LOCUS       NM_011584               4640 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus nuclear receptor subfamily 1, group D, member 2
            (Nr1d2), mRNA.
ACCESSION   NM_011584
VERSION     NM_011584.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4640)
  AUTHORS   Guan D, Bae H, Zhou D, Chen Y, Jiang C, La CM, Xiao Y, Zhu K, Hu W,
            Trinh TM, Liu P, Xiong Y, Cai B, Jang C and Lazar MA.
  TITLE     Hepatocyte SREBP signaling mediates clock communication within the
            liver
  JOURNAL   J Clin Invest 133 (8), e163018 (2023)
   PUBMED   37066875
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4640)
  AUTHORS   Li H, Song S, Tien CL, Qi L, Graves A, Nasiotis E, Burris TP, Zhao
            Y, Sun Z and Zhang L.
  TITLE     SR9009 improves heart function after pressure overload independent
            of cardiac REV-ERB
  JOURNAL   Front Cardiovasc Med 9, 952114 (2022)
   PUBMED   35911512
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4640)
  AUTHORS   Song S, Tien CL, Cui H, Basil P, Zhu N, Gong Y, Li W, Li H, Fan Q,
            Min Choi J, Luo W, Xue Y, Cao R, Zhou W, Ortiz AR, Stork B, Mundra
            V, Putluri N, York B, Chu M, Chang J, Yun Jung S, Xie L, Song J,
            Zhang L and Sun Z.
  TITLE     Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity
            Paradox
  JOURNAL   Circulation 145 (6), 448-464 (2022)
   PUBMED   35034472
REFERENCE   4  (bases 1 to 4640)
  AUTHORS   Adlanmerini M, Krusen BM, Nguyen HCB, Teng CW, Woodie LN,
            Tackenberg MC, Geisler CE, Gaisinsky J, Peed LC, Carpenter BJ,
            Hayes MR and Lazar MA.
  TITLE     REV-ERB nuclear receptors in the suprachiasmatic nucleus control
            circadian period and restrict diet-induced obesity
  JOURNAL   Sci Adv 7 (44), eabh2007 (2021)
   PUBMED   34705514
REFERENCE   5  (bases 1 to 4640)
  AUTHORS   Zhang T, Yu F, Xu H, Chen M, Chen X, Guo L, Zhou C, Xu Y, Wang F,
            Yu J and Wu B.
  TITLE     Dysregulation of REV-ERBalpha impairs GABAergic function and
            promotes epileptic seizures in preclinical models
  JOURNAL   Nat Commun 12 (1), 1216 (2021)
   PUBMED   33619249
  REMARK    GeneRIF: Dysregulation of REV-ERBalpha impairs GABAergic function
            and promotes epileptic seizures in preclinical models.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4640)
  AUTHORS   Sauve F, McBroom LD, Gallant J, Moraitis AN, Labrie F and Giguere
            V.
  TITLE     CIA, a novel estrogen receptor coactivator with a bifunctional
            nuclear receptor interacting determinant
  JOURNAL   Mol Cell Biol 21 (1), 343-353 (2001)
   PUBMED   11113208
REFERENCE   7  (bases 1 to 4640)
  AUTHORS   Bois-Joyeux B, Chauvet C, Nacer-Cherif H, Bergeret W, Mazure N,
            Giguere V, Laudet V and Danan JL.
  TITLE     Modulation of the far-upstream enhancer of the rat
            alpha-fetoprotein gene by members of the ROR alpha, Rev-erb alpha,
            and Rev-erb beta groups of monomeric orphan nuclear receptors
  JOURNAL   DNA Cell Biol 19 (10), 589-599 (2000)
   PUBMED   11058961
REFERENCE   8  (bases 1 to 4640)
  AUTHORS   Huchet M, Cassia R, Zakin L, Cereghini S and Zakin MM.
  TITLE     The early expression of Rev-erbbeta occurs in the developing
            nervous system of mouse embryo
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 44 (3), 553-556 (1998)
   PUBMED   9620453
REFERENCE   9  (bases 1 to 4640)
  AUTHORS   Forman BM, Chen J, Blumberg B, Kliewer SA, Henshaw R, Ong ES and
            Evans RM.
  TITLE     Cross-talk among ROR alpha 1 and the Rev-erb family of orphan
            nuclear receptors
  JOURNAL   Mol Endocrinol 8 (9), 1253-1261 (1994)
   PUBMED   7838158
REFERENCE   10 (bases 1 to 4640)
  AUTHORS   Retnakaran R, Flock G and Giguere V.
  TITLE     Identification of RVR, a novel orphan nuclear receptor that acts as
            a negative transcriptional regulator
  JOURNAL   Mol Endocrinol 8 (9), 1234-1244 (1994)
   PUBMED   7838156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ079681.1, AK079075.1, AK054522.1 and AV335025.1.
            
            [WARNING] On Nov 29, 2023 this sequence was replaced by
            NM_011584.5.
            
            On Jul 22, 2009 this sequence version replaced NM_011584.3.
            
            Summary: This gene encodes a member of the nuclear hormone receptor
            family, specifically the NR1 subfamily of receptors. The encoded
            protein functions as a transcriptional repressor and may play a
            role in circadian rhythms and carbohydrate and lipid metabolism.
            [provided by RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.188347.1,
                                           SRR1660817.7258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               CJ079681.1         1-114
            115-1083            AK079075.1         2-970
            1084-1084           AK054522.1         1009-1009
            1085-4578           AK079075.1         972-4465
            4579-4640           AV335025.1         162-223
FEATURES             Location/Qualifiers
     source          1..4640
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 7.08 cM"
     gene            1..4640
                     /gene="Nr1d2"
                     /gene_synonym="Rev-erb; RVR"
                     /note="nuclear receptor subfamily 1, group D, member 2"
                     /db_xref="GeneID:353187"
                     /db_xref="MGI:MGI:2449205"
     exon            1..296
                     /gene="Nr1d2"
                     /gene_synonym="Rev-erb; RVR"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..2011
                     /gene="Nr1d2"
                     /gene_synonym="Rev-erb; RVR"
                     /note="rev-erb-beta; orphan nuclear receptor RVR; Rev-erb
                     beta"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1 group D member 2"
                     /protein_id="NP_035714.3"
                     /db_xref="CCDS:CCDS36811.1"
                     /db_xref="GeneID:353187"
                     /db_xref="MGI:MGI:2449205"
                     /translation="MELNAGGVIAYISSSSSASSPASCHSEGSENSFQSSSSSVPSSP
                     NSSNCDANGNPKNADISSIDGVLKSDRTDCPVKTGKTSAPGMTKSHSGMTKFSGMVLL
                     CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCR
                     FKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQSAMKTMMNTQFSGHLQNDTLAEQHDQ
                     SALPAQEQLRPKSQLEQENIKNTPSDFAKEEVIGMVTRAHKDTFLYNQEHRENSSESM
                     PPQRGERIPRNMEQYNLNQDHRGSGIHNHFPCSERQQHLSGQYKGRNIMHYPNGHAVC
                     IANGHCMNFSSAYTQRVCDRIPVGGCSQTENRNSYLCNTGGRMHLVCPMSKSPYVDPQ
                     KSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASL
                     FDAKERTVTFLSGKKYSVDDLHSMGAGDLLSSMFEFSEKLNALQLSDEEMSLFTAVVL
                     VSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHS
                     EELLAFKVHP"
     exon            297..563
                     /gene="Nr1d2"
                     /gene_synonym="Rev-erb; RVR"
                     /inference="alignment:Splign:2.1.0"
     exon            564..652
                     /gene="Nr1d2"
                     /gene_synonym="Rev-erb; RVR"
                     /inference="alignment:Splign:2.1.0"
     exon            653..797
                     /gene="Nr1d2"
                     /gene_synonym="Rev-erb; RVR"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1417
                     /gene="Nr1d2"
                     /gene_synonym="Rev-erb; RVR"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1603
                     /gene="Nr1d2"
                     /gene_synonym="Rev-erb; RVR"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1814
                     /gene="Nr1d2"
                     /gene_synonym="Rev-erb; RVR"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..4640
                     /gene="Nr1d2"
                     /gene_synonym="Rev-erb; RVR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagaggagg agcgggcggc ctgaggagga ggagcgggcg gagtcaccgc accgccggcg
       61 gcggcggagg aggggggtgt gcgcggatca catggtcgag gagccctcca ggtcagctgc
      121 cgtgcccgct gccgagccct gccacaggaa actgctgtgc cgcgcttgtg ccgtgcggcc
      181 cccaggagcc gcccgcaccc ggtgctcatg atgtgggccc gcgagcgcca ccgcctgcag
      241 tcccgggcgg cgcggtgagg gccgcaccct gtccagcgcc atggagctga acgcaggagg
      301 tgtgattgcc tacatcagtt cctctagctc tgcctccagc cctgcctctt gtcacagtga
      361 gggttctgag aatagcttcc agtcctcgtc ctcgtctgtt ccatcttctc caaatagctc
      421 taactgtgat gccaacggca atcccaagaa cgctgatatc tctagcatcg atggtgttct
      481 gaagagtgac cgcacagatt gtcctgtgaa aacaggcaaa accagtgctc ctggcatgac
      541 taagagtcac agtggaatga caaaatttag tggcatggtt ctactgtgta aagtctgtgg
      601 ggatgtggca tcaggattcc actatggagt tcatgcttgt gaaggctgta agggtttctt
      661 tcggaggagc attcagcaaa acatccagta taagaagtgc ctgaagaatg agaactgttc
      721 catcatgagg atgaacagga accggtgcca gcagtgccgc tttaagaagt gtctgtctgt
      781 ggggatgtca cgagatgctg ttcgatttgg ccgaattcct aagcgtgaaa aacagagaat
      841 gctaattgaa atgcaaagtg caatgaagac catgatgaac acccagttca gtggccacct
      901 gcagaatgac accttagcag aacagcatga tcagtcagca ctaccagctc aggaacagct
      961 gcggcccaag tcccagctgg agcaagaaaa catcaaaaac actccttctg attttgcaaa
     1021 ggaggaagtg attggtatgg tgaccagagc ccacaaggat acctttctgt ataatcagga
     1081 acatcgagaa aactcatctg agagcatgcc acctcagaga ggagaacgga ttcccaggaa
     1141 catggagcaa tataatttaa atcaagacca tcgtggcagt gggattcaca accacttccc
     1201 ctgtagtgag aggcagcaac atctcagtgg acagtacaaa gggaggaaca taatgcatta
     1261 cccaaacggc catgccgttt gtattgcaaa tggacactgt atgaacttct ccagtgctta
     1321 tactcaaaga gtctgtgata gaattccagt aggtggatgt tctcagactg agaacagaaa
     1381 tagttacctg tgcaacactg gagggaggat gcatctggtg tgtcctatga gcaagtctcc
     1441 atatgtggac cctcagaagt ctggacatga aatctgggaa gaattttcaa tgagttttac
     1501 cccagcagta aaagaggtgg tggaatttgc aaagaggatt cctggcttcc gagatctgtc
     1561 tcagcatgat caggtcaatc tgttaaaagc tgggactttt gaggttttaa tggtacgatt
     1621 tgcttcatta tttgatgcaa aggaacggac tgtcaccttt ctaagtggta agaagtacag
     1681 tgtggatgac ctgcactcaa tgggagcagg ggatctgctc agctctatgt ttgagttcag
     1741 tgagaagctg aatgccctcc agctcagtga tgaggaaatg agcttgttca cagcagttgt
     1801 tctggtatct gcagatcgat ctggaattga aaatgtcaac tcagtggagg ctttgcagga
     1861 aacactcatc cgtgcactaa ggaccttaat aatgaaaaac catccaaatg aggcctccat
     1921 ttttacaaaa ttacttctaa agttgccaga tcttcgatct ttaaacaaca tgcactctga
     1981 ggaactcttg gcctttaaag ttcatcctta aggcctttga acatgaactg atgctaatgt
     2041 acattttatg ctgagatgtt tatttatatg tgtatactat attgtggaaa tagaaaagaa
     2101 cttagcgcca ggtcctgggc tgtctctgta gtcagtcacc agtagctgtt gggataagaa
     2161 ctcgttgtct tgttagacat tggcccaccc tcccctgtag accaatcagc tgtgttgcac
     2221 ttagactgga gaagttacac tgaattataa tcacactgaa tgttagactt tttcatctgc
     2281 caaagccaaa ataccatttg atctccccat ggtataaatc tagcgcacat tgccgatata
     2341 ggaggactta gacattaacc ctttgtgctg ggaattctgt tgtaccacaa gactgaaatg
     2401 tggtaaggga gactgagagc caagaggtct ttatgtactt ggattttgct ctgccactgt
     2461 caaagtacgt ggtggtggca gtctctgagt tttggaaaat gataattgat agtgtcccca
     2521 atgttctgcc tcaaatactg aaaactatcc ataaagcgtc tttacctctt gggagatagg
     2581 cactatgtaa ataaggtgaa gtttttatta taattgctca taatagtatt cttgtcttat
     2641 ttctaagcat ttctgggaaa ctttgacagt ccacaccaat ttattcaggg ttcctgctca
     2701 agtagggtac cctactgata aacacatatt ccaggtttat ggacacctca aatagtatgt
     2761 gtacatagtg tgtatgtgaa tataattata tataaaaatc ttacttcaca atattttaaa
     2821 ctgtgaagaa ctttatcata caataaaact taaacaagag gtgtcaagga cccaaattag
     2881 gtgcatttta cctgttgctg ctgatgtata accattgctt tacaatgttt agatggtaga
     2941 atactgaagt taatgctctt atttttgttt aaggaacatt taatgtaaaa gtgtgaagag
     3001 cagtcaaatc tggattttag aaaaaaatgt attttaggat gcatctttga tacaatctgc
     3061 agttgaaggt aatagatgtt tcagtgtttc agctttctac cttgtgctat tagtagaggt
     3121 ggtattgctg cctcttacgt gcttcaggtg gatggcagat ttggattctg tatggaggag
     3181 gttttgttta ggaaaacttt gtgacctgtt ggcatgtttg tgccaagtcc acttttcttt
     3241 ctttccctaa ataatactac agggattttg tcaatttaga tttaatataa tttgagaaac
     3301 cttttagtaa gtgacctacc tacaggctta gagatcatgg taggaaagat ggccaaagtt
     3361 aaagattcat gaacaacacc ccgtgccccc caaagtagca attcattgta ttttgggggt
     3421 aaaattactt tctgtgtaat gctagattat gtgaaattgt aacgacatta agaacctgct
     3481 ttactactta aagcctgtta cttttatgac atttaatcag aatgccttat tttgtagttt
     3541 taacttgttg ctacaggatt tgaacttctg tggtacagtt aggagagctt gagaaagata
     3601 aactcctatt gtcaaagagg aaagtgatgg tgtgtctgtc attcagtagg gaccataact
     3661 gctgcttacg ttcagtgggt atggctttta tgggatatac agctaggttt tgtgaattct
     3721 ttacatgata gcattctttt attttttttc gtaggataaa aaaatgcata gttttcttct
     3781 atgagggata gagaactttt ttgaaataat actatgttga ttctttattt ttgcctttta
     3841 cataagtgtc tttataacat gtatctttag agcagttaag tctttggaaa tatgtaacca
     3901 gaactgttag tattgcttgt gatgctttag ttagggttag tatatacatg tatacaccaa
     3961 aatacaagca tgtagatttg cattttgtct cgtaaaattt tattttaata aattcttcct
     4021 gaagtaatgg gaaacaaaat ccatagttca tatgccacat gtagtatttc tgtatttgaa
     4081 agtagcccaa agatgagcat tctaattcta aaatgaaacc agcagcctca tacaagcaca
     4141 ttctttggtt gagtcatggt ctaacagtta ataaatgaca tcagccagat agagaacctc
     4201 tgagtcagtg gggtactgtt gataattaac aatgtactgt atgaattaag tgacatgtta
     4261 accctgactt tatgtttcaa ggttaaaata tgggcattat ctcatcagac ttatgggcat
     4321 tatgttaaca agatgaacca ttttttcctg tgcttttagt atgtgatatg agaggattcc
     4381 agcttctaga gagtgaacac tgagggaaag gagagacatc gtaggataaa gtttgttctc
     4441 ctggtaatgg ttaattgcag ataaaaaaat ttgaagggtg tttcagtaga ttaatatata
     4501 gatttcatat ctacattgta agaaattacc attgtgattg ggtcagaatt gatgtgtgtt
     4561 atataaacat tgcaaagcaa agctgtgaga gaagctcaga tagatgtatc tttttgcaat
     4621 ataaagtttg ctgaatgtat
//
