LOCUS       NM_009473               2003 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus nuclear receptor subfamily 1, group H, member 2
            (Nr1h2), transcript variant 1, mRNA.
ACCESSION   NM_009473 XM_358686
VERSION     NM_009473.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2003)
  AUTHORS   Diercks,A.H., Podolskaia,I.S., Murray,T.A., Jahn,A.N., Mai,D.,
            Liu,D., Amon,L.M., Nakagawa,Y., Shimano,H., Aderem,A. and Gold,E.S.
  TITLE     Oxysterol binding protein regulates the resolution of TLR-induced
            cytokine production in macrophages
  JOURNAL   Proc Natl Acad Sci U S A 121 (33), e2406492121 (2024)
   PUBMED   39361877
REFERENCE   2  (bases 1 to 2003)
  AUTHORS   Shi,R., Li,Y., Zhu,W., Xin,H., Yang,H., Feng,X., Wang,Z., Li,S.,
            Cong,B. and Shi,W.
  TITLE     The Regulation of Frontal Cortex Cholesterol Metabolism
            Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of
            Stress-Induced Depression
  JOURNAL   Int J Mol Sci 25 (15), 8075 (2024)
   PUBMED   39125645
  REMARK    GeneRIF: The Regulation of Frontal Cortex Cholesterol Metabolism
            Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of
            Stress-Induced Depression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2003)
  AUTHORS   Ceglia,S., Berthelette,A., Howley,K., Li,Y., Mortzfeld,B.,
            Bhattarai,S.K., Yiew,N.K.H., Xu,Y., Brink,R., Cyster,J.G.,
            Hooper,L.V., Randolph,G.J., Bucci,V. and Reboldi,A.
  TITLE     An epithelial cell-derived metabolite tunes immunoglobulin A
            secretion by gut-resident plasma cells
  JOURNAL   Nat Immunol 24 (3), 531-544 (2023)
   PUBMED   36658240
REFERENCE   4  (bases 1 to 2003)
  AUTHORS   van Wouw,S.A.E., van den Berg,M., El Ouraoui,M., Meurs,A.,
            Kingma,J., Ottenhoff,R., Loix,M., Hoeksema,M.A., Prange,K.,
            Pasterkamp,G., Hendriks,J.J.A., Bogie,J.F.J., van Klinken,J.B.,
            Vaz,F.M., Jongejan,A., de Winther,M.P.J. and Zelcer,N.
  TITLE     Sterol-regulated transmembrane protein TMEM86a couples LXR
            signaling to regulation of lysoplasmalogens in macrophages
  JOURNAL   J Lipid Res 64 (2), 100325 (2023)
   PUBMED   36592658
REFERENCE   5  (bases 1 to 2003)
  AUTHORS   Song,X.Y., Wu,W.F., Dai,Y.B., Xu,H.W., Roman,A., Wang,L., Warner,M.
            and Gustafsson,J.A.
  TITLE     Ablation of Liver X receptor beta in mice leads to overactive
            macrophages and death of spiral ganglion neurons
  JOURNAL   Hear Res 422, 108534 (2022)
   PUBMED   35623301
  REMARK    GeneRIF: Ablation of Liver X receptor beta in mice leads to
            overactive macrophages and death of spiral ganglion neurons.
REFERENCE   6  (bases 1 to 2003)
  AUTHORS   Repa,J.J., Liang,G., Ou,J., Bashmakov,Y., Lobaccaro,J.M.,
            Shimomura,I., Shan,B., Brown,M.S., Goldstein,J.L. and
            Mangelsdorf,D.J.
  TITLE     Regulation of mouse sterol regulatory element-binding protein-1c
            gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
  JOURNAL   Genes Dev 14 (22), 2819-2830 (2000)
   PUBMED   11090130
REFERENCE   7  (bases 1 to 2003)
  AUTHORS   Repa,J.J., Turley,S.D., Lobaccaro,J.A., Medina,J., Li,L.,
            Lustig,K., Shan,B., Heyman,R.A., Dietschy,J.M. and Mangelsdorf,D.J.
  TITLE     Regulation of absorption and ABC1-mediated efflux of cholesterol by
            RXR heterodimers
  JOURNAL   Science 289 (5484), 1524-1529 (2000)
   PUBMED   10968783
REFERENCE   8  (bases 1 to 2003)
  AUTHORS   Alberti,S., Steffensen,K.R. and Gustafsson,J.A.
  TITLE     Structural characterisation of the mouse nuclear oxysterol receptor
            genes LXRalpha and LXRbeta
  JOURNAL   Gene 243 (1-2), 93-103 (2000)
   PUBMED   10675617
REFERENCE   9  (bases 1 to 2003)
  AUTHORS   Ganter,B. and Lipsick,J.S.
  TITLE     Myb binding sites within the N-ras promoter repress transcription
  JOURNAL   Oncogene 15 (2), 193-202 (1997)
   PUBMED   9244354
REFERENCE   10 (bases 1 to 2003)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157653.2 and AC149607.6.
            
            On Jan 20, 2023 this sequence version replaced NM_009473.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.777615.1,
                                           ERR3363660.2109167.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC157653.2         100110-100251
            143-272             AC157653.2         100348-100477
            273-333             AC157653.2         101299-101359
            334-447             AC157653.2         101436-101549
            448-738             AC157653.2         101811-102101
            739-998             AC157653.2         102197-102456
            999-1178            AC157653.2         102559-102738
            1179-1278           AC157653.2         103212-103311
            1279-1289           AC157653.2         103548-103558
            1290-1487           AC149607.6         1-198
            1488-2003           AC149607.6         367-882
FEATURES             Location/Qualifiers
     source          1..2003
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.83 cM"
     gene            1..2003
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /note="nuclear receptor subfamily 1, group H, member 2"
                     /db_xref="GeneID:22260"
                     /db_xref="MGI:MGI:1352463"
     exon            1..142
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /inference="alignment:Splign:2.1.0"
     exon            143..272
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /inference="alignment:Splign:2.1.0"
     exon            273..333
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1634
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /note="isoform a is encoded by transcript variant 1;
                     oxysterols receptor LXR-beta; LXR beta; liver X receptor
                     beta; retinoid X receptor-interacting protein No.15;
                     ubiquitously-expressed nuclear receptor 2"
                     /codon_start=1
                     /product="oxysterols receptor LXR-beta isoform a"
                     /protein_id="NP_033499.1"
                     /db_xref="CCDS:CCDS21211.1"
                     /db_xref="GeneID:22260"
                     /db_xref="MGI:MGI:1352463"
                     /translation="MSSPTSSLDTPVPGNGSPQPSTSATSPTIKEEGQETDPPPGSEG
                     SSSAYIVVILEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFF
                     RRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKR
                     IQKQQQQQPPPPSEPAASSSGRPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVA
                     AQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPG
                     FLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEF
                     INPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYT
                     RIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE"
     exon            334..447
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /inference="alignment:Splign:2.1.0"
     exon            448..738
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /inference="alignment:Splign:2.1.0"
     exon            739..998
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1178
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1278
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1487
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..2003
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1968..1973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /note="hexamer: AATAAA"
     regulatory      1982..1987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /note="hexamer: AATAAA"
     polyA_site      1987
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
                     /note="major polyA site"
     polyA_site      2003
                     /gene="Nr1h2"
                     /gene_synonym="LXR; LXRB; LXRbeta; LXRBSV; NER1; OR-1;
                     RIP15; Unr; Unr2; UR"
ORIGIN      
        1 gcagcggggt tgccggaaga agtggcgaag ttacttttgc ttttcgctca gcaagcgctg
       61 ttgcttcgag ctactcccag gcttctgaag ttacttccaa agtgctgtgg aggcacaatc
      121 accggtgcgg acacagaggc aactctcgcc tcccacggcc gtttccaggg caacagagtc
      181 ggagaccccc tgcgaccccc ctcccgatcg ccggtgcagt catgagcccc gcctccccct
      241 ggtgcacgga gaggggcggg gcctggaaca agcaggctgc ttcgtgaccc actatgtctt
      301 cccccacaag ttctctggac actcccgtgc ctgggaatgg ttctcctcag cccagtacct
      361 ccgccacgtc acccactatt aaggaagagg ggcaggagac tgatcctcct ccaggctctg
      421 aagggtccag ctctgcctac atcgtggtca tcttagagcc agaggatgag cctgagcgca
      481 agcggaagaa ggggccggcc ccgaagatgc tgggccatga gctgtgccgc gtgtgcggag
      541 acaaggcttc gggcttccac tacaacgtgc tcagctgtga aggctgcaaa ggcttcttcc
      601 ggcgcagtgt ggtccacggt ggggccgggc gctatgcctg tcggggcagc ggaacctgcc
      661 agatggatgc cttcatgcgg cgcaagtgcc agctctgccg gctgcgcaag tgcaaggagg
      721 ctggcatgcg ggagcagtgc gtgctctctg aggagcagat tcggaagaaa aggattcaga
      781 agcagcaaca gcagcagcca ccacccccat ctgagccagc agccagcagc tcaggccggc
      841 cagcggcctc ccctggcact tcggaagcaa gcagccaggg ctccggggaa ggagagggca
      901 tccagctgac cgcggctcag gagctgatga tccagcagtt agttgccgcg cagctgcagt
      961 gcaacaaacg atctttctcc gaccagccca aagtcacgcc ctggcccctg ggtgcagacc
     1021 ctcagtcccg agatgcccgt cagcaacgct ttgcccactt caccgagcta gccatcatct
     1081 cggtccagga gattgtggac tttgccaagc aggtgccagg gttcttgcag ttgggccggg
     1141 aggaccagat cgccctcctg aaggcgtcca ccattgagat catgttgcta gaaacagcca
     1201 gacgctacaa ccacgagaca gaatgcatca cgttcctgaa ggacttcacc tacagcaagg
     1261 acgacttcca ccgtgcaggc ttgcaggtgg aattcatcaa tcccatcttc gagttctcgc
     1321 gggccatgcg gcggctgggc ctggacgatg cagagtatgc cttgcttatc gccatcaaca
     1381 tcttctcagc cgatcggcct aatgtgcagg agcccagccg tgtggaggcc ctgcagcagc
     1441 cctacgtgga ggcgctcctc tcctacacga ggatcaagcg cccacaggac cagctccgct
     1501 tcccacgcat gctcatgaag ctggtgagcc tgcgcaccct cagctccgtg cactcggagc
     1561 aggtctttgc attgcgactc caggacaaga agctgccgcc cttgctgtcc gagatctggg
     1621 atgtgcacga gtaggggcag ccacaagtgc cccagccttg gtggtgtctt cttgaagatg
     1681 gactcttcac ctctcctcct ggggtgggag gacattgtca cggcccagtc cctcgggctc
     1741 agcctcaaac tcagcggcag ttggcactag aaggccccac cccacccatt gagtcttcca
     1801 agagtggtga gggtcacagg tcctagcctc tgaccgttcc cagctgccct cccacccacg
     1861 cttacacctc agcctaccac accatgcacc ttgagtggag agaggttagg gcaggtggcc
     1921 ccccacagtt gggagaccac aggccctctc ttctgcccct tttatttaat aaaaaaacaa
     1981 aaataaagtt tgagtacaag cca
//
