LOCUS       NM_198658               2835 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nuclear receptor subfamily 1, group H, member 5
            (Nr1h5), transcript variant 1, mRNA.
ACCESSION   NM_198658 XM_355415
VERSION     NM_198658.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2835)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2835)
  AUTHORS   Yi,J., Lu,L., Yanger,K., Wang,W., Sohn,B.H., Stanger,B.Z.,
            Zhang,M., Martin,J.F., Ajani,J.A., Chen,J., Lee,J.S., Song,S. and
            Johnson,R.L.
  TITLE     Large tumor suppressor homologs 1 and 2 regulate mouse liver
            progenitor cell proliferation and maturation through antagonism of
            the coactivators YAP and TAZ
  JOURNAL   Hepatology 64 (5), 1757-1772 (2016)
   PUBMED   27531557
REFERENCE   3  (bases 1 to 2835)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 2835)
  AUTHORS   Otte,K., Kranz,H., Kober,I., Thompson,P., Hoefer,M., Haubold,B.,
            Remmel,B., Voss,H., Kaiser,C., Albers,M., Cheruvallath,Z.,
            Jackson,D., Casari,G., Koegl,M., Paabo,S., Mous,J., Kremoser,C. and
            Deuschle,U.
  TITLE     Identification of farnesoid X receptor beta as a novel mammalian
            nuclear receptor sensing lanosterol
  JOURNAL   Mol Cell Biol 23 (3), 864-872 (2003)
   PUBMED   12529392
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122219.3.
            
            On Mar 21, 2008 this sequence version replaced NM_198658.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY094586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC122219.3         11532-11577
            47-169              AC122219.3         17223-17345
            170-535             AC122219.3         20778-21143
            536-676             AC122219.3         23354-23494
            677-819             AC122219.3         26042-26184
            820-924             AC122219.3         26273-26377
            925-1024            AC122219.3         26523-26622
            1025-1138           AC122219.3         27801-27914
            1139-1261           AC122219.3         29509-29631
            1262-1375           AC122219.3         30305-30418
            1376-2835           AC122219.3         34548-36007
FEATURES             Location/Qualifiers
     source          1..2835
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     gene            1..2835
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /note="nuclear receptor subfamily 1, group H, member 5"
                     /db_xref="GeneID:381463"
                     /db_xref="MGI:MGI:3026618"
     exon            1..46
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /inference="alignment:Splign:2.1.0"
     exon            47..169
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1623
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1, group H, member 5
                     isoform 1"
                     /protein_id="NP_941060.2"
                     /db_xref="CCDS:CCDS38568.1"
                     /db_xref="GeneID:381463"
                     /db_xref="MGI:MGI:3026618"
                     /translation="MANTYVATSDGYYLAEPTQYYDILPEQFHYQLCDTDFQEPPYCQ
                     YSTAQFPPALQSPSLQSHFNTHGLDPQYSGGSWCGLDARESGQSTYVVVHDDEDEFPG
                     AQRCRATCSLRWKGQDDMLCMVCGDKASGYHYNALTCEGCKGFFRRSITKNAVYSCKN
                     GGHCEMDMYMRRKCQECRLKKCKAVGMLAECLLTEIQCKSKRLRKNFKHGPALYPAIQ
                     VEDEGADTKHVSSSTRSGKGVQDNMTLTQEEHRLLNTIVTVHQKSMIPLGETSKLLQE
                     GSNPELSFLRLSEVSVLHIQGLMKFTKGLPGFENLTTEDQAALQKASKTEVMFLHVAQ
                     LYGGKDSTSGSTMRPAKPSAGTLEVHNPSADESVHSPENFLKEGYPSAPLTDITKEFI
                     ASLSYFYRRMSELHVSDTEYALLTATTVLFSDRPCLKNKQHIENLQEPVLQLLFKFSK
                     MYHPEDPQHFAHLIGRLTELRTLSHSHSEILRMWKTKDPRLVMLFSEKWDLHSFS"
     exon            170..535
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /inference="alignment:Splign:2.1.0"
     exon            536..676
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /inference="alignment:Splign:2.1.0"
     exon            677..819
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /inference="alignment:Splign:2.1.0"
     exon            820..924
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1024
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1138
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1261
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1375
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..2835
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2807..2812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /note="hexamer: AATAAA"
     polyA_site      2835
                     /gene="Nr1h5"
                     /gene_synonym="Fxrb"
                     /note="major polyA site"
ORIGIN      
        1 ctcattccat gaggaggagg gcagactgca ggaacactac ccaattgttt tgttctgaaa
       61 gtgtttagca ttgctgaagg aaacaactag aagctggacc agagaatggc aaatacctat
      121 gttgctacgt ctgatgggta ctacctcgct gaacccacac agtattatga tattttgcca
      181 gaacaattcc attatcagct gtgtgataca gatttccaag aaccacccta ttgtcaatat
      241 tctaccgctc agtttcctcc agcgttacag tccccatctt tacaaagtca tttcaacaca
      301 catggcttgg atccacagta cagtggaggc agttggtgtg gactcgacgc tcgagaatct
      361 ggtcagtcca cttatgtggt tgttcacgat gatgaagatg aattccctgg ggcacaaagg
      421 tgcagagcaa cttgttcttt acgctggaag ggtcaagatg acatgctctg catggtctgc
      481 ggtgataagg catcaggata tcactacaat gcacttactt gtgaggggtg caaaggcttt
      541 ttccggcgta gcattaccaa gaatgcagtg tattcttgca agaacggtgg tcactgtgaa
      601 atggacatgt acatgcgcag aaaatgccaa gagtgcagac tgaagaagtg taaggcggtg
      661 gggatgttgg cagaatgttt gctcacagag atccagtgta agtcgaagag acttcgcaag
      721 aacttcaagc acgggcctgc cctgtaccct gccatccaag tggaagatga aggagcagac
      781 accaaacacg tgtcatccag caccagatct gggaaagggg ttcaggacaa catgactcta
      841 actcaagagg aacatcggct tctgaatacc atagtgactg ttcaccaaaa atccatgatt
      901 cccttgggag aaacaagcaa acttctgcag gagggttcca accccgaact aagttttctg
      961 agactctcag aggtatcagt cctccacata caagggctaa tgaagtttac caagggactc
     1021 ccaggatttg aaaatttaac cactgaggat caggctgcat tacagaaggc gtcaaaaact
     1081 gaagtgatgt tccttcatgt agcccagctt tatggtggga aagactcaac ctctggaagt
     1141 actatgagac cagcaaagcc ctcagctggg acactagagg tgcataatcc tagcgctgat
     1201 gaaagtgttc attctccgga aaactttctc aaggaaggct acccttcggc tcctctaact
     1261 gatattacta aagaatttat tgcctcacta tcttacttct acagaagaat gagtgaactt
     1321 catgtatcgg atactgaata tgctctgctt acggcgacaa cagtgctttt ctcagatcgt
     1381 ccatgcctta aaaataagca gcatatagaa aacctacaag aaccagtcct gcaacttttg
     1441 tttaagtttt caaaaatgta ccatccagaa gacccacagc atttcgccca cctcataggg
     1501 aggcttactg aactgagaac tctgagtcac agccactctg aaatccttcg catgtggaaa
     1561 acaaaggacc ccaggttggt gatgttattc tctgagaaat gggatctgca ctcattttcc
     1621 tgaaaattta cagtggtgag acttgcctta aaatttcaaa atcaaaattg gatgaatgat
     1681 ttgaaaaaaa tgtgataact caaaatcatt gagttatcac acaccacctt aaaatggaga
     1741 tccaaaaggc tcatcagggt ttgtggaact ttcaactctt agaagatgaa cactccagga
     1801 ttcatctcaa gattggatgc aaaggaaaga aaaatggagc catgtggtgg cataggctct
     1861 gtagttgaga gacagagaca agaggacccc atgtttaagg cagtcctggg ctatgtagtg
     1921 agacctcatc tcagaagaaa aaagagaaga actgatggcc atcattatgt ctccaatcct
     1981 cacctaaaga aactaatttt ttgttgttgt tgtttagctg aaacacataa tgtgtaaatg
     2041 tgaacacagg taggttatgg ttaggataag gcagtttgta tgcttcactg gttaaggaca
     2101 catggatggt gtagcagcta atgcttagaa cctcttcttc atgaatgatt aacgaggaac
     2161 aagccttttc aaattgtatc tgctttatat ttttaataag tatgtgataa ttgtacagaa
     2221 tagtcaatat tgtacagaat atttcaatat gggaatttca tgtgtatata ttagatattt
     2281 ctggcgtatt tgccacccac cctgtgatgc ccacactgcc aatgcccttc tcatccccct
     2341 aacatttccc ttcctctgcc ttgccctaaa acaccagatt catacgtgca agaaaacatt
     2401 ttttaaacaa attttattag atattttctt catttacaat tcaaatgcta tcccaaaagt
     2461 cccttattcc ctccccttat cctgctctcc aacccaccca cttctgcttc ctggccctgg
     2521 tattcccctg tattggggta tataatcttt gcaagaccaa gggcctctcc tcccaacgat
     2581 ggtccactag gccatctgca agaaaacatt tgattccagt ctgagtctgt tttatttcct
     2641 ttgagtatga ctatctcgtc aatatctgca aatgacataa tttcattcct cttaaggatg
     2701 gaaaggactg gattgtgtat gtatatctgt atatattatt ttatttatcc acctgctgat
     2761 gacacctagt ttgattctgt atcttggcca ctgtgaatcg tgctataata aacctatgta
     2821 ggtttttaga tttta
//
