LOCUS       NM_010936               2540 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus nuclear receptor subfamily 1, group I, member 2
            (Nr1i2), transcript variant 1, mRNA.
ACCESSION   NM_010936 XM_489541
VERSION     NM_010936.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2540)
  AUTHORS   Shi,T., Fan,Q.Y., Liu,S.B. and Zhang,S.Y.
  TITLE     Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis
            via induction of Akr1c18 expression and prostaglandin F2alpha
            (PGF2alpha) levels
  JOURNAL   Biochem Pharmacol 225, 116309 (2024)
   PUBMED   38788959
  REMARK    GeneRIF: Pregnane X receptor (PXR) deficiency promotes
            hepatocarcinogenesis via induction of Akr1c18 expression and
            prostaglandin F2alpha (PGF2alpha) levels.
REFERENCE   2  (bases 1 to 2540)
  AUTHORS   Gebreyesus,L.H., Choi,S., Neequaye,P., Mahmoud,M., Mahmoud,M.,
            Ofosu-Boateng,M., Twum,E., Nnamani,D.O., Wang,L., Yadak,N.,
            Ghosh,S., Gonzalez,F.J. and Gyamfi,M.A.
  TITLE     Pregnane X receptor knockout mitigates weight gain and hepatic
            metabolic dysregulation in female C57BL/6J mice on a long-term
            high-fat diet
  JOURNAL   Biomed Pharmacother 173, 116341 (2024)
   PUBMED   38428309
  REMARK    GeneRIF: Pregnane X receptor knockout mitigates weight gain and
            hepatic metabolic dysregulation in female C57BL/6 J mice on a
            long-term high-fat diet.
REFERENCE   3  (bases 1 to 2540)
  AUTHORS   Cui,Q., Jiang,T., Xie,X., Wang,H., Qian,L., Cheng,Y., Li,Q., Lu,T.,
            Yao,Q., Liu,J., Lai,B., Chen,C., Xiao,L. and Wang,N.
  TITLE     S-nitrosylation attenuates pregnane X receptor hyperactivity and
            acetaminophen-induced liver injury
  JOURNAL   JCI Insight 9 (2), e172632 (2024)
   PUBMED   38032737
  REMARK    GeneRIF: S-nitrosylation attenuates pregnane X receptor
            hyperactivity and acetaminophen-induced liver injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2540)
  AUTHORS   Karpale,M., Kummu,O., Karkkainen,O., Lehtonen,M., Napankangas,J.,
            Herfurth,U.M., Braeuning,A., Rysa,J. and Hakkola,J.
  TITLE     Pregnane X receptor activation remodels glucose metabolism to
            promote NAFLD development in obese mice
  JOURNAL   Mol Metab 76, 101779 (2023)
   PUBMED   37467962
  REMARK    GeneRIF: Pregnane X receptor activation remodels glucose metabolism
            to promote NAFLD development in obese mice.
REFERENCE   5  (bases 1 to 2540)
  AUTHORS   Amini,S.E., Bresson,S.E. and Ruzzin,J.
  TITLE     Mice lacking intestinal Nr1i2 have normal intestinal homeostasis
            under steady-state conditions and are not hypersensitive to
            inflammation under lipopolysaccharide treatment
  JOURNAL   FASEB J 37 (8), e23117 (2023)
   PUBMED   37490003
REFERENCE   6  (bases 1 to 2540)
  AUTHORS   Zhang,H., LeCulyse,E., Liu,L., Hu,M., Matoney,L., Zhu,W. and Yan,B.
  TITLE     Rat pregnane X receptor: molecular cloning, tissue distribution,
            and xenobiotic regulation
  JOURNAL   Arch Biochem Biophys 368 (1), 14-22 (1999)
   PUBMED   10415106
REFERENCE   7  (bases 1 to 2540)
  AUTHORS   Blumberg,B., Sabbagh,W. Jr., Juguilon,H., Bolado,J. Jr., van
            Meter,C.M., Ong,E.S. and Evans,R.M.
  TITLE     SXR, a novel steroid and xenobiotic-sensing nuclear receptor
  JOURNAL   Genes Dev 12 (20), 3195-3205 (1998)
   PUBMED   9784494
REFERENCE   8  (bases 1 to 2540)
  AUTHORS   Bertilsson,G., Heidrich,J., Svensson,K., Asman,M., Jendeberg,L.,
            Sydow-Backman,M., Ohlsson,R., Postlind,H., Blomquist,P. and
            Berkenstam,A.
  TITLE     Identification of a human nuclear receptor defines a new signaling
            pathway for CYP3A induction
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12208-12213 (1998)
   PUBMED   9770465
REFERENCE   9  (bases 1 to 2540)
  AUTHORS   Lehmann,J.M., McKee,D.D., Watson,M.A., Willson,T.M., Moore,J.T. and
            Kliewer,S.A.
  TITLE     The human orphan nuclear receptor PXR is activated by compounds
            that regulate CYP3A4 gene expression and cause drug interactions
  JOURNAL   J Clin Invest 102 (5), 1016-1023 (1998)
   PUBMED   9727070
REFERENCE   10 (bases 1 to 2540)
  AUTHORS   Kliewer,S.A., Moore,J.T., Wade,L., Staudinger,J.L., Watson,M.A.,
            Jones,S.A., McKee,D.D., Oliver,B.B., Willson,T.M.,
            Zetterstrom,R.H., Perlmann,T. and Lehmann,J.M.
  TITLE     An orphan nuclear receptor activated by pregnanes defines a novel
            steroid signaling pathway
  JOURNAL   Cell 92 (1), 73-82 (1998)
   PUBMED   9489701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI746915.1, AK018630.1, AI595758.1 and CK383398.1.
            
            On Jun 1, 2007 this sequence version replaced NM_010936.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform (1,
            also known as PXR.1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018630.1, AF031814.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AI746915.1         1-2
            3-2145              AK018630.1         3-2145
            2146-2505           AI595758.1         1-360               c
            2506-2540           CK383398.1         388-422
FEATURES             Location/Qualifiers
     source          1..2540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.64 cM"
     gene            1..2540
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /note="nuclear receptor subfamily 1, group I, member 2"
                     /db_xref="GeneID:18171"
                     /db_xref="MGI:MGI:1337040"
     exon            1..307
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /inference="alignment:Splign:2.1.0"
     exon            308..523
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..1631
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     orphan nuclear receptor PXR; Pregnane X receptor"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1 group I member 2
                     isoform 1"
                     /protein_id="NP_035066.1"
                     /db_xref="CCDS:CCDS28164.1"
                     /db_xref="GeneID:18171"
                     /db_xref="MGI:MGI:1337040"
                     /translation="MRPEESWSRVGLVQCEEADSALEEPINVEEEDGGLQICRVCGDK
                     ANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCLES
                     GMKKEMIMSDAAVEQRRALIKRKKREKIEAPPPGGQGLTEEQQALIQELMDAQMQTFD
                     TTFSHFKDFRLPAVFHSGCELPEFLQASLLEDPATWSQIMKDRVPMKISLQLRGEDGS
                     IWNYQPPSKSDGKEIIPLLPHLADVSTYMFKGVINFAKVISYFRDLPIEDQISLLKGA
                     TFEMCILRFNTMFDTETGTWECGRLAYCFEDPNGGFQKLLLDPLMKFHCMLKKLQLHK
                     EEYVLMQAISLFSPDRPGVVQRSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMA
                     VLTELRSINAQQTQQLLRIQDSHPFATPLMQELFSSTDG"
     exon            524..657
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /inference="alignment:Splign:2.1.0"
     exon            658..845
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1120
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1263
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1380
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1486
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..2527
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2507..2512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /note="hexamer: AATAAA"
     polyA_site      2527
                     /gene="Nr1i2"
                     /gene_synonym="mPXR; PXR; PXR.1; PXR.2; PXR1; SXR"
                     /note="major polyA site"
ORIGIN      
        1 cattggacct ggggtgtact gtgggcaaga acaagtatgg ttcctatgcc tgtggacaac
       61 atagcctaag gttagctgag ggtgagaatc ggggatagat actgctcttt tgtctacttg
      121 gatggtcagc ctctccctag gggcctgacc ttggctcata ggaaacactg aggacttaag
      181 ctgagatctc catgtgcagc caggtagcca cggcaggtgt gctgagctct gggcagaacc
      241 atcgttcctg attcttcaag gtggacccca agggggaaat ccaacaaaag cagtggcccc
      301 cagacagtct aggacacaca gatgtaaacc tagagatgag acctgaggag agctggagcc
      361 gagttggcct tgtacagtgt gaagaagcag actctgcctt ggaagagccc atcaacgtag
      421 aggaggaaga tggaggtctt caaatctgcc gtgtatgtgg ggacaaggcc aatggctacc
      481 acttcaatgt catgacgtgt gaaggatgca aggggttttt cagaagggcc atgaaacgca
      541 atgtccggct gaggtgcccc ttccgcaagg gaacctgcga gatcacccgg aagacacgac
      601 ggcagtgcca ggcctgccgt ttgcgcaagt gcctggagag tggcatgaag aaagagatga
      661 tcatgtccga tgccgctgtg gagcagaggc gggccttgat caagaggaag aagagggaaa
      721 agattgaggc tccaccgcct ggagggcagg ggctgacgga agaacagcag gcgctgatcc
      781 aggagctgat ggacgctcag atgcaaacct ttgacacaac tttctcccac ttcaaggatt
      841 tccggctgcc tgcagtgttc cacagtggct gtgagcttcc agagtttctg caggcctcac
      901 tgttggaaga ccctgccaca tggagtcaaa tcatgaaaga cagggttcca atgaagatct
      961 ctctgcagct gcgcggagaa gacggcagca tctggaacta ccaaccccct tccaagagcg
     1021 acgggaaaga gatcatccct cttctgccac acctggccga tgtgtcaacc tacatgttca
     1081 agggcgtcat caacttcgcc aaagtcatat cctactttag ggacctgcct attgaggacc
     1141 agatctccct gctgaagggg gccacttttg agatgtgcat cctgaggttc aacacgatgt
     1201 tcgacacgga aacgggaacc tgggagtgcg gccggctggc ttactgcttc gaagacccta
     1261 atggtggctt ccagaaactt ctgttggatc cattgatgaa attccactgc atgctgaaga
     1321 agctacagct gcataaggag gagtatgtgc tgatgcaggc catctccctc ttctccccag
     1381 atcgtcctgg tgtggtccag cgcagcgtgg tagaccaact gcaggagagg tttgccctca
     1441 ccctgaaggc ctacattgag tgtagtcggc catatcctgc tcacaggttc ctgttcctga
     1501 agatcatggc cgtcctcact gagctgcgaa gcatcaacgc ccagcaaacc cagcagttgc
     1561 tgcgcatcca agactcgcac ccctttgcca ccccactcat gcaagagtta tttagcagca
     1621 cagatggctg agtggctgcc cctgagtgga gatctcatgg ggcagctaga cccagacatt
     1681 ctgaattgcc acttctaggg ctagacagat ggacatactg atagccaaca acgccctctg
     1741 actgcagctg gttagcattt ctcaggaaaa agacatggga gcccccaagt tcagcctgtg
     1801 ggaagtgctg gcctatgagt taagacaatc tttgtggttg ggaataaact tccaaatccc
     1861 gctaaattct caggtgttag gtgggagagg agggagcagg tcgaaccctg taacagttgt
     1921 acccccgtgc cccacacatt cccagcccca ggcttcttct cgagctgctt ctgtgttcca
     1981 gacgcgagct gatcttcagg ttcacaagta tcattgctga aggctagcag cttgtcctga
     2041 ccgtgttctg gacaaatcag tcaacttcct gcatctgccc aaacacattg ttagtcacta
     2101 acaatgtgac cagctgtgtg ggtgtgtgtc ggggaggggg ggggggaggg ggatagggtt
     2161 acagcacgaa ctcagatgta gatcccgacc tcagacttta agaagaccaa gctgaaatgg
     2221 ctgttaatag cttgtaaaac cttcttaaac aattcatgtg gagccaaaga aacggcatgt
     2281 gatatacagc caaggaactt ggtgtggggt ctgagctgca ctggggttct gtgggtcact
     2341 ggaagccaag gaaaggttcc cacattccag gaacgtgtgg aggaggggat gagaactatg
     2401 gcggtgggga cctgttcatg acttggtggg ggtcggtctg cacccacttc tgaccagctg
     2461 gcttgctccc aaggctgtga cttacagcaa agctacagtg acatacaata aatgtataat
     2521 agcacaaaaa aaaaaaaaaa
//
