LOCUS       NM_007430               1811 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nuclear receptor subfamily 0, group B, member 1
            (Nr0b1), mRNA.
ACCESSION   NM_007430
VERSION     NM_007430.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1811)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1811)
  AUTHORS   Wang,J., Huang,Y., Zhang,C., Ruan,Y., Tian,Y., Wang,F., Xu,Y.,
            Yu,M., Wang,J., Cheng,Y., Liu,L., Yang,R., Wang,J., Yang,Y.,
            Xiong,J., Hu,Y., Jian,R., Ni,B., Wu,W. and Zhang,J.
  TITLE     Identification and Functional Evaluation of Alternative Splice
            Variants of Dax1 in Mouse Embryonic Stem Cells
  JOURNAL   Stem Cells Dev 32 (17-18), 554-564 (2023)
   PUBMED   37261981
  REMARK    GeneRIF: Identification and Functional Evaluation of Alternative
            Splice Variants of Dax1 in Mouse Embryonic Stem Cells.
REFERENCE   3  (bases 1 to 1811)
  AUTHORS   Ramos-Pittol,J.M., Fernandes-Freitas,I., Milona,A., Manchishi,S.M.,
            Rainbow,K., Lam,B.Y.H., Tadross,J.A., Beucher,A., Colledge,W.H.,
            Cebola,I., Murphy,K.G., Miguel-Aliaga,I., Yeo,G.S.H., Dhillo,W.S.
            and Owen,B.M.
  TITLE     Dax1 modulates ERalpha-dependent hypothalamic estrogen sensing in
            female mice
  JOURNAL   Nat Commun 14 (1), 3076 (2023)
   PUBMED   37248237
  REMARK    GeneRIF: Dax1 modulates ERalpha-dependent hypothalamic estrogen
            sensing in female mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1811)
  AUTHORS   Yun,H.J., Suh,Y.J., Kim,Y.B., Kang,E.J., Choi,J.H., Choi,Y.K.,
            Lee,I.B., Choi,D.H., Seo,Y.J., Noh,J.R., Choi,H.S., Kim,Y.H. and
            Lee,C.H.
  TITLE     Hepatocyte DAX1 Deletion Exacerbates Inflammatory Liver Injury by
            Inducing the Recruitment of CD4+ and CD8+ T Cells through NF-kappaB
            p65 Signaling Pathway in Mice
  JOURNAL   Int J Mol Sci 23 (22), 14009 (2022)
   PUBMED   36430486
  REMARK    GeneRIF: Hepatocyte DAX1 Deletion Exacerbates Inflammatory Liver
            Injury by Inducing the Recruitment of CD4[+] and CD8[+] T Cells
            through NF-kappaB p65 Signaling Pathway in Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1811)
  AUTHORS   Prokopuk,L., Jarred,E.G., Blucher,R.O., McLaughlin,E.A.,
            Stringer,J.M. and Western,P.S.
  TITLE     An essential role for Polycomb Repressive Complex 2 in the mouse
            ovary
  JOURNAL   Reproduction 163 (3), 167-182 (2022)
   PUBMED   35084365
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1811)
  AUTHORS   Mishra,L., Tully,R.E., Monga,S.P., Yu,P., Cai,T., Makalowski,W.,
            Mezey,E., Pavan,W.J. and Mishra,B.
  TITLE     Praja1, a novel gene encoding a RING-H2 motif in mouse development
  JOURNAL   Oncogene 15 (19), 2361-2368 (1997)
   PUBMED   9393880
REFERENCE   7  (bases 1 to 1811)
  AUTHORS   Guo,W., Lovell,R.S., Zhang,Y.H., Huang,B.L., Burris,T.P.,
            Craigen,W.J. and McCabe,E.R.
  TITLE     Ahch, the mouse homologue of DAX1: cloning, characterization and
            synteny with GyK, the glycerol kinase locus
  JOURNAL   Gene 178 (1-2), 31-34 (1996)
   PUBMED   8921887
REFERENCE   8  (bases 1 to 1811)
  AUTHORS   Ikeda,Y., Swain,A., Weber,T.J., Hentges,K.E., Zanaria,E., Lalli,E.,
            Tamai,K.T., Sassone-Corsi,P., Lovell-Badge,R., Camerino,G. and
            Parker,K.L.
  TITLE     Steroidogenic factor 1 and Dax-1 colocalize in multiple cell
            lineages: potential links in endocrine development
  JOURNAL   Mol Endocrinol 10 (10), 1261-1272 (1996)
   PUBMED   9121493
REFERENCE   9  (bases 1 to 1811)
  AUTHORS   Bae,D.S., Schaefer,M.L., Partan,B.W. and Muglia,L.
  TITLE     Characterization of the mouse DAX-1 gene reveals evolutionary
            conservation of a unique amino-terminal motif and widespread
            expression in mouse tissue
  JOURNAL   Endocrinology 137 (9), 3921-3927 (1996)
   PUBMED   8756567
REFERENCE   10 (bases 1 to 1811)
  AUTHORS   Swain,A., Zanaria,E., Hacker,A., Lovell-Badge,R. and Camerino,G.
  TITLE     Mouse Dax1 expression is consistent with a role in sex
            determination as well as in adrenal and hypothalamus function
  JOURNAL   Nat Genet 12 (4), 404-409 (1996)
   PUBMED   8630494
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK141239.1, AK133411.1 and
            BB404032.1.
            
            On May 5, 2015 this sequence version replaced NM_007430.4.
            
            Summary: This gene encodes an orphan nuclear receptor protein that
            plays a key role in differentiation of the gonads. This protein
            regulates steroidogenic factor 1 (Sf-1) in a dose-dependent manner,
            sometimes functioning as a repressor of SF-1 target genes, and
            sometimes functioning as a co-activator. Overexpression of this
            gene can cause feminization of the XY male gonads. This gene is
            also involved in the maintenance of embryonic stem cell
            pluripotancy. Mutations in the related gene in human cause
            congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
            [provided by RefSeq, May 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U41568.1, AK141239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-914               AK141239.1         2-915
            915-1792            AK133411.1         920-1797
            1793-1811           BB404032.1         280-298
FEATURES             Location/Qualifiers
     source          1..1811
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 39.67 cM"
     gene            1..1811
                     /gene="Nr0b1"
                     /gene_synonym="Ahc; Ahch; AHX; DAX-1; Dax1; mDax1-134;
                     mDax1-218; mDax1-225; mDax1-249; mDax1-292; mDax1-297;
                     mDax1-300; mDax1-308; mDax1-318; mDax1-329; mDax1-337;
                     mDax1-344; mDax1-38; mDax1-404; mDax1-472"
                     /note="nuclear receptor subfamily 0, group B, member 1"
                     /db_xref="GeneID:11614"
                     /db_xref="MGI:MGI:1352460"
     exon            1..1200
                     /gene="Nr0b1"
                     /gene_synonym="Ahc; Ahch; AHX; DAX-1; Dax1; mDax1-134;
                     mDax1-218; mDax1-225; mDax1-249; mDax1-292; mDax1-297;
                     mDax1-300; mDax1-308; mDax1-318; mDax1-329; mDax1-337;
                     mDax1-344; mDax1-38; mDax1-404; mDax1-472"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1445
                     /gene="Nr0b1"
                     /gene_synonym="Ahc; Ahch; AHX; DAX-1; Dax1; mDax1-134;
                     mDax1-218; mDax1-225; mDax1-249; mDax1-292; mDax1-297;
                     mDax1-300; mDax1-308; mDax1-318; mDax1-329; mDax1-337;
                     mDax1-344; mDax1-38; mDax1-404; mDax1-472"
                     /note="adrenal hypoplasia congenita-like protein; nuclear
                     receptor DAX-1; adrenal hypoplasia, congenital homolog;
                     mDax1- 190; mDax1- 202; mDax1- 278; mDax1- 331"
                     /codon_start=1
                     /product="nuclear receptor subfamily 0 group B member 1"
                     /protein_id="NP_031456.1"
                     /db_xref="CCDS:CCDS30260.1"
                     /db_xref="GeneID:11614"
                     /db_xref="MGI:MGI:1352460"
                     /translation="MAGEDHPWQGSILYNLLMSAKQKHASQEEREVRLGAQCWGCACG
                     AQPVLGGERLSGGQARSLLYRCCFCGENHPRQGGILYSMLTNARQPSVATQAPRARFG
                     APCWGCACGSAEPLVGREGLPAGQAPSLLYRCCFCGEEHPRQGSILYSLLTSAQQTHV
                     SREAPEAHRRGEWWQLSYCTQSVGGPEGLQSTQAMAFLYRSYVCGEEQPQQISVASGT
                     PVSADQTPATPQEQPRAPWWDASPGVQRLITLKDPQVVCEAASAGLLKTLRFVKYLPC
                     FQILPLDQQLVLVRSCWAPLLMLELAQDHLHFEMMEIPETNTTQEMLTTRRQETEGPE
                     PAEPQATEQPQMVSAEAGHLLPAAAVQAIKSFFFKCWSLNIDTKEYAYLKGTVLFNPD
                     LPGLQCVKYIEGLQWRTQQILTEHIRMMQREYQIRSAELNSALFLLRFINSDVVTELF
                     FRPIIGAVSMDDMMLEMLCAKL"
     exon            1201..1797
                     /gene="Nr0b1"
                     /gene_synonym="Ahc; Ahch; AHX; DAX-1; Dax1; mDax1-134;
                     mDax1-218; mDax1-225; mDax1-249; mDax1-292; mDax1-297;
                     mDax1-300; mDax1-308; mDax1-318; mDax1-329; mDax1-337;
                     mDax1-344; mDax1-38; mDax1-404; mDax1-472"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1770..1775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nr0b1"
                     /gene_synonym="Ahc; Ahch; AHX; DAX-1; Dax1; mDax1-134;
                     mDax1-218; mDax1-225; mDax1-249; mDax1-292; mDax1-297;
                     mDax1-300; mDax1-308; mDax1-318; mDax1-329; mDax1-337;
                     mDax1-344; mDax1-38; mDax1-404; mDax1-472"
                     /note="hexamer: AATAAA"
     polyA_site      1797
                     /gene="Nr0b1"
                     /gene_synonym="Ahc; Ahch; AHX; DAX-1; Dax1; mDax1-134;
                     mDax1-218; mDax1-225; mDax1-249; mDax1-292; mDax1-297;
                     mDax1-300; mDax1-308; mDax1-318; mDax1-329; mDax1-337;
                     mDax1-344; mDax1-38; mDax1-404; mDax1-472"
                     /note="major polyA site"
ORIGIN      
        1 agaacgagct acaggagcct caggccatgg cgggtgagga ccacccgtgg cagggcagca
       61 tcctctacaa tctactgatg agcgcgaagc agaagcacgc gtctcaggaa gagcgagagg
      121 tgcgcttggg ggctcagtgc tggggttgcg cctgcggtgc tcagcccgtc ctgggtgggg
      181 agagactgtc cggcgggcaa gccaggtccc tcttgtaccg ctgctgcttt tgtggggaga
      241 atcacccgcg ccagggtggc atcctctact ctatgctcac caacgccagg cagccaagcg
      301 tggcgaccca ggcgccgagg gcacgattcg gagcaccttg ctggggctgc gcctgcggca
      361 gcgcagagcc cctggtgggc agagaggggc tgccggctgg ccaggccccc tcgctcctgt
      421 accgctgctg cttctgcgga gaagagcacc cgaggcaggg cagcatctta tacagcttgc
      481 tcactagcgc tcagcaaacg cacgtgtctc gggaagcacc cgaggcacat cgcagaggcg
      541 agtggtggca gctgtcctac tgtacccaga gtgtgggtgg cccagagggg ctgcagagca
      601 cacaggccat ggcgttcctg taccgcagct atgtgtgcgg tgaagagcag ccccagcaga
      661 tcagcgttgc ctctggcacg cccgtgagcg cagaccaaac accagcgacc ccgcaagagc
      721 agccgagggc tccctggtgg gacgcctcac ctggtgtgca gcgtctgatc acactcaagg
      781 atccacaggt ggtgtgcgag gcagcgtccg ctggcctgtt gaagaccctg cgctttgtca
      841 agtacttgcc ctgcttccag atcctgcccc tagatcagca gctggtgctg gtgcggagct
      901 gttgggcgcc cctactcatg cttgagttgg cccaagatca cctgcacttc gagatgatgg
      961 agatcccgga gaccaacacg acgcaggaaa tgcttaccac caggcggcag gagaccgaag
     1021 gtccagagcc tgcagagccc caggccacag agcagccaca gatggtgtcc gcggaggctg
     1081 ggcacttgct cccagctgct gcggtccagg ccatcaagag tttctttttc aagtgctgga
     1141 gtctgaacat tgacaccaaa gagtatgcct atctgaaagg gaccgtgctc tttaacccag
     1201 acctgcctgg cctgcagtgc gtgaaataca ttgagggtct tcagtggaga acccagcaga
     1261 tccttactga gcacatccgg atgatgcaga gagagtacca gatcagatcc gctgaactga
     1321 acagtgccct tttcctgctg agattcatca atagcgatgt cgtcactgaa ctctttttca
     1381 ggcccatcat tggtgcagtc agcatggatg atatgatgct ggagatgctc tgtgcaaagc
     1441 tgtgaaggca tatgtccact caagtgcatt ttactataga tggagaaagc ggtcgtagct
     1501 gtaggcagaa gagtgctaaa atttgtgaaa ccaaactttc ttgtattttt acatgcatag
     1561 tatatttgta ttcaattgaa gaaatacttt agttacaatg taaaaatccc tctgctccat
     1621 actggcttct tgtgaaggaa agcatttgca aacaaatcac tatttctgta tatctctaag
     1681 agtgtggtac taggctaaca agctaatttc ataaaaataa catctctttc cattaacccc
     1741 gccaaataaa atttataata ttaactttta ataaaattta aggtactaac cgttaaaaaa
     1801 aaaaaaaaaa a
//
