   9  (bases 1 to 1428)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     An orphan nuclear hormone receptor that lacks a DNA binding domain
            and heterodimerizes with other receptors
  JOURNAL   Science 272 (5266), 1336-1339 (1996)
   PUBMED   8650544
REFERENCE   10 (bases 1 to 1428)
  AUTHORS   Choi,H.S., Seol,W. and Moore,D.D.
  TITLE     A component of the 26S proteasome binds on orphan member of the
            nuclear hormone receptor superfamily
  JOURNAL   J Steroid Biochem Mol Biol 56 (1-6 Spec No), 23-30 (1996)
   PUBMED   8603043
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133515.1, AC163497.14 and AI132241.1.
            
            On Jul 16, 2011 this sequence version replaced NM_009803.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133515.1, AF009327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1100              AK133515.1         2-1101
            1101-1101           AC163497.14        2620-2620           c
            1102-1413           AK133515.1         1103-1414
            1414-1428           AI132241.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..1428
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.21 cM"
     gene            1..1428
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /note="nuclear receptor subfamily 1, group I, member 3"
                     /db_xref="GeneID:12355"
                     /db_xref="MGI:MGI:1346307"
     exon            1..204
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            205..347
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1287
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /note="isoform 1 is encoded by transcript variant 1;
                     constitutive androstane receptor; orphan nuclear receptor
                     MB67; constitutively transactivates RAREs"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1 group I member 3
                     isoform 1"
                     /protein_id="NP_033933.2"
                     /db_xref="CCDS:CCDS15480.1"
                     /db_xref="GeneID:12355"
                     /db_xref="MGI:MGI:1346307"
                     /translation="MTAMLTLETMASEEEYGPRNCVVCGDRATGYHFHALTCEGCKGF
                     FRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRA
                     RQAQRRAEKASLQLNQQQKELVQILLGAHTRHVGPMFDQFVQFKPPAYLFMHHRPFQP
                     RGPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNT
                     TFCLQTENFFCGPLCYKMEDAVHAGFQYEFLESILHFHKNLKGLHLQEPEYVLMAATA
                     LFSPDRPGVTQREEIDQLQEEMALILNNHIMEQQSRLQSRFLYAKLMGLLADLRSINN
                     AYSYELQRLEELSAMTPLLGEICS"
     exon            348..478
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            479..648
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            649..788
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            789..934
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1051
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1157
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1414
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1395..1400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /note="hexamer: AATGAA"
     polyA_site      1414
                     /gene="Nr1i3"
                     /gene_synonym="CAR; CAR-beta; Care2; ESTM32; MB67"
                     /note="major polyA site"
ORIGIN      
        1 ccagagtctg ggtcctacct acatatggca ccgaggatac ctagaggccc catgcaagag
       61 aaggcccttg ttttccaggc actgaggacc gcagtcccta attcctggca gttcctgaga
      121 tctcaaggaa agcagggtca gcgaggaggc ctggggagag gcatcctaca cccgatcttg
      181 tggcctgctg cctaagggaa acaggagacc atgacagcta tgctaacact agaaaccatg
      241 gccagtgaag aagaatatgg gccgaggaac tgtgtggtgt gtggagaccg ggccacaggc
      301 tatcatttcc acgccctgac ttgtgagggc tgcaagggct tcttcagacg aacagtcagc
      361 aaaaccattg gtcccatctg tccgtttgct ggaaggtgtg aggtcagcaa ggcccagaga
      421 cgccactgtc cagcctgcag gttgcagaag tgtctaaatg ttggcatgag gaaagacatg
      481 atactgtcag cagaagccct ggcattgcgg cgagccagac aggcacagcg gcgggcagag
      541 aaagcatctt tgcaactgaa tcagcagcag aaagaactgg tccagatcct cctgggggcc
      601 cacactcgcc atgtgggccc catgtttgac cagtttgtgc agttcaagcc tccggcctat
      661 ctgttcatgc atcaccggcc tttccagcct cggggccccg tgttgcctct gctcacacac
      721 tttgcagata tcaacacgtt tatggtgcaa cagatcatca agttcaccaa ggatctgccg
      781 ctcttccggt ccctaaccat ggaggaccag atctcccttc tcaagggagc ggctgtggaa
      841 atattgcata tctcactcaa cactacgttc tgtcttcaaa cagagaattt cttctgtggg
      901 cctctttgct acaagatgga ggacgcagtc catgcagggt tccagtacga gtttttggag
      961 tcgatcctcc acttccataa aaacctgaaa ggactgcatc tccaggagcc tgagtatgtg
     1021 ctcatggctg ccacggccct cttctcccct gacagacccg gagttaccca aagagaagag
     1081 atagatcagc tacaagagga gatggcgctg attctgaaca accacattat ggaacaacag
     1141 tctcggctcc aaagtcggtt tctgtatgca aagctgatgg gcctgctggc tgacctccgg
     1201 agtataaaca atgcatactc ctatgaactt cagcgcttgg aggaactgtc tgctatgacg
     1261 ccgctgctcg gggagatttg cagttgaggc ccaggcttgc atcctttccc cagaccccca
     1321 gggatacact ggcctggaaa gggtacagcg ctggacccca cacgggaacc agcaggaagg
     1381 agcttgggag tggcaatgaa atgctgaaca gtcaaaaaaa aaaaaaaa
//
