LOCUS       NM_145434               2782 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus nuclear receptor subfamily 1, group D, member 1
            (Nr1d1), mRNA.
ACCESSION   NM_145434
VERSION     NM_145434.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2782)
  AUTHORS   Sarrazin,D.H., Gardner,W., Marchese,C., Balzinger,M.,
            Ramanathan,C., Schott,M., Rozov,S., Veleanu,M., Vestring,S.,
            Normann,C., Rantamaki,T., Antoine,B., Barrot,M., Challet,E.,
            Bourgin,P. and Serchov,T.
  TITLE     Prefrontal cortex molecular clock modulates development of
            depression-like phenotype and rapid antidepressant response in mice
  JOURNAL   Nat Commun 15 (1), 7257 (2024)
   PUBMED   39179578
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2782)
  AUTHORS   Park,I., Choi,M., Kim,J., Jang,S., Kim,D., Kim,J., Choe,Y.,
            Geum,D., Yu,S.W., Choi,J.W., Moon,C., Choe,H.K., Son,G.H. and
            Kim,K.
  TITLE     Role of the circadian nuclear receptor REV-ERBalpha in dorsal raphe
            serotonin synthesis in mood regulation
  JOURNAL   Commun Biol 7 (1), 998 (2024)
   PUBMED   39147805
  REMARK    GeneRIF: Role of the circadian nuclear receptor REV-ERBalpha in
            dorsal raphe serotonin synthesis in mood regulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2782)
  AUTHORS   Kumar,S., Arora,R., Gupta,S., Ahuja,N., Bhagyaraj,E., Nanduri,R.,
            Kalra,R., Khare,A.K., Kumawat,S., Kaushal,V., Sharma,M. and
            Gupta,P.
  TITLE     Nuclear receptor Rev-erbalpha role in fine-tuning erythropoietin
            gene expression
  JOURNAL   Blood Adv 8 (14), 3705-3717 (2024)
   PUBMED   38748870
  REMARK    GeneRIF: Nuclear receptor Rev-erbalpha role in fine-tuning
            erythropoietin gene expression.
REFERENCE   4  (bases 1 to 2782)
  AUTHORS   Carvalho Cabral,P., Weinerman,J., Olivier,M. and Cermakian,N.
  TITLE     Time of day and circadian disruption influence host response and
            parasite growth in a mouse model of cerebral malaria
  JOURNAL   iScience 27 (5), 109684 (2024)
   PUBMED   38680656
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2782)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2782)
  AUTHORS   Curtis,A.M., Seo,S.B., Westgate,E.J., Rudic,R.D., Smyth,E.M.,
            Chakravarti,D., FitzGerald,G.A. and McNamara,P.
  TITLE     Histone acetyltransferase-dependent chromatin remodeling and the
            vascular clock
  JOURNAL   J Biol Chem 279 (8), 7091-7097 (2004)
   PUBMED   14645221
REFERENCE   7  (bases 1 to 2782)
  AUTHORS   Preitner,N., Damiola,F., Lopez-Molina,L., Zakany,J., Duboule,D.,
            Albrecht,U. and Schibler,U.
  TITLE     The orphan nuclear receptor REV-ERBalpha controls circadian
            transcription within the positive limb of the mammalian circadian
            oscillator
  JOURNAL   Cell 110 (2), 251-260 (2002)
   PUBMED   12150932
REFERENCE   8  (bases 1 to 2782)
  AUTHORS   Chomez,P., Neveu,I., Mansen,A., Kiesler,E., Larsson,L.,
            Vennstrom,B. and Arenas,E.
  TITLE     Increased cell death and delayed development in the cerebellum of
            mice lacking the rev-erbA(alpha) orphan receptor
  JOURNAL   Development 127 (7), 1489-1498 (2000)
   PUBMED   10704394
REFERENCE   9  (bases 1 to 2782)
  AUTHORS   Robyr,D., Wolffe,A.P. and Wahli,W.
  TITLE     Nuclear hormone receptor coregulators in action: diversity for
            shared tasks
  JOURNAL   Mol Endocrinol 14 (3), 329-347 (2000)
   PUBMED   10707952
  REMARK    Review article
REFERENCE   10 (bases 1 to 2782)
  AUTHORS   Forman,B.M., Chen,J., Blumberg,B., Kliewer,S.A., Henshaw,R.,
            Ong,E.S. and Evans,R.M.
  TITLE     Cross-talk among ROR alpha 1 and the Rev-erb family of orphan
            nuclear receptors
  JOURNAL   Mol Endocrinol 8 (9), 1253-1261 (1994)
   PUBMED   7838158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK155597.1 and CD776678.1.
            
            On Feb 7, 2014 this sequence version replaced NM_145434.3.
            
            Summary: This gene encodes a transcription factor that is a member
            of the nuclear receptor subfamily 1. The encoded protein is a
            ligand-sensitive transcription factor that negatively regulates the
            expression of core clock proteins. In particular this protein
            represses the circadian clock transcription factor aryl hydrocarbon
            receptor nuclear translocator-like protein 1 (Arntl). This protein
            may also be involved in regulating genes that function in
            metabolic, inflammatory and cardiovascular processes. [provided by
            RefSeq, Feb 2014].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008989.1, AK146430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2601              AK155597.1         2-2602
            2602-2782           CD776678.1         1-181               c
FEATURES             Location/Qualifiers
     source          1..2782
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.66 cM"
     gene            1..2782
                     /gene="Nr1d1"
                     /gene_synonym="A530070C09Rik"
                     /note="nuclear receptor subfamily 1, group D, member 1"
                     /db_xref="GeneID:217166"
                     /db_xref="MGI:MGI:2444210"
     exon            1..660
                     /gene="Nr1d1"
                     /gene_synonym="A530070C09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             630..2477
                     /gene="Nr1d1"
                     /gene_synonym="A530070C09Rik"
                     /note="Rev-ErbA-alpha protein; nuclear receptor protein;
                     rev-erb alpha; rev-erbA alpha; orphan nuclear receptor;
                     EAR-1; V-erbA-related protein 1; REV-ERBalpha"
                     /codon_start=1
                     /product="nuclear receptor subfamily 1 group D member 1"
                     /protein_id="NP_663409.2"
                     /db_xref="CCDS:CCDS25363.1"
                     /db_xref="GeneID:217166"
                     /db_xref="MGI:MGI:2444210"
                     /translation="MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDSSNGSFQSL
                     TQGCPTYFPPSPTGSLTQDPARSFGSAPPSLSDDSSPSSASSSSSSSSSSFYNGSPPG
                     SLQVAMEDSSRVSPSKGTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRS
                     IQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRML
                     AEMQSAMNLANNQLSSLCPLETSPTPHPTSGSMGPSPPPAPAPTPLVGFSQFPQQLTP
                     PRSPSPEPTMEDVISQVARAHREIFTYAHDKLGTSPGNFNANHASGSPSATTPHRWES
                     QGCPSAPNDNNLLAAQRHNEALNGLRQGPSSYPPTWPSGPTHHSCHQPNSNGHRLCPT
                     HVYSAPEGEAPANSLRQGNTKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVRE
                     VVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQE
                     LGAMGMGDLLNAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQET
                     LLRALRALVLKNRPSETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ"
     exon            661..1002
                     /gene="Nr1d1"
                     /gene_synonym="A530070C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1091
                     /gene="Nr1d1"
                     /gene_synonym="A530070C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1236
                     /gene="Nr1d1"
                     /gene_synonym="A530070C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1880
                     /gene="Nr1d1"
                     /gene_synonym="A530070C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2066
                     /gene="Nr1d1"
                     /gene_synonym="A530070C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2277
                     /gene="Nr1d1"
                     /gene_synonym="A530070C09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2765
                     /gene="Nr1d1"
                     /gene_synonym="A530070C09Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2765
                     /gene="Nr1d1"
                     /gene_synonym="A530070C09Rik"
                     /note="major polyA site"
ORIGIN      
        1 actggggcac gaggcgctcc ctggaatcac atggtacctg ctccagtgcc gcgtgcggcc
       61 cgggaaccct gggctgctgg cgcctgcgca gagccctctg tcccagggaa aggctcgggc
      121 aaaaggcggt tgagattggc agagtgaaat attactgctg aggaaacgta gcagggcaca
      181 cgtctctctt tgcgtcctgg tgcctcattt ctccatcacc tacttacttc ctggttgcag
      241 cttctcttcc tttgggactt ttgcacccgg agctccagat tcattaccct gcttcactgc
      301 ggagccttca ggagtggcat ccggtgcact gcagagaccc gactctcctt gctaccttat
      361 agccagaact gctgcaggct gattcttcac acacacactc tctgctcttc ccatgcaaat
      421 cagatctcag gtgcctcagc gtcctaccct tctggagggc tgcagtatag ccaccccaag
      481 accttactgc tcagtgcctg gaatcctgat tgcgaactgc ggggctcact cgtctccctc
      541 agccattgcc cagggggcga gagaggccat cacaacctcc agtttgtgtc aaggtccagt
      601 ttgaatgacc gctttcagct ggtgaagaca tgacgaccct ggactccaat aacaacacag
      661 gtggtgttat cacctacatt ggctctagtg gctcctcccc gagccggacc agcccggagt
      721 ccctctacag tgacagctcc aatggcagct tccagtccct gactcaaggt tgtcccacat
      781 acttcccacc atcacctact ggctccctca cccaggaccc tgcccgctct tttggcagtg
      841 cgccacccag tctcagtgat gatagctccc cttcttctgc atcatcgtca tcctcttcat
      901 cctcctcctc cttctataac gggagccccc caggaagtct acaagtggcc atggaagaca
      961 gcagccgagt gtcccccagc aagggcacaa gcaacattac caagctgaat ggcatggtgc
     1021 tactgtgtaa ggtgtgtggg gacgtggcct caggcttcca ctatggagtg cacgcctgtg
     1081 agggctgcaa gggctttttt cgccggagca tccaacagaa tatccagtac aaacggtgtc
     1141 tgaaaaacga aaactgctcc atcgttcgca tcaatcgcaa ccgctgccag cagtgtcgct
     1201 tcaagaagtg tctctccgtt ggcatgtcta gagatgctgt gcgttttggg cgcatcccca
     1261 agagagagaa gcaacggatg cttgccgaga tgcagagcgc catgaacttg gccaacaacc
     1321 aactgagcag cctgtgccct ctagagacct cacctactcc acatcccacc tctggctcca
     1381 tgggcccctc acctcctcct gcaccagccc ccacaccttt ggtgggcttc tctcagttcc
     1441 cacaacagct gacaccaccc aggtctccca gccctgagcc caccatggag gatgtgatat
     1501 cccaggtcgc ccgggcccat cgagaaatct tcacctatgc ccatgacaag ttaggcacct
     1561 cacctggtaa cttcaatgcc aatcatgcat caggtagccc ttcagctaca actccacacc
     1621 gctgggagag tcagggatgc ccgtctgccc ccaacgacaa caaccttttg gcggctcagc
     1681 gtcataatga agcgctgaat ggtctacgcc agggcccttc ctcctacccg cctacctggc
     1741 cttctggccc cacccaccac agctgccacc aacctaacag caatgggcac cgtctgtgcc
     1801 ccacccacgt atattcggcc ccagaagggg aggcacctgc caacagtcta cggcaaggca
     1861 acaccaagaa tgttctgctg gcatgtccca tgaacatgta tccccatgga cgcagcggcc
     1921 ggactgtgca ggagatctgg gaagacttct ctatgagctt cacgcctgcc gttcgggagg
     1981 tggtagagtt tgccaaacac atcccaggct tccgtgacct ttctcagcac gaccaggtga
     2041 ccctgcttaa ggctggcacc tttgaggtgc tgatggtgcg ctttgcatcg ttgttcaacg
     2101 tgaaggacca gacagtgatg ttcctgagcc gcacaaccta cagtctgcag gagctcggtg
     2161 ccatgggcat gggcgacctg ctcaatgcca tgtttgactt cagcgagaag ctcaactccc
     2221 tggcacttac cgaggaggag ctgggcctat tcaccgcggt ggtgcttgtc tctgcagacc
     2281 gctcgggaat ggagaattcc gcttcggtgg agcagctcca ggagacgctg ctgcgggctc
     2341 ttcgggctct ggtgctgaag aaccggccct cggagacttc ccgcttcacc aagctgctgc
     2401 tcaagctgcc ggacctgcgg accctgaaca acatgcattc cgagaagctg ctgtccttcc
     2461 gggtggacgc ccagtgaccc gcccggccgg ccttctgccg ctgccccctt gtacagaatc
     2521 gaactctgca cttctctctc ctttacgaga cgaaaaggaa aagcaaacca gaatcttatt
     2581 tatattgtta taaaatattc caagatgagc ctctggcccc ctgagccttc ttgtaaataa
     2641 ctcttccccc acccccaccg ccatgctccc atcctcccct atttaaacca ctcttgctct
     2701 ctccaccctc ctctggcccc tcgatttgtt ctgttcctgt ctcaaatcca atagttcaca
     2761 gctgaaaaaa aaaaaaaaaa aa
//
