LOCUS       NM_011850               1282 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus nuclear receptor subfamily 0, group B, member 2
            (Nr0b2), mRNA.
ACCESSION   NM_011850
VERSION     NM_011850.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1282)
  AUTHORS   Vidana Gamage,H.E., Shahoei,S.H., Wang,Y., Jacquin,E., Weisser,E.,
            Bautista,R.O., Henn,M.A., Schane,C.P., Nelczyk,A.T., Ma,L., Das
            Gupta,A., Bendre,S.V., Nguyen,T., Tiwari,S., Tjoanda,E.,
            Krawczynska,N., He,S., Albright,S.T., Farmer,R., Smith,A.J.,
            Fink,E.C., Chen,H., Sverdlov,M., Gann,P.H., Boidot,R., Vegran,F.,
            Fanning,S.W., Hergenrother,P.J., Apetoh,L. and Nelson,E.R.
  TITLE     NR0B2 re-educates myeloid immune cells to reduce regulatory T cell
            expansion and progression of breast and other solid tumors
  JOURNAL   Cancer Lett 597, 217042 (2024)
   PUBMED   38908543
REFERENCE   2  (bases 1 to 1282)
  AUTHORS   Hou,B., Hu,Y., Zhu,Y., Wang,X., Li,W., Tang,J., Jia,X., Wang,J.,
            Cong,Y., Quan,M., Yang,H., Zheng,H., Bao,Y., Chen,X.L., Wang,H.R.,
            Xu,B., Gascoigne,N.R.J. and Fu,G.
  TITLE     SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle
            Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific
            Nonredundant Functional Relay
  JOURNAL   J Immunol 212 (3), 397-409 (2024)
   PUBMED   38088801
  REMARK    GeneRIF: SHP-1 Regulates CD8+ T Cell Effector Function but Plays a
            Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific
            Nonredundant Functional Relay.
REFERENCE   3  (bases 1 to 1282)
  AUTHORS   Lambrecht,R., Delgado,M.E., Gloe,V., Schuetz,K., Plazzo,A.P.,
            Franke,B., San Phan,T., Fleming,J., Mayans,O. and Brunner,T.
  TITLE     Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation
            and TNF-induced cell death
  JOURNAL   Cell Rep 42 (12), 113513 (2023)
   PUBMED   38039134
REFERENCE   4  (bases 1 to 1282)
  AUTHORS   Mifflin,R., Park,J.E., Lee,M., Jena,P.K., Wan,Y.Y., Barton,H.A.,
            Aghayev,M., Kasumov,T., Lin,L., Wang,X., Novak,R., Li,F., Huang,H.,
            Shriver,L.P. and Lee,Y.K.
  TITLE     Microbial products linked to steatohepatitis are reduced by
            deletion of nuclear hormone receptor SHP in mice
  JOURNAL   J Lipid Res 64 (12), 100469 (2023)
   PUBMED   37922990
  REMARK    GeneRIF: Microbial products linked to steatohepatitis are reduced
            by deletion of nuclear hormone receptor SHP in mice.
REFERENCE   5  (bases 1 to 1282)
  AUTHORS   Lee,Y.K., Park,J.E., Lee,M., Mifflin,R., Xu,Y., Novak,R., Zhang,Y.
            and Hardwick,J.P.
  TITLE     Deletion of hepatic small heterodimer partner ameliorates
            development of nonalcoholic steatohepatitis in mice
  JOURNAL   J Lipid Res 64 (11), 100454 (2023)
   PUBMED   37827334
  REMARK    GeneRIF: Deletion of hepatic small heterodimer partner ameliorates
            development of nonalcoholic steatohepatitis in mice.
REFERENCE   6  (bases 1 to 1282)
  AUTHORS   Goodwin,B., Jones,S.A., Price,R.R., Watson,M.A., McKee,D.D.,
            Moore,L.B., Galardi,C., Wilson,J.G., Lewis,M.C., Roth,M.E.,
            Maloney,P.R., Willson,T.M. and Kliewer,S.A.
  TITLE     A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1
            represses bile acid biosynthesis
  JOURNAL   Mol Cell 6 (3), 517-526 (2000)
   PUBMED   11030332
REFERENCE   7  (bases 1 to 1282)
  AUTHORS   Carlyle,J.R., Martin,A., Mehra,A., Attisano,L., Tsui,F.W. and
            Zuniga-Pflucker,J.C.
  TITLE     Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function
  JOURNAL   J Immunol 162 (10), 5917-5923 (1999)
   PUBMED   10229828
REFERENCE   8  (bases 1 to 1282)
  AUTHORS   Kung,S.K., Su,R.C., Shannon,J. and Miller,R.G.
  TITLE     The NKR-P1B gene product is an inhibitory receptor on SJL/J NK
            cells
  JOURNAL   J Immunol 162 (10), 5876-5887 (1999)
   PUBMED   10229823
REFERENCE   9  (bases 1 to 1282)
  AUTHORS   Lee,H.K., Lee,Y.K., Park,S.H., Kim,Y.S., Park,S.H., Lee,J.W.,
            Kwon,H.B., Soh,J., Moore,D.D. and Choi,H.S.
  TITLE     Structure and expression of the orphan nuclear receptor SHP gene
  JOURNAL   J Biol Chem 273 (23), 14398-14402 (1998)
   PUBMED   9603951
REFERENCE   10 (bases 1 to 1282)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     An orphan nuclear hormone receptor that lacks a DNA binding domain
            and heterodimerizes with other receptors
  JOURNAL   Science 272 (5266), 1336-1339 (1996)
   PUBMED   8650544
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL627228.31, AK004930.1 and
            BG087125.2.
            
            On Aug 22, 2015 this sequence version replaced NM_011850.2.
            
            Summary: This gene encodes a member of the nuclear hormone receptor
            family of proteins. The encoded orphan receptor lacks a DNA binding
            domain but modulates gene expression by interacting with other
            hormone receptors to competitively inhibit binding of coactivators
            while also acting as a transcriptional corepressor. The encoded
            receptor may regulate bile acid synthesis and sexual maturation in
            males. Homozygous knockout mice exhibit accumulation of bile acids,
            reduced levels of low density lipoprotein cholesterol (LDL-C), and
            in male mice, earlier testicular maturation. [provided by RefSeq,
            Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019540.1, CB948852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL627228.31        129291-129294
            5-215               AK004930.1         2-212
            216-216             BG087125.2         199-199
            217-1131            AK004930.1         213-1127
            1132-1282           AL627228.31        132451-132601
FEATURES             Location/Qualifiers
     source          1..1282
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.25 cM"
     gene            1..1282
                     /gene="Nr0b2"
                     /gene_synonym="SHP; SHP-1; Shp1"
                     /note="nuclear receptor subfamily 0, group B, member 2"
                     /db_xref="GeneID:23957"
                     /db_xref="MGI:MGI:1346344"
     exon            1..590
                     /gene="Nr0b2"
                     /gene_synonym="SHP; SHP-1; Shp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..832
                     /gene="Nr0b2"
                     /gene_synonym="SHP; SHP-1; Shp1"
                     /note="orphan nuclear receptor SHP; small heterodimer
                     partner"
                     /codon_start=1
                     /product="nuclear receptor subfamily 0 group B member 2"
                     /protein_id="NP_035980.1"
                     /db_xref="CCDS:CCDS18751.1"
                     /db_xref="GeneID:23957"
                     /db_xref="MGI:MGI:1346344"
                     /translation="MSSGQSGVCPCQGSAGRPTILYALLSPSPRTRPVAPASHSHCLC
                     QQQRPVRLCAPHRTCREALDVLAKTVAFLRNLPSFCHLPHEDQRRLLECCWGPLFLLG
                     LAQDAVTFEVAEAPVPSILKKILLEEASSGTQGAQPSDRPQPSLAAVQWLQRCLESFW
                     SLELGPKEYAYLKGTILFNPDVPGLRASCHIAHLQQEAHWALCEVLEPWYPASQGRLA
                     RILLMASTLKNIPGTLLVDLFFRPIMGDVDITELLEDMLLLR"
     exon            591..1282
                     /gene="Nr0b2"
                     /gene_synonym="SHP; SHP-1; Shp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1111..1116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr0b2"
                     /gene_synonym="SHP; SHP-1; Shp1"
                     /note="hexamer: AATAAA"
     polyA_site      1132
                     /gene="Nr0b2"
                     /gene_synonym="SHP; SHP-1; Shp1"
                     /note="major polyA site"
ORIGIN      
        1 gagagagagg gccagatagc tgggaagaaa caggaacaag atactaacca tgagctccgg
       61 ccagtcaggg gtctgcccat gccagggctc tgcaggtcgt ccgactattc tgtatgcact
      121 tctgagcccc agccccagga ccaggcccgt tgcacctgca tctcacagcc actgcctgtg
      181 ccagcagcag cggcctgtgc gtctgtgtgc tccgcaccgc acctgcaggg aggccttgga
      241 tgtcctagcc aagacagtag ccttcctcag gaacctgccg tccttctgcc acctgcccca
      301 tgaggatcag cggcggctgc tagagtgctg ctggggccct ctcttcctgc tggggttggc
      361 ccaggatgct gtgaccttcg aggtggctga ggctccggtg cccagtatac ttaagaagat
      421 cctgctagag gaagccagca gcggtaccca gggtgcccag ccatcagacc ggccacaacc
      481 ctcactggct gcagttcagt ggctgcagcg ctgcctggag tctttctgga gccttgagct
      541 gggtcccaag gagtatgcgt acctgaaggg cacgatcctc ttcaacccag atgtgccagg
      601 cctccgtgcc tcctgccaca tcgcacacct gcaacaggag gctcactggg cactgtgtga
      661 agtcttggag ccctggtacc cagccagcca aggccgcctg gcccgaatcc tcctcatggc
      721 ctctaccctc aagaacattc caggcaccct tctggtagat ctcttcttcc gccctatcat
      781 gggagacgtt gacatcactg aactccttga agacatgctt ttgctgaggt gacccgtgga
      841 atggagtctg gtgcctccaa aggggagcct gaaaggcagc cctcaactcc cctggagctg
      901 ccctcagctc agccacaccc ctagctcgga cttccttgct ttggatacag tgtacactac
      961 taactgtcca gcaagccctt gatgactccc caaacctcca ggccaaaatg tctttccctg
     1021 cctgggtagg gatgggagca ggaagctgta ctttcaagcc agaatccctc ctgactttgt
     1081 acagaactaa attaagttat tgttttttgt aataaaacat atgacctcct gacactgtag
     1141 ttgcttgtgg aaaggaccaa ccaatctcca gggtgcacct tagtcttgct ggaggggact
     1201 catgggaaag actaactccc tgatggctta ggcagggatg ctgatacccg tgctggggat
     1261 taaggttcat tttgcaactg ac
//
